mechlorethamine and melphalan

mechlorethamine has been researched along with melphalan in 161 studies

Research

Studies (161)

TimeframeStudies, this research(%)All Research%
pre-1990109 (67.70)18.7374
1990's29 (18.01)18.2507
2000's12 (7.45)29.6817
2010's11 (6.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hansch, C; Khwaja, TA; Selassie, CD1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Balzarini, J; Das, U; De Clercq, E; Dimmock, JR; Hashimoto, K; Kawase, M; Pati, HN; Sakagami, H1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ames, BN; Baker, MS; Benedict, WF; Choi, E; Haroun, L1
Furno, F; Giovanelli, E; Locatelli, F; Neretto, G; Pellerito, R1
Sieber, SM1
Glatstein, E; Hoppe, RT; Kaplan, HS; Portlock, CS; Rosenberg, SA1
Bruntsch, U; Gallmeier, WM1
Brody, JI1
Filipski, J; Kohn, KW; Zwelling, LA1
Lewensohn, R; Ringborg, U2
Morley, AA; Seshadri, RS; Trainor, KJ1
Ewig, RA; Kohn, KW; Ross, WE1
Merriman, RL; Sladek, NE1
Kornfeld, S; Minnich, V; Smith, ME; Thompson, D1
Bergsagel, DE; Pruzanski, W1
Goldenberg, GJ1
Kahn, SB1
Carter, RD; Krementz, ET1
Alaoui-Jamali, MA; Batist, G; Centurioni, GM; Lehnert, S; Panasci, L; Schecter, R1
Bauer, GB; Bennett, RA; Povirk, LF; Wang, P1
Caravelli, J; Chapman, D; Clarkson, BD; Gaynor, JJ; Merke, DP; Myers, J; Straus, DJ; Yahalom, J1
Bastion, Y; Coiffier, B; Tigaud, JD1
Deutsch, WA; Erickson, LC; Futscher, BW; Grabowski, DT; Kelley, MR; Pieper, RO1
Edgren, M; Fichtinger-Schepman, AM; Hansson, J; Ringborg, U1
Bernard, GS; Hobbs, ML; Mellard, DN; Meyn, RE; Murray, D; vanAnkeren, SC1
Caldecott, K; Jeggo, P1
Petru, E; Schmähl, D1
Erickson, LC; Futscher, BW1
Erickson, LC; Pieper, RO1
Kohn, KW; O'Connor, PM1
Jestrimski, KW; Lowenthal, RM1
Koziner, B; Zori Comba, A1
Straus, DJ1
Caravelli, J; Chapman, D; Clarkson, BD; Gaynor, J; Lee, BJ; Merke, D; Myers, J; Nisce, LZ; Straus, DJ1
Erickson, LC; Futscher, BW; Pieper, RO1
Cantrell, JE; Green, D; Schein, PS1
Hansson, J; Lewensohn, R; Nilsson, B; Ringborg, U1
Dean, SW; Green, D; McPherson, E; Schein, PS1
Hartley, JA; Kohn, KW; Mattes, WB1
Lehner, T; Rosenoer, VM; Smith, J1
Leĭkina, FI; Smolianskaia, AZ1
Bradley, SG; Munson, AE; Rose, WC1
Everett, J1
Du Priest, RW; Fletcher, WS1
Rutledge, F; Smith, JP1
Damnavits, J; Goepfert, H; Rochlin, DB1
Donelli, MG; Garattini, S; Rosso, R1
Frei, E; Goldin, A; Schabel, FM1
Tolen, SJ; Valeriote, FA1
Krementz, ET; Ryan, RF1
Greenwald, ES1
Pavone-Macaluso, M1
Bergsagel, DE; McCulloch, EA; Ogawa, M1
Gschwind, C; Hersh, EM; McBride, CM1
Iamshanov, VA; Kraĭz, BO; Petrov, AS1
Astrakhan, VI; Bychkov, MB; Garin, AM; Vvedenskaia, NA1
Burns, BC; Rutledge, F; Smith, JP; Soffar, S1
Mahaley, MS; Woodhall, B1
Edwards, AJ; Rowland, GF2
Fomina, IP; Navashin, SM; Terent'eva, TG1
Smirnova, IN1
Cheliapov, NV; Doronina, TN; Gorin, AI; Tseĭtlin, PI1
McBride, CM1
Bihler, I; Goldenberg, GJ; Iise, D; Israels, LG; Vanstone, CL1
Fennelly, JJ1
Lelieveld, P; van Putten, LM1
Bishop, RC1
Eridani, S; Ponti, GB; Tiso, R; Valentini, R1
Griffin, AC; Klatt, O; McBride, C; Stehlin, JS1
Unger, E1
Kumkumadzhian, VA; Papoian, SA1
Williamson, CE; Witten, B1
Dill, PL; Macaluso, CK; Marsden, JA; Weisenthal, LM1
Clarkson, BD; Koziner, B; Lee, BJ; Myers, J; Straus, DJ1
Arlin, Z; Gee, T; Kempin, S; Koziner, B; Lee, BJ; McCormick, B; Mertelsmann, R; Myers, J; Nisce, LZ; Straus, DJ1
Culo, F; Spellman, JM; Yuhas, JM1
Arrick, BA; Nathan, CF1
Cornbleet, MA; Leonard, RC; Smyth, JF1
Collins, FG; Skibba, JL2
Bergfeld, WF; Guirguis, MN; Hanke, CW; Lewis, LJ1
Aigner, K; Schwemmle, K1
Parsons, PG1
Dantas, ME; Glode, LM; Koeppler, H; Morton, N; Robinson, WA; Sutherland, J; Thomas, MR1
Aigner, K; Hild, P; Hundeiker, M1
Benckhuysen, C; van der Steen, J; van Wichen, BH1
Adams, GE; Horsman, MR; Kandaiya, S; Rajaratnam, S; Smith, E; Stratford, IJ; Williamson, C1
Naujokaitis, SA1
Lomova, TIu; Shakhova, IK; Shkodinskaia, EN1
Horton, JK; Srivastava, DK; Wilson, SH; Zmudzka, BZ1
Alessandrino, EP; Astori, C; Bernasconi, P; Brusamolino, E; Canevari, A; Castelli, G; Lazzarino, M; Morra, E; Orlandi, E; Pagnucco, G1
Povirk, LF; Shuker, DE1
Behar, RA; Hoppe, RT; Horning, SJ1
Brice, P; Castaigne, S; Gisselbrecht, C; Marolleau, JP; Pautier, P1
Carter, RD; Creech, O; Krementz, ET; Muchmore, JH; Ryan, RF; Sutherland, CM1
Alaoui-Jamali, MA; Batist, G; Fahl, WE; Schecter, RL; Woo, A1
Callery, PS; Egorin, MJ; Eiseman, JL; Hu, LT; Li, Y; Pan, SS; Rogers, FA; Sentz, DL1
Doi, T; Nagai, H; Suzuki, T; Tsukuda, R1
Laval, J; Lee, CS; Mattes, WB; O'Connor, TR1
Demers, GW; Galloway, DA; Hawkins, DS1
Luedtke, NW; Millard, JT; Spencer, RJ1
Bauer, GB; Povirk, LF1
Hopkins, PB; Millard, JT; Spencer, RJ1
Bass, G; Bloxham, D; Gandhi, MK; Jestice, K; Marcus, RE; Scott, MA1
Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D1
Fenselau, C; Szilágyi, Z1
Ara, G; Bunnell, C; Elias, A; Frei, E; Richardson, P; Teicher, B; Tew, K; Wheeler, C1
Calsou, P; Muller, C; Salles, B1
Beauséjour, CM; Cournoyer, D; Delisle, JS; Létourneau, S; Momparler, RL; Palerme, JS1
Angrilli, F; Ascari, E; Bertè, R; Broglia, C; Cavanna, L; Di Renzo, N; Ghirardelli, ML; Gobbi, PG; Iannitto, E; Molica, S; Petrilli, MP1
Avigdor, A; Ben-Bassat, I; Grotto, I; Hardan, I; Raanani, P; Shpilberg, O1
Hulst, AG; Jansen, R; Noort, D1
LUCK, JM2
CASTELLANO, M; LOVISETTO, P1
TRUSHEIKINA, VI1
GALTON, DA; PAPAC, R; TILL, M; WILTSHAW, E1
ALTENBURG, E; ALTENBURG, LS1
KHOMCHENOVSKII, EI2
SPASSKAIA, IG1
NOVIKOVA, MA1
IAKOVLEV, AM; KRASOVSKII, II1
DAVYDOVA, SIa; SAPOZHNIKOVA, MB1
SYRKIN, AB1
VIAZOVA, OI1
ARIEL, IM; PACK, GT1
DIDDLE, AW; JENKINS, HH; WATTS, G; WATTS, J1
BURKITT, D; CLIFFORD, P; OETTGEN, HF1
KUKRAL, JC; PRESTON, FW; STALEY, CJ1
AIZENMAN, BIu; BREDIKHINA, AM; KINRIANOVA, OA; MANDRYK, TP; SHVAIGER, MO1
ERIDANI, S; TAGLIORETTI, D; TESTERO, S; TISO, R1
GYERGYAY, F; KREPSZ, I; PUPP, A1
IGLESIAS, F; KOKAME, GM; KREMENTZ, ET1
CREECH, O; KREMENTZ, ET1
BECKERLING, C; DURR, MH; MARCHAND, P; PLESSISL, DU1
KNOCK, FE1
CHUMAKOV, VM; SYRKIN, AB1
NORIN, T1
LEBRUN, J; SMETS, W1
PARKER, RT; SHINGLETON, WW1
FITZGERALD, P; MCCARTHY, JJ; O'MALLEY, E1
HU, CC; KU, KY; LU, KH1
Balcome, S; Hafner, L; Park, S; Phillips, L; Quirk Dorr, DR; Tretyakova, N1
Angelucci, E; Baldini, L; Bordonaro, R; Broglia, C; Cavanna, L; Chisesi, T; Deliliers, GL; Federico, M; Gobbi, PG; Levis, A; Liberati, M; Merli, F; Pavone, V; Santini, G; Stelitano, C; Vitolo, U1
Diehl, V; Evens, AM; Hutchings, M1
García-Sanz, R; González-López, TJ; Graciani, IF; Hermida, G; San Miguel, JF; Vázquez, L1
Kuruvilla, J1
Brenner, C; Gallerne, C; Lemaire, C; Sharaf el dein, O1
Baik, MH; Polavarapu, A; Stillabower, JA; Stubblefield, SG; Taylor, WM1
Advani, RH; Balise, R; Greenberg, PL; Hoppe, RT; Horning, SJ; Koontz, MZ; Rosenberg, SA1
Back, AR; Lee, J; Phillips, JC; Schleis, SE; Smith, AN; Smrkovski, OA1
HSU, TC; STUBBLEFIELD, E1
Nagai, H1
Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME1
Martin, OA; Price, J1

