medetomidine has been researched along with atipamezole in 255 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (2.75) | 18.7374 |
| 1990's | 122 (47.84) | 18.2507 |
| 2000's | 68 (26.67) | 29.6817 |
| 2010's | 48 (18.82) | 24.3611 |
| 2020's | 10 (3.92) | 2.80 |
| Authors | Studies |
|---|---|
| Wolfensohn, SE | 1 |
| Abdul-Rasool, I; Bloor, B; Hadlock, S; Hsieh, J; Kobayashi, D; Nguyen, D; Singer, F; Ward, D | 1 |
| Correa-Sales, C; Maze, M; Rabin, BC | 1 |
| Bloor, BC; Blow, KD; Flacke, JW; Flacke, WE; McIntee, DF | 1 |
| Jyväsjärvi, E; Kauppila, T; Pertovaara, A | 1 |
| Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF | 1 |
| Bosnjak, ZJ; Coughlan, MG; Kampine, JP; Lee, JG; Schmeling, WT; Warltier, DC | 1 |
| Carlson, S; Mecke, E; Pertovaara, A; Rämä, P; Tanila, H | 1 |
| Arnemo, JM; Søli, NE | 3 |
| Kim, H; Matsunaga, S; Nishimura, R; Sakaguchi, M; Sasaki, N; Takeuchi, A; Tamura, H | 1 |
| Harada, T; Kigure, T; Nishizawa, O; Noto, H; Tsuchida, S; Watarai, J; Yoshida, K | 1 |
| Haapalinna, A; Harju, M; Riekkinen, P; Riekkinen, PJ; Sirviö, J | 1 |
| Flecknell, PA; Hu, C; Liles, JH | 1 |
| Kallio, A; Karhuvaara, S; Koulu, M; Ojala-Karlsson, P; Scheinin, M | 1 |
| Lewis, JC | 1 |
| Kallio, A; Karhuvaara, S; Salonen, M; Scheinin, M; Tuominen, J | 1 |
| Kauppila, T; Kemppainen, P; Pertovaara, A | 1 |
| Kalso, EA; Pöyhiä, R; Rosenberg, PH | 1 |
| Albrecht, RF; Hoffman, WE; Kochs, E; Thomas, C; Werner, C | 1 |
| Niemi, P; Tuominen, J; Vähä-Vahe, T | 1 |
| Vähä-Vahe, T; Vainio, O | 1 |
| Kallio, A; Karhuvaara, S; Koulu, M; Scheinin, H; Scheinin, M | 1 |
| Kauppila, T; Pertovaara, A; Tukeva, T | 1 |
| Korpi, ER | 1 |
| Vähä-Vahe, AT | 1 |
| Jalanka, HH | 1 |
| Blix, AS; Hotvedt, R; Sørensen, DR; Tyler, NJ | 1 |
| Donnay, I; Ectors, F; Fargetton, X; Verstegen, J; Zanker, S | 1 |
| Vainio, O | 1 |
| Durcan, MJ; Linnoila, M; Lister, RG | 1 |
| Fargetton, X; Vähä-Vahe, T | 1 |
| Chen, BX; Doze, VA; Maze, M | 1 |
| Jalanka, H | 1 |
| Virtanen, R | 1 |
| Savola, JM | 1 |
| Haapalinna, A; Lammintausta, R; MacDonald, E; Virtanen, R | 1 |
| Kalso, EA; Kontinen, VK | 1 |
| Hayashi, Y; Kamibayashi, T; Mammoto, T; Sasaki, S; Takada, K; Yamatodani, A; Yoshiya, I | 1 |
| Hämäläinen, MM; Jyväsjärvi, E; Pertovaara, A | 1 |
| Björn, M; Idänpään-Heikkilä, JJ; Seppälä, T | 1 |
| Dement, WC; Edgar, DM; Maze, M; Seidel, WF | 1 |
| Dalley, JW; Stanford, SC | 1 |
| Abdul-Latif, AR; Mohammad, FK; Zangana, IK | 1 |
| Ko, JC; McGrath, CJ | 1 |
| Hämäläinen, MM; Pertovaara, A | 2 |
| Mansikka, H; Pertovaara, A | 2 |
| Faghihi, SM; van Duin, CT; van Miert, AS | 1 |
| Ebukuro, S; Ejima, H; Hara, Y; Hioki, K; Komori, S; Saito, TR; Tagawa, M; Takahashi, KW | 1 |
| Hayashi, K; Kim, HY; Matsunaga, S; Nishimura, R; Sasaki, N; Takeuchi, A; Yamaki, A | 1 |
| Haapalinna, A; Lahtinen, H; Mazurkiewicz, M; Riekkinen, P; Riekkinen, PJ; Sirviö, J | 1 |
| Hayashi, K; Kim, H; Matsunaga, S; Nishimura, R; Sasaki, N; Takeuchi, A; Yamaki, A | 1 |
| Hayashi, K; Kim, H; Matsunaga, S; Nishimura, R; Sasaki, N; Takeuchi, A; Tamura, H | 1 |
| Hall, LW; Lagerweij, E; Nolan, AM; Sear, JW | 1 |
| Idänpään-Heikkilä, JJ; Mattila, MJ; Seppälä, T; Strömberg, C | 1 |
| Ozaki, GT; Penning, JP; Sabbe, MB; Yaksh, TL | 1 |
| Hug, CC; Salmenperä, MT; Szlam, F | 1 |
| Ferrè, JP; Intorre, L; Maugeri, S; Soldani, G | 1 |
| Hayashi, K; Kim, HY; Matsunaga, S; Nishimura, R; Sasaki, N; Takeuchi, A; Tamura, H | 2 |
| Carlson, S; Hämäläinen, MM; Kauppila, T; Mecke, E; Pertovaara, A | 1 |
| Fale, A; Kirsch, JR; McPherson, RW | 1 |
| McPherson, RW; Mirski, MA; Rossell, LA; Traystman, RJ | 1 |
| Idänpään-Heikkilä, JJ; Kalso, EA; Seppälä, T | 1 |
| Dickenson, AH; Stanfa, LC | 1 |
| Groot Bruinderink, GW; Wensing, T; Wolkers, J | 1 |
| Constantinou, CE; Harada, T | 1 |
| Day, TK; Muir, WW | 1 |
| Ewing, KK; Mohammed, HO; Scarlett, JM; Short, CE | 1 |
| Bloor, BC; Flacke, JW; Flacke, WE; McIntee, DF; Sagan, M | 1 |
| Kauppila, T; Taira, T; Tanila, H | 1 |
| Petcho, A; Verstegen, J | 1 |
| Bravo, R; Herdegen, T; Pertovaara, A | 1 |
| Jorm, CM; Stamford, JA | 1 |
| Porkka-Heiskanen, T; Stenberg, D; Toppila, J | 1 |
| Ekonsalo, T; Lammintausta, R; Riekkinen, P; Sirviö, J | 1 |
| Haapalinna, A; Halonen, T; Riekkinen, P; Valtonen, P | 1 |
| Anttila, M; Salonen, S; Vainio, O; Vuorilehto, L | 1 |
| Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J | 1 |
| Ishiguro, T; Nishimura, R; Sakaguchi, M; Sasaki, N; Takeuchi, A; Tamura, H | 1 |
| Castillo-Olivares, JL; Mascías, A; San Román, F; Santos, M; Segura, IA; Tendillo, FJ | 1 |
| Pypendop, B; Serteyn, D; Verstegen, J | 1 |
| Carlson, S; Rämä, P; Tanila, H | 1 |
| Dyson, DH; McDonell, WN; Pettifer, GR | 1 |
| de Lange, S; Prinzen, FW; Roekaerts, PM | 1 |
| Idänpään-Heikkilä, JJ; Mansikka, H; Pertovaara, A | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 1 |
| Cullen, LK | 1 |
| Izumisawa, Y; Kotani, T; Yamashita, K; Yonezawa, K | 1 |
| Carlson, S; Linnankoski, I; Pertovaara, A; Rämä, P; Tanila, H | 1 |
| Haapalinna, A; Riekkinen, PJ; Ruotsalainen, S; Sirviö, J | 1 |
| Dowlatshahi, P; Yaksh, TL | 1 |
| Hätönen, T; Johansson-Alila, A; Laakso, ML; Mustanoja, SM | 1 |
| Asano, Y; Kawaguchi, T; Koehler, RC; McPherson, RW | 1 |
| Cattet, MR; Caulkett, NA; Polischuk, SC; Ramsay, MA | 2 |
| Cattet, MR; Caulkett, NA | 1 |
| Carlson, S; Linnankoski, I; Rämä, P | 1 |
| Arnemo, JM; Horsberg, TE; Nymoen, U; Ranheim, B; Søli, NE; Tyler, NJ | 1 |
| Pertovaara, A; Wei, H | 1 |
| Mohammad, FK; Yakoub, LK | 1 |
| Haapalinna, A; Heinonen, E; MacDonald, E; Savola, JM; Tuomisto, L; Viitamaa, T; Virtanen, R | 1 |
| DeGraves, FJ; Lin, HC; Pugh, DG; Waldridge, BM | 1 |
| Haapalinna, A; Lappalainen, R; MacDonald, E; Sirviö, J; Yavich, L | 1 |
| Burzaco, OH; Cruz, JI; Loste, JM | 1 |
| Gordon, ES; Koman, LA; Li, Z; Smith, BP; Smith, TL | 1 |
| Haapalinna, A; Kobilka, BK; Sallinen, J; Scheinin, M; Viitamaa, T | 1 |
| Benson, GJ; Grimm, KA; Olson, WA; Thurmon, JC; Tranquilli, WJ | 1 |
| De Graaf, GJ; Jager, LP; Widjaja-Greefkes, HC | 1 |
| De Thoisy, B; Fournier, P; Fournier-Chambrillon, C; Genty, C; Kéravec, J; Vié, JC | 1 |
| de Thoisy, B; Vié, JC; Vogel, I | 1 |
| Björklund, M; Jäkälä, P; Kobilka, BK; Puoliväli, J; Riekkinen, P; Sallinen, J; Scheinin, M; Sirviö, J | 1 |
| Fournier, P; Fournier-Chambrillon, C; Vié, JC | 1 |
| Talke, P | 1 |
| Aantaa, R; Anttila, M; Hakola, P; Helminen, A; Karhuvaara, S; Scheinin, H | 1 |
| Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L | 1 |
| Guo, TZ; Kingery, WS; Maze, M; Poree, LR | 1 |
| Citino, SB; Deem, SL; Ko, JC | 1 |
| Arnemo, JM; Horsberg, TE; Ranheim, B; Ryeng, KA; Søli, NE | 3 |
| Haapalinna, A; Larson, J; Niittykoski, M; Ruotsalainen, S; Sirviö, J | 1 |
| Alila-Johansson, A; Hätönen, T; Laakso, ML; Mustanoja, SM | 1 |
| Alila-Johansson, A; Bäck, N; Laakso, ML; Mustanoja, SM | 1 |
| Jinma, K; Kaji, K; Suzuki, M; Takahashi, H; Tsuruga, H | 1 |
| Calkins, DG; Gulland, FM; Haulena, M; Spraker, TR | 1 |
| Ritacco, G; Schilling, AM; Skeans, S; Young, SS | 1 |
| Harper, DD; Richardson, CA; Talke, PO; Traber, DL; Traber, LD | 1 |
| Fox, SM; Ko, JC; Mandsager, RE | 1 |
| Gaynor, J; Sleeman, JM | 1 |
| Nieminen, M; Salonen, JS; Sankari, S; Soveri, T | 1 |
| Haupt, MA; Meltzer, DG; Nel, PJ; Taylor, A | 1 |
| Aguirre, AA; Angerbjörn, A; Mörner, T; Principe, B; Tannerfeldt, M | 1 |
| Flecknell, PA; Hedenqvist, P; Roughan, JV | 1 |
| Arnemo, JM; Horsberg, TE; Ranheim, B; Stuen, S | 1 |
