mci 9038 has been researched along with hirudin in 187 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.53) | 18.7374 |
| 1990's | 25 (13.37) | 18.2507 |
| 2000's | 101 (54.01) | 29.6817 |
| 2010's | 54 (28.88) | 24.3611 |
| 2020's | 6 (3.21) | 2.80 |
| Authors | Studies |
|---|---|
| Loscalzo, J; Scharfstein, J | 1 |
| De Meester, I; Hendriks, D; Scharpe, S; van Sande, M; Vanhoof, G; Vriend, G | 1 |
| Breddin, HK; Haarmann, W; Krupinski, K; Markwardt, F | 1 |
| Callas, DD; Fareed, J | 2 |
| Callas, DD; Fareed, J; Hoppensteadt, D | 1 |
| Berry, CN; Girardot, C; Lecoffre, C; Lunven, C | 1 |
| Banner, DW; Hadváry, P | 1 |
| Claeson, G; Ehrhardt, C; Metternich, R; Scully, MF; Stone, SR; Tapparelli, C; Zurini, M | 1 |
| Berry, CN; Gauffeny, C; Lecoffre, C; Lunven, C; O'Brien, DP; Roome, NO | 1 |
| Coulombe, R; Cygler, M; Féthière, J; Konishi, Y; Tsuda, Y | 1 |
| Kleiman, NS | 1 |
| Verstraete, M | 2 |
| Callas, D; Fareed, J; Hayes, JM; Iqbal, O; Jeske, W | 1 |
| Hermann, JP; Kutryk, MJ; Serruys, PW | 1 |
| Prasa, D; Stürzebecher, J; Svendsen, L | 1 |
| Deinum, J; Elg, M; Gustafsson, D | 1 |
| Deschenes, I; DiMaio, J; Finkle, CD; Leblond, L; St Pierre, A; Winocour, PD | 1 |
| Barrowcliffe, TW; Goodnight, SH; Green, D; Laposata, M; Sosolik, RC; Van Cott, EM | 1 |
| Berry, CN; Gandossi, E; Gauffeny, C; Lunven, C; Roome, NO | 1 |
| Fukazawa, T; Goto, Y; Hayashi, H; Inoue, Y; Komatsu, Y | 1 |
| Agnelli, G; Taliani, MR | 1 |
| Jang, IK; Januzzi, JL | 1 |
| Armstrong, PW; Choy, JB | 1 |
| Cella, G; Girolami, A; Sasahara, AA | 1 |
| Greinacher, A; Lubenow, N | 2 |
| Baglin, TP | 1 |
| Hauptmann, J; Steinmetzer, T; Sturzebecher, J | 1 |
| Fleischer, K; Gulba, DC; Lankes, W | 1 |
| Creekmore, F | 1 |
| Dager, WE; White, RH | 1 |
| Chew, D; Reginelli, JP | 1 |
| Wittkowsky, AK | 1 |
| Mendez, MN; Tong, LM | 1 |
| Warkentin, TE | 4 |
| Smythe, MA; Warkentin, TE | 1 |
| Jeske, WP; Walenga, JM | 1 |
| Mattson, JC; Smythe, MA; Stephens, JL; Warkentin, TE; Zakalik, D | 1 |
| Fenyvesi, T; Harenberg, J; Jörg, I | 1 |
| Fenyvesi, T; Harenberg, J; Joerg, I | 1 |
| Nguyen, PH; Rice, L; Vann, AR | 1 |
| Mukundan, S; Zeigler, ZR | 1 |
| Bates, ER; Weitz, JI | 1 |
| Califf, RM; O'Shea, S; Reddan, D; Szczech, LA | 1 |
| Kaplan, KL | 1 |
| Adams, TE; Everse, SJ; Mann, KG | 1 |
| Nielsen, VG | 1 |
| Lincoff, AM | 1 |
| Jang, IK; Kathiresan, S; Wykrzykowska, JJ | 1 |
| Greinacher, A | 1 |
| Cleveland, KW | 1 |
| Heddle, N; Hirsh, J; Kelton, JG | 1 |
| Dager, WE; Gosselin, RC; Janatpour, K; King, JH; Larkin, EC; Mahackian, K; Owings, JT | 1 |
| Dager, WE; Gosselin, RC; Janatpour, KA; King, JH; Larkin, EC; Owings, JT | 1 |
| Call, JT; Deliargyris, EN; Sane, DC | 1 |