Reviews

15 review(s) available for mechlorethamine and melphalan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The action of antitumor agents: a double-edged sword?
    Medical and pediatric oncology, 1977, Volume: 3, Issue:2

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Immunosuppressive Agents; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Prednisone; Pregnancy; Procarbazine; Time Factors; Vincristine

1977
[Treatment of relapses and failures in disseminated Hodgkin's disease].
    Presse medicale (Paris, France : 1983), 1991, Nov-02, Volume: 20, Issue:35

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Carmustine; Cisplatin; Cyclophosphamide; Cytarabine; Dacarbazine; Doxorubicin; Epirubicin; Etoposide; Hodgkin Disease; Humans; Ifosfamide; Mechlorethamine; Melphalan; Methotrexate; Mitoguazone; Prednisone; Procarbazine; Remission Induction; Transplantation, Autologous; Transplantation, Homologous; Vinblastine; Vincristine

1991
Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects.
    Neoplasma, 1991, Volume: 38, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Hodgkin Disease; Humans; Leukemia; Mechlorethamine; Melphalan; Neoplasms, Multiple Primary; Ovarian Neoplasms; Prednisone; Procarbazine; Randomized Controlled Trials as Topic; Retrospective Studies; Vincristine

1991
Corticosteroid drugs: their role in oncological practice.
    The Medical journal of Australia, 1986, Jan-20, Volume: 144, Issue:2

    Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast Neoplasms; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Therapy, Combination; Dyspnea; Fluorouracil; Hodgkin Disease; Humans; Hypercalcemia; Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Melphalan; Methotrexate; Multiple Myeloma; Palliative Care; Prednisone; Procarbazine; Receptors, Glucocorticoid; Vinblastine; Vincristine; Vomiting

1986
[Rescue treatment in Hodgkin's disease].
    Sangre, 1987, Volume: 32, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin; Hodgkin Disease; Humans; Lomustine; Mechlorethamine; Melphalan; Prednisone; Procarbazine; Vinblastine; Vincristine; Vindesine

1987
Treatment of advanced Hodgkin's disease.
    Hematology/oncology clinics of North America, 1989, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia; Lomustine; Lymphoma; Male; Mechlorethamine; Melphalan; Middle Aged; Neoplasms, Multiple Primary; Prednisone; Procarbazine; Remission Induction; Vinblastine; Vincristine; Vindesine

1989
Cancer chemotherapy. I.
    New York state journal of medicine, 1972, Oct-15, Volume: 72, Issue:20

    Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Mechlorethamine; Melphalan; Methotrexate; Mice; Neoplasms; Thiotepa

1972
Glutathione metabolism as a determinant of therapeutic efficacy: a review.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Biological Transport; Carmustine; Cyclophosphamide; Cytochrome P-450 Enzyme System; Glutathione; Humans; Mechlorethamine; Melphalan; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental

1984
High-dose alkylating agent therapy: a review of clinical experiences.
    Cancer drug delivery, 1984,Summer, Volume: 1, Issue:3

    Topics: Alkylating Agents; Busulfan; Carcinoma, Bronchogenic; Carmustine; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Mechlorethamine; Melphalan; Neoplasms; Ovarian Neoplasms; Testicular Neoplasms

1984
DNA damage and mutagenesis induced by nitrogen mustards.
    Mutation research, 1994, Volume: 318, Issue:3

    Topics: Animals; Base Sequence; Chlorambucil; Cyclophosphamide; DNA; DNA Damage; DNA Repair; Humans; Mechlorethamine; Melphalan; Molecular Sequence Data; Mutagenesis; Nitrogen Mustard Compounds; Phosphoramide Mustards

1994
NEWER ANTICANCER AGENTS.
    The Medical clinics of North America, 1964, Volume: 48

    Topics: Alkylating Agents; Antineoplastic Agents; Arsenicals; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Mechlorethamine; Melphalan; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Pharmacology; Steroids; Triethylenemelamine; Vinblastine; Vincristine

1964
Treatment of Hodgkin lymphoma: the past, present, and future.
    Nature clinical practice. Oncology, 2008, Volume: 5, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials, Phase III as Topic; Cyclophosphamide; Dacarbazine; Disease-Free Survival; Doxorubicin; Etoposide; Hodgkin Disease; Humans; Lomustine; Mechlorethamine; Melphalan; Multicenter Studies as Topic; Neoplasm Staging; Prednisone; Procarbazine; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Vinblastine; Vincristine; Vindesine

2008
Standard therapy of advanced Hodgkin lymphoma.
    Hematology. American Society of Hematology. Education Program, 2009

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Dexamethasone; Disease-Free Survival; Doxorubicin; Etoposide; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Mechlorethamine; Melphalan; Methylprednisolone; Positron-Emission Tomography; Prednisone; Procarbazine; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Salvage Therapy; Transplantation, Autologous; Treatment Outcome; Vinblastine; Vincristine; Vindesine

2009
[Treatment strategy of Hodgkin lymphoma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:10

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brentuximab Vedotin; Carmustine; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Dexamethasone; Doxorubicin; Etoposide; Hodgkin Disease; Humans; Immunoconjugates; Mechlorethamine; Melphalan; Molecular Targeted Therapy; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prednisone; Procarbazine; Prognosis; Radiotherapy, Adjuvant; Rituximab; Vinblastine; Vincristine

2014

Trials

7 trial(s) available for mechlorethamine and melphalan

ArticleYear
Alternating chemotherapy and irradiation in the treatment of advanced Hodgkin's disease.
    Cancer, 1979, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Male; Mechlorethamine; Melphalan; Middle Aged; Prednisone; Procarbazine; Remission, Spontaneous; Vinblastine; Vincristine

1979
Prognostic factors among 185 adults with newly diagnosed advanced Hodgkin's disease treated with alternating potentially noncross-resistant chemotherapy and intermediate-dose radiation therapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin; Female; Hematocrit; Hodgkin Disease; Humans; Lomustine; Lymphatic Metastasis; Male; Mechlorethamine; Melphalan; Middle Aged; Models, Biological; Neoplasm Staging; Prednisone; Procarbazine; Prognosis; Remission Induction; Survival Analysis; Vinblastine; Vincristine; Vindesine

1990
Treatment of advanced Hodgkin's disease.
    Hematology/oncology clinics of North America, 1989, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia; Lomustine; Lymphoma; Male; Mechlorethamine; Melphalan; Middle Aged; Neoplasms, Multiple Primary; Prednisone; Procarbazine; Remission Induction; Vinblastine; Vincristine; Vindesine

1989
Results and prognostic factors following optimal treatment of advanced Hodgkin's disease.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1989, Volume: 117