| Bush, M; Grobler, DG; Lance, WR; Phillips, LG; Raath, JP; Stamper, MA | 1 |
| Harvey, RC; Jones, MP; Langan, JN; Orosz, SE; Pollock, C; Schumacher, J | 1 |
| Albertsen, G; Arnemo, JM; Larsen, S; Ranheim, B; Ryeng, KA | 1 |
| Bettschart-Wolfensberger, R; Clarke, KW; Freeman, SL; Jäggin-Schmucker, N | 1 |
| Diggs, HE; Greer, LL; Jenne, KJ | 1 |
| Kaivosaari, S; Mortensen, J; Salonen, JS; Taskinen, J | 1 |
| Wallin-Håkanson, B; Wallin-Håkanson, N | 1 |
| Hayes, KE; Taylor, R; Toth, LA | 1 |
| Fernandez-Moran, J; Manteca-Vilanova, X; Perez, E; Saavedra, D; Sanmartin, M | 1 |
| Gulland, FM; Haulena, M | 1 |
| Bettschart, RW; Bettschart-Wolfensberger, R; Bowen, MI; Clarke, KW; Feller, R; Freeman, SL; Nolan, A | 1 |
| Cripps, PJ; Jones, RS; Robinson, KJ | 1 |
| Kaivosaari, S; Salonen, JS; Taskinen, J | 1 |
| Badura, LL; Dodge, JC | 1 |
| Dennis, PM; Heard, DJ | 1 |
| Heaton-Jones, DL; Heaton-Jones, TG; Ko, JC | 1 |
| Atalan, G; Cenesiz, M; Demirkan, I; Uzun, M; Yildiz, S | 1 |
| Horne, WA; Kelly, BT; Larsen, RS; Loomis, MR; Sladky, KK; Stoskopf, MK | 1 |
| Joubert, KE; Lobetti, R | 1 |
| Ambrisko, TD; Hikasa, Y | 1 |
| Arnemo, JM; Larsen, S; Ryeng, KA | 1 |
| Pinson, DM; Sun, FJ; Wright, DE | 1 |
| Chusseau, JP; Dupuch, J; Fournier, P; Fournier-Chambrillon, C; Maizeret, C | 1 |
| Fontenot, D; Mangold, B; Miller, M; Neiffer, D; Stetter, M; Weber, M | 1 |
| Aithal, HP; Amarpal, GR; Gupta, OP; Kinjavdekar, P; Pawde, AM | 1 |
| Spelman, LH | 1 |
| Bush, M; Lance, W; Phillips, LG; Raath, JP | 1 |
| Block, BA; Rollins, M; Williams, TD | 1 |
| Jeong, SM; Kim, MS; Nam, TC; Park, JH; Seo, KM | 1 |
| Campos, JM; Cramer, C; Morris, PJ; Sutherland-Smith, M; Thorstadt, C; Toone, W | 1 |
| Baker, SE; Buesching, CD; Johnson, DD; Johnson, PJ; Macdonald, DW; Newman, C; Slater, D; Thornton, PD | 1 |
| Eisen, L; Eisen, RJ; Hahn, N; Lane, RS | 1 |
| Bay, TN; Brown, SR; Gopalan, C; Hegade, GM; Talcott, MR | 1 |
| Bakshi, VP; Carasso, BS; Geyer, MA; Palomo, J; Powell, SB | 1 |
| Carroll, GL; Champney, TH; Geller, SC; Haley, EL; Hartsfield, SM; Martinez, EA | 1 |
| Arnemo, JM; Khadka, CB; Storaas, T; Wegge, P | 1 |
| Arnemo, JM; Fahlman, A; Foggin, C; Loveridge, A; Nyman, G; Wenham, C | 1 |
| Aspegrén, JC; Granholm, M; McKusick, BC; Westerholm, FC | 2 |
| Aarhaug, P; Arnemo, JM; Bauer, H; Enriquez, B; Jacquier, M | 1 |
| Boher, F; Flores, G; Medina-Vogel, G; Mora, E; Santibañez, A; Soto-Azat, C | 1 |
| Bosi, EJ; Fahlman, A; Nyman, G | 1 |
| Domínguez, JM; Galka, ME; Gómez-Villamandos, RJ; Granados, MM; Velarde, J; Villalobos, CM | 1 |
| Haydon, T; Kitao, T; Ko, JC; Payton, M; Weil, AB | 1 |
| Campbell, M; Crognale, MA; Eckert, SA; Harms, CA; Kubis, SA; Levenson, DH | 1 |
| Hikasa, Y; Ueoka, N | 2 |
| Brouillard, L; Cuvelliez, S; Kaartinen, MJ; Kona-Boun, JJ; Rondenay, Y; Troncy, E | 1 |
| Barreiro, A; Espino, L; Miño, N | 1 |
| Abbo, LA; Johnson, BM; Ko, JC; Payton, M; Weil, AB | 1 |
| Baumgartner, C; Ebner, J; Erhardt, W; Henke, J; Wehr, U | 1 |
| Williams, AM; Wyatt, JD | 1 |
| Niekrasz, MA; Reed, DA; Theriault, BR | 1 |
| Enouri, SS; Kerr, CL; McDonell, WN; Rioja, E | 1 |
| Muir, WW; Ueyama, Y; Ueyema, Y; Waselau, AC; Wiese, AJ | 1 |
| Bdolah-Abram, T; Epstein, A; King, R; Lapid, R; Shilo, Y | 2 |
| Choi, HS; Jang, HS; Jang, KH; Lee, MG; Lee, SH | 1 |
| Aanes, R; Arnemo, JM | 1 |
| Jang, HS; Lee, MG | 1 |
| Hikasa, Y; Matsuu, A; Sato, K; Takahashi, H; Talukder, MH | 1 |
| Berry, K; Bouts, T; Gasthuys, F; Harrison, N; Routh, A; Taylor, P | 1 |
| Calle, PP; Georoff, TA; James, SB; Kalk, P; Martin-Flores, M | 1 |
| Bauquier, SH; Hinshaw, KC; Ialeggio, DM; Montgomery, CL; Perkowski, SZ | 1 |
| Caulkett, NA; Shury, TK; Woodbury, MR | 1 |
| Alves, HN; Antunes, LM; da Silva, AL; Olsson, IA; Orden, JM | 1 |
| Arnemo, JM; Evans, AL; Miller, AL; Os, Ø | 1 |
| Bektas, R; Bettschart-Wolfensberger, R; Fahrion, A; Hammer, S; Martin-Jurado, O | 1 |
| Bosmans, T; Polis, I; Samoy, Y; Van Ryssen, B; Van Vynckt, D; Verschooten, F | 1 |
| Berry, K; Bouts, T; Dodds, J; Gasthuys, F; Karunaratna, D; Routh, A; Taylor, P | 1 |
| Garant, D; Pelletier, F; Robert, K | 1 |
| Baker, NJ; Caswell, MD; McLellan, AD; Schofield, JC | 1 |
| Boardman, WS; Campbell, S; Hampton, JO; Lethbridge, MR; Rose, K; Sharp, T; Woolnough, AP | 1 |
| Olsson, A; Phalen, D | 3 |
| Hermes, R; Horowitz, I; Knauer, F; Petit, T; Saragusty, J; Stalder, GL; Walzer, C | 1 |
| Hikasa, Y; Kusunose, S; Shimura, I; Yokota, S | 1 |
| Ahlqvist, P; Arnemo, JM; Evans, AL; Liberg, O; Segerström, P | 1 |
| Kalk, P; Moore, RP; Rainwater, KL; Sykes, JM; Valitutto, MT | 1 |
| Hikasa, Y; Miki, Y; Murahata, Y; Yamamoto, A | 1 |
| Banzato, T; Bellini, L; Contiero, B; Zotti, A | 1 |
| Davis, TR; Fisher, MC; Miller, MW; Wolfe, LL | 1 |
| Chirife, AD; Millán, J | 1 |
| de Morais, AM; de Oliveira, MF; de Oliveira, MG; de Paiva, AL; de Paula, VV; Dos Santos, EA; Nunes, TL; Silva, AR | 1 |
| Kirihara, Y; Kobayashi, Y; Kurosaki, K; Saito, Y; Takechi, M; Takeuchi, T | 2 |
| Chen, K; Chuang, KH; Lew, SK; Low, SA; Nasrallah, FA | 1 |
| Arnemo, JM; Caulkett, N; Fahlman, Å; Ozeki, LM; Stenhouse, G | 1 |
| Lapid, R; Shilo-Benjamini, Y | 1 |
| Arras, M; Cesarovic, N; Fleischmann, T; Henke, J; Jirkof, P | 1 |
| Bonarrigo, T; Di Pietro, S; Giudice, E; Macrì, F; Palumbo Piccionello, A; Pugliese, A | 1 |
| Antony, L; Arun, AS; Krishna, S; Pillai, HC; Suresh, S; Venkataramanappa, M | 1 |
| Buck, RK; Fosgate, GT; Gerlach, C; Kästner, SBR; Kummrow, M; Meyer, LRC; Stegmann, GF; Zeiler, GE | 1 |
| Chinnadurai, SK; Thurber, M; Watson, MK | 1 |
| Bdolah-Abram, T; Cohen, L; Kushnir, Y; Shilo-Benjamini, Y; Toledano, N | 1 |
| Dantsuka, A; Elewa, YHA; Hattori, H; Ichii, O; Karakida, N; Kon, Y; Nagasaki, KI; Nakamura, T; Yoshiyasu, T | 1 |
| DE Gaspar Simón, I; Evans, MN; Goossens, B; Guerrero-Sánchez, S; Hearn, AJ; Macdonald, DW; Nájera, F; Nathan, SKSS; Ramírez Saldivar, DA; Revuelta Rueda, L; Ross, J | 1 |
| Fisher, MC; Lance, WR; Mays, T; McCollum, MP; Miller, MW; Nol, P; Wehtje, ME; Wolfe, LL | 1 |
| Bertini, S; Colla, C; Menozzi, A; Placenza, G; Poli, E; Pozzoli, C | 1 |
| Adam, M; Honkavaara, JM; Kajula, M; Keskitalo, T; Mölsä, S; Raekallio, MR; Scheinin, M; Vainio, OM | 1 |
| Dantsuka, A; Hosotani, M; Ichii, O; Irie, T; Kon, Y; Kouguchi, H; Nagasaki, KI; Nakamura, S; Nakamura, T; Sato, S; Sotozaki, K; Yoshiyasu, T | 1 |
| Adam, M; Raekallio, MR; Vainio, OM | 1 |
| Cushing, AC; Gompf, RE; Price, JM; Rodriguez, KT; Smith, CK | 1 |
| Burnside, WM; Cameron, AI; Malinowski, CM; Nunamaker, EA; West, SE | 1 |
| Kajitani, N; Kirihara, Y; Kurosaki, K; Matsuo, H; Saito, Y; Takechi, M | 1 |
| Adam, M; Hautajärvi, HJ; Honkavaara, JM; Kallio-Kujala, IJ; Larenza Menzies, P; Männikkö, SK; Nevanperä, K; Raekallio, MR; Restitutti, F; Scheinin, M; Turunen, H; Vainio, OM | 1 |
| Kamio, K; Kashimoto, J; Shibuta, H; Suda, A; Yamana, R | 1 |
| Iba, Y; Kimura, T; Murai, H; Suzuki, H; Tanji, H | 1 |
| Hikasa, Y; Matsukawa, T | 1 |
| Bischof, HJ; Ikebuchi, M; Okanoya, K | 1 |
| Fisher, MC; Mays, T; Miller, MW; Wolfe, LL | 1 |
| Gardner, BR; Kotze, PGH; McCue, SA; Musson, M; Seakamela, SM; Spolander, B | 1 |
| Adami, C; Nannarone, S | 1 |
| Arnemo, JM; Corti, P | 1 |
| Hikasa, Y; Kamohara, H; Kamohara, T | 1 |
| Tashiro, M; Tohei, A | 1 |
2 review(s) available for medetomidine and atipamezole
| Article | Year |
|---|---|
Pharmacological profiles of medetomidine and its antagonist, atipamezole.
