mechlorethamine and hydroxyurea

mechlorethamine has been researched along with hydroxyurea in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199032 (82.05)18.7374
1990's3 (7.69)18.2507
2000's2 (5.13)29.6817
2010's2 (5.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hansch, C; Khwaja, TA; Selassie, CD1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Kaidbey, KH1
Carr, DT; Hansen, HH; Sealy, R; Selawry, OS; Simon, R; Tucker, RD; van Wyk, CE1
Rees, RB1
Bains, E; Jett, J; Maruyama, Y; Raju, MR1
Baker, H1
King, LS; Kobayashi, T; Kubo, K; Newman, JH1
Bode, HR; Koizumi, O1
Chi, E; Harlan, J; Maunder, R; Winn, R1
Bode, HR; Heimfeld, S1
Bland, RD; Hazinski, TA; Raj, JU1
Devik, F; Hagen, S1
Yu, KY1
Cohen, LS; Studzinski, GP1
Selawry, OS1
Falkson, G; Falkson, HC; Sandison, AG; van der Merwe, AM; van Dyk, JJ1
Conroy, JF1
Merker, PC; Sapru, HN1
Benckhuijsen, C1
von Kreybig, T1
Burns, BC; Rutledge, F; Smith, JP; Soffar, S1
Lo, TM; McCann, JJ; Webster, DA1
Bonder, RH; Van Scott, EJ2
Haas, RJ1
Farber, E; Lieberman, MW; Rutman, JZ1
Madoc-Jones, H; Mauro, F1
Farber, E; Landay, M; Lee, TN; Liang, H; Lieberman, MW; Starr, R; Verbin, RS1
Soukup, S; Takacs, E; Warkany, J1
Hittelman, WN; Sen, P1
Glick, JH; Taylor, SG; Zehngebot, LM1
Lewensohn, R; Ringborg, U1
Baral, E; Lambert, B; Lewensohn, R; Ringborg, U1
Kornacka, L; Malec, J; Sawecka, J1
Henriques, JA; Pereira, VR; Saffi, J1

Reviews

8 review(s) available for mechlorethamine and hydroxyurea

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Psoriasis: a review. II.
    Dermatologica, 1975, Volume: 150, Issue:3

    Topics: Adrenal Cortex Hormones; Anthralin; Azathioprine; Azauridine; Fluorouracil; Humans; Hydroxyurea; Lomustine; Mechlorethamine; Methotrexate; Psoriasis; Tars; Tretinoin; Ultraviolet Therapy

1975
[Some developments in psoriasis research abroad].
    Zhonghua yi xue za zhi, 1974, Volume: 4

    Topics: Aza Compounds; Female; Humans; Hydroxyurea; Male; Mechlorethamine; Methotrexate; Psoriasis; Uridine

1974
Monochemotherapy of bronchogenic carcinoma withs special reference to cell type.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2

    Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Carcinoma, Bronchogenic; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Floxuridine; Humans; Hydroxyurea; Lung Neoplasms; Mechlorethamine; Methotrexate; Mitomycins; Nitrosourea Compounds; Plicamycin; Porfiromycin; Procarbazine; Streptonigrin; Thiotepa; Vinblastine

1973
Lung cancer: perspectives and prospects.
    Annals of internal medicine, 1970, Volume: 73, Issue:6

    Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Synergism; Humans; Hydroxyurea; Lung Neoplasms; Mechlorethamine; Prognosis

1970
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
    Folia medica Neerlandica, 1969, Dec-02, Volume: 12, Issue:2

    Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Hydroxyurea; In Vitro Techniques; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitroso Compounds; Prednisone; Thymidine; Time Factors; Tritium; Vinblastine; Vincristine

1969
[Carcinogenesis and teratogenesis. Comparative studies from the viewpoint of teratology].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:5

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Cyclophosphamide; Embryo, Mammalian; Female; Fetus; Fluorouracil; Gestational Age; Hydroxamic Acids; Hydroxyurea; Mannomustine; Mechlorethamine; Mercaptopurine; Nitroso Compounds; Pregnancy; Rats; Urethane

1970
Chemotherapy for squamous cell carcinoma of the head and neck: a progress report.
    American journal of otolaryngology, 1980, Volume: 1, Issue:4

    Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Head and Neck Neoplasms; Humans; Hydroxyurea; Mechlorethamine; Mercaptopurine; Methotrexate; Procarbazine; Vinblastine

1980

Trials

3 trial(s) available for mechlorethamine and hydroxyurea

ArticleYear
Combination chemotherapy of advanced lung cancer: a randomized trial.
    Cancer, 1976, Volume: 38, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Leukopenia; Lomustine; Lung Neoplasms; Male; Mechlorethamine; Methotrexate; Middle Aged; Procarbazine; Thrombocytopenia; Vincristine

1976
Advanced lung cancer: A clinical trial of radiotherapy plus two drug combination regimens.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Nov-24, Volume: 47, Issue:46

    Topics: Adenocarcinoma; Amides; Antineoplastic Agents; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Drug Therapy, Combination; Fluorouracil; Humans; Hydroxyurea; Imidazoles; Lung Neoplasms; Mechlorethamine; Nitrosourea Compounds; Radioisotope Teletherapy; Remission, Spontaneous; Triazenes; Vincristine

1973
Chemotherapy for squamous cell carcinoma of the head and neck: a progress report.
    American journal of otolaryngology, 1980, Volume: 1, Issue:4

    Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Head and Neck Neoplasms; Humans; Hydroxyurea; Mechlorethamine; Mercaptopurine; Methotrexate; Procarbazine; Vinblastine

1980

Other Studies

29 other study(ies) available for mechlorethamine and hydroxyurea

ArticleYear
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Hair growth inhibition as a method of screening drugs for local antimitotic activity.
    The Journal of investigative dermatology, 1977, Volume: 68, Issue:2

    Topics: Animals; Antineoplastic Agents; Bleomycin; Colchicine; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Fluorouracil; Guinea Pigs; Hair; Hydroxyurea; Injections, Intradermal; Mechlorethamine; Methotrexate; Mitosis; Thiotepa; Vincristine

1977
Psoriasis: clinical aspects and management.
    Cutis, 1976, Volume: 18, Issue:2

    Topics: Administration, Topical; Age Factors; Azauridine; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine; Methotrexate; Methoxsalen; Nitrosourea Compounds; Psoriasis; Thiotepa; Triamcinolone Acetonide

1976
Study of in vivo tumor state and response to therapy by analysis of DNA distribution.
    Cancer treatment reports, 1976, Volume: 60, Issue:5

    Topics: Animals; Carmustine; Cell Survival; Cobalt Radioisotopes; DNA, Neoplasm; Female; Hydroxyurea; Kinetics; Lymphoma; Mechlorethamine; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Radioisotope Teletherapy; Thymidine

1976
Differing effects of nitrogen mustard and hydroxyurea on lung O2 toxicity in adult sheep.
    The American review of respiratory disease, 1992, Volume: 145, Issue:1

    Topics: Animals; Carbon Dioxide; Extravascular Lung Water; Hemodynamics; Hydroxyurea; Leukocyte Count; Lung; Mechlorethamine; Neutrophils; Oxygen; Pulmonary Circulation; Respiratory Insufficiency; Sheep; Vasoconstriction

1992
Plasticity in the nervous system of adult hydra. III. Conversion of neurons to expression of a vasopressin-like immunoreactivity depends on axial location.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1991, Volume: 11, Issue:7

    Topics: Animals; Cell Count; Cell Differentiation; Hydra; Hydroxyurea; Immunohistochemistry; Mechlorethamine; Nervous System; Neuronal Plasticity; Neurons; Stem Cells; Vasopressins

1991
Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 62, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Blood Proteins; Body Water; Cardiac Output; Endotoxins; Escherichia coli; Goats; Hydroxyurea; Leukocyte Count; Mechlorethamine; Neutrophils; Oxygen; Pulmonary Artery; Pulmonary Edema; Pulmonary Wedge Pressure; Thromboxane B2

1987
Growth regulation of the interstitial cell population in hydra. IV. Control of nerve cell and nematocyte differentiation by amplification of non-stem interstitial cells.
    Developmental biology, 1986, Volume: 116, Issue:1

    Topics: Animals; Cell Differentiation; Cell Division; Hydra; Hydroxyurea; Mechlorethamine; Neurons