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; Doxorubicin; Hodgkin Disease; Humans; Lomustine; Mechlorethamine; Melphalan; Middle Aged; Prednisone; Procarbazine; Randomized Controlled Trials as Topic; Vinblastine; Vincristine; Vindesine

1989
Treatment of advanced Hodgkin's disease with chemotherapy and irradiation. Controlled trial of two versus three alternating, potentially non-cross-resistant drug combinations.
    The American journal of medicine, 1984, Volume: 76, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Doxorubicin; Female; Hodgkin Disease; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Prednisone; Procarbazine; Vinblastine; Vincristine; Vindesine

1984
Lomustine and melphalan cannot be replaced by cyclophosphamide and etoposide without reducing efficacy in MOPPEBVCAD chemotherapy for advanced Hodgkin's disease.
    Haematologica, 2000, Volume: 85, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Epirubicin; Etoposide; Female; Hodgkin Disease; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Prednisone; Procarbazine; Prospective Studies; Treatment Outcome; Vinblastine; Vincristine; Vindesine

2000
ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin's lymphoma: final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-20, Volume: 23, Issue:36

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Hodgkin Disease; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Prednisone; Procarbazine; Treatment Outcome; Vinblastine; Vincristine; Vindesine

2005

Other Studies

140 other study(ies) available for mechlorethamine and melphalan

ArticleYear
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Animals; Benzylidene Compounds; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Piperidines; Structure-Activity Relationship; Sulfides

2011
Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test.
    Cancer research, 1977, Volume: 37, Issue:7 Pt 1

    Topics: 2-Naphthylamine; Animals; Antineoplastic Agents; Carcinogens; Cisplatin; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Hycanthone; Ifosfamide; In Vitro Techniques; Male; Mechlorethamine; Melphalan; Mercaptopurine; Mesylates; Microsomes, Liver; Mutagens; Nitrogen Mustard Compounds; Propylamines; Rats; Salmonella typhimurium; Thiotepa; Tilorone; Uracil Mustard

1977
[Survival and therapy of multiple myeloma. Apropos of 56 observed cases].
    Minerva medica, 1979, Mar-17, Volume: 70, Issue:13

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Male; Mechlorethamine; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Prognosis; Vincristine

1979
[Chemotherapy of the ovarian carcinoma (author's transl)].
    Strahlentherapie, 1977, Volume: 153, Issue:5

    Topics: Altretamine; Antineoplastic Agents; Chlorambucil; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Hydroxyprogesterones; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Nitrosourea Compounds; Ovarian Neoplasms; Thiotepa; Vinblastine; Vincristine

1977
In vitro effects of single alkylating agents on normal peripheral blood lymphocytes.
    The Journal of laboratory and clinical medicine, 1979, Volume: 94, Issue:1

    Topics: Adult; Cell Membrane Permeability; DNA; Erythrosine; Female; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Male; Mechlorethamine; Melphalan; Pokeweed Mitogens; Protein Biosynthesis; RNA

1979
Effect of thiourea on survival and DNA cross-link formation in cells treated with platinum(II) complexes, L-phenylalanine mustard, and bis(2-chloroethyl)methylamine.
    Cancer research, 1979, Volume: 39, Issue:12

    Topics: Animals; Cell Survival; Cells, Cultured; Cisplatin; Cross-Linking Reagents; DNA, Neoplasm; Leukemia L1210; Mechlorethamine; Melphalan; Mice; Thiourea

1979
Induction of unscheduled DNA synthesis in human bone marrow cells by bifunctional alkylating agents.
    Blood, 1979, Volume: 54, Issue:6

    Topics: Alkylating Agents; Autoradiography; Bone Marrow; Cell Differentiation; DNA; Dose-Response Relationship, Drug; Humans; Mechlorethamine; Melphalan; Thymidine; Time Factors

1979
Residual marrow injury following cytotoxic drugs.
    Leukemia research, 1979, Volume: 3, Issue:4

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Chlorambucil; Dacarbazine; Doxorubicin; Female; Granulocytes; Hematopoietic Stem Cells; Mechlorethamine; Melphalan; Mice; Mice, Inbred BALB C; Mitomycins

1979
Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.
    Cancer research, 1978, Volume: 38, Issue:6

    Topics: Animals; Cell Survival; Cells, Cultured; DNA Repair; DNA, Neoplasm; DNA, Single-Stranded; Leukemia L1210; Mechlorethamine; Melphalan; Time Factors; X-Rays

1978
Cytotoxic activity of mechlorethamine and melphalan against cultured tumor cells: potentiation by caffeine.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 206, Issue:2

    Topics: Animals; Antineoplastic Agents; Caffeine; Carcinoma 256, Walker; Cells, Cultured; Drug Synergism; Lymphoma; Mechlorethamine; Melphalan; Rats; Time Factors

1978
Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium.
    Cancer, 1976, Volume: 38, Issue:3

    Topics: Antineoplastic Agents; Biological Assay; Cyclophosphamide; Ethylnitrosourea; Fluorouracil; Humans; Mechlorethamine; Melphalan; Metronidazole; Mitomycins; Mutagens; Neoplasms; Salmonella typhimurium

1976
Treatment of plasma cell myeloma with cytotoxic agents.
    Archives of internal medicine, 1975, Volume: 135, Issue:1

    Topics: Acute Disease; Alkylating Agents; Bence Jones Protein; Bone Neoplasms; Carmustine; Cell Count; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Mechlorethamine; Melphalan; Multiple Myeloma; Myeloma Proteins; Prednisone; Remission, Spontaneous; Time Factors

1975
The role of drug transport in resistance to nitrogen mustard and other alkylating agents in L518Y lymphoblsts.
    Cancer research, 1975, Volume: 35, Issue:7

    Topics: Alkylating Agents; Animals; Binding, Competitive; Biological Transport; Carmustine; Cell Line; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance; Female; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Melphalan; Mice; Mice, Inbred DBA; Mitomycins

1975
Unusual toxicities from cancer and immunosuppressive therapy.
    American family physician, 1975, Volume: 11, Issue:2

    Topics: Antimetabolites; Antineoplastic Agents; Carcinogens; Chromosomes; Depression, Chemical; DNA, Neoplasm; Humans; Immunosuppressive Agents; Mechlorethamine; Melphalan; Mutagens

1975
Chemotherapy of rhabdomyosarcoma by regional perfusion: a case report.
    The American surgeon, 1976, Volume: 42, Issue:3

    Topics: Adjuvants, Pharmaceutic; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Female; Humans; Infant; Leg; Mechlorethamine; Melphalan; Rhabdomyosarcoma

1976
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:5

    Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Survival; Chlorambucil; DNA; Drug Interactions; Drug Resistance; Glutathione; Glutathione Transferase; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Methionine Sulfoximine; Rats; RNA, Messenger; Tumor Cells, Cultured

1992
Thermolabile adenine adducts and A.T base pair substitutions induced by nitrogen mustard analogues in an SV40-based shuttle plasmid.
    Biochemistry, 1991, Dec-10, Volume: 30, Issue:49

    Topics: Adenine Nucleotides; Alkylating Agents; Base Composition; Base Sequence; Chlorambucil; Genetic Vectors; Hot Temperature; Mechlorethamine; Melphalan; Molecular Sequence Data; Mutagenesis; Plasmids; Simian virus 40; Thymine Nucleotides

1991
Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines.
    Carcinogenesis, 1992, Volume: 13, Issue:2

    Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Cyclophosphamide; DNA Probes; DNA Repair; Electrophoresis, Agar Gel; Gene Expression; Humans; Mechlorethamine; Melphalan; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phosphoproteins; Ribosomal Proteins; Tumor Cells, Cultured

1992
Comparative study of two human melanoma cell lines with different sensitivities to mustine and cisplatin.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:8

    Topics: Cell Line; Cell Survival; Cisplatin; DNA, Neoplasm; Glutathione; Humans; Mechlorethamine; Melanoma; Melphalan; Platinum; Tumor Cells, Cultured

1991
Isolation and characterization of nitrogen mustard-sensitive mutants of Chinese hamster ovary cells.
    Mutation research, 1991, Volume: 254, Issue:2

    Topics: Aminacrine; Animals; Cells, Cultured; Cisplatin; Cricetinae; Cross Reactions; DNA; Dose-Response Relationship, Drug; Female; Gamma Rays; In Vitro Techniques; Mechlorethamine; Melphalan; Mitomycin; Mitomycins; Mutagens; Mutation; Nitrogen Mustard Compounds

1991
Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents.
    Mutation research, 1991, Volume: 255, Issue:2

    Topics: Animals; Camptothecin; Cell Line; Cell Survival; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Cross-Linking Reagents; DNA Damage; Female; Guinea Pigs; Mechlorethamine; Melphalan; Mitomycin; Mutation; Radiation Tolerance; Ultraviolet Rays

1991
Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents.
    Cancer research, 1990, Jan-01, Volume: 50, Issue:1