Topics: Adrenergic alpha-Agonists; Animals; Imidazoles; Isomerism; Medetomidine; Receptors, Adrenergic, alpha | 1989 |
Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Animals; Cats; Dogs; Imidazoles; Medetomidine | 1996 |
34 trial(s) available for medetomidine and atipamezole
| Article | Year |
|---|---|
Antagonism of medetomidine sedation by atipamezole in pigs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Swine | 1992 |
Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers.
Topics: Adult; Benzamides; Chromatography, High Pressure Liquid; Electrochemistry; Epinephrine; Humans; Imidazoles; Male; Medetomidine; Methoxyhydroxyphenylglycol; Moclobemide; Norepinephrine; Receptors, Adrenergic, alpha; Reference Values | 1991 |
Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Pressure; Heart Rate; Humans; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Norepinephrine; Random Allocation; Salivation; Single-Blind Method | 1991 |
No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Clinical Trials as Topic; Double-Blind Method; Humans; Imidazoles; Male; Medetomidine; Prolactin; Receptors, Adrenergic, alpha; Reference Values | 1990 |
The clinical effectiveness of atipamezole as a medetomidine antagonist in the dog.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Clinical Trials as Topic; Dogs; Double-Blind Method; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Randomized Controlled Trials as Topic; Vomiting | 1990 |
Reversal of medetomidine-induced cardiovascular and respiratory changes with atipamezole in dogs.
Topics: Animals; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Dogs; Electrocardiography; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Respiration; Time Factors | 1990 |
Effects of atipamezole and yohimbine on medetomidine-induced central nervous system depression and cardiorespiratory changes in lambs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Central Nervous System; Heart; Hypnotics and Sedatives; Imidazoles; Medetomidine; Random Allocation; Respiratory System; Sheep; Yohimbine | 1995 |
Reduction of isoflurane anesthetic requirement by medetomidine and its restoration by atipamezole in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Dogs; Female; Heart Rate; Imidazoles; Isoflurane; Medetomidine | 1993 |
Sedative effects of medetomidine and its reversal by atipamezole in llamas.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Gas Analysis; Camelids, New World; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Medetomidine; Oxygen; Prospective Studies; Respiration; Time Factors | 1997 |
Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Norepinephrine; Receptors, Adrenergic, alpha-2; Sympatholytics | 1998 |
Preliminary comparison of four anaesthetic techniques in badgers (Meles meles).
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Antagonists; Analgesics; Anesthesia; Animals; Female; Imidazoles; Injections, Intramuscular; Ketamine; Male; Medetomidine; Midazolam; Mustelidae; Prospective Studies; Treatment Outcome | 2005 |
Effect of medetomidine and its antagonism with atipamezole on stress-related hormones, metabolites, physiologic responses, sedation, and mechanical threshold in goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Glucose; Blood Pressure; Body Temperature; Drug Interactions; Epinephrine; Female; Goats; Heart Rate; Hydrocortisone; Imidazoles; Infusions, Intravenous; Male; Medetomidine; Norepinephrine; Prospective Studies; Respiration | 2005 |
Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Prospective Studies; Respiration; Treatment Outcome | 2006 |
Sevoflurane anaesthesia in Iberian lynx (Lynx pardinus).
Topics: Adrenergic alpha-Antagonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Hypnotics and Sedatives; Imidazoles; Lynx; Medetomidine; Methyl Ethers; Sevoflurane | 2007 |
Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Body Temperature; Dexmedetomidine; Dogs; Drug Administration Routes; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Respiration; Time Factors | 2007 |
Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Pressure; Butorphanol; Cross-Over Studies; Dogs; Female; Glycopyrrolate; Heart Rate; Hypoxia; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Narcotics; Respiration; Tiletamine; Time Factors; Treatment Outcome; Xylazine; Zolazepam | 2007 |
Effects of medetomidine on Doppler variables of major abdominal arteries in normal dogs.
Topics: Abdomen; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Blood Flow Velocity; Dogs; Female; Hemodynamics; Imidazoles; Male; Medetomidine; Ultrasonography, Doppler | 2008 |
A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol- medetomidine in cats.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Pressure; Butorphanol; Cats; Cross-Over Studies; Female; Glycopyrrolate; Heart Rate; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Narcotics; Respiration; Tiletamine; Time Factors; Treatment Outcome; Xylazine; Zolazepam | 2007 |
Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Cattle; Drug Interactions; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Vascular Resistance; Xylazine | 2008 |
Evaluation of medetomidine-ketamine-butorphanol anesthesia with atipamezole-naltrexone antagonism in captive male guanacos (Lama guanicoe).
Topics: Adrenergic alpha-Antagonists; Anesthetics; Animals; Butorphanol; Camelids, New World; Imidazoles; Ketamine; Male; Medetomidine; Naltrexone; Narcotic Antagonists | 2010 |
Comparison of the effects of racemic ketamine and S-ketamine for anesthesia in Rheem gazelles (Gazella subgutturosa marica) and Subgutturosa gazelles (Gazella subgutturosa subgutturosa).
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Antelopes; Body Temperature; Cross-Over Studies; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Medetomidine; Oximetry; Oxygen; Prospective Studies; Random Allocation; Respiratory Rate; Species Specificity | 2011 |
Evaluation of medetomidine-alfaxalone and medetomidine-ketamine in semi-free ranging Bennett's wallabies (Macropus rufogriseus).
Topics: Acid-Base Imbalance; Adrenergic alpha-2 Receptor Antagonists; Anesthetics; Animals; Animals, Zoo; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Immobilization; Ketamine; Macropodidae; Medetomidine; Pilot Projects; Pregnanediones; Respiratory Rate | 2011 |
The effects of decreased body temperature on the onset, duration and action of medetomidine and its antagonist atipamezole in juvenile farmed estuarine crocodiles (Crocodylus porosus).
Topics: Adrenergic alpha-2 Receptor Antagonists; Aging; Alligators and Crocodiles; Anesthesia Recovery Period; Animals; Body Temperature; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Respiration | 2013 |
Evaluation of three medetomidine-based protocols for chemical restraint and sedation for non-painful procedures in companion rats (Rattus norvegicus).
Topics: Adrenergic alpha-Antagonists; Animals; Butorphanol; Dose-Response Relationship, Drug; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Midazolam; Pets; Rats; Reflex, Righting; Respiratory Rate; Single-Blind Method | 2014 |
Effects of atipamezole and medetomidine administration on seminal variables and functions of erection and ejaculation of the collared peccary (Tayassu tajacu) after electroejaculation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Artiodactyla; Cross-Over Studies; Ejaculation; Electric Stimulation; Imidazoles; Male; Medetomidine; Penile Erection; Semen Analysis; Sperm Count | 2014 |
IMMOBILIZATION OF CAPTIVE NUBIAN IBEX (CAPRA NUBIANA) WITH BUTORPHANOL-MIDAZOLAM-MEDETOMIDINE OR BUTORPHANOL-AZAPERONE-MEDETOMIDINE AND ATIPAMEZOLE REVERSAL.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Azaperone; Butorphanol; Drug Therapy, Combination; Female; Goats; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Midazolam | 2015 |
Injection anaesthesia with fentanyl-midazolam-medetomidine in adult female mice: importance of antagonization and perioperative care.
Topics: Analgesics; Anesthetics, Combined; Animals; Body Temperature; Female; Fentanyl; Flumazenil; Heart Rate; Imidazoles; Injections, Intraperitoneal; Medetomidine; Mice; Mice, Inbred C57BL; Midazolam; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Perioperative Care | 2016 |
Effects of a medetomidine-ketamine combination on Schirmer tear test I results of clinically normal cats.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Cats; Drug Combinations; Female; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Medetomidine; Tears | 2016 |
Effective Reversible Immobilization of Captive Himalayan Black Bears (Selenarctos thibetanus laniger) with Medetomidine-Tiletamine-Zolazepam and Atipamezole.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Anti-Anxiety Agents; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Tiletamine; Ursidae; Zolazepam | 2016 |
COMPARISON OF MEDETOMIDINE-KETAMINE AND BUTORPHANOL-AZAPERONE-MEDETOMIDINE IN CAPTIVE BENNETT'S WALLABIES (MACROPUS RUFOGRISEUS).
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Animals, Zoo; Azaperone; Butorphanol; Hypnotics and Sedatives; Imidazoles; Ketamine; Marsupialia; Medetomidine | 2016 |
Intratesticular and incisional line infiltration with ropivacaine for castration in medetomidine-butorphanol-midazolam sedated dogs.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Antagonists; Amides; Analgesia; Anesthesia, General; Animals; Butorphanol; Dogs; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Midazolam; Orchiectomy; Ropivacaine; Testis; Time Factors | 2017 |
The impact of MK-467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Body Temperature; Conscious Sedation; Cross-Over Studies; Drug Interactions; Female; Hemoglobins; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Medetomidine; Oxygen; Prospective Studies; Quinolizines; Respiration; Sheep; Visual Analog Scale | 2018 |
Sedative effect of intramuscular medetomidine with and without vatinoxan (MK-467), and its reversal with atipamezole in sheep.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cross-Over Studies; Drug Interactions; Female; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Medetomidine; Quinolizines; Sheep; Single-Blind Method | 2018 |
Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Cardiac Output; Cardiovascular System; Cross-Over Studies; Dexmedetomidine; Dogs; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Quinolizines; Random Allocation; Single-Blind Method | 2019 |
219 other study(ies) available for medetomidine and atipamezole
| Article | Year |
|---|---|
Use of medetomidine-fentanyl-fluanisone combinations in the badger.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Wild; Butyrophenones; Carnivora; Female; Fentanyl; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Naloxone | 1992 |
Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Hypercapnia; Imidazoles; Isoflurane; Medetomidine; Respiration | 1992 |
A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Imidazoles; Locus Coeruleus; Male; Medetomidine; Prazosin; Rats; Rats, Inbred Strains | 1992 |
Effect of dexmedetomidine, an alpha 2-adrenergic agonist, in the isolated heart.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atrial Function, Left; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Epinephrine; Female; Heart; Heart Rate; Imidazoles; Lung; Male; Medetomidine; Myocardial Contraction; Norepinephrine; Prazosin; Propranolol; Vascular Resistance; Venous Pressure | 1992 |
Effects of atipamezole, an alpha 2-adrenoceptor antagonist, on the anesthesia induced by barbiturates and medetomidine.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics; Animals; Barbiturates; Drug Interactions; Drug Synergism; Imidazoles; Male; Medetomidine; Methohexital; Nociceptors; Pain Measurement; Pentobarbital; Rats; Rats, Inbred Strains; Reflex; Time Factors | 1992 |
The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analgesics; Anesthesia; Animals; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Imidazoles; Male; Medetomidine; Naloxone; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord | 1992 |
Direct coronary and cerebral vascular responses to dexmedetomidine. Significance of endogenous nitric oxide synthesis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arginine; Cerebral Arteries; Coronary Vessels; Dogs; Female; Imidazoles; In Vitro Techniques; Indomethacin; Male; Medetomidine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Vasoconstriction | 1992 |
Effects of medetomidine, an alpha-2 adrenoceptor agonist, and atipamezole, an alpha-2 antagonist, on spatial memory performance in adult and aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Imidazoles; Male; Medetomidine; Memory; Psychomotor Performance; Rats; Rats, Wistar; Space Perception | 1992 |
Immobilization of mink (Mustela vison) with medetomidine-ketamine and remobilization with atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blinking; Body Temperature; Female; Heart Rate; Imidazoles; Immobilization; Ketamine; Medetomidine; Mink; Reproduction; Respiration | 1992 |
The effect of alpha-2 agonists and antagonists on the upper urinary tract of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Female; Imidazoles; Kidney Pelvis; Manometry; Medetomidine; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Ureter; Urodynamics | 1992 |
Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Brain Chemistry; Conditioning, Operant; Imidazoles; Male; Medetomidine; Memory, Short-Term; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reinforcement Schedule; Space Perception; Tacrine | 1992 |
Fentanyl and medetomidine anaesthesia in the rat and its reversal using atipamazole and either nalbuphine or butorphanol.
