mecamylamine and epibatidine

mecamylamine has been researched along with epibatidine in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	16 (31.37)	18.2507
2000's	25 (49.02)	29.6817
2010's	9 (17.65)	24.3611
2020's	1 (1.96)	2.80

Authors

Authors	Studies
Dart, MJ; Holladay, MW; Lynch, JK	1
Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T	1
Arneric, SP; Bannon, AW; Decker, MW; Gunther, KL	1
Bannon, AW; Decker, MW; Gunther, KL	1
Bley, KR; Bonhaus, DW; Broka, CA; Fontana, DJ; Leung, E; Lewis, R; Shieh, A; Wong, EH	1
Biftu, T; Eckman, J; Ip, S; Li, T; Libertine-Garahan, L; Qian, C; Shen, TY	1
Baranyi, M; Lajtha, A; Lendvai, B; Santha, E; Sershen, H; Vizi, ES	1
Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M	1
Anderson, DJ; Barlocco, D; Bartolini, A; Cignarella, G; Colombo, D; Galeotti, N; Ghelardini, C; Kuntzweiler, TA; Toma, L; Tondi, D; Vianello, P; Villa, S	1
Hashimoto, K; Minabe, Y; Nishimura, T; Tsunashima, K; Watanabe, K	1
Arneric, SP; Bannon, AW; Curzon, P; Decker, MW; Nikkel, AL	1
Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL	1
Bottlaender, M; Coulon, C; Crouzel, C; Dollé, F; Fuseau, C; Guenther, I; Hinnen, F; Ottaviani, M; Valette, H	1
Lawand, NB; Lu, Y; Westlund, KN	1
Flores, CM; Mogil, JS; Wilson, SG	1
Nordberg, A; Svensson, AL	1
Belluardo, N; Blum, M; Caniglia, G; Cheng, Q; Dell'Albani, P; Fuxe, K; Mudò, G	1
Boye, S; Clarke, PB; Reuben, M	1
Boyce, S; Hill, RG; Rupniak, NMJ; Russell, MGN; Shepheard, SL; Webb, JK	1
Booth, S; Breese, CR; Caggiula, AR; Donny, EC; Lee, MJ; Leonard, S; McCallum, SE; Sved, AF	1
Decker, MW; Meyer, MD; Rueter, LE	1
Clark, TM; Flores, CM; Gilbert, SD	1
Hama, AT; Lloyd, GK; Menzaghi, F	1
Casida, JE; Cowan, A; Tomizawa, M	1
Gentry, CL; Lukas, RJ; Wilkins, LH	1
Adams, P; Correa, LD; Rao, TS; Sacaan, AI; Santori, EM	1
Matsumoto, A; Matsuyama, S	1
Dussor, GO; Flores, CM; Gracia, NB; Hargreaves, KM; Kilo, S; Leong, AS; Price, TJ	1
Caban, AJ; Hama, AT; Lee, JW; Sagen, J	1
De Biasi, M; Pieri, F; Salas, R	1
Jozwiak, K; Moaddel, R; Wainer, IW; Whittington, K	1
Jones, IW; Pullar, IA; Rousseau, SJ; Wonnacott, S	1
Boyd, RT; Free, RB; Kaser, DJ; McKay, DB	1
Abelson, KS; Goldkuhl, RR; Höglund, AU; Nylund, A	1
Kiss, JP; Mandl, P	1
Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR	1
Drisdel, RC; Green, WN; Hales, TG; Henderson, T; Sharp, D	1
Chaijale, N; Cucchiaro, G; Ganesh, A; Gonzalez-Sulser, A	1
Kuryatov, A; Lindstrom, J; Onksen, J	1
Cucchiaro, G; Gonzalez-Sulser, A; Kellar, KJ; Xiao, Y	1
Gandía, L; García, AG; García-Eguiagaray, J; Tapia, L	1
Arias, HR; Feuerbach, D; Jozwiak, K; Maciejewski, R; Sullivan, CJ; Targowska-Duda, KM	1
Bordia, T; Campos, C; McIntosh, JM; Quik, M	1
Arias, HR; Feuerbach, D; Jozwiak, K; Moaddel, R; Rosenberg, A; Targowska-Duda, KM; Wainer, IW	1
Brooks, EA; Jutkiewicz, EM; Kynaston, AD; Rice, KC; Woods, JH	1
Feng, CS; Liu, Y; Piao, MH; Qiu, JP; Wang, YS	1
Carroll, FI; Cunningham, CS; McMahon, LR; Moura, FB; Ondachi, P; Rodriguez, JS	1
Farshid, AA; Tamaddonfard, E; Yousofizadeh, S	1
de Moura, FB; McMahon, LR	1
Cai, J; Fan, J; Huang, L; Li, W; Wang, BH; Wang, Y	1
de Moura, FB; Hiranita, T; McMahon, LR	1

