meclocycline and flunoxaprofen

A trial was performed in 30 patients affected by non-specific vaginitis. The results show that the topical application (by vaginal washings) of flunoxaprofen produces a high therapeutic activity like that of meclocycline. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Therefore, the normalization of vaginal flora, with a remarkable increase of Döderlein bacillus, is exclusively due to local antiphlogistic activity of flunoxaprofen. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses.

Topics: Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Female; Humans; Oxytetracycline; Vaginitis