| Dangas, GD; Nikolsky, E | 1 |
| Dager, WH; Gosselin, RC; Janatpur, KA; King, JH; Larkin, EC; Owings, JT | 1 |
| Elliott, WG; Gurbuz, AT; Zia, AA | 1 |
| Bates, ER; Mukherjee, D | 1 |
| Bhatt, DL; Gurm, HS | 1 |
| White, CM | 1 |
| Fareed, J; Harenberg, J; Kemkes-Matthes, B; Walenga, JM | 1 |
| Bartholomew, JR | 1 |
| Woodyard, DN | 1 |
| Almahameed, A; Bartholomew, JR; Begelman, SM | 1 |
| Kam, PC; Kaur, N; Thong, CL | 1 |
| Fenyvesi, T; Harenberg, J; Ingrid, J; Job, H; Jörg, I; Lukas, P; Piazolo, L; Tivadar, F | 1 |
| Gray, E; Harenberg, J | 1 |
| Abrams, CS; Pollak, ES | 1 |
| Smith, KM; Taylor, LM | 1 |
| Genzen, JR; Miller, JL | 1 |
| Charest, AF; Geerts, WH; Grand'Maison, A | 1 |
| McIntosh, BA | 1 |
| Hyers, TM | 1 |
| Chesebro, JH; Grill, DE; Hassinger, NL; McBane, RD; Mruk, JS | 1 |
| Hallisey, RK; John, TE | 1 |
| Pengo, V | 1 |
| Bick, RL; Fareed, J; Messmore, HL; Walenga, JM | 1 |
| Koerber, JM; Mattson, JC; Smythe, MA; Stephens, JL | 1 |
| Fish, DN; Jung, R; Kiser, TH; MacLaren, R | 1 |
| Craven, S; Dewar, L; Greinacher, A; Ofosu, FA; Sheppard, JA; Warkentin, TE | 1 |
| Matthai, WH | 1 |
| Baker, KM; Flattery, MP | 1 |
| Dang, CH; Durkalski, VL; Nappi, JM | 1 |
| Gurley, WQ; Kirklin, JK; Lell, WA; Nielsen, VG; Pereira, SJ; Steenwyk, BL | 1 |
| Boshkov, LK; Kirby, A; Shen, I; Ungerleider, RM | 1 |
| Das, P; Hamdalla, H; Jozic, J; Moliterno, DJ; Mukherjee, D; Steinhubl, SR; Ziada, K | 1 |
| Almahameed, A; Napolitano, LM; Nasraway, SA; Warkentin, TE | 1 |
| Cooney, MF | 1 |
| Hursting, MJ; Lewis, BE | 1 |
| Fraser, JF; O'Connor, ED | 1 |
| Haas, S; Höhnke, C | 1 |
| Blain, RC; Lovejoy, AE; Nakagawa, PA; Nugent, DJ; Yonekawa, KE; Young, G | 1 |
| Marymont, JH; Murphy, GS | 1 |
| Greinacher, A; Selleng, K; Warkentin, TE | 1 |
| Dager, WE; Dougherty, JA; Militello, MA; Nguyen, PH; Smythe, MA | 1 |
| Baroletti, S; Fanikos, J; Fiumara, K; Goldhaber, SZ; Luppi, C; Mehta, A; Saniuk, C; Silverman, J | 1 |
| Fischer, KG | 1 |
| Bong, M; Di Cesare, PE; Patel, VP | 1 |
| Ahmed, I; Majeed, A; Powell, R | 1 |
| Jolicoeur, EM; Lopes, RD; Ohman, EM; Wang, T | 1 |
| Cappellini, MD; Cassinerio, E; Castelli, R; Fabris, F; Graziadei, G; Porro, F | 1 |
| Agnelli, G; Filippucci, E; Iorio, A; Vedovati, MC | 1 |
| Lepor, NE | 1 |
| Cruz-González, I; Jang, IK; Sánchez, PL; Sánchez-Ledesma, M | 1 |
| Stief, TW | 1 |
| Chiappe, J; Fugate, S | 1 |
| Prechel, M; Walenga, JM | 1 |
| Ansell, JE; Dinwoodey, DL | 1 |
| Chevalier, A; Nutescu, EA; Shapiro, NL | 1 |
| Rolfes, C; Steinfeldt, T | 1 |
| Bauer, KA; Donati, MB; Gould, M; Hirsh, J; Samama, MM; Weitz, JI | 1 |
| Colemen, CI; Talati, R; White, CM | 1 |