Reviews

2 review(s) available for mecamylamine and epibatidine

Article	Year
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26 Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship	1997
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic	2005

Article

Year

Neuronal nicotinic acetylcholine receptors as targets for drug discovery.

Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship

1997

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15

Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic

2005

Other Studies

49 other study(ies) available for mecamylamine and epibatidine

Article	Year
The influence of Bay K 8644 treatment on (+/-)-epibatidine-induced analgesia. Brain research, 1995, Apr-24, Volume: 678, Issue:1-2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesia; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotinic Agonists; Pyridines; Time Factors	1995
Is epibatidine really analgesic? Dissociation of the activity, temperature, and analgesic effects of (+/-)-epibatidine. Pharmacology, biochemistry, and behavior, 1995, Volume: 51, Issue:4 Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorisondamine; Male; Mecamylamine; Mice; Motor Activity; Pain Measurement; Postural Balance; Psychomotor Performance; Pyridines; Stereoisomerism; Time Factors	1995
Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3 Topics: Analgesics; Animals; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Guinea Pigs; In Vitro Techniques; Male; Mecamylamine; Morphine; Motor Activity; Naloxone; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Vagus Nerve	1995
Epibatidine is a nicotinic analgesic. European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3 Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Mecamylamine; Mice; Nicotine; Pyridines; Quinolizines; Rats; Receptors, Nicotinic	1993
Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices. Neuropharmacology, 1996, Volume: 35, Issue:12 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tritium; Tubocurarine	1996
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science (New York, N.Y.), 1998, Jan-02, Volume: 279, Issue:5347 Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission	1998
Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling. Journal of medicinal chemistry, 1998, Feb-26, Volume: 41, Issue:5 Topics: Abdominal Muscles; Analgesia; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Humans; Kinetics; Magnetic Resonance Spectroscopy; Male; Mecamylamine; Mice; Models, Molecular; Molecular Conformation; Muscle Contraction; Naloxone; Narcotic Antagonists; Pain Threshold; Pyridazines; Pyridines; Rats; Receptors, Cholinergic	1998
Expression of fos protein in rat brain following administration of a nicotinic acetylcholine receptor agonist epibatidine. Brain research, 1998, Jun-22, Volume: 797, Issue:1 Topics: Animals; Benzazepines; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Sulpiride	1998
Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3 Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Chlorisondamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Lidocaine; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley	1998
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology, 1998, Volume: 37, Issue:12 Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal	1998
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo. Life sciences, 1999, Volume: 64, Issue:5 Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution	1999
Nicotinic cholinergic receptors: potential targets for inflammatory pain relief. Pain, 1999, Volume: 80, Issue:1-2 Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Hyperalgesia; Injections, Spinal; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic	1999
Pharmacogenetic variability in neuronal nicotinic receptor-mediated antinociception. Pharmacogenetics, 1999, Volume: 9, Issue:5 Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Genetic Variation; Humans; Male; Mecamylamine; Mice; Mice, Inbred Strains; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pharmacogenetics; Pyridines; Receptors, Nicotinic; Species Specificity	1999
Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors. Neuroreport, 1999, Nov-26, Volume: 10, Issue:17 Topics: Aconitine; Amyloid beta-Peptides; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cell Survival; Cholinesterase Inhibitors; Estradiol; Formazans; Humans; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Tetrazolium Salts; Tumor Cells, Cultured	1999
The nicotinic acetylcholine receptor agonist (+/-)-epibatidine increases FGF-2 mRNA and protein levels in the rat brain. Brain research. Molecular brain research, 1999, Dec-10, Volume: 74, Issue:1-2 Topics: Animals; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; In Situ Hybridization; Mecamylamine; Nerve Growth Factors; Nerve Tissue Proteins; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Specific Pathogen-Free Organisms; Time Factors	1999
Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically. European journal of pharmacology, 2000, Mar-30, Volume: 393, Issue:1-3 Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Hippocampus; Male; Mecamylamine; Motor Activity; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Synaptosomes; Tetrodotoxin; Tritium	2000
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats. Pain, 2000, Volume: 85, Issue:3 Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Hot Temperature; Hypertension; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Postural Balance; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Substance-Related Disorders	2000