Topics: Anesthesia; Animals; Butorphanol; Drinking Behavior; Drug Combinations; Eating; Fentanyl; Foot; Imidazoles; Medetomidine; Nalbuphine; Narcotic Antagonists; Rats; Rats, Inbred Strains; Reflex; Respiration; Tail | 1992 |
Reversible immobilisation of Asian small-clawed otters with medetomidine and ketamine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Imidazoles; Immobilization; Ketamine; Medetomidine; Otters | 1991 |
The effects of medetomidine, an alpha-2-adrenoceptor agonist, and cocaine on the tooth pulp-evoked jaw-opening reflex in cat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Cats; Cocaine; Dental Pulp; Dose-Response Relationship, Drug; Electric Stimulation; Electromyography; Imidazoles; Jaw; Medetomidine; Pain; Reflex | 1991 |
Spinal antinociception by dexmedetomidine, a highly selective alpha 2-adrenergic agonist.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Dose-Response Relationship, Drug; Imidazoles; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Male; Medetomidine; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time | 1991 |
Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Brain Ischemia; Dose-Response Relationship, Drug; Epinephrine; Imidazoles; Injections, Intraperitoneal; Male; Medetomidine; Motor Activity; Norepinephrine; Rats; Rats, Inbred Strains | 1991 |
Chemical restraint-reversal with medetomidine and atipamezole in veterinary small animal practice: a survey on the opinions of the dog owners and veterinarians.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dogs; Imidazoles; Immobilization; Medetomidine; Surveys and Questionnaires | 1991 |
Reversal of medetomidine sedation by atipamezole in dogs.
Topics: Adrenergic alpha-Antagonists; Anesthesia Recovery Period; Animals; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Random Allocation; Time Factors | 1990 |
The effect of medetomidine, an alpha 2-adrenoceptor agonist, in various pain tests.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Motor Activity; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time | 1990 |
Effects of alpha 2-adrenergic drugs on the alcohol consumption of alcohol-preferring rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alcohol Drinking; Animals; Brain; Imidazoles; Injections, Subcutaneous; Male; Medetomidine; Methoxyhydroxyphenylglycol; Rats; Rats, Inbred Strains | 1990 |
Medetomidine- and medetomidine-ketamine-induced immobilization in blue foxes (Alopex lagopus) and its reversal by atipamezole.
Topics: Adrenergic alpha-Antagonists; Animals; Female; Foxes; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine | 1990 |
Immobilization of Norwegian reindeer (Rangifer tarandus tarandus) and Svalbard Reindeer (R. t. platyrhynchus) with medetomidine and medetomidine-ketamine and reversal of immobilization with atipamezole.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Medetomidine; Reindeer | 1990 |
Antagonistic activities of atipamezole, 4-aminopyridine and yohimbine against medetomidine/ketamine-induced anaesthesia in cats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Cats; Heart Rate; Imidazoles; Injections, Intramuscular; Ketamine; Medetomidine; Posture; Respiration; Yohimbine | 1991 |
Interactions of alpha 2-adrenoceptor antagonists with medetomidine and with ethanol in a holeboard test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Ethanol; Idazoxan; Imidazoles; Male; Medetomidine; Mice | 1989 |
Medetomidine and atipamezole in small animal practice.
Topics: Adrenergic alpha-Agonists; Animals; Cat Diseases; Cats; Chemical Phenomena; Chemistry; Dog Diseases; Dogs; Imidazoles; Medetomidine | 1989 |
Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Anesthetics; Animals; Dioxanes; Hypnotics and Sedatives; Idazoxan; Imidazoles; Injections, Intraperitoneal; Male; Medetomidine; Muscle Relaxation; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
The use of medetomidine, medetomidine-ketamine combinations and atipamezole at Helsinki Zoo--a review of 240 cases.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Zoo; Imidazoles; Immobilization; Ketamine; Medetomidine; Species Specificity | 1989 |
Cardiovascular actions of medetomidine and their reversal by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Decerebrate State; Heart Rate; Hemodynamics; Imidazoles; Male; Medetomidine; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1989 |
Effects of acute administration of medetomidine on the behaviour, temperature and turnover rates of brain biogenic amines in rodents and reversal of these effects by atipamezole.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Biogenic Amines; Body Temperature; Brain; Imidazoles; Male; Medetomidine; Mice; Rats; Rats, Inbred Strains | 1989 |
Is there any cross-antagonism between mu-opioid and alpha 2-adrenergic receptors in the rat spinal cord?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Drug Interactions; Imidazoles; Male; Medetomidine; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord | 1995 |
Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dogs; Drug Interactions; Epinephrine; Female; Halothane; Hemodynamics; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medetomidine; Receptors, Drug; Ventricular Premature Complexes | 1995 |
Can the alpha 2-adrenoceptor agonist-mediated suppression of nocifensive reflex responses be due to action on motoneurons or peripheral nociceptors?
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Imidazoles; Male; Medetomidine; Motor Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex; Time Factors | 1995 |
The effects of ethanol in combination with the alpha 2-adrenoceptor agonist dexmedetomidine and the alpha 2-adrenoceptor antagonist atipamezole on brain monoamine metabolites and motor performance of mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Ethanol; Homovanillic Acid; Hydroxyindoleacetic Acid; Imidazoles; Male; Medetomidine; Methoxyhydroxyphenylglycol; Mice; Motor Activity; Postural Balance; Psychomotor Performance | 1995 |
Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Motor Activity; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sleep; Sleep, REM | 1995 |
Contrasting effects of the imidazol(in)e alpha 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Frontal Lobe; Imidazoles; Male; Medetomidine; Microdialysis; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors | 1995 |
Reversal of medetomidine sedation in sheep by atipamezole and yohimbine.
Topics: Adrenergic alpha-Antagonists; Animals; Drug Interactions; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Sheep; Yohimbine | 1995 |
The antinociceptive action of an alpha 2-adrenoceptor agonist in the spinal dorsal horn is due to a direct spinal action and not to activation of descending inhibition.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Cordotomy; Dose-Response Relationship, Drug; Evoked Potentials; Imidazoles; Male; Medetomidine; Nerve Fibers; Nerve Fibers, Myelinated; Neural Pathways; Neurons; Rats; Rats, Wistar; Spinal Cord | 1995 |
The role of alpha 2-adrenoceptors of the medullary lateral reticular nucleus in spinal antinociception in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Lidocaine; Male; Medetomidine; Medulla Oblongata; Microinjections; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Adrenergic, alpha-2; Spinal Cord | 1995 |
Food intake and rumen motility in dwarf goats. Effects of atipamezole on the inhibitory effects induced by detomidine, medetomidine and romifidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Eating; Female; Gastrointestinal Motility; Goats; Imidazoles; Infusions, Intravenous; Male; Medetomidine; Rumen | 1994 |
Sedative effect of medetomidine and its reversal by atipamezole in house musk shrews (Suncus murinus).
Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Imidazoles; Kinetics; Male; Medetomidine; Shrews | 1995 |
Cardiopulmonary effects of medetomidine, medetomidine-midazolam and medetomidine-midazolam-atipamezole in dogs.
Topics: Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Dogs; Drug Interactions; Female; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Midazolam; Respiration | 1995 |
Immobilization of free-ranging cattle with medetomidine and its reversal by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Female; Imidazoles; Immobilization; Injections, Intramuscular; Male; Medetomidine; Pregnancy | 1995 |
The effects of selective alpha-2 adrenergic agents on the performance of rats in a 5-choice serial reaction time task.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Animals; Arousal; Attention; Discrimination Learning; Imidazoles; Male; Medetomidine; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time | 1994 |
Antagonistic effects of antipamezole on medetomidine-midazolam induced sedation in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arousal; Body Temperature; Dogs; Drug Interactions; Heart Rate; Hypnotics and Sedatives; Imidazoles; Medetomidine; Midazolam; Respiration; Time Factors | 1994 |
Antagonistic effects of atipamezole and flumazenil on medetomidine-midazolam induced sedation in laboratory pigs.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Laboratory; Arousal; Body Temperature; Castration; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Heart Rate; Hypnotics and Sedatives; Imidazoles; Medetomidine; Midazolam; Swine; Time Factors | 1993 |
Effect of medetomidine on the pharmacokinetics of propofol in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dogs; Female; Imidazoles; Male; Medetomidine; Metabolic Clearance Rate; Motor Activity; Orchiectomy; Ovariectomy; Propofol; Time Factors | 1994 |
Ethanol antagonism by atipamezole on motor performance in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Imidazoles; Male; Medetomidine; Mice; Motor Activity | 1994 |
Spinal and systemic action of the alpha 2 receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide response.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia, Epidural; Anesthesia, Spinal; Animals; Body Temperature; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Forelimb; Heart Rate; Hindlimb; Imidazoles; Infusions, Intravenous; Infusions, Parenteral; Medetomidine; Motor Activity; Naloxone; Pain; Receptors, Adrenergic, alpha-2; Respiration | 1994 |
Anesthetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs.
Topics: Adrenergic alpha-Antagonists; Anesthetics; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enflurane; Fentanyl; Heart Rate; Hemodynamics; Imidazoles; Medetomidine; Models, Biological; Naloxone; Pulmonary Alveoli | 1994 |
Chemical capture of free-ranging cattle: immobilization with xylazine or medetomidine, and reversal with atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Drug Evaluation; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Pregnancy; Xylazine | 1993 |
Effects of medetomidine on intestinal and colonic motility in the dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Colon; Dogs; Drug Interactions; Electrophysiology; Gastrointestinal Motility; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Jejunum; Medetomidine; Yohimbine | 1994 |
Cardiopulmonary effects of medetomidine-midazolam and medetomidine-midazolam- atipamezole in laboratory pigs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Laboratory; Blood Pressure; Carbon Dioxide; Cardiac Output; Drug Interactions; Heart Rate; Hemodynamics; Imidazoles; Male; Medetomidine; Midazolam; Orchiectomy; Oxygen; Partial Pressure; Pulmonary Artery; Pulmonary Circulation; Respiration; Swine; Vascular Resistance | 1994 |
Dissociation of the alpha 2-adrenergic antinociception from sedation following microinjection of medetomidine into the locus coeruleus in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Decerebrate State; Formaldehyde; Hypnotics and Sedatives; Imidazoles; Locus Coeruleus; Male; Medetomidine; Microinjections; Motor Activity; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord | 1994 |
Effects of medetomidine-midazolam on plasma glucose and insulin concentrations in laboratory pigs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Laboratory; Blood Glucose; Drug Interactions; Imidazoles; Injections, Intramuscular; Insulin; Kinetics; Medetomidine; Midazolam; Swine; Time Factors | 1994 |
Alpha 2-adrenergic agonist effects on normocapnic and hypercapnic cerebral blood flow in the dog are anesthetic dependent.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cerebrovascular Circulation; Dogs; Hypercapnia; Imidazoles; Isoflurane; Medetomidine; Oxygen Consumption; Pentobarbital | 1994 |
Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Imidazoles; Infusion Pumps; Male; Medetomidine; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 1994 |
Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U-50,488H against noxious thermal, mechanical and inflammatory stimuli.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Male; Medetomidine; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa | 1994 |
Enhanced alpha-2 adrenergic controls and spinal morphine potency in inflammation.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Carrageenan; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Evoked Potentials; Idazoxan; Imidazoles; Inflammation; Injections, Spinal; Male; Medetomidine; Morphine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Sedation of wild boar (Sus scrofa) and red deer (Cervus elaphus) with medetomidine and the influence on some haematological and serum biochemical variables.