| Greinacher, A; Haneya, A; Hirt, S; Schmid, C; Selleng, K; Selleng, S | 1 |
| Billett, HH; Cheng-Lai, A; Curzio, KM; Kheyfets, V; Sinnet, M | 1 |
| Kalb, ML; Kozek-Langenecker, SA; Potura, L; Scharbert, G | 1 |
| Chong, BH; Isaacs, A | 1 |
| Christoffersen, C; Gøtze, JP; Lethagen, S | 1 |
| Buerke, M; Friedrich, I; Hamilton, K; Hauroeder, B; Linde, T; Maegdefessel, L; Michel, T; Raaz, U; Schlitt, A; Schubert, S; Steinseifer, U; Werdan, K | 1 |
| Chong, BH; Lip, GYH; Shantsila, E | 1 |
| Levy, JH; Winkler, AM | 1 |
| Ortel, TL | 1 |
| Bark, N; Blombäck, M; He, S; Johnsson, H; Wallén, NH | 1 |
| Bartholomew, JR; Frame, JN; Rice, L; Whelton, A | 1 |
| Ivandic, B; Zorn, M | 1 |
| Bandyk, DF; Bartholomew, JR; Boyce, SW; Frame, JN; Rice, L | 1 |
| Arnold, H; Deal, EN; Hollands, JM; Martinez, EJ; Micek, ST; Skrupky, LP; Smith, JR | 1 |
| Oo, TH | 1 |
| Ansell, JE; Lee, CJ | 1 |
| Hassell, KL; Kiser, TH; Mann, AM; Trujillo, TC | 1 |
| Fries, D | 1 |
| Ageno, W; Streif, W | 1 |
| Antovic, JP; Armstrong, E; Baghaei, F; Dalsgaard-Nielsen, J; Hillarp, A; Holme, PA; Holmström, M; Johnsson, H; Joutsi-Korhonen, L; Lassila, R; Sandset, PM | 1 |
| Young, G | 2 |
| Kennedy, K; King, S; Poe, K; Reeves, J; Short, M; Steinke, D | 1 |
| Corbets, LR; Forsyth, LL; Koerber, JM; Mehta, TP; Melendy, SM; Parikh, R; Smythe, MA; Sykes, E | 1 |
| Baglin, TP; Garcia, DA; Samama, MM; Weitz, JI | 1 |
| Aguilera, TA; Baik, FM; Baird, SM; Crisp, JL; Friedman, B; Jiang, T; Nguyen, QT; Olson, ES; Tsien, RY; Tsimikas, S; Whitney, MA | 1 |
| Knovich, MA; Lesser, GJ; Strowd, RE | 1 |
| Argueta-Morales, IR; DeCampli, WM; Felix, DE; Munro, HM; Olsen, MC | 1 |
| Abel, EE; Kane-Gill, SL; Kellum, JA; Seybert, AL | 1 |
| Cruz-González, I; López-Jiménez, R; Perez-Rivera, A; Yan, BP | 1 |
| Coppens, M; Eikelboom, JW; Gustafsson, D; Hirsh, J; Weitz, JI | 1 |
| Curvers, J; Scharnhorst, V; Stroobants, AK; van de Kerkhof, D; van den Dool, EJ | 1 |
| Cooper, T; Kokko, H; Mazur, J; Taber, D; Uber, WE; White, CL | 1 |
| Fritsma, GA | 1 |
| Pötzsch, B | 1 |
| Bereczky, Z; Boda, Z; Kappelmayer, J; Kerenyi, A; Olah, Z; Szarvas, M | 1 |
| Bleker, SM; Büller, HR; Coppens, M; van Es, N | 1 |
| Boyle, ME; Fisher, S; Ishimoto, J; Kiser, TH; Lind, SE; Trujillo, TC | 1 |
| Bartholomew, JR; Casanegra, AI; Dhariwal, M; Gomes, MP; Gornik, HL; Joseph, L; Militello, MA; Raju, MG; Smith, MA | 1 |
| Moffett, BS; Teruya, J | 1 |
| Kadauke, S; Khor, B; Van Cott, EM | 1 |
| Bahlmann, A; Beiderlinden, M; Brezina, T; Geib, J; Golla, E; Greinacher, A; Kienbaum, P; Kindgen-Milles, D; Pannen, B; Schaefer, MS; Treschan, TA; Werner, P | 1 |
| Lin, JK; Tong, LM; Vo, QA | 1 |
| Adams, CD; Anne Hirning, B; Blum, RM; Fanikos, J; Gilmore, JF; Matta, L | 1 |