    Topics: Blotting, Northern; Cell Line; Colonic Neoplasms; Gene Expression; Humans; Kinetics; Mechlorethamine; Melphalan; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; RNA, Messenger; Transcription, Genetic

1990
DNA adenine adducts induced by nitrogen mustards and their role in transcription termination in vitro.
    Carcinogenesis, 1990, Volume: 11, Issue:10

    Topics: Amino Acid Sequence; Chlorambucil; DNA; DNA Damage; Genes, myc; Mechlorethamine; Melphalan; Molecular Sequence Data; Templates, Genetic; Transcription, Genetic

1990
Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards.
    Cancer communications, 1990, Volume: 2, Issue:12

    Topics: Animals; Colony-Forming Units Assay; Computer Simulation; Crossing Over, Genetic; DNA Damage; In Vitro Techniques; Leukemia L1210; Mechlorethamine; Melphalan; Mice; Nitrogen Mustard Compounds; Quinacrine Mustard; Uracil Mustard

1990
Transcription-terminating lesions induced by bifunctional alkylating agents in vitro.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Alkylating Agents; Alkylation; Base Sequence; Chlorambucil; Cyclophosphamide; DNA; DNA Damage; Exons; Genetic Vectors; Guanine; Humans; Mechlorethamine; Melphalan; Molecular Sequence Data; Plasmids; Proto-Oncogenes; Templates, Genetic; Transcription, Genetic

1989
Antitumor activity and bone marrow toxicity of aminoglucose mustard anticancer agents in mice.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Amino Sugars; Animals; Antineoplastic Agents; Blood Glucose; Bone Marrow; DNA; Leukemia P388; Leukemia, Experimental; Leukocyte Count; Male; Mechlorethamine; Melphalan; Mice; Nitrogen Mustard Compounds; Streptozocin; Structure-Activity Relationship

1986
Formation and removal of DNA cross-links induced by melphalan and nitrogen mustard in relation to drug-induced cytotoxicity in human melanoma cells.
    Cancer research, 1987, May-15, Volume: 47, Issue:10

    Topics: Cell Line; Cell Survival; DNA; Humans; Mathematics; Mechlorethamine; Melanoma; Melphalan; Neoplastic Stem Cells

1987
6-[Bis(2-chloroethyl)amino]-6-deoxygalactopyranose hydrochloride (C6-galactose mustard), a new alkylating agent with reduced bone marrow toxicity.
    Cancer research, 1987, Feb-01, Volume: 47, Issue:3

    Topics: Animals; Bone Marrow; DNA Replication; Drug Evaluation, Preclinical; Female; Galactosamine; Hematopoietic Stem Cells; Leukemia P388; Leukemia, Experimental; Leukopenia; Male; Mechlorethamine; Melphalan; Mice; Mice, Inbred DBA; Neutrophils; Structure-Activity Relationship

1987
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
    Nucleic acids research, 1986, Apr-11, Volume: 14, Issue:7

    Topics: Alkylation; Base Sequence; Densitometry; DNA, Viral; Formates; Guanine; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Quinacrine Mustard; Structure-Activity Relationship; Substrate Specificity; Sulfuric Acid Esters; T-Phages; Uracil Mustard

1986
Amyloidosis in mice bearing a transplantable plasma cell tumour.
    The Journal of pathology and bacteriology, 1967, Volume: 94, Issue:1

    Topics: Amyloidosis; Animals; Cortisone; Diet; Electrophoresis; gamma-Globulins; Mechlorethamine; Melphalan; Mice; Microscopy, Electron; Multiple Myeloma; Neoplasm Transplantation; Neoplasms, Experimental; Plasmacytoma

1967
[Detection of a moderate staphylococcal phage by means of antineoplastic agents].
    Antibiotiki, 1970, Volume: 15, Issue:6

    Topics: Aminopterin; Antibiotics, Antineoplastic; Anticholesteremic Agents; Antimetabolites; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Dactinomycin; Drug Resistance, Microbial; Flavonoids; Fluorouracil; Lysogeny; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Nitrogen Mustard Compounds; Olivomycins; Staphylococcus; Staphylococcus Phages; Thiotepa; Ultraviolet Rays; Uracil; Vinblastine; Vincristine

1970
Synergistic lethal action of alkylating agents and sodium pentobarbital in the mouse.
    Pharmacology, 1974, Volume: 11, Issue:4

    Topics: Alkylating Agents; Animals; Atropine; Chlorambucil; Cyclophosphamide; Decamethonium Compounds; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Hexamethonium Compounds; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Male; Mechlorethamine; Melphalan; Mice; Pentobarbital; Thiotepa; Time Factors

1974
Walker carcinosarcoma 256 in study of anticancer agents. II. Results.
    Cancer research, 1966, Volume: 26, Issue:8 Pt 2

    Topics: Acetates; Animals; Antineoplastic Agents; Azirines; Benzene; Benzoates; Butyrates; Carcinoma 256, Walker; Glycine; Mannitol; Mechlorethamine; Melphalan; Niacinamide; Oxides; Phthalic Acids; Pyridines; Rats; Sulfhydryl Compounds; Toluene; Xylenes

1966
Chemotherapy of testicular germinal tumors.
    Oncology, 1973, Volume: 28, Issue:2

    Topics: Alkylating Agents; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Dysgerminoma; Humans; Male; Mechlorethamine; Melphalan; Methotrexate; Nitrofurazone; Pharmaceutic Aids; Plicamycin; Prognosis; Testicular Neoplasms; Testis; Vincristine

1973
Chemotherapy in the treatment of cancer of the ovary.
    American journal of obstetrics and gynecology, 1970, Jul-01, Volume: 107, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Cyclophosphamide; Cystadenocarcinoma; Dactinomycin; Female; Fluorouracil; Humans; Mechlorethamine; Melphalan; Ovarian Neoplasms; Thiotepa; Vinblastine

1970
The effect of antihistamines in decreasing the toxicity of alkylating agents.
    Surgery, gynecology & obstetrics, 1967, Volume: 124, Issue:4

    Topics: Alkylating Agents; Animals; Carcinoma, Ehrlich Tumor; Histamine H1 Antagonists; Mechlorethamine; Melphalan; Methyldopa; Methysergide; Mice

1967
On the neurotoxic effects induced by alkylating agents.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:11

    Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervous System; Chlorambucil; Cyclophosphamide; Cysteine; Drug Antagonism; Glycine; Male; Mannitol; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Phenobarbital; Phenytoin; Rats; Seizures; Spasm; Thiourea; Triethylenemelamine; Tryptophan

1966
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
    Cancer research, 1974, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Models, Animal; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Fluorouracil; Hodgkin Disease; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Male; Mechlorethamine; Melphalan; Mice; Mice, Inbred AKR; Multiple Myeloma; Nitrosourea Compounds; Prednisone; Remission, Spontaneous; Vinblastine; Vincristine

1974
Survival of hematopoietic and lymphoma colony-forming cells in vivo following the administration of a variety of alkylating agents.
    Cancer research, 1972, Volume: 32, Issue:3

    Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Chlorambucil; Clone Cells; Cyclophosphamide; Female; Hematopoietic Stem Cells; Lethal Dose 50; Lymphoma; Mechlorethamine; Melphalan; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Nitrosourea Compounds; Thiotepa; Triethylenemelamine

1972
Chemotherapy of melanoma of the extremities by perfusion: fourteen years clinical experience.
    Annals of surgery, 1972, Volume: 175, Issue:6

    Topics: Adult; Aged; Arm; Chemotherapy, Cancer, Regional Perfusion; Female; Humans; Leg; Male; Mechlorethamine; Melanoma; Melphalan; Neoplasm Metastasis; Postoperative Complications; Skin Transplantation; Thiotepa

1972
[Local chemotherapy of papillary neoplasms of the bladder].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1973, Apr-02, Volume: 28, Issue:14

    Topics: Antineoplastic Agents; Cyclophosphamide; Evaluation Studies as Topic; Humans; Mechlorethamine; Melphalan; Papilloma; Peptides; Therapeutic Irrigation; Thiotepa; Triaziquone; Urinary Bladder Neoplasms

1973
Chemotherapy of mouse myeloma: quantitative cell cultures predictive of response in vivo.
    Blood, 1973, Volume: 41, Issue:1

    Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cells, Cultured; Cyclophosphamide; Female; Fluorouracil; Mechlorethamine; Melphalan; Mice; Multiple Myeloma; Nitrosourea Compounds; Radiation Chimera; Rodent Diseases; Spleen

1973
Local and systemic immunologic effects of perfusion therapy for malignant melanoma.
    Surgery, gynecology & obstetrics, 1973, Volume: 137, Issue:3

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Extremities; Graft Rejection; Humans; Immunosuppression Therapy; Lectins; Lymphocyte Activation; Lymphocyte Depletion; Lymphocytes; Mechlorethamine; Melanoma; Melphalan; Prognosis; Streptolysins; Stress, Physiological

