medetomidine has been researched along with idazoxan in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 18 (72.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisher, B; Peterson, BM; Yaksh, TL; Zornow, MH | 1 |
| Chhajlani, V; Uhlén, S; Wikberg, JE | 1 |
| Ogidigben, MJ; Potter, DE | 1 |
| Zornow, MH | 1 |
| Furst, SR; Weinger, MB | 1 |
| Drummond, JC; Fleischer, JE; Nakakimura, K; Scheller, MS; Zornow, MH | 1 |
| Durcan, MJ; Linnoila, M; Lister, RG | 1 |
| Aslanian, V; Renaud, B | 1 |
| Chen, BX; Doze, VA; Maze, M | 1 |
| Maze, M; Segal, IS; Weinger, MB | 1 |
| Doze, VA; Maze, M; Segal, IS; Vickery, RG; Walton, JK | 1 |
| Scheinin, H | 1 |
| Hayashi, Y; Kamibayashi, T; Mammoto, T; Sasaki, S; Takada, K; Yamatodani, A; Yoshiya, I | 1 |
| Durcan, MJ; Linnoila, M; Morgan, PF; Van Etten, ML | 1 |
| Dickenson, AH; Stanfa, LC | 1 |
| Butelman, ER; Woods, JH | 1 |
| Detweiler, DJ; Eisenach, JC; Jackson, C; Tong, C | 1 |
| Koskinen, S; Koulu, M; Pesonen, U; Scheinin, H; Scheinin, M; Virtanen, R | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM | 1 |
| Barsh, GS; Haapalinna, A; Kobilka, BK; Kulatunga, M; Leino, T; Link, RE; Macdonald, E; Pelto-Huikko, M; Sallinen, J; Scheinin, M; Sjöholm, B; Viitamaa, T | 1 |
| Bol, CJ; Danhof, M; IJzerman, AP; Mandema, JW | 1 |
| Audinot, V; Cistarelli, L; Gobert, A; Millan, MJ; Newman-Tancredi, A; Rivet, JM | 1 |
| Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L | 1 |
| Colpaert, FC; Pauwels, PJ | 1 |
1 trial(s) available for medetomidine and idazoxan
| Article | Year |
|---|---|
A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Dioxanes; Female; Humans; Idazoxan; Imidazoles; Injections, Spinal; Medetomidine; Receptors, Cholinergic; Sheep | 1993 |
24 other study(ies) available for medetomidine and idazoxan
| Article | Year |
|---|---|
Antinociceptive properties of intrathecal dexmedetomidine in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dioxanes; Idazoxan; Imidazoles; Injections, Spinal; Male; Medetomidine; Rats; Rats, Inbred Strains | 1991 |
Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cerebral Cortex; Dioxanes; Guinea Pigs; Idazoxan; Ileum; Imidazoles; Kinetics; Medetomidine; Muscle, Smooth; Receptors, Adrenergic, alpha; Receptors, Drug; Stereoisomerism; Tritium | 1991 |
Medetomidine-induced alterations of intraocular pressure and contraction of the nictitating membrane.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Imidazoles; Intraocular Pressure; Male; Medetomidine; Muscle Contraction; Nictitating Membrane; Rabbits; Sympathectomy | 1991 |
Ventilatory, hemodynamic and sedative effects of the alpha 2 adrenergic agonist, dexmedetomidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Carbon Dioxide; Dioxanes; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Idazoxan; Imidazoles; Medetomidine; Rabbits; Respiration | 1991 |
Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alfentanil; Animals; Dioxanes; Drug Interactions; Hemodynamics; Idazoxan; Imidazoles; Male; Medetomidine; Rats; Rats, Inbred Strains; Respiration | 1990 |
Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia, Inhalation; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Dioxanes; Dogs; Electroencephalography; Idazoxan; Imidazoles; Infusions, Intravenous; Isoflurane; Medetomidine; Oxygen; Pulmonary Wedge Pressure | 1990 |
Interactions of alpha 2-adrenoceptor antagonists with medetomidine and with ethanol in a holeboard test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Ethanol; Idazoxan; Imidazoles; Male; Medetomidine; Mice | 1989 |
Changes in serotonin metabolism in the rat raphe magnus and cardiovascular modifications following systemic administration of clonidine and other central alpha 2-agonists: an in vivo voltammetry study.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dioxanes; Electrochemistry; Heart Rate; Hemodynamics; Idazoxan; Imidazoles; Immunohistochemistry; Male; Medetomidine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Anesthetics; Animals; Dioxanes; Hypnotics and Sedatives; Idazoxan; Imidazoles; Injections, Intraperitoneal; Male; Medetomidine; Muscle Relaxation; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alfentanil; Analgesics, Opioid; Animals; Dioxanes; Fentanyl; Idazoxan; Imidazoles; Male; Medetomidine; Muscle Rigidity; Rats; Rats, Inbred Strains | 1989 |
Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor.
Topics: Animals; Benzylamines; Brain; Dioxanes; Halothane; Idazoxan; Imidazoles; Male; Medetomidine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Stereoisomerism; Theophylline | 1988 |
Enhanced noradrenergic neuronal activity increases homovanillic acid levels in cerebrospinal fluid.
Topics: Animals; Dioxanes; Dopamine; Homovanillic Acid; Idazoxan; Imidazoles; Male; Medetomidine; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dogs; Drug Interactions; Epinephrine; Female; Halothane; Hemodynamics; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medetomidine; Receptors, Drug; Ventricular Premature Complexes | 1995 |
Covariation of alpha 2-adrenoceptor density and function following irreversible antagonism with EEDQ.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Dioxanes; Drug Interactions; Exploratory Behavior; Hypnotics and Sedatives; Idazoxan; Imidazoles; Male; Medetomidine; Mice; Motor Activity; Quinolines; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1994 |
Enhanced alpha-2 adrenergic controls and spinal morphine potency in inflammation.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Carrageenan; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Evoked Potentials; Idazoxan; Imidazoles; Inflammation; Injections, Spinal; Male; Medetomidine; Morphine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Azocines; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Rate; Hot Temperature; Idazoxan; Imidazoles; Macaca mulatta; Male; Medetomidine; Muscle Relaxation; Pain Threshold; Respiration; Xylazine | 1993 |
Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective alpha 2-adrenoceptor agonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Monoamines; Brain; Dioxanes; Hydrazines; Idazoxan; Imidazoles; Male; Medetomidine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic | 1993 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Medetomidine; Muscle Contraction; Nordefrin; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Vasoconstrictor Agents; Xylazine; Yohimbine | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Biogenic Monoamines; Body Temperature; Brain Chemistry; Idazoxan; Imidazoles; Medetomidine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Receptors, Adrenergic, alpha-2; RNA, Messenger | 1997 |
Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Clonidine; Idazoxan; Imidazoles; Magnesium; Male; Manganese; Medetomidine; Membranes; Radioligand Assay; Rats; Reproducibility of Results; Retina; Sensitivity and Specificity; Tritium | 1997 |
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Dopamine; Dopamine Agonists; Frontal Lobe; Guanabenz; Guinea Pigs; Homeostasis; Idazoxan; Imidazoles; Indoles; Isoindoles; Male; Medetomidine; Models, Neurological; Motor Activity; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Raclopride; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Serotonin | 1998 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Calcium; CHO Cells; Clonidine; Cricetinae; DNA, Recombinant; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Idazoxan; Kinetics; Medetomidine; Mice; Oxymetazoline; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Transfection | 2000 |