Mecamylamine prevents tolerance but enhances whole brain [3H]epibatidine binding in response to repeated nicotine administration in rats. Psychopharmacology, 2000, Volume: 150, Issue:1 Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Tolerance; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2000
Spinal mechanisms underlying A-85380-induced effects on acute thermal pain. Brain research, 2000, Jul-28, Volume: 872, Issue:1-2 Topics: Adrenergic alpha-Agonists; Animals; Azetidines; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Clonidine; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Spinal; Lumbosacral Region; Male; Mecamylamine; Microdialysis; Muscarinic Antagonists; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin; Serotonin Antagonists; Spinal Cord	2000
Antihyperalgesic activity of epibatidine in the formalin model of facial pain. Pain, 2001, Volume: 89, Issue:2-3 Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Hyperalgesia; Male; Mecamylamine; Nicotinic Antagonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors	2001
The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats. Pain, 2001, Volume: 91, Issue:1-2 Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Drug Combinations; Formaldehyde; Injections, Spinal; Male; Mecamylamine; Neostigmine; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Palliative Care; Pyridines; Rats; Rats, Sprague-Dawley	2001
Analgesic and toxic effects of neonicotinoid insecticides in mice. Toxicology and applied pharmacology, 2001, Nov-15, Volume: 177, Issue:1 Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Imidazoles; Insecticides; Mecamylamine; Mice; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiazines; Time Factors	2001
Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1 Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Cholinergic Agents; Humans; In Situ Hybridization; Ligands; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Rubidium Radioisotopes	2003
Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists. Brain research, 2003, Nov-14, Volume: 990, Issue:1-2 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Prefrontal Cortex; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tetrodotoxin	2003
Epibatidine induces long-term potentiation (LTP) via activation of alpha4beta2 nicotinic acetylcholine receptors (nAChRs) in vivo in the intact mouse dentate gyrus: both alpha7 and alpha4beta2 nAChRs essential to nicotinic LTP. Journal of pharmacological sciences, 2003, Volume: 93, Issue:2 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Choline; Dentate Gyrus; Drug Synergism; In Vitro Techniques; Long-Term Potentiation; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic	2003
Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine. The European journal of neuroscience, 2003, Volume: 18, Issue:9 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; In Situ Hybridization; Male; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion	2003
Enhanced antinociception by nicotinic receptor agonist epibatidine and adrenal medullary transplants in the spinal subarachnoid space. Neuropharmacology, 2004, Volume: 47, Issue:1 Topics: Adrenal Medulla; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Spine; Subarachnoid Space; Transplantation, Isogeneic	2004
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45 Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hyperalgesia; Infusion Pumps, Implantable; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Pyridines; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tremor	2004
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors. Analytical chemistry, 2005, Feb-01, Volume: 77, Issue:3 Topics: Alkaloids; Azocines; Binding, Competitive; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Dextromethorphan; Mecamylamine; Membranes, Artificial; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic	2005
Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro. Neuropharmacology, 2005, Volume: 49, Issue:1 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Aspartic Acid; Azetidines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Choline; Cyanobacteria Toxins; Dicarboxylic Acids; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Frontal Lobe; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Mecamylamine; Microcystins; Microscopy, Confocal; Neurotransmitter Uptake Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphopyruvate Hydratase; Potassium Chloride; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium; Tropanes	2005
Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native alpha3beta4* nicotinic receptors. Neuroscience letters, 2006, Jan-09, Volume: 392, Issue:1-2 Topics: Alkylation; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Line; Cysteine; Drug Interactions; Humans; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Recombinant Fusion Proteins; Transfection; Tritium	2006
The effect of ketamine on intraspinal acetylcholine release: involvement of spinal nicotinic receptors. European journal of pharmacology, 2006, Mar-18, Volume: 534, Issue:1-3 Topics: Acetylcholine; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Bridged Bicyclo Compounds, Heterocyclic; Isoflurane; Ketamine; Male; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Time Factors	2006
Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons. Neurochemistry international, 2006, Volume: 49, Issue:4 Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Electric Stimulation; Guinea Pigs; Hemicholinium 3; Ileum; In Vitro Techniques; Isometric Contraction; Male; Mecamylamine; Motor Neurons; Myenteric Plexus; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Receptors, Presynaptic; Tetrodotoxin	2006