| Bain, J; Meyer, A | 1 |
| Albers, EL; Dickey, R; Falconer, A; Jefferis Kirk, C; Latham, GJ; McMullan, DM | 1 |
| Golovin, A; Kopylov, A; Pavlova, G; Ustinov, N; Zavyalova, E | 1 |
| Adams, DH; Evans, AS; Fischer, GW; Heller, J; Salter, BS; Trinh, MA; Weiner, MM | 1 |
| Kopylov, AM; Ustinov, NB; Zav'yalova, EG | 1 |
| Harada, MY; Hoang, DM; Ley, EJ; Margulies, DR; Mason, R; Murry, JS; Nuño, M; Sun, BJ; Volod, O; Zaw, AA | 1 |
| Lei, BZ; Sendowski, M; Shatzel, JJ | 1 |
| Dager, WE; Roberts, AJ; Van Cott, EM | 1 |
| Kolde, HJ; Seidel, H | 1 |
| Male, C; van Ommen, CH; Young, G | 1 |
| Lan, X; Li, S; Sun, Z; Tang, Z; Xi, Y; Zhao, H | 1 |
| Banik, N; Beyer-Westendorf, J; Brachmann, J; Dohmen, PM; Eberle, S; Hankowitz, J; Klamroth, R; Kropff, S; Lindhoff-Last, E; Madlener, K; Müller, MM; Pötzsch, B; Schellong, S; Schindewolf, M; Steindl, J | 1 |
| Faraoni, D; Koster, A; Levy, JH | 1 |
| Ananth, CV; D'Alton, ME; Eisenberger, AB; Friedman, AM; Sagaram, D; Siddiq, Z; Wright, JD | 1 |
| Bahlmann, A; Beiderlinden, M; Brezina, T; Görlinger, K; Kemper, J; Kienbaum, P; Schäfer, M; Seidel, H; Treschan, TA; Werner, P | 1 |
| Chang, HT; Chu, HW; Huang, CC; Lai, PX; Mao, JY; Unnikrishnan, B; Wu, CW | 1 |
| Arepally, GM; Chong, BH; Cines, DB; Cuker, A; Greinacher, A; Gruel, Y; Linkins, LA; Morgan, RL; Mustafa, RA; Rodner, SB; Santesso, N; Selleng, S; Warkentin, TE; Wex, A | 1 |
| Beyer, JT; Fisher, S; Kiser, TH; Lind, SE; Trujillo, TC; Wempe, MF | 1 |
| Briski, MJ; Duewell, BE; Feih, JT; Rinka, JRG; Tawil, JN | 1 |
| Allender, JE; Coons, JC; Cox, JF; DiDomenico, RJ; Jennings, DL; Johnson, D; Oliphant, CS; Reed, BN | 1 |
| Berlioz, B; Guru, PK; Kaseer, HS; Sanghavi, DK | 1 |
| Boyle, G; Buchholz, H; Cantor, RS; Conway, J; Fynn-Thompson, F; Griffiths, E; Hawkins, B; Lorts, A; Lytrivi, ID; Machado, D; May, L; Niebler, RA; Rossano, J; Sutcliffe, DL; VanderPluym, CJ | 1 |
| González-Rodríguez, M; Lázaro-García, A; Llamas-Sillero, P; Martínez-Alfonzo, I; Tomás-Mallebrera, M; Velasco-Rodríguez, D; Vidal-Laso, R | 1 |
| Chandler, WL; Friedland-Little, JM; Hasan, RA; Kirk, CJ; Pak, J | 1 |
85 review(s) available for mci 9038 and hirudin
| Article | Year |
|---|---|
Molecular approaches to antithrombotic therapy.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Protease Inhibitors; Sulfonamides; Thrombin; Warfarin | 1992 |
Proteases and their inhibitors: today and tomorrow.
Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Endopeptidases; Heparin; Hirudins; HIV Protease; HIV Protease Inhibitors; Humans; Molecular Sequence Data; Peptidyl-Dipeptidase A; Pipecolic Acids; Protease Inhibitors; Recombinant Proteins; Renin; Sulfonamides; Thrombin | 1991 |
