mdl 74156 has been researched along with dolasetron in 13 studies
| Studies (mdl 74156) | Trials (mdl 74156) | Recent Studies (post-2010) (mdl 74156) | Studies (dolasetron) | Trials (dolasetron) | Recent Studies (post-2010) (dolasetron) |
|---|---|---|---|---|---|
| 14 | 5 | 2 | 191 | 89 | 14 |
| Protein | Taxonomy | mdl 74156 (IC50) | dolasetron (IC50) |
|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 6.0004 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L; Sun, H | 1 |
| Baron, BM; Boeijinga, PH; Dudley, MW; Galvan, M; Siegel, BW; Slone, AL | 1 |
| Haegele, KD; Huebert, ND; Sanwald, P | 1 |
| Chin, C; Dempsey, E; Gow, R; Howard, DR; Keung, AC; Lerman, J; Sikich, N; Sims, C | 1 |
| Haegele, KD; Huebert, ND; Schwach, V; Schwartz, JJ; Zeidler, L | 1 |
| Eichemeier, LS; McElvain, JS; Vandiver, VJ | 1 |
| Arumugham, T; Cramer, MB; Dimmitt, DC; Hahne, W; Hunt, TL; Shah, AK; Spalitto, AJ | 1 |
| Dimmitt, DC; Hahne, WF; Martin, LA; Pready, N; Stubbs, K | 1 |
| Arumugham, T; Cramer, MB; Dimmitt, DC; Halstenson, C; Horton, M; Shah, AK; Weir, SJ | 1 |
| Arumugham, T; Choo, YS; Dimmitt, DC; Hahne, WF; Martin, LA; Weir, SJ | 1 |
| Cramer, MB; Dimmitt, DC; Hahne, WF; Lippert, CL; Martin, L; Plezia, P | 1 |
| Ahmed, T; Li, SX; Lupinacci, P; Majumdar, A; Murphy, MG; Panebianco, D; Pequignot, E; Petty, KJ; Rosen, L; Royalty, JE; Rushmore, TH | 1 |
| Chen, B; Chen, J; Chen, S; Hu, Y; Liu, G; Yao, S | 1 |
5 trial(s) available for mdl 74156 and dolasetron
| Article | Year |
|---|---|
Effect of infusion rate on the pharmacokinetics and tolerance of intravenous dolasetron mesylate.
Topics: Adolescent; Adult; Antiemetics; Double-Blind Method; Humans; Indoles; Infusions, Intravenous; Male; Middle Aged; Quinolizines; Serotonin Antagonists | 1998 |
Pharmacokinetics of oral and intravenous dolasetron mesylate in patients with renal impairment.
Topics: Administration, Oral; Adult; Aged; Cross-Over Studies; Female; Humans; Indoles; Kidney Diseases; Male; Middle Aged; Quinolizines; Serotonin Antagonists | 1998 |
Single- and multiple-dose pharmacokinetics of oral dolasetron and its active metabolites in healthy volunteers: part 2.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Half-Life; Humans; Indoles; Male; Metabolic Clearance Rate; Middle Aged; Quinolizines; Serotonin Antagonists; Stereoisomerism | 1999 |
Pharmacokinetics of intravenous dolasetron in cancer patients receiving high-dose cisplatin-containing chemotherapy.
Topics: Aged; Antiemetics; Antineoplastic Agents; Cisplatin; Double-Blind Method; Female; Humans; Indoles; Male; Middle Aged; Neoplasms; Quinolizines; Serotonin Antagonists; Time Factors | 1999 |
Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers.
Topics: Administration, Oral; Adult; Antiemetics; Aprepitant; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Humans; Indoles; Male; Middle Aged; Morpholines; Quinolizines; Reference Values; Serotonin Antagonists | 2006 |
8 other study(ies) available for mdl 74156 and dolasetron
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cells.
Topics: Animals; Binding, Competitive; Glioma; Hybrid Cells; Imidazoles; Indoles; Membrane Potentials; Mice; Neuroblastoma; Quinolizines; Rats; Receptors, Serotonin; Serotonin Antagonists | 1992 |
Simultaneous measurement of the major metabolites of dolasetron mesilate in human urine using solid-phase extraction and high-performance liquid chromatography.
Topics: Antiemetics; Chromatography, High Pressure Liquid; Humans; Indoles; Male; Quinolizines; Serotonin Antagonists | 1994 |
Pharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized children.
Topics: Administration, Oral; Anesthesia; Antiemetics; Child; Child, Preschool; Electrocardiography; Female; Humans; Indoles; Injections, Intravenous; Male; Quinolizines; Serotonin Antagonists | 1996 |
Simultaneous measurement of dolasetron and its major metabolite, MDL 74,156, in human plasma and urine.
Topics: Alcohols; Chromatography, High Pressure Liquid; Circadian Rhythm; Fluorometry; Humans; Indoles; Injections, Intravenous; Linear Models; Osmolar Concentration; Quinolizines; Reproducibility of Results; Serotonin Antagonists; Time Factors | 1996 |
Validation of a reversed-phase HPLC method for directly quantifying the enantiomers of MDL 74,156, the primary metabolite of dolasetron mesylate, in human plasma.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Indoles; Quinolizines; Reference Standards; Serotonin Antagonists; Stereoisomerism | 1997 |
Pharmacokinetics of dolasetron after oral and intravenous administration of dolasetron mesylate in healthy volunteers and patients with hepatic dysfunction.
Topics: Administration, Oral; Adolescent; Adult; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Indoles; Injections, Intravenous; Isoenzymes; Liver Diseases; Male; Middle Aged; Quinolizines; Serotonin Antagonists | 1997 |
Optimization of sample pretreatment methods for simultaneous determination of dolasetron and hydrodolasetron in human plasma by HPLC-ESI-MS.
Topics: Carbonates; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Stability; Humans; Indoles; Quinolizines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2012 |