Page last updated: 2024-09-04

mdl 74156 and dolasetron

mdl 74156 has been researched along with dolasetron in 13 studies

Compound Research Comparison

Studies
(mdl 74156)
Trials
(mdl 74156)
Recent Studies (post-2010)
(mdl 74156)
Studies
(dolasetron)
Trials
(dolasetron)
Recent Studies (post-2010) (dolasetron)
14521918914

Protein Interaction Comparison

ProteinTaxonomymdl 74156 (IC50)dolasetron (IC50)
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)6.0004

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (76.92)18.2507
2000's2 (15.38)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jia, L; Sun, H1
Baron, BM; Boeijinga, PH; Dudley, MW; Galvan, M; Siegel, BW; Slone, AL1
Haegele, KD; Huebert, ND; Sanwald, P1
Chin, C; Dempsey, E; Gow, R; Howard, DR; Keung, AC; Lerman, J; Sikich, N; Sims, C1
Haegele, KD; Huebert, ND; Schwach, V; Schwartz, JJ; Zeidler, L1
Eichemeier, LS; McElvain, JS; Vandiver, VJ1
Arumugham, T; Cramer, MB; Dimmitt, DC; Hahne, W; Hunt, TL; Shah, AK; Spalitto, AJ1
Dimmitt, DC; Hahne, WF; Martin, LA; Pready, N; Stubbs, K1
Arumugham, T; Cramer, MB; Dimmitt, DC; Halstenson, C; Horton, M; Shah, AK; Weir, SJ1
Arumugham, T; Choo, YS; Dimmitt, DC; Hahne, WF; Martin, LA; Weir, SJ1
Cramer, MB; Dimmitt, DC; Hahne, WF; Lippert, CL; Martin, L; Plezia, P1
Ahmed, T; Li, SX; Lupinacci, P; Majumdar, A; Murphy, MG; Panebianco, D; Pequignot, E; Petty, KJ; Rosen, L; Royalty, JE; Rushmore, TH1
Chen, B; Chen, J; Chen, S; Hu, Y; Liu, G; Yao, S1

Trials

5 trial(s) available for mdl 74156 and dolasetron

ArticleYear
Effect of infusion rate on the pharmacokinetics and tolerance of intravenous dolasetron mesylate.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Antiemetics; Double-Blind Method; Humans; Indoles; Infusions, Intravenous; Male; Middle Aged; Quinolizines; Serotonin Antagonists

1998
Pharmacokinetics of oral and intravenous dolasetron mesylate in patients with renal impairment.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:9

    Topics: Administration, Oral; Adult; Aged; Cross-Over Studies; Female; Humans; Indoles; Kidney Diseases; Male; Middle Aged; Quinolizines; Serotonin Antagonists

1998
Single- and multiple-dose pharmacokinetics of oral dolasetron and its active metabolites in healthy volunteers: part 2.
    Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:1

    Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Half-Life; Humans; Indoles; Male; Metabolic Clearance Rate; Middle Aged; Quinolizines; Serotonin Antagonists; Stereoisomerism

1999
Pharmacokinetics of intravenous dolasetron in cancer patients receiving high-dose cisplatin-containing chemotherapy.
    American journal of therapeutics, 1999, Volume: 6, Issue:3

    Topics: Aged; Antiemetics; Antineoplastic Agents; Cisplatin; Double-Blind Method; Female; Humans; Indoles; Male; Middle Aged; Neoplasms; Quinolizines; Serotonin Antagonists; Time Factors

1999
Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:7

    Topics: Administration, Oral; Adult; Antiemetics; Aprepitant; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Humans; Indoles; Male; Middle Aged; Morpholines; Quinolizines; Reference Values; Serotonin Antagonists

2006

Other Studies

8 other study(ies) available for mdl 74156 and dolasetron

ArticleYear
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cells.
    European journal of pharmacology, 1992, Aug-14, Volume: 219, Issue:1

    Topics: Animals; Binding, Competitive; Glioma; Hybrid Cells; Imidazoles; Indoles; Membrane Potentials; Mice; Neuroblastoma; Quinolizines; Rats; Receptors, Serotonin; Serotonin Antagonists

1992
Simultaneous measurement of the major metabolites of dolasetron mesilate in human urine using solid-phase extraction and high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1994, Nov-04, Volume: 661, Issue:1

    Topics: Antiemetics; Chromatography, High Pressure Liquid; Humans; Indoles; Male; Quinolizines; Serotonin Antagonists

1994
Pharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized children.
    Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:5

    Topics: Administration, Oral; Anesthesia; Antiemetics; Child; Child, Preschool; Electrocardiography; Female; Humans; Indoles; Injections, Intravenous; Male; Quinolizines; Serotonin Antagonists

1996
Simultaneous measurement of dolasetron and its major metabolite, MDL 74,156, in human plasma and urine.
    Journal of chromatography. B, Biomedical applications, 1996, Oct-25, Volume: 685, Issue:2

    Topics: Alcohols; Chromatography, High Pressure Liquid; Circadian Rhythm; Fluorometry; Humans; Indoles; Injections, Intravenous; Linear Models; Osmolar Concentration; Quinolizines; Reproducibility of Results; Serotonin Antagonists; Time Factors

1996
Validation of a reversed-phase HPLC method for directly quantifying the enantiomers of MDL 74,156, the primary metabolite of dolasetron mesylate, in human plasma.
    Journal of pharmaceutical and biomedical analysis, 1997, Volume: 15, Issue:4

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Indoles; Quinolizines; Reference Standards; Serotonin Antagonists; Stereoisomerism

1997
Pharmacokinetics of dolasetron after oral and intravenous administration of dolasetron mesylate in healthy volunteers and patients with hepatic dysfunction.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Indoles; Injections, Intravenous; Isoenzymes; Liver Diseases; Male; Middle Aged; Quinolizines; Serotonin Antagonists

1997
Optimization of sample pretreatment methods for simultaneous determination of dolasetron and hydrodolasetron in human plasma by HPLC-ESI-MS.
    Journal of chromatographic science, 2012, Volume: 50, Issue:9

    Topics: Carbonates; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Stability; Humans; Indoles; Quinolizines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2012