Inhibitor binding to thrombin: x-ray crystallographic studies.
Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Crystallography, X-Ray; Dipeptides; Hirudins; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Sulfonamides; Thrombin | 1993 |
Clinical trials of conjunctive anticoagulant strategies in thrombolysis.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Platelets; Clinical Trials as Topic; Epoprostenol; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Oligopeptides; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin; Thrombolytic Therapy | 1996 |
Modulating platelet function with selective thrombin inhibitors.
Topics: Administration, Oral; Adult; Animals; Antithrombins; Arginine; Blood Platelets; Boron Compounds; Clinical Trials as Topic; Dogs; Drug Evaluation, Preclinical; Glycine; Hirudin Therapy; Hirudins; Humans; Naphthalenes; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Recombinant Proteins; Sulfonamides; Thrombin | 1996 |
Direct thrombin inhibitors: appraisal of the antithrombotic/hemorrhagic balance.
Topics: Antithrombins; Arginine; Clinical Trials, Phase III as Topic; Fibrinolytic Agents; Hemorrhage; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 1997 |
Clinical trials of direct thrombin inhibitors during invasive procedures.
Topics: Antithrombins; Arginine; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Endothelium, Vascular; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Sulfonamides | 1997 |
College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: the clinical use and laboratory monitoring of low-molecular-weight heparin, danaparoid, hirudin and related compounds, and argatroban.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Drug Monitoring; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pathology, Clinical; Pipecolic Acids; Sulfonamides; Thromboembolism | 1998 |
[New antithrombotic drugs].
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Arginine; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Dermatan Sulfate; Eptifibatide; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Immunoglobulin Fab Fragments; Multicenter Studies as Topic; Peptide Fragments; Peptides; Pilot Projects; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides | 1999 |
Heparin induced thrombocytopenia: diagnosis and contemporary antithrombin management.
Topics: Ancrod; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Forecasting; Gangrene; Hemorrhage; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation; Protein C; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Warfarin | 1999 |
Anticoagulant therapy in unstable angina.