Topics: Animals; Blood Chemical Analysis; Deer; Female; Hematocrit; Hemoglobins; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Medetomidine; Swine; Time Factors | 1994 |
The effect of alpha 2 agonists and antagonists on the lower urinary tract of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Dose-Response Relationship, Drug; Female; Imidazoles; Medetomidine; Rats; Rats, Sprague-Dawley; Urethra; Urinary Bladder; Urination | 1993 |
Alpha 2-adrenergic receptor agonist effects on supraventricular and ventricular automaticity in dogs with complete atrioventricular block.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dog Diseases; Dogs; Formaldehyde; Glycopyrrolate; Heart Block; Heart Rate; Imidazoles; Medetomidine; Prazosin; Ventricular Function; Xylazine | 1993 |
Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia, Inhalation; Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Vessels; Dogs; Enflurane; Epinephrine; Female; Heart; Heart Rate; Imidazoles; Lactates; Male; Medetomidine; Myocardial Contraction; Myocardium; Norepinephrine; Oxygen Consumption; Vascular Resistance; Ventricular Function, Left | 1993 |
Inhibition of intestinal motility and reversal of postlaparotomy ileus by selective alpha 2-adrenergic drugs in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Motility; Imidazoles; Intestinal Obstruction; Laparotomy; Male; Medetomidine; Morphine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Medetomidine-butorphanol-midazolam for anaesthesia in dogs and its reversal by atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics; Animals; Butorphanol; Dogs; Drug Combinations; Female; Heart Rate; Hypothermia; Imidazoles; Male; Medetomidine; Midazolam; Muscle Relaxation | 1993 |
Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, fos; Genes, jun; Imidazoles; Immediate-Early Proteins; Male; Medetomidine; Pain; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord; Thalamus; Transcription Factors | 1993 |
Actions of the hypnotic anaesthetic, dexmedetomidine, on noradrenaline release and cell firing in rat locus coeruleus slices.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Locus Coeruleus; Medetomidine; Norepinephrine; Rats | 1993 |
Alpha 2-adrenoceptors and vigilance in cats: antagonism of medetomidine sedation by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arousal; Cats; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrodes; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Receptors, Adrenergic, alpha; Sleep | 1993 |
The effects of alpha 2-adrenoceptor stimulation on neocortical EEG activity in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Imidazoles; Injections, Subcutaneous; Locus Coeruleus; Male; Medetomidine; Oxidopamine; Rats; Rats, Wistar | 1993 |
The rostroventromedial medulla is not involved in alpha 2-adrenoceptor-mediated antinociception in the rat.
Topics: Analysis of Variance; Animals; Cerebellum; Clonidine; Dose-Response Relationship, Drug; Hot Temperature; Imidazoles; Lidocaine; Male; Medetomidine; Medulla Oblongata; Microinjections; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reflex; Skin Temperature; Spinal Cord; Time Factors | 1993 |
Influence of selective alpha 2-adrenergic agents on mustard oil-induced central hyperalgesia in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Imidazoles; Male; Medetomidine; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reflex | 1995 |
Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acids; Animals; Aspartic Acid; Calcium; Epilepsy; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Imidazoles; Male; Medetomidine; Microdialysis; Potassium; Rats; Rats, Wistar; Seizures; Spectrometry, Fluorescence | 1995 |
Atipamezole increases medetomidine clearance in the dog: an agonist-antagonist interaction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Biotransformation; Dogs; Drug Interactions; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Male; Medetomidine | 1995 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Histocytochemistry; Imidazoles; Kainic Acid; Male; Medetomidine; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Seizures; Status Epilepticus; Vigabatrin | 1995 |
Anesthesia induced in pigs by use of a combination of medetomidine, butorphanol, and ketamine and its reversal by administration of atipamezole.
Topics: Adrenergic alpha-Antagonists; Analgesics; Anesthesia, General; Anesthetics, Dissociative; Animals; Blood Pressure; Butorphanol; Cardiac Output; Drug Interactions; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Ketamine; Male; Medetomidine; Orchiectomy; Oxygen; Partial Pressure; Pulmonary Artery; Reflex; Stroke Volume; Swine; Vascular Resistance | 1996 |
Cardiopulmonary and analgesic effects of xylazine, detomidine, medetomidine, and the antagonist atipamezole in isoflurane-anesthetized swine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Analgesics; Anesthesia; Animals; Blood Pressure; Heart; Heart Rate; Imidazoles; Isoflurane; Lung; Medetomidine; Swine; Vascular Resistance; Xylazine | 1996 |
Hemodynamic effects of medetomidine-midazolam-butorphanol and medetomidine-midazolam-buprenorphine combinations and reversibility by atipamezole in dogs.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Anti-Anxiety Agents; Blood Gas Analysis; Blood Pressure; Body Temperature; Body Weight; Buprenorphine; Butorphanol; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Imidazoles; Medetomidine; Midazolam; Pulmonary Wedge Pressure; Stroke Volume; Vascular Resistance | 1996 |
The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Imidazoles; Lidocaine; Male; Medetomidine; Memory; Microinjections; Prefrontal Cortex; Psychomotor Performance; Rats; Rats, Wistar; Space Perception | 1996 |
An evaluation of the influence of medetomidine hydrochloride and atipamezole hydrochloride on the arrhythmogenic dose of epinephrine in dogs during halothane anesthesia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Cardiovascular System; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; Female; Halothane; Heart Rate; Imidazoles; Male; Medetomidine; Time Factors | 1996 |
Coronary vascular effects of dexmedetomidine during reactive hyperemia in the anesthetized dog.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Coronary Circulation; Dogs; Female; Hyperemia; Imidazoles; Lactic Acid; Male; Medetomidine; Myocardial Ischemia; Oxygen; Vascular Resistance | 1996 |
Different roles of alpha 2-adrenoceptors of the medulla versus the spinal cord in modulation of mustard oil-induced central hyperalgesia in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Medetomidine; Medulla Oblongata; Mustard Plant; Pain Threshold; Physical Stimulation; Plant Extracts; Plant Oils; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reticular Formation; Spinal Cord | 1996 |
Role of spinal and peripheral alpha 2 adrenoceptors in micturition in normal conscious rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Consciousness; Female; Imidazoles; Injections, Intra-Arterial; Injections, Intravenous; Injections, Spinal; Medetomidine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spine; Urinary Bladder; Urination | 1996 |
Antagonistic effects of atipamezole on medetomidine-induced sedation in horses.
Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Dose-Response Relationship, Drug; Female; Heart Rate; Horses; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Respiration | 1996 |
Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Drug Interactions; Female; Guanfacine; Imidazoles; Macaca; Male; Medetomidine; Memory; Receptors, Adrenergic, alpha-2 | 1996 |
Dexmedetomidine reduces response tendency, but not accuracy of rats in attention and short-term memory tasks.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Attention; Benzylamines; Biogenic Monoamines; Brain Chemistry; Imidazoles; Male; Medetomidine; Memory, Short-Term; Neurotransmitter Uptake Inhibitors; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Serial Learning | 1997 |
Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Conscious Sedation; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Feeding Behavior; Imidazoles; Injections, Intraventricular; Male; Medetomidine; Methoxamine; Prazosin; Rats; Rats, Sprague-Dawley; Yohimbine | 1997 |
Pineal melatonin in rats: suppression by the selective alpha2-adrenoceptor agonist medetomidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Female; Imidazoles; Isoproterenol; Medetomidine; Melatonin; Pineal Gland; Rats; Rats, Wistar | 1997 |
Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arterioles; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Imidazoles; Injections, Intravenous; Male; Medetomidine; Perfusion; Pia Mater; Rats; Rats, Wistar; Vasoconstriction | 1997 |
Reversible immobilization of free-ranging polar bears with medetomidine-zolazepam-tiletamine and atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Tiletamine; Ursidae; Zolazepam | 1997 |
Physiological effects of medetomidine-zolazepam-tiletamine immobilization in black bears.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Pressure; Body Temperature; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Oxygen; Respiration; Tiletamine; Ursidae; Zolazepam | 1997 |
The effects of alpha-2 agonist, medetomidine and its antagonist, atipamezole on reaction and movement times in a visual choice reaction time task in monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Choice Behavior; Cues; Imidazoles; Macaca; Medetomidine; Movement; Photic Stimulation; Reaction Time; Time Factors | 1997 |
Reversal of medetomidine-induced sedation in reindeer (Rangifer tarandus tarandus) with atipamezole increases the medetomidine concentration in plasma.
Topics: Adrenergic alpha-Antagonists; Animals; Area Under Curve; Behavior, Animal; Deer; Dose-Response Relationship, Drug; Female; Half-Life; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Medetomidine; Seasons | 1997 |
Peripherally administered alpha2-adrenoceptor agonist in the modulation of chronic allodynia induced by spinal nerve ligation in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Imidazoles; Ligation; Male; Medetomidine; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Nerves | 1997 |
Medetomidine protection against diazinon-induced toxicosis in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazinon; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Imidazoles; Insecticides; Lethal Dose 50; Male; Medetomidine; Mice; Nervous System Diseases; Parasympatholytics; Survival Rate | 1997 |
Evaluation of the effects of a specific alpha 2-adrenoceptor antagonist, atipamezole, on alpha 1- and alpha 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Biogenic Amines; Brain; Female; Imidazoles; Male; Medetomidine; Mice; Motor Activity; Prazosin; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Serotonin; Yohimbine | 1997 |
Alpha2-adrenergic control of dopamine overflow and metabolism in mouse striatum.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dopamine; Electric Stimulation; Imidazoles; Male; Medetomidine; Mice; Mice, Inbred BALB C; Visual Cortex | 1997 |
Observations on the use of medetomidine/ketamine and its reversal with atipamezole for chemical restraint in the mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Anesthesia; Anesthesia Recovery Period; Anesthetics, Combined; Animals; Body Temperature; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Mice; Oximetry; Pilot Projects; Random Allocation | 1998 |
Alpha adrenoceptors in the rabbit ear thermoregulatory microcirculation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature Regulation; Ear, External; Imidazoles; Male; Medetomidine; Microcirculation; Models, Cardiovascular; Phenylephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Skin; Vasoconstriction | 1998 |
Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aggression; Amphetamine; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Imidazoles; Male; Medetomidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Neural Inhibition; Phencyclidine; Receptors, Adrenergic, alpha-2; Reflex, Startle; Social Behavior | 1998 |
The pharmacodynamics of thiopental, medetomidine, butorphanol and atropine in beagle dogs.
Topics: Adjuvants, Anesthesia; Anesthesia; Animals; Arousal; Atropine; Blood Pressure; Butorphanol; Dogs; Drug Interactions; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Medetomidine; Thiopental | 1998 |
Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Gonadal Steroid Hormones; Imidazoles; In Vitro Techniques; Medetomidine; Protein Binding; Receptors, Adrenergic, alpha-2; Swine | 1998 |
Anesthesia of wild red howler monkeys (Alouatta seniculus) with medetomidine/ketamine and reversal by atipamezole.
