Compounds > mecamylamine

mecamylamine and varenicline

mecamylamine has been researched along with varenicline in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (4.17)29.6817
2010's22 (91.67)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Rose, JE1
Papke, RL; Stitzel, JA; Wecker, L1
Bartlett, SE; Chatterjee, S1
Biala, G; Budzynska, B; Staniak, N1
Biala, G; Staniak, N1
Bergman, J; Desai, RI1
Cunningham, CS; McMahon, LR2
Dong, E; Guidotti, A; Kadriu, B; Maloku, E; Pibiri, F; Satta, R; Zhubi, A1
Brooks, EA; Jutkiewicz, EM; Kynaston, AD; Rice, KC; Woods, JH1
Czoty, PW; Gould, RW; Nader, MA; Nader, SH1
Grady, SR; Marks, MJ; O'Neill, HC; Ortiz, NC1
Cunningham, CS; Javors, MA; McMahon, LR1
Biała, G; Budzyńska, B; Kruk-Słomka, M1
Dixon-McDougall, T; Nowak, C; Pereira, S; Qian, C; Sellings, L; Tyndale, RF; van der Kooy, D; Zhao, B1
Antilla, JC; Bickford, PC; Engberg, ME; Hudson, CE; Kang, CW; Lambert, CS; Philpot, RM; Rowell, PP; Wecker, L; Zesiewicz, TA1
Evins, AE; Fullerton, CA; Hoeppner, SS; Roh, S; Schoenfeld, D; Stoeckel, LE1
Ebbert, JO; Elrashidi, MY1
Abdullah, R; Banks, ML; Bettinger, JC; Carroll, FI; Damaj, IM; Dawson, A; Jackson, A; Miles, MF; Muldoon, PP; O'Brien, M; Slater, CA; Soll, LG; Tapper, AR1
Bartlett, SE; Belmer, A; Holgate, J; Morgan, M; Patkar, OL; Quik, M; Shariff, M; Tam, V1
de Moura, FB; McMahon, LR1
McMahon, LR1
Ding, ZM; Gao, Y; Sentir, AM; Tan, X1

Reviews

5 review(s) available for mecamylamine and varenicline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
New findings on nicotine addiction and treatment.
    Nebraska Symposium on Motivation. Nebraska Symposium on Motivation, 2009, Volume: 55

    Topics: Animals; Benzazepines; Bupropion; Humans; Mecamylamine; Motivation; Nicotine; Nicotinic Antagonists; Quinoxalines; Reward; Smoking Cessation; Tobacco Use Disorder; Vaccines; Varenicline

2009
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.
    CNS & neurological disorders drug targets, 2010, Volume: 9, Issue:1

    Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Benzazepines; Brain; Humans; Mecamylamine; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Receptors, Nicotinic; Tobacco Use Disorder; Varenicline

2010
Emerging drugs for the treatment of tobacco dependence: 2014 update.
    Expert opinion on emerging drugs, 2014, Volume: 19, Issue:2

    Topics: Atomoxetine Hydrochloride; Benzazepines; Bupropion; Clinical Trials as Topic; Clonidine; Humans; Mecamylamine; Nicotine; Nortriptyline; Propylamines; Quinoxalines; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline

2014
Green tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics.
    Expert review of clinical pharmacology, 2019, Volume: 12, Issue:3

    Topics: Agricultural Workers' Diseases; Humans; Mecamylamine; Nicotiana; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Plant Leaves; Vaccines; Varenicline

2019

Trials

1 trial(s) available for mecamylamine and varenicline

ArticleYear
Acute effects of mecamylamine and varenicline on cognitive performance in non-smokers with and without schizophrenia.
    Psychopharmacology, 2014, Volume: 231, Issue:4

    Topics: Adult; Antipsychotic Agents; Attention; Benzazepines; Cognition; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Mecamylamine; Middle Aged; Neuropsychological Tests; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Reaction Time; Schizophrenia; Schizophrenic Psychology; Smoking Cessation; Task Performance and Analysis; Varenicline

2014

Other Studies

18 other study(ies) available for mecamylamine and varenicline

ArticleYear
Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:2

    Topics: Acetylcholine; Alkaloids; Animals; Azocines; Benzazepines; Decamethonium Compounds; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electrophysiology; Gene Expression; Hexamethonium; Humans; Mecamylamine; Mice; Mice, Transgenic; Muscle, Skeletal; Nicotinic Antagonists; Oocytes; Quinolizines; Quinoxalines; Rats; Receptors, Nicotinic; Varenicline; Xenopus laevis

2010
Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2010, Volume: 381, Issue:4