Topics: Angina, Unstable; Anticoagulants; Antithrombins; Arginine; Clinical Trials as Topic; Coronary Thrombosis; Disease Progression; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Warfarin | 1999 |
Management of patients with heparin-induced thrombocytopenia: focus on recombinant hirudin.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Clinical Trials as Topic; Critical Pathways; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparinoids; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2000 |
Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment.
Topics: Anticoagulants; Arginine; Heparin; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Platelet Count; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2001 |
Advances in the development of thrombin inhibitors.
Topics: Arginine; Azetidines; Benzylamines; Clinical Trials as Topic; Glycine; Hirudin Therapy; Hirudins; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2001 |
[Direct thrombin antagonists].
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Glycine; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Time Factors | 2001 |
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data.
Topics: Angina, Unstable; Antithrombins; Arginine; Glycine; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Survival Rate; Thrombin | 2002 |
Treatment of heparin-induced thrombocytopenia.
Topics: Animals; Anticoagulants; Arginine; Chondroitin Sulfates; Clinical Trials as Topic; Coronary Disease; Dermatan Sulfate; Drug Combinations; Female; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Pregnancy; Rabbits; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Direct thrombin inhibitors for percutaneous coronary intervention in the current era of platelet glycoprotein IIb/IIIa inhibition.
Topics: Angioplasty, Balloon, Coronary; Arginine; Coronary Thrombosis; Drug Therapy, Combination; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Sulfonamides | 2002 |
The role of thrombin inhibition during percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Arginine; Clinical Trials as Topic; Coronary Disease; Coronary Thrombosis; Fibrinolytic Agents; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin | 2002 |
Therapeutic considerations in the management of patients with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Fondaparinux; Heparin; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Prodrugs; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2002 |
Current agents for the treatment of patients with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Autoimmune Diseases; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Warfarin | 2002 |
Antithrombotic drugs for the treatment of heparin-induced thrombocytopenia.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Hirudin in heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Chondroitin Sulfates; Clinical Trials as Topic; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2002 |
Direct thrombin inhibitors in cardiac disease.
Topics: Arginine; Coronary Disease; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin | 2003 |
Direct thrombin inhibitors.
Topics: Antithrombins; Arginine; Coronary Disease; Half-Life; Hirudins; Humans; Metabolic Clearance Rate; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Venous Thrombosis | 2003 |
Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban.
Topics: Anticoagulants; Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; Middle Aged; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2003 |
Direct thrombin inhibitors for non-ST-segment elevation acute coronary syndromes: what, when, and where?
Topics: Angioplasty, Balloon, Coronary; Arginine; Clinical Trials as Topic; Coronary Disease; Fibrinolytic Agents; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombolytic Therapy | 2003 |
Argatroban, a new treatment option for heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Blood Coagulation Tests; Chondroitin Sulfates; Critical Care; Dermatan Sulfate; Drug Combinations; Drug Costs; Drug Monitoring; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2003 |
Treatment of heparin-induced thrombocytopenia: a critical review.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
Direct thrombin inhibitors in the treatment of immune-mediated heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Binding Sites; Heparin; Hirudins; Humans; Models, Biological; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombocytopenia; Treatment Outcome | 2004 |
Percutaneous interventions in patients with immune-mediated heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Blood Platelets; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Skin; Sulfonamides; Thrombin; Thrombocytopenia; Time Factors | 2004 |
Heparin-induced thrombocytopenia: diagnosis and management.
Topics: Anticoagulants; Aortic Valve Insufficiency; Arginine; Autoantibodies; Autoimmune Diseases; Female; Fingers; Heart Valve Prosthesis Implantation; Heparin; Hirudins; Humans; Ischemia; Middle Aged; Necrosis; Pipecolic Acids; Platelet Activation; Platelet Factor 4; Postoperative Complications; Raynaud Disease; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Toes; Warfarin | 2004 |
Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines.
Topics: Ancrod; Antibodies; Anticoagulants; Arginine; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Practice Guidelines as Topic; Purpura, Thrombocytopenic, Idiopathic; Recombinant Proteins; Sulfonamides; Thrombin | 2005 |
Current role of antithrombotic agents in the treatment of acute coronary syndromes.
