Compounds > mdl 72527

mdl 72527 and spermine

mdl 72527 has been researched along with spermine in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (5.56)	18.7374
1990's	5 (27.78)	18.2507
2000's	10 (55.56)	29.6817
2010's	2 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brunton, VG; Grant, MH; Wallace, HM	1
Bey, P; Bolkenius, FN; Seiler, N	1
Baudry, M; Najm, I	1
Hunter, KJ; Müller, S; Walter, RD	1
Hu, RH; Pegg, AE	1
Cleveland, JL; Dai, H; Kramer, DL; Murti, KG; Porter, CW; Yang, C	1
Alhonen, L; Herzig, KH; Jänne, J; Keinanen, T; Parkkinen, JJ; Sinervirta, R	1
Duranton, B; Gossé, F; Raul, F; Seiler, N	1
Badolo, L; Duranton, B; Gossé, F; Raul, F; Schneider, Y; Seiler, N; Vincent, F	1
Seiler, N	1
Berberich, T; Kusano, T; Mitsuya, Y; Miyazaki, A; Takahashi, H; Takahashi, Y; Uehara, Y	1
Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD	1
Agostinelli, E; Arancia, G; Belli, F; Condello, M; Seiler, N; Vedova, LD	1
Agostinelli, E; Arancia, G; Condello, M; Dalla Vedova, L; Tempera, G	1
Alm, K; Dahlberg, E; Holst, CM; Johansson, VM; Myhre, L; Oredsson, SM; Söderstjerna, E	1
Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N	1
Agostinelli, E; Bonaiuto, E; Colone, M; Di Paolo, ML; Grancara, S; Macone, A; Martinis, P; Stevanato, R; Stringaro, A; Toninello, A; Vianello, F	1
Aagaard, A; Barlind, L; Fjellström, O; Kaminski, TP; Kashima, A; Kumanomidou, T; Sjögren, T; Snijder, A; Wassvik, CM; Yokota, T	1

Reviews

1 review(s) available for mdl 72527 and spermine

Article	Year
How important is the oxidative degradation of spermine?: minireview article. Amino acids, 2004, Volume: 26, Issue:4 Topics: Animals; Erythrocytes; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine	2004

Other Studies

17 other study(ies) available for mdl 72527 and spermine

Article	Year
Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress. The Biochemical journal, 1991, Nov-15, Volume: 280 ( Pt 1) Topics: Animals; Carmustine; Catalase; Cell Line; Cell Survival; Cricetinae; Glutathione Reductase; Guanidines; Kidney; Kinetics; Models, Biological; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Spermine	1991
Specific inhibition of polyamine oxidase in vivo is a method for the elucidation of its physiological role. Biochimica et biophysica acta, 1985, Jan-28, Volume: 838, Issue:1 Topics: Animals; Brain; Carbon Tetrachloride; Dose-Response Relationship, Drug; Kidney; Kinetics; Liver; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine	1985
Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain. Neuroscience letters, 1994, Apr-25, Volume: 171, Issue:1-2 Topics: Acetylation; Acetyltransferases; Animals; Biogenic Polyamines; Brain; Brain Chemistry; Kainic Acid; Male; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Rats; Rats, Sprague-Dawley; Seizures; Spermidine; Spermine	1994
Effect of haloallylamines on polyamine oxidase activity and spermine levels in Ascaris suum. Parasitology research, 1996, Volume: 82, Issue:6 Topics: Allylamine; Animals; Antinematodal Agents; Ascaris suum; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermine	1996
Rapid induction of apoptosis by deregulated uptake of polyamine analogues. The Biochemical journal, 1997, Nov-15, Volume: 328 ( Pt 1) Topics: Alkylation; Animals; Apoptosis; Cell Death; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Eflornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Spermidine; Spermine	1997
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects. Cancer research, 1999, Oct-01, Volume: 59, Issue:19 Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Eflornithine; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Lysosomes; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Proto-Oncogene Proteins c-bcl-2; Putrescine; Spermidine; Spermine	1999
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Proceedings of the National Academy of Sciences of the United States of America, 2000, Jul-18, Volume: 97, Issue:15 Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Enzyme Induction; Female; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Pancreatitis; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Wistar; Spermine; Zinc	2000
Spermine cytotoxicity to human colon carcinoma-derived cells (CaCo-2). Cell biology and toxicology, 2000, Volume: 16, Issue:2 Topics: Apoptosis; Caco-2 Cells; Cell Differentiation; DNA Fragmentation; G2 Phase; Humans; Mitosis; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermine	2000
Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity. The international journal of biochemistry & cell biology, 2000, Volume: 32, Issue:10 Topics: Amine Oxidase (Copper-Containing); Animals; Caco-2 Cells; Calmodulin; Cell Cycle; Cell Death; Drug Synergism; Eflornithine; Guanidines; Humans; Molecular Structure; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Putrescine; Rats; Spermine; Sulfonamides; Trifluoperazine; Tumor Cells, Cultured	2000
Identification of a novel Cys2/His2-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco. Journal of plant physiology, 2007, Volume: 164, Issue:6 Topics: Amino Acid Sequence; Cell Nucleus; Green Fluorescent Proteins; Guanidines; Molecular Sequence Data; Nicotiana; Oxidation-Reduction; Oxidoreductases; Phylogeny; Plant Proteins; Polyamines; Putrescine; Sequence Alignment; Signal Transduction; Spermine; Tobacco Mosaic Virus; Transcription Factors; Up-Regulation; Zinc Fingers	2007
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochimica et biophysica acta, 2006, Volume: 1763, Issue:10 Topics: Animals; Annexin A5; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Hot Temperature; Humans; Melanoma; Microscopy, Electron; Molecular Structure; Monoamine Oxidase; Oxidation-Reduction; Putrescine; Reactive Oxygen Species; Spermine; Time Factors	2006
Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound. International journal of oncology, 2006, Volume: 29, Issue:4 Topics: Adenocarcinoma; Aldehydes; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Cattle; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; Hydrogen Peroxide; Lysosomes; Putrescine; Reactive Oxygen Species; Spermine; Tumor Cells, Cultured	2006
MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells. Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2 Topics: Animals; Cell Line, Tumor; Cell Survival; Humans; Lysosomes; Mitochondria; Oxidation-Reduction; Putrescine; Spermine; Vacuoles	2007
Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction. Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2 Topics: Animals; Apoptosis; Cell Cycle; Cell Death; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Humans; Polyamines; Putrescine; Spermine	2007
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. International journal of oncology, 2009, Volume: 35, Issue:3 Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Lysosomes; Melanoma; Microscopy, Confocal; Microscopy, Electron, Transmission; Oxidation-Reduction; Putrescine; Spermine	2009
A novel enzyme with spermine oxidase properties in bovine liver mitochondria: identification and kinetic characterization. Free radical biology & medicine, 2015, Volume: 81 Topics: Animals; Catalytic Domain; Cattle; Hydrogen Peroxide; Kinetics; Liver; Mitochondria, Liver; Osmolar Concentration; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine; Static Electricity; Substrate Specificity	2015
The Structure of Murine N Biochemistry, 2017, 01-24, Volume: 56, Issue:3 Topics: Aldehydes; Animals; Catalytic Domain; Gene Expression; Hydrogen Peroxide; Kinetics; Mice; Models, Molecular; Oxidation-Reduction; Oxidoreductases; Propylamines; Protein Structure, Secondary; Putrescine; Spermidine; Spermine	2017