1973
[Interaction of DNA with alkylating agents of different classes].
    Voprosy onkologii, 1973, Volume: 19, Issue:2

    Topics: Alkylating Agents; DNA; Hot Temperature; Mechlorethamine; Melphalan; Nucleic Acid Denaturation; Triazines

1973
[Chemotherapy in the terminal stages of tumors].
    Voprosy onkologii, 1968, Volume: 14, Issue:6

    Topics: Alkylating Agents; Bone Neoplasms; Cyclophosphamide; Dysgerminoma; Lymphatic Metastasis; Lymphoma, Large B-Cell, Diffuse; Male; Mechlorethamine; Melphalan; Neoplasm Metastasis; Testicular Neoplasms

1968
Systemic chemotherapy for carcinoma of the cervix.
    American journal of obstetrics and gynecology, 1967, Mar-15, Volume: 97, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine; Melphalan; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Progestins; Thiotepa; Urea; Uterine Cervical Neoplasms

1967
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
    Annals of surgery, 1967, Volume: 166, Issue:2

    Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Ethylenediamines; Facial Neoplasms; Fibrosarcoma; Glioma; Humans; Infusions, Parenteral; Mechlorethamine; Melanoma; Melphalan; Meningioma; Methotrexate; Osteosarcoma; Perfusion; Quinones; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Thiotepa

1967
Relative effects of varying concentrations of cytotoxic drugs in vitro on tumour and reticulo-endothelial tissue.
    The British journal of surgery, 1968, Volume: 55, Issue:9

    Topics: Animals; Antineoplastic Agents; DNA; DNA, Neoplasm; Fluorouracil; Glucose; In Vitro Techniques; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Methotrexate; Mice; Mononuclear Phagocyte System; Neoplasm Proteins; Neoplasms, Experimental; Protein Biosynthesis; RNA; RNA, Neoplasm; Spleen; Thiotepa; Tritium; Vinblastine

1968
[Experimental study of the antineoplastic effect of the antibiotic polymycin].
    Antibiotiki, 1970, Volume: 15, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Antiviral Agents; Ascites; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Depression, Chemical; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia, Experimental; Mechlorethamine; Melphalan; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats; Sarcoma; Sarcoma 180; Thiotepa; Uracil

1970
[Results of treatment of tonsillar tumors by olivomycin].
    Antibiotiki, 1969, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Chlorpromazine; Cyclophosphamide; Female; Fever; Humans; Liver Neoplasms; Lymphatic Metastasis; Lymphoma, Large B-Cell, Diffuse; Male; Mechlorethamine; Melphalan; Middle Aged; Nasopharyngeal Neoplasms; Nausea; Neoplasm Recurrence, Local; Olivomycins; Thiotepa; Thrombocytopenia; Tonsillar Neoplasms; Vomiting

1969
[Effect of embichin and sarcolysin on the structure of total histone].
    Biulleten' eksperimental'noi biologii i meditsiny, 1971, Volume: 72, Issue:10

    Topics: Animals; Cattle; Histones; Mechlorethamine; Melphalan; Optical Rotatory Dispersion; Phenylalanine; Spectrophotometry; Thymus Gland; Viscosity

1971
Differential effects of nitrogen mustard, melphalan and vinblastine on the metabolism of mouse tumour and spleen slices.
    European journal of cancer, 1969, Volume: 5, Issue:5

    Topics: Adenocarcinoma; Animals; DNA; Female; Mechlorethamine; Melphalan; Mice; Neoplasms, Experimental; Protein Biosynthesis; RNA; Spleen; Vinblastine

1969
Advanced melanoma of the extremities.
    Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:2

    Topics: Adolescent; Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Child; Dactinomycin; Female; Humans; Leg; Male; Mechlorethamine; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Prognosis; Skin Neoplasms

1970
Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.
    Cancer research, 1970, Volume: 30, Issue:9

    Topics: Biological Transport, Active; Carbon Isotopes; Cell Line; Chlorambucil; Culture Techniques; Cyclophosphamide; Kinetics; Lymphocytes; Mechlorethamine; Melphalan; Nitrophenols; Ouabain; Protein Binding

1970
Drugs and their abuse no. V--misuse of cytotoxic drugs.
    Journal of the Irish Medical Association, 1971, Jul-22, Volume: 64, Issue:416

    Topics: Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Humans; Leukemia; Mechlorethamine; Melphalan; Methotrexate; Substance-Related Disorders; Vinblastine; Vincristine

1971
Factors determining cell killing by chemotherapeutic agents in vivo. II. Melphalan, chlorambucil and nitrogen mustard.
    European journal of cancer, 1971, Volume: 7, Issue:1

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Survival; Chlorambucil; Cyclophosphamide; DNA; Female; Hematopoietic Stem Cells; Male; Mechlorethamine; Melphalan; Mice; Spleen

1971
Chemotherapy of Hodgkin's disease, lymphoma, and leukemia.
    Radiologic clinics of North America, 1968, Volume: 6, Issue:1

    Topics: Adult; Antineoplastic Agents; Busulfan; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Lymphoma; Male; Mechlorethamine; Melphalan; Vinblastine

1968
Biologic effects of recent antimitotic compounds. A comparative evaluation.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Animals; Antineoplastic Agents; Chick Embryo; Colchicine; Cyclophosphamide; DNA; Fluorouracil; Humans; Hydrazines; In Vitro Techniques; Leukocytes; Mechlorethamine; Melphalan; Mitosis; Prednisolone; RNA; Triaziquone; Vinblastine; Vincristine

1968
The effect of nitrogen mustard treatment on the deoxyribonucleic acid of sensitive and resistant Ehrlich tumor cells.
    Cancer research, 1969, Volume: 29, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Centrifugation, Density Gradient; DNA, Neoplasm; In Vitro Techniques; Injections, Intraperitoneal; Mechlorethamine; Melphalan; Mice; Protein Binding; Thymidine; Time Factors; Tritium

1969
The effect of x-irradiation on the take and growth of the guerin-tumour. II. Histological experiments.
    Neoplasma, 1965, Volume: 12, Issue:5

    Topics: Animals; Mannomustine; Mechlorethamine; Melphalan; Neoplasm Transplantation; Neoplasms, Experimental; Radiation Effects; Rats

1965
[Antiblastic effect of various chemotherapeutic preparations on the cells of the Ehrlich ascites tumor].
    Voprosy onkologii, 1966, Volume: 12, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Busulfan; Carcinoma, Ehrlich Tumor; Fluorouracil; Mechlorethamine; Melphalan; Mercaptopurine; Mice; Nitrogen Mustard Compounds; Uracil

1966
Reaction mechanism of some aromatic nitrogen mustards.
    Cancer research, 1967, Volume: 27, Issue:1

    Topics: Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Kinetics; Mechlorethamine; Melphalan; Mercaptoethanol; Solutions

1967
A novel dye exclusion method for testing in vitro chemosensitivity of human tumors.
    Cancer research, 1983, Volume: 43, Issue:2

    Topics: Antineoplastic Agents; Cell Line; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Eosine Yellowish-(YS); Etoposide; Fluorouracil; Hematoxylin; Humans; Leukemia, Myeloid, Acute; Mechlorethamine; Melphalan; Neoplasms; Staining and Labeling

1983
Combination chemotherapy for the treatment of Hodgkin's disease in relapse. Results with lomustine (CCNU), melphalan (Alkeran), and vindesine (DVA) alone (CAD) and in alternation with MOPP and doxorubicin (Adriamycin), bleomycin, and vinblastine (ABV).
    Cancer chemotherapy and pharmacology, 1983, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Doxorubicin; Female; Hodgkin Disease; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Prednisone; Procarbazine; Vinblastine; Vincristine; Vindesine

1983
The role of WR-2721 in radiotherapy and/or chemotherapy.
    Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3

    Topics: Alkylating Agents; Amifostine; Animals; Breast Neoplasms; Cyclophosphamide; Humans; In Vitro Techniques; Mechlorethamine; Melphalan; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Organothiophosphorus Compounds; Platinum; Rabbits; Radiation-Protective Agents; Rats; Time Factors

1980
Altered hepatic functions and microsomal activity in perfused rat liver by hyperthermia combined with alkylating agents.
    Cancer biochemistry biophysics, 1983, Volume: 6, Issue:4

    Topics: Alkylating Agents; Animals; Antipyrine; Biotransformation; Cyclophosphamide; Gluconeogenesis; Liver; Male; Mechlorethamine; Melphalan; Microsomes, Liver; Oxygen Consumption; Rats; Urea

1983
Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy.
    Cleveland Clinic quarterly, 1983,Summer, Volume: 50, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Humans; Leg Dermatoses; Male; Mechlorethamine; Melphalan; Methotrexate; Myxedema