Topics: Aged; Anticoagulants; Arginine; Blood Platelets; Clinical Trials as Topic; Enoxaparin; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudins; Humans; Middle Aged; Models, Biological; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Risk; Sulfonamides; Thrombin | 2004 |
Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Atrial Fibrillation; Azetidines; Benzylamines; Clinical Trials as Topic; Coronary Disease; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Venous Thrombosis | 2005 |
Thrombin-directed inhibitors: pharmacology and clinical use.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2005 |
Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia.
Topics: Administration, Oral; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Factors; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Gangrene; Heparin; Heparitin Sulfate; Hirudins; Humans; Ischemia; Leg; Necrosis; Pipecolic Acids; Recombinant Proteins; Skin; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2005 |
An anesthesia provider's perspective of heparin-induced thrombocytopenia.
Topics: Anesthesia, General; Anticoagulants; Arginine; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Heparin; Hirudins; Humans; Intraoperative Care; Nurse Anesthetists; Pipecolic Acids; Platelet Count; Recombinant Proteins; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2005 |
Heparin-induced thrombocytopenia: principles for early recognition and management.
Topics: Anticoagulants; Arginine; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Platelet Count; Practice Guidelines as Topic; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; Time Factors | 2005 |
Direct thrombin inhibitors: pharmacology and clinical relevance.
Topics: Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Hirudins; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2005 |
Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Risk Assessment; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2005 |
Anticoagulant use in patients with chronic renal impairment.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Fondaparinux; Heparin; Hirudins; Humans; Kidney Failure, Chronic; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Warfarin | 2005 |
Developing an algorithm for treating heparin-induced thrombocytopenia.
Topics: Algorithms; Anticoagulants; Antigen-Antibody Complex; Arginine; Clinical Trials as Topic; Diagnosis, Differential; Disease Management; Follow-Up Studies; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Immunoglobulin G; Pipecolic Acids; Platelet Activation; Platelet Count; Platelet Factor 4; Prognosis; Purpura, Thrombocytopenic, Idiopathic; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombophilia; Time Factors | 2004 |
Heparin and other rapidly acting anticoagulants.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Embolism; Enzyme Inhibitors; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Venous Thrombosis | 2005 |
New trends in anticoagulant treatments.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Drug Design; Fibrinolytic Agents; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Prodrugs; Recombinant Proteins; Sulfonamides; Thrombosis | 2005 |
Treatment of heparin-induced thrombocytopenia in cardiovascular patients.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Drug Administration Schedule; Factor Xa Inhibitors; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Postoperative Complications; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2006 |
Recognition and management of heparin-induced thrombocytopenia in pediatric cardiopulmonary bypass patients.
Topics: Adolescent; Anticoagulants; Arginine; Autoantibodies; Cardiopulmonary Bypass; Child; Child, Preschool; Clinical Trials as Topic; Fatal Outcome; Female; Heart Defects, Congenital; Heparin; Hirudins; Hospitals, University; Humans; Hypoplastic Left Heart Syndrome; Infant; Infant, Newborn; Male; Multicenter Studies as Topic; Pipecolic Acids; Platelet Factor 4; Postoperative Complications; Postoperative Hemorrhage; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome | 2006 |
Heparin-induced thrombocytopenia and cardiovascular diseases.
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Diagnosis, Differential; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sensitivity and Specificity; Sulfonamides; Thrombocytopenia; Thrombosis | 2006 |
Heparin-induced thrombocytopenia in the critical care setting: diagnosis and management.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Clinical Trials as Topic; Critical Care; Dermatan Sulfate; Heparin; Heparinoids; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Platelet Count; Recombinant Proteins; Risk Factors; Sulfonamides; Thrombin; Thrombocytopenia | 2006 |
Heparin-induced thrombocytopenia: advances in diagnosis and treatment.