1986
Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 58, Issue:3

    Topics: Agranulocytosis; Animals; Blood Pressure; Capillary Permeability; Cardiac Output; Hydroxyurea; Lung; Lymph; Mechlorethamine; Microcirculation; Neutropenia; Oxygen; Proteins; Pulmonary Edema; Rabbits; Respiratory Insufficiency; Sheep; Water-Electrolyte Balance

1985
Effects of X-rays and cytotoxic agents on the cell population of the crypts of the small intestine in mice. Cell proliferation kinetics after single administrations and effects of variations in multiple dose schedules.
    Virchows Archiv. B, Cell pathology, 1973, Mar-06, Volume: 12, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Cell Count; Cyclophosphamide; Female; Hydroxyurea; Intestinal Mucosa; Intestine, Small; Male; Mechlorethamine; Methotrexate; Mice; Mitosis; Radiation Genetics; Time Factors

1973
Correlation between cell enlargement and nucleic acid and protein content of HeLa cells in unbalanced growth produced by inhibitors of DNA synthesis.
    Journal of cellular physiology, 1967, Volume: 69, Issue:3

    Topics: Cell Division; Culture Techniques; Cytarabine; DNA, Neoplasm; Female; Floxuridine; Growth; HeLa Cells; Humans; Hydroxyurea; Mechlorethamine; Mitomycins; Neoplasm Proteins; Nitrogen Mustard Compounds; RNA, Neoplasm; Thymidine

1967
Cancer chemotherapy: mechanisms of action.
    Seminars in drug treatment, 1973,Summer, Volume: 3, Issue:1

    Topics: Alkaloids; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Binding Sites; Cytarabine; Drug Synergism; Enzyme Therapy; Folic Acid Antagonists; Humans; Hydroxyurea; Leucovorin; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Neoplasms; Nucleic Acids; Purines; Pyrimidines; Steroids; Thioguanine; Vinblastine; Vincristine

1973
The action of hydroxyurea, 2,3 bis(2-chloroethyl)-1-nitrosourea (BCNU) and nitrogen mustard on glucose and water absorption from the small intestine of the rat.
    Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:3

    Topics: Animals; Carmustine; Depression, Chemical; Glucose; Hydroxyurea; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Mechlorethamine; Organ Size; Rats; Time Factors; Water

1973
Systemic chemotherapy for carcinoma of the cervix.
    American journal of obstetrics and gynecology, 1967, Mar-15, Volume: 97, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine; Melphalan; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Progestins; Thiotepa; Urea; Uterine Cervical Neoplasms

1967
Cross-linking of DNA by alkylating agents and effects on DNA function in the chick embryo.
    Cancer research, 1971, Volume: 31, Issue:11

    Topics: Animals; Chick Embryo; Depression, Chemical; DNA; Hydroxyurea; Leucine; Mechlorethamine; Mitomycins; Nucleic Acid Denaturation; Protein Biosynthesis; RNA; Thiotepa; Thymidine; Tritium; Uridine

1971
Use of mouse vaginal and rectal epithelium to screen antimitotic effects of systemically administered drugs.
    Cancer research, 1971, Volume: 31, Issue:6

    Topics: Animals; Antineoplastic Agents; Cytarabine; Epithelial Cells; Epithelium; Female; Fluorouracil; Hydroxyurea; Mechlorethamine; Methotrexate; Mice; Mitosis; Podophyllin; Rectum; Vagina; Vinblastine

1971
[The role of cytokinetically resting cells for the regeneration of an aplastic bone marrow. Autoradiographic studies on rat].
    Arztliche Forschung, 1971, Jun-10, Volume: 25, Issue:6

    Topics: Animals; Animals, Newborn; Autoradiography; Bone Marrow; Bone Marrow Cells; Epithelium; Female; Hematopoiesis; Hydroxyurea; Lymphocytes; Mechlorethamine; Mononuclear Phagocyte System; Pregnancy; Radiation Injuries, Experimental; Rats; Regeneration; Thymidine; Tritium

1971
Thymidine labeling of pyrimidine isostichs from human lymphocyte DNA during repair after damage with N-acetoxy acetylaminofluorene or nitrogen mustard.
    Biochimica et biophysica acta, 1971, Volume: 247, Issue:3

