medetomidine has been researched along with l 659066 in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 19 (61.29) | 24.3611 |
| 2020's | 8 (25.81) | 2.80 |
| Authors | Studies |
|---|---|
| Devcic, A; Farber, NE; Hettrick, DA; Kersten, JR; Pagel, PS; Proctor, LT; Schmeling, WT; Tessmer, JP; Warltier, DC | 1 |
| Guo, TZ; Kingery, WS; Maze, M; Poree, LR | 1 |
| Alila-Johansson, A; Hätönen, T; Laakso, M; Mustanoja, SM | 1 |
| Enouri, SS; Kerr, CL; McDonell, WN; Neto, FJ; O'Sullivan, ML | 1 |
| Kerr, CL; McDonell, WN; Rolfe, NG | 1 |
| Junnila, J; Raekallio, M; Restitutti, F; Salla, K; Snellman, M; Vainio, O; Vainionpää, M | 1 |
| Bennett, RC; Junnila, J; Raekallio, M; Restitutti, F; Salla, K; Vainio, O | 1 |
| Honkavaara, J; Junnila, J; Kuusela, E; Raekallio, M; Restitutti, F; Salla, K; Vainio, O; Vainionpää, M | 1 |
| del Castillo, JR; Kaartinen, J; Raekallio, MR; Salla, K; Troncy, E; Vainio, OM | 1 |
| Bastman, S; Chrusciel, P; Ranta-Panula, V; Ruohonen, ST; Scheinin, M; Streng, T | 1 |
| Bennett, RC; Hokkanen, J; Raekallio, MR; Vainio, OM | 1 |
| Bennett, RC; Hänninen, L; Raekallio, MR; Rinne, VM; Salla, KM; Scheinin, M; Vainio, OM | 1 |
| Del Castillo, JRE; Kaartinen, MJ; Mikkola, E; Raekallio, MR; Restitutti, F; Scheinin, M; Vainio, OM; Wejberg, O | 1 |
| Bennett, RC; Raekallio, MR; Salla, KM; Scheinin, M; Vainio, OM | 1 |
| Bennett, RC; Kuusela, E; Raekallio, MR; Salla, KM; Scheinin, M; Tuns, CI; Vainio, OM | 1 |
| Adam, M; Honkavaara, JM; Kajula, M; Keskitalo, T; Mölsä, S; Raekallio, MR; Scheinin, M; Vainio, OM | 1 |
| Bennett, RC; Hautajärvi, H; Honkavaara, J; Kallio-Kujala, IJ; Raekallio, MR; Scheinin, M; Turunen, H; Vainio, O | 1 |
| Adam, M; Raekallio, MR; Vainio, OM | 1 |
| Bennett, RC; Männikkö, S; Mykkänen, A; Raekallio, MR; Scheinin, M; Tapio, H; Vainio, O | 1 |
| Adam, M; Jantunen, N; Mykkänen, A; Raekallio, M; Sainmaa, S; Vainio, O | 1 |
| Al-Ramahi, D; Hautajärvi, HJ; Männikkö, S; Mykkänen, AK; Raekallio, MR; Scheinin, M; Tapio, HA; Vainio, O | 1 |
| Hanifeh, M; Junnila, J; Määttä, M; Mykkänen, A; Raekallio, M; Rajamäki, MM; Rossi, H; Tapio, H | 1 |
| Adam, M; Hautajärvi, HJ; Honkavaara, JM; Kallio-Kujala, IJ; Larenza Menzies, P; Männikkö, SK; Nevanperä, K; Raekallio, MR; Restitutti, F; Scheinin, M; Turunen, H; Vainio, OM | 1 |
| Honkavaara, JM; Kallio-Kujala, IJ; Knych, HK; Pypendop, BH; Raekallio, MR; Syrja, PM; Vainio, OM | 1 |
| Auer, U; Einwaller, J; Gasch, K; Painer, J; Raekallio, M; Restitutti, F; Stalder, GL | 1 |
| Bennett, R; Hautajärvi, H; Honkavaara, J; Jaakkola, J; Männikkö, S; Raekallio, M; Scheinin, M; Turunen, H; Vainio, O | 1 |
| Bertelsen, MF; Greunz, EM; Grøndahl, C; Limón, D; Petersen, RL; Raekallio, MR | 1 |
| Auer, U; Einwaller, J; Haw, A; Meyer, LCR; Nowack, J; Painer, J; Raekallio, M; Stalder, G; Vetter, S | 1 |
| Hartnack, S; Joerger, FB; Kutter, AP; Niemann, L; Steblaj, B; Wieser, ML | 1 |
| Björkenheim, P; Casoni, DC; Kallio-Kujala, IJ; Lepajoe, J; Pekkola, V; Raekallio, MR; Salla, KM; Turunen, HA; Vainio, O | 1 |
| Joerger, FB; Kutter, AP; Niemann, L; Steblaj, B; Turunen, H; Wieser, ML | 1 |
19 trial(s) available for medetomidine and l 659066
| Article | Year |
|---|---|
Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Blood Gas Analysis; Cross-Over Studies; Dogs; Drug Therapy, Combination; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Injections, Intramuscular; Injections, Intravenous; Male; Medetomidine; Quinolizines | 2012 |
Thermographic imaging of superficial temperature in dogs sedated with medetomidine and butorphanol with and without MK-467 (L-659'066).