Topics: Alouatta; Anesthesia; Anesthetics, Dissociative; Animals; Body Temperature; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Medetomidine; Respiration | 1998 |
Comparison of injectable anesthetic combinations in free-ranging two-toed sloths in French guiana.
Topics: Acepromazine; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Combined; Animals; Animals, Wild; Body Temperature; Female; French Guiana; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Male; Medetomidine; Muscle Relaxation; Oxyhemoglobins; Respiration; Sloths; Tiletamine; Xylazine; Zolazepam | 1998 |
Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electroencephalography; Escape Reaction; Female; Imidazoles; Medetomidine; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Adrenergic, alpha-2; Signal Transduction; Spatial Behavior; Species Specificity | 1998 |
Immobilization of wild kinkajous (Potos flavus) with medetomidine-ketamine and reversal by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Body Temperature; Carnivora; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Oxygen; Respiration | 1998 |
Receptor-specific reversible sedation: beginning of new era of anesthesia?
Topics: Adrenergic alpha-Antagonists; Anesthesia; Humans; Hypnotics and Sedatives; Imidazoles; Medetomidine; Receptors, Adrenergic, alpha | 1998 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Male; Medetomidine; Pain; Pain Threshold; Quinolizines; Rats; Rats, Sprague-Dawley; Spinal Nerves | 1998 |
Anesthetic and cardiorespiratory effects of tiletamine-zolazepam-medetomidine in cheetahs.
Topics: Acid-Base Equilibrium; Acinonyx; Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Dissociative; Animals; Blood Pressure; Body Temperature; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Oxygen; Respiration; Tiletamine; Zolazepam | 1998 |
Pharmacokinetics of medetomidine and atipamezole in dairy calves: an agonist-antagonist interaction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Under Curve; Cattle; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Antagonism; Female; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Male; Medetomidine | 1998 |
Activation of muscarinic M3-like receptors and beta-adrenoceptors, but not M2-like muscarinic receptors or alpha-adrenoceptors, directly modulates corticostriatal neurotransmission in vitro.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic Fibers; Animals; Carbachol; Cerebral Cortex; Cholinergic Fibers; Corpus Striatum; Diamines; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Imidazoles; Isoproterenol; Male; Medetomidine; Mice; Mice, Inbred DBA; Muscarinic Agonists; Muscarinic Antagonists; Phenylephrine; Piperidines; Pirenzepine; Pyrrolidinones; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, AMPA; Receptors, Muscarinic; Scopolamine; Synaptic Transmission | 1999 |
Evidence against alpha2-adrenoceptor involvement in the regulation of rat melatonin synthesis by ambient lighting.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Circadian Rhythm; Imidazoles; Lighting; Male; Medetomidine; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Yohimbine | 1999 |
Melatonin release from rat pineals in vitro is stimulated by both the alpha(2)-adrenoceptor agonist medetomidine and the antagonist atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Imidazoles; In Vitro Techniques; Male; Medetomidine; Melatonin; Pineal Gland; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 1999 |
Anesthesia of polar bears (Ursus maritimus) with zolazepam-tiletamine, medetomidine-ketamine, and medetomidine-zolazepam-tiletamine.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Wild; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Body Temperature; Female; Handling, Psychological; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Pulse; Respiration; Tiletamine; Ursidae; Zolazepam | 1999 |
Immobilization of sika deer with medetomidine and ketamine, and antagonism by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Body Temperature; Body Weight; Deer; Female; Heart Rate; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Male; Medetomidine; Respiration | 1999 |
A pharmacokinetic study including some relevant clinical effect of medetomidine and atipamezole in lactating dairy cows.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Under Curve; Body Temperature; Cattle; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Lactation; Medetomidine; Random Allocation; Respiration | 1999 |
Immobilization of California sea lions using medetomidine plus ketamine with and without isoflurane and reversal with atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthetics; Animals; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Isoflurane; Ketamine; Male; Medetomidine; Respiration; Sea Lions; Time Factors | 2000 |
Short duration anaesthesia with medetomidine and ketamine in cynomolgus monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Gas Analysis; Blood Pressure; Body Temperature; Heart Rate; Imidazoles; Injections, Intramuscular; Ketamine; Macaca fascicularis; Male; Medetomidine; Random Allocation; Respiration | 1999 |
The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbon Dioxide; Cardiac Output; Conscious Sedation; Female; Fluorescent Dyes; Hemodynamics; Imidazoles; Medetomidine; Microspheres; Oxygen; Regional Blood Flow; Sheep; Vascular Resistance | 2000 |
Sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, and medetomidine-ketamine in dogs.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Blood Pressure; Butorphanol; Cross-Over Studies; Dogs; Drug Combinations; Glycopyrrolate; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Intubation, Intratracheal; Ketamine; Medetomidine; Pain Measurement; Random Allocation; Respiration | 2000 |
Sedative and cardiopulmonary effects of medetomidine and reversal with atipamezole in desert tortoises (Gopherus agassizii).
Topics: Acid-Base Equilibrium; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Gas Analysis; Blood Pressure; Electrolytes; Heart Rate; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Imidazoles; Medetomidine; Oxygen; Respiration; Turtles | 2000 |
Effects of immobilization with medetomidine and reversal with atipamezole on blood chemistry of semi-domesticated reindeer (Rangifer tarandus tarandus L.) in autumn and late winter.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Chemical Analysis; Blood Glucose; Cholesterol; Creatine Kinase; Creatinine; Electrolytes; Fatty Acids; Female; Imidazoles; Immobilization; Medetomidine; Pregnancy; Proteins; Reindeer; Seasons; Urea | 1999 |
Capture and immobilisation of aardvark (Orycteropus afer) using different drug combinations.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Animals; Female; Halothane; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Midazolam; Xenarthra; Xylazine | 2000 |
Field anesthesia of wild arctic fox (Alopex lagopus) cubs in the Swedish lapland using medetomidine-ketamine-atipamezole.
Topics: Adrenergic alpha-Agonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Body Temperature; Conservation of Natural Resources; Female; Foxes; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Ketamine; Male; Medetomidine; Oximetry; Sweden | 2000 |
Sufentanil and medetomidine anaesthesia in the rat and its reversal with atipamezole and butorphanol.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Animals, Outbred Strains; Behavior, Animal; Butorphanol; Drug Combinations; Female; Imidazoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Medetomidine; Narcotic Antagonists; Oximetry; Oxygen; Rats; Rats, Wistar; Sufentanil; Time Factors | 2000 |
The effects of medetomidine and its reversal with atipamezole on plasma glucose, cortisol and noradrenaline in cattle and sheep.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Blood Glucose; Cattle; Cross-Over Studies; Drug Interactions; Female; Hydrocortisone; Imidazoles; Injections, Intravenous; Medetomidine; Norepinephrine; Sheep | 2000 |
Medetomidine and atipamezole in sheep: disposition and clinical effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Conscious Sedation; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Female; Half-Life; Imidazoles; Injections, Intravenous; Medetomidine; Metabolic Clearance Rate; Sheep | 2000 |
Use of medetomidine and ketamine for immobilization of free-ranging giraffes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Wild; Blood Gas Analysis; Blood Pressure; Body Temperature; Female; Heart Rate; Hydrogen-Ion Concentration; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Male; Medetomidine; Oximetry; Ruminants | 2001 |
Cardiopulmonary and anesthetic effects of medetomidine-ketamine-butorphanol and antagonism with atipamezole in servals (Felis serval).
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Gas Analysis; Butorphanol; Carnivora; Drug Combinations; Female; Heart; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Ketamine; Lung; Male; Medetomidine; Respiration | 2000 |
Clinical evaluation of established optimal immobilizing doses of medetomidine-ketamine in captive reindeer (Rangifer tarandus tarandus).
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Body Temperature; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Oximetry; Reindeer; Reproducibility of Results; Respiration | 2001 |
Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies.
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Anesthetics, Intravenous; Animals; Blood Pressure; Body Temperature; Drug Therapy, Combination; Heart Rate; Horses; Hypnotics and Sedatives; Imidazoles; Infusions, Intravenous; Medetomidine; Pain Measurement; Propofol; Random Allocation | 2001 |
Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans).
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Dissociative; Animals; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intramuscular; Intubation, Intratracheal; Ketamine; Medetomidine; Muscle, Skeletal; Random Allocation; Turtles | 2001 |
High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase.
Topics: Aminobiphenyl Compounds; Amitriptyline; Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; Imidazoles; Kinetics; Medetomidine; Microsomes, Liver; Nitrophenols; Radiochemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Time Factors; Ultraviolet Rays | 2001 |
The effects of topical tropicamide and systemic medetomidine, followed by atipamezole reversal, on pupil size and intraocular pressure in normal dogs.
Topics: Administration, Oral; Administration, Topical; Adrenergic alpha-Antagonists; Animals; Dogs; Female; Hypnotics and Sedatives; Imidazoles; Intraocular Pressure; Male; Medetomidine; Mydriatics; Pupil; Reference Values; Tropicamide | 2001 |
Evaluation of an anesthetic regimen for retroorbital blood collection from mice.
Topics: Adrenergic alpha-Antagonists; Analgesics; Anesthesia; Anesthetics, Local; Animal Welfare; Animals; Blood Specimen Collection; Drug Interactions; Drug Therapy, Combination; Female; Imidazoles; Ketamine; Male; Medetomidine; Mice; Mice, Inbred Strains; Orbit; Propoxycaine; Rats | 2000 |
Reversible immobilization of eurasian otters with a combination of ketamine and medetomidine.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Drug Synergism; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Otters; Oximetry; Respiration; Safety; Treatment Outcome | 2001 |
Use of medetomidine-zolazepam-tiletamine with and without atipamezole reversal to immobilize captive California sea lions.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Anti-Anxiety Agents; Benzodiazepines; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Respiration; Sea Lions; Tiletamine; Time Factors; Zolazepam | 2001 |
Cardiopulmonary effects of prolonged anesthesia via propofol-medetomidine infusion in ponies.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Intravenous; Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Cardiovascular System; Horses; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Medetomidine; Oxygen; Propofol; Random Allocation; Respiration | 2001 |
Effects of medetomidine and buprenorphine administered for sedation in dogs.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Anesthesia Recovery Period; Animals; Buprenorphine; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Medetomidine; Respiration; Time Factors | 2001 |
N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Detergents; Dogs; Enzyme Activation; Glucuronosyltransferase; Humans; Imidazoles; In Vitro Techniques; Isoenzymes; Kinetics; Male; Medetomidine; Microsomes, Liver; Octoxynol; Rats; Rats, Wistar; Species Specificity; Stereoisomerism; Structure-Activity Relationship | 2002 |
Infusion of alpha-2-adrenergic agents into the paraventricular and arcuate nuclei of the hypothalamus in the Siberian hamster: opposing effects on basal prolactin.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arcuate Nucleus of Hypothalamus; Cricetinae; Imidazoles; Male; Medetomidine; Paraventricular Hypothalamic Nucleus; Phodopus; Prolactin; Receptors, Adrenergic, alpha-2 | 2002 |
Cardiopulmonary effects of a medetomidine-ketamine combination administered intravenously in gopher tortoises.
Topics: Adrenergic alpha-Agonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Blood Pressure; Body Temperature; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intravenous; Ketamine; Male; Medetomidine; Oxygen Consumption; Prospective Studies; Respiration; Turtles | 2002 |
Evaluation of medetomidine-ketamine anesthesia with atipamezole reversal in American alligators (Alligator mississippiensis).
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alligators and Crocodiles; Analgesics, Non-Narcotic; Anesthesia; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Electrocardiography; Heart Rate; Imidazoles; Ketamine; Medetomidine; Reflex; Respiration; Restraint, Physical | 2002 |
Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons.