1983
[Technic of isolated perfusion of the extremities. Experience with 171 cases].
    Langenbecks Archiv fur Chirurgie, 1983, Volume: 359, Issue:2

    Topics: Arm; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dacarbazine; Drug Therapy, Combination; Extracorporeal Circulation; Humans; Hyperthermia, Induced; Leg; Mechlorethamine; Melanoma; Melphalan; Postoperative Care; Soft Tissue Neoplasms

1983
Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines.
    Cancer research, 1984, Volume: 44, Issue:7

    Topics: Caffeine; Cell Line; Cell Survival; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Hot Temperature; Humans; Kinetics; Mechlorethamine; Melanoma; Melphalan; Methyl Methanesulfonate; Thymidine

1984
Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Cell Survival; Colony-Forming Units Assay; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lymphatic Metastasis; Male; Mechlorethamine; Melanoma; Melphalan; Middle Aged; Transplantation, Autologous

1982
[New modifications in isolated extremity perfusion ].
    Zeitschrift fur Hautkrankheiten, 1982, Jul-15, Volume: 57, Issue:14

    Topics: Antineoplastic Agents; Arm; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Hot Temperature; Humans; Leg; Mechlorethamine; Melanoma; Melphalan; Skin Neoplasms

1982
Effects of alkylating agents on the DNA replication of cultured Yoshida sarcoma cells.
    Chemico-biological interactions, 1982, Mar-15, Volume: 39, Issue:2

    Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Survival; Chlorambucil; Cyclophosphamide; DNA Replication; Doxorubicin; Kinetics; Mechlorethamine; Melphalan; Mice; Sarcoma, Yoshida; Structure-Activity Relationship

1982
The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.
    Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Cricetinae; Hot Temperature; Hypoxia; Mechlorethamine; Melphalan; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents

1980
Thiamine protection of murine L1210 leukemia cells against mechlorethamine cytotoxicity and its relation to the choline uptake system.
    Research communications in chemical pathology and pharmacology, 1981, Volume: 32, Issue:2

    Topics: Animals; Biological Transport; Choline; Leukemia L1210; Male; Mechlorethamine; Melphalan; Mice; Thiamine

1981
[Repair of DNA-protein cross-links induced by antineoplastic alkylating agents].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:7

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; DNA; DNA Repair; Fibroblasts; Mechlorethamine; Melphalan; Nucleoproteins

1981
Induction of unscheduled DNA synthesis in human myeloma cells.
    Blood, 1980, Volume: 55, Issue:2

    Topics: Alkylating Agents; Bone Marrow; Cell Transformation, Neoplastic; DNA; Humans; Mechlorethamine; Melphalan; Multiple Myeloma; Time Factors; Ultraviolet Rays

1980
Modification of the 4-(p-nitrobenzyl) pyridine assay for measurement of melphalan and mechlorethamine in plasma.
    Journal of pharmacological methods, 1980, Volume: 4, Issue:2

    Topics: Animals; Chromogenic Compounds; Colorimetry; Liver; Male; Mechlorethamine; Melphalan; Nitrobenzenes; Perfusion; Pyridines; Rats

1980
Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents.
    Nucleic acids research, 1995, Oct-11, Volume: 23, Issue:19

    Topics: 3T3 Cells; Animals; Antineoplastic Agents; Bleomycin; Carmustine; Cell Death; Cisplatin; DNA; DNA Damage; DNA Polymerase I; Gene Expression Regulation; Humans; Mechlorethamine; Melphalan; Methyl Methanesulfonate; Mice; RNA, Antisense; Transfection; Ultraviolet Rays; Zinc

1995
Results of CAV regimen (CCNU, melphalan, and VP-16) as third-line salvage therapy for Hodgkin's disease.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1994, Volume: 5, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Doxorubicin; Drug Resistance; Etoposide; Female; Hodgkin Disease; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Pancytopenia; Prednisone; Procarbazine; Prospective Studies; Recurrence; Remission Induction; Salvage Therapy; Survival Rate; Vinblastine; Vincristine

1994
Hodgkin's disease with bulky mediastinal involvement: effective management with combined modality therapy.
    International journal of radiation oncology, biology, physics, 1993, Apr-02, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dacarbazine; Doxorubicin; Female; Hodgkin Disease; Humans; Male; Mechlorethamine; Mediastinal Neoplasms; Melphalan; Middle Aged; Prednisone; Procarbazine; Radiotherapy; Radiotherapy Dosage; Survival Rate; Vinblastine; Vincristine

1993
Pregnancy after autologous bone marrow transplantation for malignant lymphomas.
    Nouvelle revue francaise d'hematologie, 1994, Volume: 36, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Infant, Newborn; Lymphoma, Large B-Cell, Diffuse; Mechlorethamine; Melphalan; Podophyllotoxin; Prednisone; Pregnancy; Pregnancy Outcome; Procarbazine; Remission Induction; Salvage Therapy; Vincristine

1994
Regional chemotherapy for melanoma. A 35-year experience.
    Annals of surgery, 1994, Volume: 220, Issue:4

    Topics: Adult; Aged; Chemotherapy, Cancer, Regional Perfusion; Clinical Trials as Topic; Combined Modality Therapy; Extracorporeal Membrane Oxygenation; Female; Humans; Lymphatic Metastasis; Male; Mechlorethamine; Melanoma; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Skin Neoplasms; Survival Analysis; Survival Rate; Thiotepa; Time Factors

1994
Expression of a rat glutathione-S-transferase complementary DNA in rat mammary carcinoma cells: impact upon alkylator-induced toxicity.
    Cancer research, 1993, Oct-15, Volume: 53, Issue:20

    Topics: Alkylating Agents; Animals; Biological Transport; Cell Line; Cell Nucleus; Chlorambucil; Cisplatin; DNA, Complementary; Gene Expression; Genetic Vectors; Glutathione Transferase; Macromolecular Substances; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Rats; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1993
Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Animals; Antineoplastic Agents; Aziridines; Cross-Linking Reagents; DNA; Electrophoresis, Agar Gel; Female; Leukemia L1210; Mechlorethamine; Melphalan; Mice; Mice, Inbred Strains; Spermine; Thiotepa

1996
Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents.
    Toxicology, 1996, Jan-22, Volume: 107, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cell Count; Cell Survival; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Hemolytic Plaque Technique; Immune System; Injections, Intravenous; Male; Mechlorethamine; Melphalan; Organ Size; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spleen

1996
Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases.
    Carcinogenesis, 1996, Volume: 17, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Chlorambucil; DNA Adducts; DNA Glycosylases; Escherichia coli; Guanine; Humans; Mechlorethamine; Melphalan; Molecular Sequence Data; N-Glycosyl Hydrolases; Rats

1996
Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.
    Cancer research, 1996, Feb-15, Volume: 56, Issue:4

    Topics: Animals; Antineoplastic Agents; Aphidicolin; Carboplatin; Cell Cycle; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Embryo, Mammalian; Fibroblasts; Genes, p53; Genes, Retinoblastoma; Heterozygote; Homozygote; Humans; Infant, Newborn; Kinetics; Male; Mechlorethamine; Melphalan; Mice; Oncogene Proteins, Viral; Paclitaxel; Papillomaviridae; Papillomavirus E7 Proteins; Repressor Proteins; Skin; Time Factors

1996
The 5'-GNC preference for mustard cross-linking is preserved in a restriction fragment.
    Anti-cancer drug design, 1996, Volume: 11, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Chlorambucil; Cross-Linking Reagents; Deoxyribonuclease EcoRI; DNA; DNA Damage; Mechlorethamine; Melphalan; Molecular Sequence Data; Nitrogen Mustard Compounds; Oligodeoxyribonucleotides; Structure-Activity Relationship; Substrate Specificity; Xenopus

1996
Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence.
    Nucleic acids research, 1997, Mar-15, Volume: 25, Issue:6

    Topics: Adenine Phosphoribosyltransferase; Alkylation; Animals; Base Sequence; CHO Cells; Cricetinae; DNA Damage; DNA Methylation; Kinetics; Mechlorethamine; Melphalan; Models, Molecular; Mutagenesis; Nitrogen Mustard Compounds; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Phosphoramide Mustards

1997
Effect of nucleosome structure on DNA interstrand cross-linking reactions.
    Biochemistry, 1998, Apr-14, Volume: 37, Issue:15

    Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Chlorambucil; Cross-Linking Reagents; DNA, Ribosomal; Mechlorethamine; Melphalan; Molecular Sequence Data; Nitrogen Mustard Compounds; Nucleosomes; RNA, Ribosomal, 5S; Xenopus

1998
The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients.
    Bone marrow transplantation, 1999, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Carmustine; Combined Modality Therapy; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Transplantation, Autologous