Topics: Analgesics, Opioid; Animals; Body Temperature; Butorphanol; Cross-Over Studies; Dogs; Female; Foot; Hypnotics and Sedatives; Male; Medetomidine; Quinolizines; Time Factors | 2013 |
A comparison in dogs of medetomidine, with or without MK-467, and the combination acepromazine-butorphanol as premedication prior to anaesthesia induced by propofol and maintained with isoflurane.
Topics: Acepromazine; Anesthesia; Animals; Blood Pressure; Butorphanol; Cross-Over Studies; Dogs; Drug Therapy, Combination; Female; Isoflurane; Male; Medetomidine; Oxygen; Propofol; Quinolizines | 2014 |
The cardiopulmonary effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in dogs sedated with a combination of medetomidine and butorphanol.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Butorphanol; Cardiac Output; Cross-Over Studies; Dogs; Female; Heart; Heart Rate; Hypnotics and Sedatives; Injections, Intramuscular; Injections, Intravenous; Lung; Male; Medetomidine; Quinolizines; Respiratory Rate; Vascular Resistance | 2014 |
Haemodynamic interactions of medetomidine and the peripheral alpha-2 antagonist MK-467 during step infusions in isoflurane-anaesthetised dogs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Inhalation; Animals; Cross-Over Studies; Dogs; Drug Combinations; Female; Hemodynamics; Infusions, Intravenous; Isoflurane; Male; Medetomidine; Quinolizines | 2014 |
Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Cardiac Output; Cross-Over Studies; Dogs; Female; Heart Rate; Hypnotics and Sedatives; Injections, Intramuscular; Male; Medetomidine; Prospective Studies; Quinolizines | 2017 |
Effects of the α
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Cross-Over Studies; Dogs; Female; Infusions, Intravenous; Male; Medetomidine; Pregnanediones; Quinolizines; Receptors, Adrenergic | 2017 |
Cardiovascular effects of premedication with medetomidine alone and in combination with MK-467 or glycopyrrolate in dogs subsequently anesthetized with isoflurane.
Topics: Adjuvants, Anesthesia; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Cross-Over Studies; Dexmedetomidine; Dogs; Female; Glycopyrrolate; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Isoflurane; Ketamine; Male; Medetomidine; Premedication; Quinolizines | 2017 |
The impact of MK-467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Body Temperature; Conscious Sedation; Cross-Over Studies; Drug Interactions; Female; Hemoglobins; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Medetomidine; Oxygen; Prospective Studies; Quinolizines; Respiration; Sheep; Visual Analog Scale | 2018 |
Peripheral α
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Butorphanol; Chromatography, High Pressure Liquid; Cross-Over Studies; Deep Sedation; Dogs; Drug Combinations; Drug Interactions; Female; Heart Rate; Hypnotics and Sedatives; Injections, Intramuscular; Male; Medetomidine; Midazolam; Quinolizines; Tandem Mass Spectrometry | 2018 |
Sedative effect of intramuscular medetomidine with and without vatinoxan (MK-467), and its reversal with atipamezole in sheep.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cross-Over Studies; Drug Interactions; Female; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Medetomidine; Quinolizines; Sheep; Single-Blind Method | 2018 |
Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant-rate medetomidine infusion in standing horses.
Topics: Animals; Area Under Curve; Cross-Over Studies; Female; Gastrointestinal Motility; Half-Life; Heart Rate; Horses; Hypnotics and Sedatives; Male; Medetomidine; Quinolizines; Respiration; Vascular Resistance | 2019 |
INTRAVENOUS VATINOXAN IN MARKHORS (
Topics: Administration, Intravenous; Adrenergic alpha-Antagonists; Animals; Cardiovascular Physiological Phenomena; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Goats; Hypnotics and Sedatives; Immobilization; Ketamine; Male; Medetomidine; Quinolizines; Random Allocation; Respiratory Physiological Phenomena | 2019 |
Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Cardiac Output; Cardiovascular System; Cross-Over Studies; Dexmedetomidine; Dogs; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Quinolizines; Random Allocation; Single-Blind Method | 2019 |
Cardiovascular effects of intravenous vatinoxan (MK-467) in medetomidine-tiletamine-zolazepam anaesthetised red deer (Cervus elaphus).