    Topics: Animals; Benzazepines; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Mecamylamine; Morphine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Tobacco Use Disorder; Varenicline

2010
Varenicline and mecamylamine attenuate locomotor sensitization and cross-sensitization induced by nicotine and morphine in mice.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 96, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Mice; Morphine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Varenicline

2010
Drug discrimination in methamphetamine-trained rats: effects of cholinergic nicotinic compounds.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: Animals; Behavior, Animal; Benzazepines; Cholinergic Agents; Cholinesterase Inhibitors; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Methamphetamine; Muscarinic Antagonists; Nicotinic Agonists; Nicotinic Antagonists; Pentobarbital; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Varenicline

2010
The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.
    European journal of pharmacology, 2011, Mar-01, Volume: 654, Issue:1

    Topics: Alkaloids; Animals; Azocines; Benzazepines; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Reinforcement Schedule; Smoking Cessation; Time Factors; Varenicline

2011
Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:7

    Topics: Analysis of Variance; Animals; Azetidines; Behavior, Animal; Benzazepines; Cerebral Cortex; Conditioning, Classical; Cues; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenomics; Exploratory Behavior; Fear; Freezing Reaction, Cataleptic; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Male; Mecamylamine; Methyl-CpG-Binding Protein 2; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Promoter Regions, Genetic; Quinoxalines; Receptors, Nicotinic; RNA, Messenger; Varenicline

2011
Patterns of nicotinic receptor antagonism: nicotine discrimination studies.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1

    Topics: Animals; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Data Interpretation, Statistical; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Varenicline

2011
Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:2

    Topics: Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Reinforcement, Psychology; Self Administration; Time Factors; Varenicline

2011
Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Volume: 14, Issue:6

    Topics: Animals; Benzazepines; Dose-Response Relationship, Drug; Female; Genotype; Hexamethonium; Hypothermia; Inhibitory Concentration 50; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Motor Activity; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Quinoxalines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Varenicline

2012
Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:3

    Topics: Alkaloids; Animals; Azocines; Benzazepines; Cocaine; Conditioning, Operant; Discrimination Learning; Dopamine Uptake Inhibitors; Drug Interactions; Female; Hypnotics and Sedatives; Macaca mulatta; Male; Mecamylamine; Midazolam; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Varenicline

2012
Involvement of cholinergic receptors in the different stages of memory measured in the modified elevated plus maze test in mice.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:5

    Topics: Animals; Benzazepines; Male; Maze Learning; Mecamylamine; Memory; Mice; Motor Activity; Nicotine; Quinoxalines; Receptors, Cholinergic; Scopolamine; Varenicline

2012
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.
    The European journal of neuroscience, 2013, Volume: 37, Issue:5

    Topics: Age Factors; Animals; Behavior, Animal; Benzazepines; Butanones; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chemotaxis; Chlorides; Fasting; Mecamylamine; Muscles; Mutation; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Quinoxalines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Nicotinic; Reward; Sodium; Taste; Time Factors; Varenicline

2013
Multiple nicotine training doses in mice as a basis for differentiating the effects of smoking cessation aids.
    Psychopharmacology, 2013, Volume: 228, Issue:2

    Topics: Alkaloids; Animals; Azocines; Benzazepines; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Morphine; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Smoking Cessation; Tobacco Use Cessation Devices; Varenicline

2013
Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.
    Neuropharmacology, 2013, Volume: 73

    Topics: Animals; Ataxia; Benzazepines; Cerebellum; Dose-Response Relationship, Drug; Gait; Male; Mecamylamine; Motor Activity; Nerve Degeneration; Neural Pathways; Niacinamide; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Olivary Nucleus; Postural Balance; Pyridines; Quinoxalines; Rats; Rotarod Performance Test; Varenicline

2013
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Body Temperature; Central Nervous System Depressants; Drug Interactions; Ethanol; Hypnotics and Sedatives; Hypothermia; Ketamine; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pentobarbital; Pyridines; Receptors, Nicotinic; Reflex, Righting; Varenicline

2016
Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Alkaloids; Animals; Azocines; Drug Evaluation, Preclinical; Food Preferences; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Quinolizines; Rats, Wistar; Receptors, Nicotinic; Sucrose; Varenicline

2016
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.
    Psychopharmacology, 2017, Volume: 234, Issue:5

    Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline

2017
Self-Administration of Cotinine in Wistar Rats: Comparisons to Nicotine.
    The Journal of pharmacology and experimental therapeutics, 2021, Volume: 376, Issue:3

    Topics: Animals; Cotinine; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Self Administration; Varenicline

2021