Topics: Adrenergic alpha-Antagonists; Animals; Butorphanol; Cloaca; Columbidae; Drug Administration Schedule; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Ketamine; Male; Medetomidine; Respiration; Temperature | 2002 |
Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Zoo; Blood Pressure; Body Temperature; Butorphanol; Diazepam; Drug Combinations; Female; Flumazenil; GABA Modulators; Heart Rate; Hypertension; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Muscle Relaxation; Naloxone; Narcotic Antagonists; Narcotics; Respiration; Wolves | 2002 |
The cardiovascular and respiratory effects of medetomidine and thiopentone anaesthesia in dogs breathing at an altitude of 1486 m.
Topics: Adrenergic alpha-Antagonists; Altitude; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Dogs; Drug Interactions; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Oxygen; Respiration; Thiopental | 2002 |
The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; Fatty Acids, Nonesterified; Female; Hydrocortisone; Hypnotics and Sedatives; Imidazoles; Insulin; Medetomidine; Norepinephrine; Random Allocation; Stress, Physiological; Yohimbine | 2003 |
Medetomidine-ketamine in reindeer (Rangifer tarandus tarandus): effective immobilization by hand- and dart-administered injection.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Medetomidine; Reindeer; Time Factors | 2002 |
Comparison of ketamine versus combination of ketamine and medetomidine in injectable anesthetic protocols: chemical immobilization in macaques and tissue reaction in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthesia Recovery Period; Anesthetics, Dissociative; Animals; Behavior, Animal; Drug Therapy, Combination; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Macaca mulatta; Male; Medetomidine; Muscle, Skeletal; Rats | 2003 |
Immobilization of free-ranging European mink (Mustela lutreola) an polecat (Mustela putorius) with medetomidine-ketamine and reversal by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia Recovery Period; Anesthetics, Dissociative; Animals; Animals, Wild; Body Temperature; Female; Ferrets; Heart Rate; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Mink; Respiration; Time Factors | 2003 |
Anesthetic induction of captive tigers (Panthera tigris) using a medetomidine-ketamine combination.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Carnivora; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Medetomidine; Transportation | 2003 |
Influence of yohimbine and atipamezole on haemodynamics and ECG after lumbosacral subarachnoid administration of medetomidine in goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cross-Over Studies; Electrocardiography; Female; Goats; Hemodynamics; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Random Allocation; Yohimbine | 2003 |
Reversible anesthesia of captive California sea lions (Zalophus californianus) with medetomidine, midazolam, butorphanol, and isoflurane.
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Animals; Antidotes; Butorphanol; Dose-Response Relationship, Drug; Female; Flumazenil; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Isoflurane; Medetomidine; Midazolam; Naltrexone; Narcotic Antagonists; Narcotics; Respiration; Sea Lions; Time Factors | 2004 |
Immobilisation of impala (Aepyceros melampus) with a ketamine hydrochloride/medetomidine hydrochloride combination, and reversal with atipamezole hydrochloride.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Antelopes; Dose-Response Relationship, Drug; Drug Synergism; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Ketamine; Male; Medetomidine; Random Allocation | 2004 |
Intramuscular anesthesia of bonito and Pacific mackerel with ketamine and medetomidine and reversal of anesthesia with atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Dissociative; Animals; Dose-Response Relationship, Drug; Drug Combinations; Imidazoles; Injections, Intramuscular; Ketamine; Medetomidine; Perciformes; Random Allocation; Safety; Time Factors | 2004 |
Reversal of medetomidine-ketamine combination anesthesia in rabbits by atipamezole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Anesthesia; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Female; Heart Rate; Imidazoles; Ketamine; Male; Medetomidine; Rabbits; Time Factors | 2004 |
Immobilization of Chacoan peccaries (Catagonus wagneri) using medetomidine, Telazol, and ketamine.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Artiodactyla; Drug Combinations; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Medetomidine; Oximetry; Oxygen; Respiration; Tiletamine; Time Factors; Zolazepam | 2004 |
Ketamine-medetomidine anesthesia with atipamezole reversal: practical anesthesia for rodents under field conditions.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics; Animals; Drug Interactions; Female; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Medetomidine; Rodentia; Time Factors | 2005 |
Tribromoethanol-medetomidine combination provides a safe and reversible anesthetic effect in Sprague-Dawley rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Anesthetics, Combined; Animals; Dose-Response Relationship, Drug; Ethanol; Hypnotics and Sedatives; Imidazoles; Injections, Intraperitoneal; Liver; Male; Medetomidine; Rats; Rats, Sprague-Dawley; Safety | 2005 |
Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guanfacine; Imidazoles; Injections; Male; Medetomidine; Neural Inhibition; Piperazines; Prazosin; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-2; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Yohimbine | 2005 |
Use of medetomidine-ketamine and atipamezole for reversible immobilization of free-ranging hog deer (Axis porcinus) captured in drive nets.
Topics: Animals; Deer; Drug Combinations; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Male; Medetomidine | 2005 |
Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Wild; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Lions; Male; Medetomidine; Respiration; Tiletamine; Time Factors; Zimbabwe; Zolazepam | 2005 |
Reversible immobilization of free-ranging African lions (Panthera leo) with medetomidine-tiletamine-zolazepam and atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Wild; Blood Pressure; Body Temperature; Cameroon; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Lions; Male; Medetomidine; Tiletamine; Time Factors; Zolazepam | 2006 |
Reversible anesthesia in wild marine otters (Lontra felina) using ketamine and medetomidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Wild; Body Temperature; Heart Rate; Imidazoles; Injections, Intramuscular; Ketamine; Medetomidine; Otters; Respiration; Time Factors | 2006 |
Reversible anesthesia of Southeast Asian primates with medetomidine, zolazepam, and tiletamine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia Recovery Period; Anesthetics, Combined; Animals; Animals, Wild; Female; Heart Rate; Hylobates; Imidazoles; Macaca fascicularis; Macaca nemestrina; Male; Medetomidine; Pongo pygmaeus; Respiration; Species Specificity; Tiletamine; Time Factors; Zolazepam | 2006 |
Field anaesthesia of leatherback sea turtles (Dermochelys coriacea).
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Drug Administration Schedule; Electroretinography; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Infusions, Intravenous; Injections, Intramuscular; Ketamine; Medetomidine; Turtles | 2007 |
Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats.
Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Arousal; Body Temperature; Cats; Dose-Response Relationship, Drug; Flumazenil; Heart Rate; Imidazoles; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Medetomidine; Midazolam | 2008 |
Survey of utilization of medetomidine and atipamezole in private veterinary practice in Quebec in 2002.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Hypnotics and Sedatives; Imidazoles; Medetomidine; Practice Patterns, Physicians'; Quebec; Veterinary Drugs; Veterinary Medicine | 2007 |
Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Heart Rate; Imidazoles; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Medetomidine; Midazolam; Respiration; Time Factors | 2007 |
Comparison of subcutaneous and intramuscular ketamine-medetomidine with and without reversal by atipamezole in Dutch belted rabbits (Oryctolagus cuniculus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Animals, Laboratory; Drug Combinations; Heart Rate; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Male; Medetomidine; Rabbits; Random Allocation; Reflex; Respiratory Mechanics | 2007 |
Reversible medetomidine/ketamine anesthesia in captive capuchin monkeys (Cebus apella).
Topics: Anesthesia; Animals; Biomechanical Phenomena; Cebus; Imidazoles; Ketamine; Male; Mastication; Medetomidine; Restraint, Physical | 2008 |
Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogs.
Topics: Adrenergic alpha-Antagonists; Analgesia; Anesthesia; Anesthetics; Animals; Dogs; Drug Therapy, Combination; Female; Imidazoles; Ketamine; Male; Medetomidine; Morphine; Time Factors | 2008 |
Field anesthesia of golden jackals (Canis aureus) with the use of medetomidine-ketamine or medetomidine-midazolam with atipamezole reversal.
Topics: Adrenergic alpha-Antagonists; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Wild; Blood Pressure; Body Temperature; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Jackals; Ketamine; Male; Medetomidine; Midazolam; Oxygen Consumption; Respiration; Time Factors | 2008 |
Evaluation of the anaesthetic effects of medetomidine and ketamine in rats and their reversal with atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Anesthetics, Dissociative; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hypnotics and Sedatives; Imidazoles; Ketamine; Male; Medetomidine; Rats; Rats, Sprague-Dawley | 2009 |
Reversible immobilization of free-ranging Svalbard reindeer (Rangifer tarandus platyrhynchus) with medetomidine-ketamine and atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Wild; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Injections, Subcutaneous; Ketamine; Medetomidine; Reindeer | 2009 |
Atipamezole changes the antinociceptive effects of butorphanol after medetomidine-ketamine anaesthesia in rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Butorphanol; Imidazoles; Ketamine; Male; Medetomidine; Rats; Rats, Sprague-Dawley | 2009 |
Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Under Curve; Arginine Vasopressin; Atrial Natriuretic Factor; Diuresis; Dogs; Imidazoles; Male; Medetomidine; Osmolar Concentration; Random Allocation; Specific Gravity; Yohimbine | 2009 |
Comparison of three anaesthetic protocols in Bennett's wallabies (Macropus rufogriseus).
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Animals; Blood Gas Analysis; Body Temperature; Dexmedetomidine; Drug Therapy, Combination; Female; Heart Rate; Imidazoles; Injections, Intramuscular; Ketamine; Macropodidae; Male; Medetomidine; Respiratory Rate; Xylazine | 2010 |
Reversible immobilization of giant otters (Pteronura brasiliensis) using medetomidine-ketamine and atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Dissociative; Animals; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Otters | 2010 |
Intranasal naltrexone and atipamezole for reversal of white-tailed deer immobilized with carfentanil and medetomidine.
Topics: Administration, Intranasal; Adrenergic alpha-Antagonists; Animals; Cross-Over Studies; Deer; Dose-Response Relationship, Drug; Drug Combinations; Female; Fentanyl; Imidazoles; Immobilization; Injections, Intramuscular; Medetomidine; Naltrexone; Narcotic Antagonists; Random Allocation | 2010 |
Immobilization of red fox (Vulpes vulpes) with medetomidine-ketamine or medetomidine-midazolam and antagonism with atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Dissociative; Animals; Animals, Wild; Blood Pressure; Body Temperature; Foxes; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Medetomidine; Midazolam; Oxygen; Respiration | 2010 |
Anesthesia with intraperitoneal propofol, medetomidine, and fentanyl in rats.
Topics: Anesthesia; Anesthetics; Animals; Fentanyl; Imidazoles; Injections, Intraperitoneal; Laboratory Animal Science; Male; Medetomidine; Propofol; Rats; Rats, Wistar | 2010 |
Effective immobilizing doses of medetomidine-ketamine in free-ranging, wild Norwegian reindeer (Rangifer tarandus tarandus).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Wild; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Norway; Reindeer; Time Factors | 2011 |
Evaluation of two sedation protocols for use before diagnostic intra-articular anaesthesia in lame dogs.
Topics: Acepromazine; Anesthesia; Animals; Conscious Sedation; Dog Diseases; Dogs; Female; Hypnotics and Sedatives; Imidazoles; Injections, Intra-Articular; Lameness, Animal; Male; Medetomidine; Methadone; Random Allocation | 2011 |
Chemical immobilization of raccoons (Procyon lotor) with ketamine-medetomidine mixture and reversal with atipamezole.
Topics: Anesthesia Recovery Period; Animals; Animals, Wild; Female; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Male; Medetomidine; Raccoons; Seasons; Sex Factors | 2012 |
Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice.