Topics: Administration, Oral; Anticoagulants; Arginine; Critical Care; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Heparin; Hirudins; Humans; International Normalized Ratio; Nurse's Role; Nursing Assessment; Partial Thromboplastin Time; Patient Selection; Pipecolic Acids; Platelet Count; Practice Guidelines as Topic; Recombinant Proteins; Risk Factors; Sulfonamides; Syndrome; Thrombocytopenia; Time Factors | 2006 |
Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Antithrombins; Arginine; Drug Interactions; Economics, Pharmaceutical; Fibrinolytic Agents; Hemorrhage; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Heparin-induced thrombocytopenia without thrombosis: an evidence-based review of current literature.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Evidence-Based Medicine; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2006 |
Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery.
Topics: Ancrod; Anticoagulants; Arginine; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2007 |
Heparin-induced thrombocytopenia in intensive care patients.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Extracorporeal Circulation; Heparin; Heparitin Sulfate; Hirudins; Humans; Intensive Care Units; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2007 |
Heparin-induced thrombocytopenia: treatment options and special considerations.
Topics: Anticoagulants; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Essentials of anticoagulation in hemodialysis.
Topics: Anticoagulants; Arginine; Blood Coagulation; Chondroitin Sulfates; Dermatan Sulfate; Equipment Failure; Hemorrhage; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Renal Dialysis; Renal Insufficiency, Chronic; Sulfonamides | 2007 |
Heparin-induced thrombocytopenia and thrombosis.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Heparin induced thrombocytopenia: diagnosis and management update.
Topics: Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Hemorrhage; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Renal Dialysis; Sulfonamides; Thrombocytopenia; Warfarin | 2007 |
Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia.
Topics: Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Chondroitin Sulfates; Comorbidity; Dermatan Sulfate; Drug Therapy, Combination; Fibrinolytic Agents; Fondaparinux; Heparin; Heparinoids; Heparitin Sulfate; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Syndrome; Thrombocytopenia; Vitamin K | 2007 |
Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects.
Topics: Animals; Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2007 |
Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors.
Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Fondaparinux; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Models, Molecular; Molecular Structure; Myocardial Ischemia; Peptide Fragments; Pipecolic Acids; Platelet Activation; Polysaccharides; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombosis | 2007 |
[Heparin-induced thrombocytopenia].
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2007 |
The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Enzyme-Linked Immunosorbent Assay; Factor Xa Inhibitors; Heparin; Heparitin Sulfate; Hirudins; Peptide Fragments; Pipecolic Acids; Platelet Factor 4; Platelet Function Tests; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2008 |
Heparins, low-molecular-weight heparins, and pentasaccharides: use in the older patient.
Topics: Aged; Anticoagulants; Arginine; Enoxaparin; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides | 2008 |
New anticoagulant agents: direct thrombin inhibitors.
Topics: Anticoagulants; Arginine; Atrial Fibrillation; Benzimidazoles; Dabigatran; Fibrinolytic Agents; Half-Life; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Pyridines; Recombinant Proteins; Stroke; Sulfonamides; Thrombin | 2008 |
Heparin-induced thrombocytopenia: a review of current pharmacologic treatment.
Topics: Anticoagulants; Antithrombin III; Arginine; Fondaparinux; Heparin; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2008 |
Heparin-induced thrombocytopenia: what clinicians need to know.
Topics: Anticoagulants; Arginine; Autoantibodies; Chondroitin Sulfates; Dermatan Sulfate; Drug Monitoring; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Count; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2009 |
Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparitin Sulfate; Hirudins; Humans; Male; Monitoring, Physiologic; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Prognosis; Randomized Controlled Trials as Topic; Recombinant Proteins; Risk Factors; Safety Management; Severity of Illness Index; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Time Factors | 2009 |
Heparin-induced thrombocytopenia and cardiac surgery.
Topics: Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Activation; Platelet Count; Platelet Factor 4; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia | 2010 |
Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation.
Topics: Anticoagulants; Arginine; Autoantibodies; Contraindications; Disseminated Intravascular Coagulation; