mdl-25637 has been researched along with validamycins* in 1 studies
1 other study(ies) available for mdl-25637 and validamycins
Article | Year |
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Time-dependent inhibition of porcine kidney trehalase by aminosugars.
The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25,637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t1/2 = 1.2 h). To our knowledge, this is the first report of time-dependent inhibition exhibited by either these particular aminosugars or a trehalase. Topics: Amino Sugars; Animals; In Vitro Techniques; Inositol; Kidney; Kinetics; Substrate Specificity; Sugar Alcohols; Swine; Trehalase; Trehalose | 1990 |