Topics: Anesthesia; Anesthesia Recovery Period; Animals; Imidazoles; Ketamine; Medetomidine; Mice; Reflex; Time Factors | 2011 |
Field immobilization of feral 'Judas' donkeys (Equus asinus) by remote injection of medetomidine and ketamine and antagonism with atipamezole.
Topics: Animals; Animals, Wild; Drug Combinations; Equidae; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Ketamine; Male; Medetomidine | 2012 |
Medetomidine immobilisation and atipamezole reversal in large estuarine crocodiles (Crocodylus porosus) using metabolically scaled dosages.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Alligators and Crocodiles; Animals; Animals, Wild; Animals, Zoo; Body Surface Area; Body Weight; Dose-Response Relationship, Drug; Imidazoles; Immobilization; Male; Medetomidine | 2012 |
Preliminary studies of chemical immobilization of captive juvenile estuarine (Crocodylus porosus) and Australian freshwater (C. johnstoni) crocodiles with medetomidine and reversal with atipamezole.
Topics: Alligators and Crocodiles; Animals; Body Weight; Hypnotics and Sedatives; Imidazoles; Immobilization; Injections, Intramuscular; Male; Medetomidine; Monitoring, Physiologic | 2012 |
Use of a medetomidine-ketamine combination for anesthesia in captive common hippopotami (Hippopotamus amphibius).
Topics: Anesthetics, Combined; Anesthetics, Dissociative; Animals; Animals, Zoo; Artiodactyla; Blood Gas Analysis; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Ketamine; Male; Medetomidine; Orchiectomy; Oxygen; Respiratory Rate; Time Factors | 2012 |
Effects of imidazoline and nonimidazoline alpha-adrenergic agents, including xylazine, medetomidine, yohimbine, tolazoline, and atipamezole, on aggregation of bovine and equine platelets.
Topics: Adrenergic Agents; Animals; Cattle; Female; Horses; Imidazoles; Imidazolines; Inhibitory Concentration 50; Male; Medetomidine; Platelet Aggregation; Tolazoline; Xylazine; Yohimbine | 2013 |
Evaluation of medetomidine-ketamine and atipamezole for reversible anesthesia of free-ranging gray wolves (Canis lupus).
Topics: Anesthesia Recovery Period; Anesthetics, Dissociative; Animals; Animals, Newborn; Animals, Wild; Cause of Death; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Male; Malignant Hyperthermia; Medetomidine; Wolves | 2013 |
Comparison of two injectable immobilization combinations in Himalayan tahr (Hemitragus jemlahicus): medetomidine, ketamine, and atipamezole versus carfentanil, xylazine, naltrexone, and atipamezole.
Topics: Animals; Fentanyl; Hypnotics and Sedatives; Imidazoles; Ketamine; Medetomidine; Naltrexone; Ruminants; Xylazine | 2013 |
Antagonistic effects of atipamezole, yohimbine and prazosin on medetomidine-induced diuresis in healthy cats.
Topics: Animals; Area Under Curve; Arginine Vasopressin; Cats; Creatinine; Diuresis; Electrolytes; Hydrogen-Ion Concentration; Imidazoles; Medetomidine; Osmolar Concentration; Prazosin; Specific Gravity; Urinalysis; Yohimbine | 2014 |
Efficacy of a low-dosage combination of butorphanol, azaperone, and medetomidine (BAM) to immobilize Rocky Mountain elk.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Azaperone; Butorphanol; Deer; Dose-Response Relationship, Drug; Drug Combinations; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Male; Medetomidine; Tolazoline | 2014 |
Field immobilization of wood mice (Apodemus sylvaticus) with medetomidine and ketamine and antagonism with atipamezole.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Dissociative; Animals; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Medetomidine; Murinae | 2014 |
Anesthetic effects of a three-drugs mixture--comparison of administrative routes and antagonistic effects of atipamezole in mice.
Topics: Anesthesia Recovery Period; Anesthetics, Combined; Animals; Butorphanol; Female; Imidazoles; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Male; Medetomidine; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Midazolam | 2015 |
Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brain; Brain Mapping; Cerebrovascular Circulation; Electroencephalography; Evoked Potentials; Image Processing, Computer-Assisted; Imidazoles; Magnetic Resonance Imaging; Male; Medetomidine; Neural Pathways; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rest; Synaptic Transmission | 2014 |
Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
Topics: 4-Aminopyridine; Anesthesia; Anesthetics, Combined; Animals; Arousal; Cats; Dose-Response Relationship, Drug; Flumazenil; Imidazoles; Ketamine; Medetomidine; Midazolam; Respiration | 2015 |
EFFECT OF ACTIVE COOLING AND α-2 ADRENOCEPTOR ANTAGONISM ON CORE TEMPERATURE IN ANESTHETIZED BROWN BEARS (URSUS ARCTOS).
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Animals, Wild; Body Temperature; Fever; Hypnotics and Sedatives; Imidazoles; Immobilization; Medetomidine; Ursidae; Xylazine | 2015 |
Effects of an anesthetic mixture of medetomidine, midazolam, and butorphanol in rats-strain difference and antagonism by atipamezole.
Topics: Anesthesia Recovery Period; Anesthetics, Combined; Animals; Butorphanol; Imidazoles; Male; Medetomidine; Midazolam; Oximetry; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Time Factors | 2016 |
Propofol-medetomidine-ketamine total intravenous anaesthesia in thiafentanil-medetomidine-immobilized impala (Aepyceros melampus).
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia, Intravenous; Anesthetics, Combined; Animals; Antelopes; Female; Fentanyl; Heart Rate; Hypnotics and Sedatives; Imidazoles; Ketamine; Medetomidine; Naltrexone; Narcotic Antagonists; Propofol; Prospective Studies; Respiratory Rate | 2017 |
Effects of a mixture of medetomidine, midazolam and butorphanol on anesthesia and blood biochemistry and the antagonizing action of atipamezole in hamsters.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Anesthetics, Combined; Animals; Butorphanol; Calcium; Dose-Response Relationship, Drug; Imidazoles; Injections, Intramuscular; Male; Medetomidine; Mesocricetus; Midazolam; Phosphorus; Sodium | 2017 |
Chemical immobilization of free-ranging and captive Sunda clouded leopards (Neofelis diardi) with two anesthetic protocols: medetomidine-ketamine and tiletamine-zolazepam.
Topics: Anesthetics, Combined; Animals; Animals, Wild; Body Temperature; Borneo; Felidae; Female; Heart Rate; Imidazoles; Immobilization; Ketamine; Male; Medetomidine; Tiletamine; Zolazepam | 2017 |
Tissue Residue Levels after Immobilization of Rocky Mountain Elk ( Cervus elaphus nelsoni) using a Combination of Nalbuphine, Medetomidine, and Azaperone Antagonized with Naltrexone, Atipamezole, and Tolazoline.
Topics: Animals; Azaperone; Deer; Drug Combinations; Drug Residues; Female; Hypnotics and Sedatives; Imidazoles; Immobilization; Medetomidine; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Tolazoline | 2018 |
Effects of selective α
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Bronchi; Carbachol; Electric Stimulation; Horses; Imidazoles; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Xylazine | 2018 |
Usefulness of an anesthetic mixture of medetomidine, midazolam, and butorphanol in cotton rats (Sigmodn hispidus).
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthesia; Anesthetics, Combined; Animals; Butorphanol; Female; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Midazolam; Sigmodontinae | 2016 |
ECHOCARDIOGRAPHIC PARAMETERS IN EIGHT ADULT TIGERS ( PANTHERA TIGRIS) DURING TWO PHASES OF AN ANESTHETIC PROTOCOL.
Topics: Anesthesia, General; Animals; Blood Pressure; Echocardiography; Female; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Tigers | 2018 |
Butorphanol-Azaperone-Medetomidine for the Immobilization of Rhesus Macaques (
Topics: Analgesics, Opioid; Animals; Azaperone; Butorphanol; Drug Combinations; Female; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Macaca mulatta; Male; Medetomidine; Pilot Projects | 2019 |
Effects of an anesthetic mixture of medetomidine, midazolam, and butorphanol and antagonism by atipamezole in rabbits.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthetics, Combined; Animals; Butorphanol; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Ketamine; Male; Medetomidine; Midazolam; Rabbits; Xylazine | 2019 |
Comparison of the anesthetic effect by the injection route of mixed anesthesia (medetomidine, midazolam and butorphanol) and the effect of this anesthetic agent on the respiratory function.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthesia; Anesthetics, Combined; Animals; Blood Gas Analysis; Butorphanol; Hypnotics and Sedatives; Imidazoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Medetomidine; Midazolam; Rats, Sprague-Dawley; Respiration | 2020 |
A simple method using anesthetics to test effects of sleep-inducing substances in mice.
Topics: Anesthesia; Anesthetics; Animals; Azepines; Butorphanol; Chlorpromazine; Drug Combinations; Imidazoles; Indenes; Isoflurane; Male; Medetomidine; Mice; Mice, Inbred ICR; Midazolam; Orexin Receptor Antagonists; Sleep Aids, Pharmaceutical; Triazoles | 2020 |
Effects of imidazoline and nonimidazoline α-adrenoceptor agonists and antagonists, including xylazine, medetomidine, dexmedetomidine, yohimbine, and atipamezole, on aggregation of feline platelets.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Platelets; Cats; Dexmedetomidine; Imidazoles; Imidazolines; Medetomidine; Xylazine; Yohimbine | 2020 |
Different Reactions of Zebra Finches and Bengalese Finches to a Three-Component Mixture of Anesthetics.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Anesthetics, Combined; Animals; Butorphanol; Female; Finches; Hypnotics and Sedatives; Imidazoles; Injections, Intramuscular; Ketamine; Male; Medetomidine; Midazolam; Xylazine | 2020 |
Tissue Residue Levels of the Tranquilizer Combination of Butorphanol, Azaperone, and Medetomidine, and the Antagonists, Naltrexone, Atipamezole, and Tolazoline, in Black Bears (Ursus americanus) Postimmobilization.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Antihypertensive Agents; Azaperone; Butorphanol; Drug Combinations; Drug Residues; Hypnotics and Sedatives; Imidazoles; Immobilization; Medetomidine; Naltrexone; Narcotic Antagonists; Tolazoline; Ursidae | 2020 |
Disentanglement of Cape fur seals (Arctocephalus pusillus pusillus) with reversible medetomidine-midazolam-butorphanol.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Butorphanol; Conscious Sedation; Drug Combinations; Fur Seals; Hypnotics and Sedatives; Imidazoles; Medetomidine; Midazolam; Naltrexone; Narcotic Antagonists | 2021 |
Inadvertent injection of medetomidine in the cerebromedullaris cisterna of a dog during myelographic exam.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Dogs; Hypnotics and Sedatives; Imidazoles; Medetomidine; Medical Errors; Myelography; Treatment Outcome | 2021 |
Partially Reversible Immobilization of Free-Ranging Huemul Deer (Hippocamelus bisulcus) with Medetomidine-Ketamine and Atipamezole.
Topics: Anesthetics, Dissociative; Animals; Deer; Heart Rate; Hypnotics and Sedatives; Imidazoles; Immobilization; Ketamine; Medetomidine | 2021 |
Reversal effects of atipamezole, flumazenil, and 4-aminopyridine on bradycardia and increases in blood pressures induced by medetomidine, midazolam, and ketamine in isoflurane-anesthetized cats.
Topics: 4-Aminopyridine; Animals; Blood Pressure; Bradycardia; Cat Diseases; Cats; Flumazenil; Heart Rate; Imidazoles; Isoflurane; Ketamine; Medetomidine; Midazolam; Prospective Studies | 2022 |
Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.
Topics: Animals; Butorphanol; Hypnotics and Sedatives; Hypothermia; Imidazoles; Medetomidine; Mice; Midazolam | 2022 |