1999
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
    British journal of cancer, 1999, Volume: 81, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Child; Child, Preschool; Chlorambucil; Cohort Studies; Combined Modality Therapy; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Incidence; Infant; Leukemia, Myeloid; Life Tables; Lomustine; Male; Mechlorethamine; Melphalan; Middle Aged; Myelodysplastic Syndromes; Neoplasms, Second Primary; Podophyllotoxin; Prednisolone; Prednisone; Procarbazine; Retrospective Studies; Risk; Salvage Therapy; Vinblastine; Vincristine

1999
Molecular dynamics simulation of metallothionein-drug complexes.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:2

    Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Chlorambucil; Computer Simulation; Crystallography, X-Ray; Cysteine; Mechlorethamine; Melphalan; Metallothionein; Models, Structural; Nitrogen Mustard Compounds; Protein Binding; Zinc

2000
Double high-dose chemotherapy with stem cell rescue (HD-SCR) in patients with breast cancer - effect of sequence.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Breast Neoplasms; Carmustine; Cell Survival; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Hematopoietic Stem Cell Transplantation; Humans; Mechlorethamine; Melphalan; Mice; Neoplasms, Experimental; Tumor Cells, Cultured

2000
The activity of the DNA-dependent protein kinase (DNA-PK) complex is determinant in the cellular response to nitrogen mustards.
    Biochimie, 2000, Volume: 82, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Antigens, Nuclear; Bleomycin; Cell Line; Cell Survival; Cross-Linking Reagents; DNA; DNA Damage; DNA Helicases; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Ku Autoantigen; Mechlorethamine; Melphalan; Mice; Mice, SCID; Mutation; Nitrogen Mustard Compounds; Nuclear Proteins; Protein Serine-Threonine Kinases; Transfection; Zinostatin

2000
Coexpression of rat glutathione S-transferase A3 and human cytidine deaminase by a bicistronic retroviral vector confers in vitro resistance to nitrogen mustards and cytosine arabinoside in murine fibroblasts.
    Cancer gene therapy, 2000, Volume: 7, Issue:5

    Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blotting, Southern; Cell Division; Cytarabine; Cytidine Deaminase; DNA, Complementary; Drug Resistance, Neoplasm; Fibroblasts; Gene Transfer Techniques; Genetic Vectors; Glutathione Transferase; Humans; Mechlorethamine; Melphalan; Mice; Protein Biosynthesis; Rats; Retroviridae; Tetrazolium Salts; Thiazoles; Transduction, Genetic

2000
[High-dose chemotherapy and autologous stem cell transplantation for refractory and relapsing Hodgkin's disease as first-line therapy-- studies at Sheba Medical Center--Tel Hashomer].
    Harefuah, 2000, Volume: 139, Issue:5-6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carmustine; Combined Modality Therapy; Cytarabine; Dacarbazine; Doxorubicin; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Male; Mechlorethamine; Melphalan; Middle Aged; Podophyllotoxin; Prednisone; Procarbazine; Recurrence; Retrospective Studies; Survival Rate; Time Factors; Vinblastine; Vincristine

2000
Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.
    Archives of toxicology, 2002, Volume: 76, Issue:2

    Topics: Binding Sites; Chlorambucil; Cyclophosphamide; Cysteine; Drug Monitoring; Humans; In Vitro Techniques; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Protein Binding; Serum Albumin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2002
The action of the phenylalanine mustards and of several homologs on mouse melanoma.
    Cancer research, 1957, Volume: 17, Issue:11

    Topics: Animals; Mechlorethamine; Melanoma; Melphalan; Neoplasms, Experimental; Nitrogen Mustard Compounds

1957
[P-bis-(beta-chloroethyl) aminophenylalanine (sarcolysin) in antiblastic chemotherapy with special reference to lymphatic blood diseases].
    Haematologica, 1958, Volume: 43, Issue:4

    Topics: Hodgkin Disease; Humans; Leukemia; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Melphalan; Multiple Myeloma; Nitrogen Mustard Compounds; Phenylalanine; Plasma Cells; Sarcoma

1958
[Anti-tumor activity of optic isomers of sarcolysin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1958, Volume: 46, Issue:9

    Topics: Isomerism; Mechlorethamine; Melphalan; Neoplasms; Nitrogen Mustard Compounds; Phenylalanine

1958
Preliminary clinical trial of p-di-2-chloroethyl-amino-L-phenylalanine (CB 3025, melphalan) and of di-2-chloroethyl methanesulfonate (CB 1506).
    Annals of the New York Academy of Sciences, 1958, Apr-24, Volume: 68, Issue:3

    Topics: Antineoplastic Agents; Humans; Mechlorethamine; Melphalan; Mesylates; Nitrogen Mustard Compounds; Phenylalanine

1958
Ratio of visible to lethal mutations produced in Drosophila by phenylalanine mustard.
    Nature, 1959, Mar-07, Volume: 183, Issue:4662

    Topics: Animals; Chromosomes; Drosophila; Mechlorethamine; Melphalan; Mutation; Nitrogen Mustard Compounds; Phenylalanine

1959
[Mechanism of anti-tumor effects of dl-N-di-(2-chloroethyl)-aminophenylalanine (sarcolysin) and triethyleneimino-S-triazine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1959, Volume: 47, Issue:2

    Topics: Humans; Mechlorethamine; Melphalan; Neoplasms; Nitrogen Mustard Compounds; Triazines; Triethylenemelamine

1959
[Combined effect of radioactive methionine and of sarcolysin on animal tumors].
    Voprosy onkologii, 1959, Volume: 5, Issue:1

    Topics: Animals; Mechlorethamine; Melphalan; Methionine; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds

1959
[Distribution of sarcolysin-C14 in the body of rats with sarcoma 45 and with drug-resistant variant of this tumor].
    Voprosy onkologii, 1961, Volume: 7(3)

    Topics: Animals; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Rats; Sarcoma; Sarcoma, Experimental

1961
[A case of prolonged remission of lymphosarcomatosis after sarcolysin and roentgen-ray therapy].
    Voprosy onkologii, 1960, Volume: 6(11)

    Topics: Lymphoma, Non-Hodgkin; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds

1960
[Regional fractional method of administration of sarcolysin in various primary tumors].
    Voprosy onkologii, 1961, Volume: 7(3)

    Topics: Mechlorethamine; Melphalan; Neoplasms; Nitrogen Mustard Compounds

1961
Further observations on the efficacy of phenylalanine mustards against mouse melanoma.
    Cancer research, 1961, Volume: 21

    Topics: Animals; Mechlorethamine; Melanoma, Experimental; Melphalan; Mice; Nitrogen Mustard Compounds; Phenylalanine

1961
[The effect of sarcolysin and dopan on the biosynthesis of pyrimidines of nucleic acid in transplanted tumors and tissues of the recipient organism].
    Biulleten' eksperimental'noi biologii i meditsiny, 1960, Volume: 49

    Topics: Mechlorethamine; Melphalan; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nucleic Acids; Phenylalanine; Pyrimidines; Uracil Mustard

1960
[Effect of aminazin and of dinitrophenol on the activity of dopan and sarcolysin].
    Voprosy onkologii, 1960, Volume: 6(3)

    Topics: Chlorpromazine; Dinitrophenols; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Nitrophenols; Uracil Mustard

1960
[Changes of encolytic properties of the blood serum from rats bearing Guerin's carcinoma during therapy with sarcolysin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1959, Volume: 48

    Topics: Animals; Carcinoma; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Rats; Serum

1959
Treatment of disseminated melanoma with phenylalanine mustard (melphelan) and autogenous bone marrow transplants.
    Surgery, 1962, Volume: 51

    Topics: Bone Marrow; Bone Marrow Transplantation; Humans; Mechlorethamine; Melanoma; Melphalan; Nitrogen Mustard Compounds

1962
Nitrogen and phenylalanine mustard. Use in women with intrauterine cancer.
    American journal of obstetrics and gynecology, 1962, Feb-15, Volume: 83

    Topics: Female; Humans; Mechlorethamine; Melphalan; Neoplasms; Nitrogen; Nitrogen Mustard Compounds; Phenylalanine; Uterine Neoplasms

1962
Malignant lymphoma involving the jaw in African children: treatment with alkylating agents and actinomycin D.
    Cancer chemotherapy reports, 1963, Volume: 28

    Topics: Alkylating Agents; Aziridines; Child; Cyclophosphamide; Dactinomycin; Humans; Jaw; Lymphoma; Mechlorethamine; Melphalan

1963
Effect of anticancer drugs on experimental wound healing.
    Surgical forum, 1962, Volume: 13

    Topics: Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Humans; Mechlorethamine; Melphalan; Thiotepa; Wound Healing

1962
[COMPARISON OF CERTAIN METHODS OF INITIAL SELECTION OF ANTINEOPLASTIC SUBSTANCES IN VITRO].
    Mikrobiolohichnyi zhurnal, 1963, Volume: 25

    Topics: Antineoplastic Agents; In Vitro Techniques; Mechlorethamine; Melphalan; Mercaptopurine; Research; Thiotepa