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3 Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord	2007
High affinity binding of epibatidine to serotonin type 3 receptors. The Journal of biological chemistry, 2008, Apr-11, Volume: 283, Issue:15 Topics: Animals; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Humans; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists	2008
Electrophysiologic effects of systemic and locally infused epibatidine on locus coeruleus neurons. European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1 Topics: Action Potentials; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Infusions, Parenteral; Injections, Subcutaneous; Locus Coeruleus; Male; Mecamylamine; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Time Factors	2008
Roles of accessory subunits in alpha4beta2() nicotinic receptors. Molecular pharmacology, 2008, Volume: 74, Issue:1* Topics: Acetylcholine; Allosteric Regulation; Antibodies, Monoclonal; Binding Sites; Biotinylation; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Galantamine; Humans; Inhibitory Concentration 50; Kidney; Mecamylamine; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioimmunoassay; Receptors, Nicotinic; Transfection; Up-Regulation	2008
Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug. Anesthesiology, 2008, Volume: 109, Issue:3 Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Motor Activity; Naloxone; Narcotic Antagonists; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sodium Chloride	2008
Preconditioning stimuli that augment chromaffin cell secretion. American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:4 Topics: Acetylcholine; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Catecholamines; Cattle; Cells, Cultured; Choline; Chromaffin Cells; Dose-Response Relationship, Drug; Mecamylamine; Methacholine Chloride; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Potassium; Pyridines; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Time Factors	2009
Different interaction between tricyclic antidepressants and mecamylamine with the human alpha3beta4 nicotinic acetylcholine receptor ion channel. Neurochemistry international, 2010, Volume: 56, Issue:4 Topics: Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Cells, Cultured; Humans; Imipramine; Ion Channels; Mecamylamine; Models, Molecular; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Conformation; Pyridines; Receptors, Nicotinic	2010
Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:3 Topics: Amphetamine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Central Nervous System Stimulants; Cocaine; Conotoxins; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereotyped Behavior	2010
Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel. The international journal of biochemistry & cell biology, 2010, Volume: 42, Issue:6 Topics: Antidepressive Agents, Tricyclic; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cell Line; Humans; Imipramine; Ion Channels; Mecamylamine; Nicotinic Antagonists; Protein Binding; Protein Conformation; Pyridines; Receptors, Nicotinic	2010
Patterns of nicotinic receptor antagonism: nicotine discrimination studies. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1 Topics: Animals; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Data Interpretation, Statistical; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Varenicline	2011
Volatile anesthetic isoflurane inhibits LTP induction of hippocampal CA1 neurons through α4β2 nAChR subtype-mediated mechanisms. Annales francaises d'anesthesie et de reanimation, 2013, Volume: 32, Issue:10 Topics: Anesthetics, Inhalation; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Drug Interactions; Electric Stimulation; In Vitro Techniques; Isoflurane; Long-Term Potentiation; Mecamylamine; Muscarinic Agonists; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2013
Discriminative stimulus and hypothermic effects of some derivatives of the nAChR agonist epibatidine in mice. Psychopharmacology, 2014, Volume: 231, Issue:23 Topics: Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Discrimination Learning; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic	2014
The role of nicotinic acetylcholine and opioid systems of the ventral orbital cortex in modulation of formalin-induced orofacial pain in rats. European journal of pharmacology, 2015, Jul-05, Volume: 758 Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Drug Therapy, Combination; Facial Pain; Formaldehyde; Locomotion; Male; Mecamylamine; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Prefrontal Cortex; Pyridines; Rats	2015
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice. Psychopharmacology, 2017, Volume: 234, Issue:5 Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline	2017
Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors. Science China. Life sciences, 2018, Volume: 61, Issue:6 Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Constriction, Pathologic; Disease Models, Animal; Formaldehyde; HEK293 Cells; Humans; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotinic Agonists; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2018
The discriminative stimulus effects of epibatidine in C57BL/6J mice. Behavioural pharmacology, 2020, Volume: 31, Issue:6 Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Discrimination Learning; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Pyridines	2020