Compounds > mechlorethamine

mechlorethamine and tirapazamine

mechlorethamine has been researched along with tirapazamine in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anderson, RF; Denny, WA; Hogg, A; Lee, AE; Lee, HH; Siim, BG; Tercel, M; Wilson, WR1
Cahill, A; Carthew, P; Davies, A; White, IN1
Bridges, JM; Lappin, TR; MacManus, MP; McAleer, JJ; McKeown, SR1
Cahill, A; White, IN1
Cahill, A; Jenkins, TC; Pickering, P; White, IN1
Barnes, CL; Gates, KS; Johnson, KM; Parsons, ZD1

Other Studies

6 other study(ies) available for mechlorethamine and tirapazamine

ArticleYear
Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Journal of medicinal chemistry, 2001, Oct-11, Volume: 44, Issue:21

    Topics: Animals; Antineoplastic Agents; Cell Death; Cell Hypoxia; Cell Line; Cell Survival; Comet Assay; Cricetinae; Cross-Linking Reagents; DNA; Drug Screening Assays, Antitumor; Humans; Imidazoles; Maximum Tolerated Dose; Mice; Neoplasm Transplantation; Nitro Compounds; Nitrogen Mustard Compounds; Oxidation-Reduction; Prodrugs; Quaternary Ammonium Compounds; Tumor Cells, Cultured

2001
Acute lesions in rats caused by 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) or nitromin: a comparison with rates of reduction in microsomal systems from target organs.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; In Vitro Techniques; Male; Mechlorethamine; Microsomes; Organ Specificity; Oxidation-Reduction; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tirapazamine; Triazines

1992
Hypobaric hypoxia: a method for testing bioreductive drugs in vivo.
    International journal of radiation oncology, biology, physics, 1992, Volume: 23, Issue:3

    Topics: Animals; Biotransformation; Cell Hypoxia; Dose-Response Relationship, Drug; Mammary Neoplasms, Experimental; Mechlorethamine; Mice; Mice, Inbred Strains; Misonidazole; Radiation-Sensitizing Agents; Tirapazamine; Triazines

1992
Reductive activation of N-oxides to cause DNA strand breakage in cell lines in vitro.
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: Aerobiosis; Anaerobiosis; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Line; Cell Transformation, Neoplastic; DNA Damage; DNA Replication; Kinetics; Mechlorethamine; Mice; Nitrogen Mustard Compounds; Rats; Thymidine; Tirapazamine; Triazines

1991
Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions.
    Chemico-biological interactions, 1995, Mar-30, Volume: 95, Issue:1-2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aerobiosis; Animals; Antineoplastic Agents; Biotransformation; Carcinoma 256, Walker; Cell Hypoxia; Deoxyguanosine; DNA Damage; DNA, Single-Stranded; Liver; Mechlorethamine; Oxidation-Reduction; Rats; Tirapazamine; Triazines; Tumor Cells, Cultured

1995
Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    The Journal of organic chemistry, 2014, Aug-15, Volume: 79, Issue:16

    Topics: Alkylating Agents; Antineoplastic Agents; Cyclic N-Oxides; DNA Damage; Gas Chromatography-Mass Spectrometry; Hypoxia; Mechlorethamine; Molecular Structure; Oxidation-Reduction; Prodrugs; Tirapazamine; Triazines

2014