Topics: Anesthetics, Combined; Anesthetics, Intravenous; Animals; Bradycardia; Cardiovascular System; Cross-Over Studies; Deer; Drug Interactions; Female; Hypertension; Male; Medetomidine; Quinolizines; Tiletamine; Zolazepam | 2020 |
Effects of intramuscular vatinoxan (MK-467), co-administered with medetomidine and butorphanol, on cardiopulmonary and anaesthetic effects of intravenous ketamine in dogs.
Topics: Analgesics, Opioid; Anesthesia; Animals; Blood Pressure; Butorphanol; Cross-Over Studies; Dogs; Female; Heart Rate; Hypnotics and Sedatives; Male; Medetomidine; Quinolizines; Vascular Resistance | 2020 |
Cardiovascular effects of intravenous vatinoxan in wild boars (Sus scrofa) anaesthetised with intramuscular medetomidine-tiletamine-zolazepam.
Topics: Animals; Cross-Over Studies; Heart Rate; Hypnotics and Sedatives; Medetomidine; Quinolizines; Sus scrofa; Swine; Tiletamine; Zolazepam | 2022 |
Effects of vatinoxan in dogs premedicated with medetomidine and butorphanol followed by sevoflurane anaesthesia: a randomized clinical study.
Topics: Anesthesia; Animals; Butorphanol; Carbon Dioxide; Dogs; Heart Rate; Hypnotics and Sedatives; Medetomidine; Sevoflurane | 2022 |
Evaluation of cardiovascular effects of intramuscular medetomidine and a medetomidine-vatinoxan combination in Beagle dogs: A randomized blinded crossover laboratory study.
Topics: Animals; Arteries; Cross-Over Studies; Dogs; Heart; Medetomidine | 2023 |
12 other study(ies) available for medetomidine and l 659066
| Article | Year |
|---|---|
A novel alpha 2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Cardiac Output; Consciousness; Coronary Circulation; Coronary Vessels; Dogs; Drug Interactions; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Medetomidine; Prospective Studies; Quinolizines; Random Allocation; Time Factors; Vascular Resistance; Vasoconstrictor Agents; Ventricular Function, Left; Ventricular Pressure | 1998 |
The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Male; Medetomidine; Pain; Pain Threshold; Quinolizines; Rats; Rats, Sprague-Dawley; Spinal Nerves | 1998 |
Evidence for central alpha(2)-adrenergic modulation of rat pineal melatonin synthesis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Circadian Rhythm; Clonidine; Male; Medetomidine; Melatonin; Pineal Gland; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine | 2000 |
Effects of a peripheral alpha2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs.
Topics: Adrenergic Antagonists; Analgesics, Non-Narcotic; Animals; Blood Pressure; Cardiac Output; Cross-Over Studies; Dogs; Drug Interactions; Glycopyrrolate; Heart Rate; Male; Medetomidine; Muscarinic Antagonists; Quinolizines; Random Allocation; Respiration; Vascular Resistance | 2008 |
Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Arterial Pressure; Biomarkers; Blood Glucose; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Glyburide; Heart Rate; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Medetomidine; Mice, Inbred C57BL; Quinolizines; Telemetry; Time Factors | 2015 |
The impact of medetomidine on the protein-binding characteristics of MK-467 in canine plasma.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dogs; Drug Interactions; Male; Medetomidine; Orosomucoid; Protein Binding; Quinolizines; Serum Albumin | 2016 |
Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs.
Topics: Analgesics; Animals; Dogs; Drug Interactions; Electroencephalography; Female; Hypnotics and Sedatives; Male; Medetomidine; Pain Measurement; Quinolizines | 2016 |
Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cross-Over Studies; Female; Gastrointestinal Motility; Heart Rate; Horses; Hypnotics and Sedatives; Isoflurane; Male; Medetomidine; Quinolizines | 2019 |
Effects of general anaesthesia in dorsal recumbency with and without vatinoxan on bronchoalveolar lavage cytology of healthy horses.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Cross-Over Studies; Horses; Hypnotics and Sedatives; Inflammation; Isoflurane; Medetomidine; Posture; Quinolizines; Serum Amyloid A Protein | 2019 |
Concentrations of medetomidine enantiomers and vatinoxan, an α
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Brain; Dogs; Drug Therapy, Combination; Female; Hypnotics and Sedatives; Infusions, Intravenous; Male; Medetomidine; Nerve Tissue; Quinolizines | 2020 |
The impact of vatinoxan on medetomidine-ketamine-midazolam immobilization in Patagonian maras (Dolichotis patagonum).
Topics: Animals; Cross-Over Studies; Heart Rate; Hypnotics and Sedatives; Immobilization; Ketamine; Medetomidine; Midazolam; Quinolizines | 2021 |
The impact of vatinoxan on microcirculation after intramuscular co-administration with medetomidine in Beagle dogs: a blinded crossover study.
Topics: Animals; Cross-Over Studies; Dogs; Medetomidine; Microcirculation; Quinolizines | 2022 |