1963
[EVALUATION OF THE CURRENT THERAPEUTIC TRENDS IN HODGKIN'S DISEASE. CRITICAL REVIEW AND CASUISTIC CONTRIBUTION].
    Archivio di patologia e clinica medica, 1963, Volume: 40

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Aziridines; Bone Marrow Transplantation; Colchicine; Cyclophosphamide; Dactinomycin; Hodgkin Disease; Mechlorethamine; Melphalan; Neoplasms; Radioisotopes; Radiotherapy, High-Energy; Triethylenemelamine; Vinblastine

1963
[THE REDUCTION OF RADIOPHOSPHORUS 32 INCORPORATION INTO CANCER CELLS BY NONTOXIC DOSES OF CYTOSTATIC SUBSTANCES].
    Radiobiologia, radiotherapia, 1963, Volume: 4

    Topics: Animals; Carcinoma; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Cytostatic Agents; Mannomustine; Mechlorethamine; Melphalan; Metabolism; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Phosphorus Isotopes; Radiation Injuries; Radiation Injuries, Experimental; Research; Triethylenemelamine

1963
CURRENT STATUS OF CHEMOTHERAPY OF CANCER.
    Postgraduate medicine, 1964, Volume: 35

    Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Black People; Chemotherapy, Cancer, Regional Perfusion; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Dermatologic Agents; DNA; DNA, Neoplasm; Fluorouracil; Geriatrics; Humans; Mechlorethamine; Melphalan; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Thiotepa; Toxicology; Triethylenemelamine; Vinblastine; Vincristine

1964
REGIONAL PERFUSION IN MELANOMA OF LIMBS.
    JAMA, 1964, Jun-08, Volume: 188

    Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Extremities; Humans; Mechlorethamine; Melanoma; Melphalan; Neoplasm Metastasis; Neoplasms; Postoperative Complications; Surgical Procedures, Operative; Thiotepa; Toxicology; Wound Healing

1964
EXTRACORPOREAL HYPOTHERMIA WITHOUT THORACOTOMY. AN EXPERIMENTAL STUDY IN THE USE OF COLD FOR NEUROSURGERY AND CANCERICIDAL PERFUSIONS.
    The British journal of surgery, 1964, Volume: 51

    Topics: Blood Flow Velocity; Body Temperature; Cardiac Surgical Procedures; Chemotherapy, Cancer, Regional Perfusion; Cold Temperature; Dogs; Electric Countershock; Electrocardiography; Femoral Artery; Heart, Artificial; Hypothermia; Hypothermia, Induced; Jugular Veins; Mechlorethamine; Melphalan; Neoplasms; Neurosurgery; Perfusion; Research; Thiotepa; Thoracic Surgery; Thoracotomy; Ventricular Fibrillation

1964
INFLUENCE OF SOME ANTITUMOR DRUGS ON BODY AND ORGANS GROWTH IN RATS.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Adrenal Glands; Antineoplastic Agents; Body Weight; Bone and Bones; Brain; Chlorambucil; Diaphragm; Esophagus; Gastrointestinal Tract; Growth; Heart; Humans; Kidney; Liver; Lung; Male; Mechlorethamine; Melphalan; Pharmacology; Prostate; Rats; Research; Spleen; Testis; Thiotepa; Thymus Gland; Urinary Bladder

1964
MELPHALAN (PHENYLALANIN NITROGEN MUSTARD) -TREATMENT IN MYELOMATOSIS.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Albuminuria; Blood Protein Electrophoresis; Humans; Leukocyte Disorders; Leukopenia; Mechlorethamine; Melphalan; Multiple Myeloma; Neoplasms; Thrombocytopenia

1964
[REGIONAL PERFUSION BY EXTRACORPOREAL CIRCULATION. INITIAL RESULTS].
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Chemotherapy, Cancer, Regional Perfusion; Heart, Artificial; Mechlorethamine; Melphalan; Neoplasms; Perfusion; Thiotepa

1964
ABDOMINAL PERFUSION FOR CANCER CHEMOTHERAPY USING HYPOTHERMIA AND HYPERTHERMIA.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Abdomen; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Cyclophosphamide; Female; Geriatrics; Hodgkin Disease; Humans; Hypothermia; Hypothermia, Induced; Leiomyosarcoma; Mechlorethamine; Melanoma; Melphalan; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Pelvis; Rectal Neoplasms; Retroperitoneal Neoplasms; Uterine Cervical Neoplasms; Vaginal Neoplasms

1964
INTRALYMPHATIC CHEMOTHERAPY WITH CYTOTOXIC DRUGS IN RABBITS.
    The British journal of surgery, 1964, Volume: 51

    Topics: Antineoplastic Agents; Cyclophosphamide; Injections; Injections, Intralymphatic; Lymphatic System; Mechlorethamine; Melphalan; Oils; Pathology; Propylene Glycols; Rabbits; Research; Toxicology; Triaziquone

1964
[Studies on the effect of sarcolysine on transplantable tumors of mice].
    Shi yan sheng wu xue bao, 1961, Volume: 7

    Topics: Animals; Mechlorethamine; Melphalan; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds

1961
Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards.
    Chemical research in toxicology, 2004, Volume: 17, Issue:7

    Topics: Adenine; Animals; Antineoplastic Agents, Alkylating; Cattle; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA; DNA Damage; Mechlorethamine; Melphalan; Spectrometry, Mass, Electrospray Ionization

2004
The combination of thalidomide, cyclophosphamide and dexamethasone is potentially useful in highly resistant Hodgkin's lymphoma.
    European journal of haematology, 2010, Volume: 84, Issue:3

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carmustine; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Deoxycytidine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Hodgkin Disease; Humans; Male; Mechlorethamine; Melphalan; Organoplatinum Compounds; Paclitaxel; Peripheral Blood Stem Cell Transplantation; Prednisolone; Prednisone; Procarbazine; Remission Induction; Rituximab; Salvage Therapy; Thalidomide; Topotecan; Transplantation, Autologous; Vidarabine; Vinblastine; Vincristine

2010
Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents.
    Biochemical pharmacology, 2012, May-01, Volume: 83, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Cross-Linking Reagents; DNA; Female; HeLa Cells; Humans; Mechlorethamine; Melphalan; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Proto-Oncogene Proteins c-bcl-2; Uterine Cervical Neoplasms; Voltage-Dependent Anion Channel 1

2012
The mechanism of guanine alkylation by nitrogen mustards: a computational study.
    The Journal of organic chemistry, 2012, Jul-20, Volume: 77, Issue:14

    Topics: Adenine; Alkylation; Antineoplastic Agents, Alkylating; Guanine; Kinetics; Mechlorethamine; Melphalan; Molecular Structure; Quantum Theory; Thermodynamics

2012
Risk of therapy-related secondary leukemia in Hodgkin lymphoma: the Stanford University experience over three generations of clinical trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Feb-10, Volume: 31, Issue:5

    Topics: Academic Medical Centers; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; California; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dacarbazine; Databases, Factual; Doxorubicin; Drug Administration Schedule; Female; Hodgkin Disease; Humans; Incidence; Leukemia, Myeloid, Acute; Male; Mechlorethamine; Melphalan; Methotrexate; Myelodysplastic Syndromes; Neoplasm Staging; Neoplasms, Second Primary; Prednisone; Procarbazine; Radiotherapy Dosage; Radiotherapy, Adjuvant; Retrospective Studies; Risk; Vinblastine; Vincristine

2013
Mechlorethamine, vincristine, melphalan and prednisone (MOMP) for the treatment of relapsed lymphoma in dogs.
    Veterinary and comparative oncology, 2015, Volume: 13, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dog Diseases; Dogs; Female; Lymphoma; Lymphoma, B-Cell; Lymphoma, T-Cell; Male; Mechlorethamine; Melphalan; Prednisone; Recurrence; Survival Analysis; Vincristine

2015
Effect of phenylalanine nitrogen mustard on tissues in culture.
    Antibiotics & chemotherapy (Northfield, Ill.), 1957, Volume: 7, Issue:9

    Topics: Immunologic Tests; Mechlorethamine; Melphalan; Nitrogen Mustard Compounds; Phenylalanine; Research Design; Tissue Culture Techniques

1957
Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug Synergism; Humans; Indazoles; Male; Mechlorethamine; Melanoma; Melphalan; Mice; Mice, Nude; Mice, SCID; Xenograft Model Antitumor Assays

2016
Mechlorethamine, vincristine, melphalan and prednisolone rescue chemotherapy protocol for resistant feline lymphoma.
    Journal of feline medicine and surgery, 2018, Volume: 20, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cat Diseases; Cats; Disease-Free Survival; Female; Lymphoma; Male; Mechlorethamine; Melphalan; Neoplasm Recurrence, Local; Prednisolone; Records; Retrospective Studies; Tennessee; Treatment Outcome; Vincristine

2018