Compounds > mefloquine
Page last updated: 2024-08-23

mefloquine and desethylamodiaquine

mefloquine has been researched along with desethylamodiaquine in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's0 (0.00)18.2507
2000's4 (23.53)29.6817
2010's9 (52.94)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Arimondo, PB; Bon, C; Cadet-Daniel, V; Claes, A; Dobrescu, I; Erdmann, D; Halby, L; Hammam, E; Mairet-Khedim, M; Mecheri, S; Nardella, F; Peronet, R; Roesch, C; Scherf, A; Tafit, A; Viluma, J; Witkowski, B1
Agnamey, P; Azas, N; Cohen, A; Damiani, C; Dassonville-Klimpt, A; Dormoi, J; Guillon, J; Marchivie, M; Mullié, C; Pradines, B; Schneider, J; Sonnet, P; Taudon, N; Tisnerat, C; Totet, A1
Boudreau, EF; Childs, GE; Davidson, DE; Milhous, WK; Pang, L; Pooyindee, N; Wimonwattratee, T1
Biaud, JM; Calmel, MB; Clausse, JL; Deloron, P; Hatin, I; Le Bras, J; Marchais, H; Porte, J; Ramanamirija, JA; Simon, F1
Andrianantenaina, HB; Ariey, F; Domarle, O; Randrianarivelojosia, M; Rason, MA; Raveloson, A1
Stepniewska, K; White, NJ1
Arango, E; Cravo, P; Do Rosário, VE; Maestre, A; Restrepo-Pineda, E1
Amalvict, R; Baret, E; Briolant, S; Fontaine, A; Fraisse, L; Fusaï, T; Henry, M; Mosnier, J; Pradines, B; Rogier, C1
Almeras, L; Amalvict, R; Baret, E; Briolant, S; Gil, M; Henry, M; Parquet, V; Pradines, B; Rogier, C; Wurtz, N1
Assi, SB; Basco, LK; Bla, KB; Djaman, AJ; Koné, M; Mazabraud, A; Yavo, W1
Amalvict, R; Baret, E; Briolant, S; Charras, S; Feraud, M; Henry, M; Huyghues des Etages, E; Pascual, A; Pradines, B; Rogier, C1
Anvikar, AR; Bhatt, RM; Dash, AP; Ghosh, SK; Kumar, A; Mohanty, SS; Pillai, CR; Sharma, B; Sharma, SK; Valecha, N1
Cooksey, R; Dahlström, S; Fairhurst, RM; Flegg, JA; Guerin, PJ; Johnson, JD; Le Bras, J; Le Nagard, H; Lim, P; Ménard, D; Mentré, F; Murillo, C; Musset, L; Noedl, H; Nosten, F; Nsobya, SL; Pradines, B; Quashie, NB; Sibley, CH; Sinou, V; Sriprawat, K; Woodrow, CJ1
Aubouy, A; Dahlström, S; Deloron, P; Ezinmègnon, S; Faucher, JF; Houzé, P; Houzé, S; Kendjo, E; Le Bras, J; Maïga-Ascofaré, O; Massougbodji, A; Wakpo, A1
Baret, E; Bercion, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, KB; Fall, M; Mbaye, PS; Nakoulima, A; Pascual, A; Pradines, B; Wade, B; Wurtz, N1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Byaruhanga, O; Ceja, FG; Conrad, MD; Cooper, RA; Katairo, T; Nsobya, SL; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK1

Trials

1 trial(s) available for mefloquine and desethylamodiaquine

ArticleYear
Changing Antimalarial Drug Sensitivities in Uganda.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethanolamines; Female; Fluorenes; Gene Expression; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Uganda; Young Adult

2017

Other Studies

16 other study(ies) available for mefloquine and desethylamodiaquine

ArticleYear
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
    Journal of medicinal chemistry, 2021, 07-22, Volume: 64, Issue:14

    Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hydroxamic Acids; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Procainamide; Structure-Activity Relationship

2021
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
    European journal of medicinal chemistry, 2022, Jan-15, Volume: 228

    Topics: Amino Alcohols; Animals; Antimalarials; Cell Line; Cricetulus; Dose-Response Relationship, Drug; Drug Design; Ether-A-Go-Go Potassium Channels; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Structure-Activity Relationship

2022
A comparison of the in vitro activities of amodiaquine and desethylamodiaquine against isolates of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1989, Volume: 40, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Plasmodium falciparum; Quinolines; Thailand

1989
[Sensitivity of Plasmodium falciparum to quinolines and therapeutic strategies: comparison of the situation in Africa and Madagascar between 1983 and 1986].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Amodiaquine; Angola; Animals; Antimalarials; Burkina Faso; Cameroon; Chloroquine; Drug Resistance; Humans; Madagascar; Malaria; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

1987
Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.
    The American journal of tropical medicine and hygiene, 2007, Volume: 76, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Humans; Inhibitory Concentration 50; Madagascar; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Protozoan Proteins; Quinine; Rural Population

2007
Pharmacokinetic determinants of the window of selection for antimalarial drug resistance.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Algorithms; Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Drug Resistance; Malaria; Mefloquine; Models, Theoretical; Pyrimethamine; Quinine

2008
Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.
    Parasitology, 2008, Volume: 135, Issue:5

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Colombia; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Protozoan Proteins

2008
In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:8

    Topics: Aminoquinolines; Amodiaquine; Animals; Chloroquine; Drug Resistance, Bacterial; Ferrous Compounds; Mefloquine; Membrane Transport Proteins; Metallocenes; Microsatellite Repeats; Molecular Structure; Plasmodium falciparum; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines

2008
Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:7

    Topics: Amodiaquine; Antimalarials; Atorvastatin; Chloroquine; DNA, Protozoan; Drug Synergism; Gene Dosage; Genotype; Heptanoic Acids; Humans; Inhibitory Concentration 50; Mefloquine; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrroles

2010
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
    African health sciences, 2010, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Young Adult

2010
In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5

    Topics: Amodiaquine; Antimalarials; Chloroquine; Ethanolamines; Fluorenes; Inhibitory Concentration 50; Lumefantrine; Mefloquine; Methylene Blue; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine

2011
In vitro assessment of drug resistance in Plasmodium falciparum in five States of India.
    The Indian journal of medical research, 2012, Volume: 135, Issue:4

    Topics: Amodiaquine; Artemisinins; Artesunate; Biomarkers, Pharmacological; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; India; Mefloquine; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Protozoan Proteins

2012
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemisinins; Automation, Laboratory; Chloroquine; Drug Resistance; Drug Therapy, Combination; High-Throughput Screening Assays; Internet; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine

2013
Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1

    Topics: Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Inhibitory Concentration 50; Lumefantrine; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Pyrimethamine; Quinine; Sulfadoxine

2014
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:12

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Biological Transport; Child; Chloroquine; Drug Resistance; Erythrocytes; Ethanolamines; Female; Fluorenes; Gene Expression; Haplotypes; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Quinine; Senegal

2014
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017