    Topics: Acetamides; Aniline Compounds; Chromatography, DEAE-Cellulose; DNA; DNA Repair; Fluorenes; Formates; Humans; Hydroxyurea; Lymphocytes; Mechlorethamine; Nitrogen Mustard Compounds; Pyrimidine Nucleotides; Thymidine; Tritium

1971
Age responses of cultured mammalian cells to cytotoxic drugs.
    Cancer research, 1970, Volume: 30, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Benzocycloheptenes; Colchicine; Cricetinae; Culture Techniques; Cycloheximide; Dactinomycin; DNA; Griseofulvin; HeLa Cells; Hydroxylamines; Hydroxyurea; Mechlorethamine; Mitosis; Naphthacenes; Nitrites; Novobiocin; Potassium; Puromycin; RNA; Sulfates; Sulfides; Uracil Mustard; Vinblastine; Vincristine

1970
A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation.
    Cancer research, 1970, Volume: 30, Issue:4

    Topics: Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Cycloheximide; Cytarabine; DNA; Epithelium; Hydroxyurea; Intestinal Mucosa; Intestine, Small; Ketones; Leucine; Male; Mechlorethamine; Protein Biosynthesis; Proteins; Pyrroles; Radiation Effects; Rats; RNA; Thymidine; Time Factors

1970
Intravaginal and intrarectal screening of antimitotic drugs for topical effectiveness.
    The Journal of investigative dermatology, 1971, Volume: 56, Issue:2

    Topics: Animals; Antineoplastic Agents; Colchicine; Cytarabine; Daunorubicin; Evaluation Studies as Topic; Female; Fluorouracil; Hydroxyurea; Intestinal Mucosa; Mechlorethamine; Methods; Methotrexate; Mice; Mitosis; Mucous Membrane; Nitrosourea Compounds; Podophyllin; Rectum; Vagina; Vinblastine; Vincristine

1971
Chromosome changes in embryos treated with various teratogens.
    Journal of embryology and experimental morphology, 1967, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyurea; Mechlorethamine; Mitosis; Nitrogen Mustard Compounds; Pregnancy; Rabbits; Rats; Streptonigrin; Thalidomide

1967
Induction of chromosome damage by Neurospora endonuclease in repair-inhibited quiescent normal human fibroblasts.
    Mutation research, 1984, Volume: 129, Issue:3

    Topics: Cell Line; Chromosome Aberrations; Cytarabine; DNA Repair; Endonucleases; Fibroblasts; HeLa Cells; Humans; Hydroxyurea; Karyotyping; Kinetics; Mechlorethamine; Single-Strand Specific DNA and RNA Endonucleases

1984
DNA-repair synthesis in blast cells from patients with acute myeloblastic leukaemia.
    Scandinavian journal of haematology, 1982, Volume: 28, Issue:5

    Topics: Alkylating Agents; Autoradiography; Bone Marrow; Cell Transformation, Neoplastic; DNA; DNA Repair; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Mechlorethamine; Multiple Myeloma

1982
DNA repair synthesis in subpopulations of human lymphocytes.
    Journal of cell science, 1982, Volume: 54

    Topics: B-Lymphocytes; Cells, Cultured; DNA Repair; Humans; Hydroxyurea; Lymphocytes; Mechlorethamine; Methyl Methanesulfonate; T-Lymphocytes; Ultraviolet Rays

1982
Distribution of DNA repair and the extent of enzymatic DNA methylation in alkylated human lymphocytes carrying their DNA synthesis in the presence or absence of hydroxyurea.
    Biochemical and biophysical research communications, 1980, Jul-16, Volume: 95, Issue:1

    Topics: Cytosine; Deoxyribonucleases; DNA; DNA Repair; Humans; Hydroxyurea; Lymphocytes; Mechlorethamine; Methylation; Oligodeoxyribonucleotides

1980
Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae.
    Current genetics, 2000, Volume: 37, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Cell Division; DNA Helicases; DNA Repair; Hydrogen Peroxide; Hydroxyurea; Mechlorethamine; Methyl Methanesulfonate; Mutagens; Mutation; Quinolones; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays

2000