mefloquine has been researched along with ketoconazole in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
| Avery, VM; Sykes, ML | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF | 1 |
| Back, DJ; Bangchang, KN; Karbwang, J | 1 |
| Coulaud, JP; Ngo Van, P | 1 |
| Mahatthanatrakul, W; Raungsri, N; Ridtitid, W; Sunbhanich, M; Wongnawa, M | 1 |
| Awasthi, A; Dutta, GP; Tripathi, R | 1 |
| Boonprasert, K; Chaijaroenkul, W; Na-Bangchang, K; Sangsuwan, P; Tantisawat, J; Wisedpanichkij, R | 1 |
| Dwivedi, H; Pandey, SK; Rizvi, A; Saxena, JK; Tripathi, R | 1 |
| Cleary, Y; Johnson, TN; Parrott, N; Reigner, B; Smith, JR; Toovey, S | 1 |
3 review(s) available for mefloquine and ketoconazole
| Article | Year |
|---|---|
Approaches to protozoan drug discovery: phenotypic screening.
Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells | 2022 |
1 trial(s) available for mefloquine and ketoconazole
| Article | Year |
|---|---|
Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers.
Topics: Adolescent; Adult; Antifungal Agents; Antimalarials; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Half-Life; Humans; Ketoconazole; Male; Mefloquine | 2005 |
7 other study(ies) available for mefloquine and ketoconazole
| Article | Year |
|---|---|
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
Mefloquine metabolism by human liver microsomes. Effect of other antimalarial drugs.
Topics: Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Humans; Ketoconazole; Kinetics; Mefloquine; Microsomes, Liver; Primaquine; Quinine | 1992 |
[New antiparasitic drugs].
Topics: Amebicides; Anthelmintics; Antifungal Agents; Antimalarials; Artemisinins; Fluconazole; Humans; Itraconazole; Ketoconazole; Mefloquine; Phenanthrenes; Quinolines; Sesquiterpenes; Triazoles | 1988 |
Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria.
Topics: Animals; Antimalarials; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Enzyme Inhibitors; Ketoconazole; Macaca mulatta; Malaria; Mefloquine; Plasmodium knowlesi | 2005 |
In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors.
Topics: Animals; Antimalarials; Cytochrome P-450 Enzyme Inhibitors; Drug Synergism; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Mefloquine; Plasmodium falciparum; Quinidine | 2009 |
Ketoconazole, a cytochrome P(450) inhibitor can potentiate the antimalarial action of α/β arteether against MDR Plasmodium yoelii nigeriensis.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance, Multiple; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Liver; Malaria; Male; Mefloquine; Mice; Plasmodium falciparum; Plasmodium yoelii; Quinine | 2013 |
Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.
Topics: Adult; Age Factors; Antimalarials; Child; Child, Preschool; Drug Dosage Calculations; Drug Interactions; Female; Humans; Infant; Ketoconazole; Malaria; Mefloquine; Middle Aged; Models, Biological; Rifampin; Treatment Outcome; White People; Young Adult | 2019 |