mdl 100240 has been researched along with midazolam in 1 studies
*Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. [MeSH]
*Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. [MeSH]
| Studies (mdl 100240) | Trials (mdl 100240) | Recent Studies (post-2010) (mdl 100240) | Studies (midazolam) | Trials (midazolam) | Recent Studies (post-2010) (midazolam) |
|---|---|---|---|---|---|
| 21 | 9 | 0 | 9,834 | 3,191 | 3,301 |
| Protein | Taxonomy | mdl 100240 (IC50) | midazolam (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 2.7427 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrett, JS; Cirillo, I; Howell, SR; Martin, LL; Martin, NE | 1 |
1 trial(s) available for mdl 100240 and midazolam
| Article | Year |
|---|---|
No clinically relevant CYP3A induction with the dual angiotensin-converting enzyme/neutral endopeptidase inhibitor, M100240.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzazepines; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Humans; Male; Midazolam; Middle Aged; Neprilysin; Oxidoreductases, N-Demethylating; Pyridines | 2004 |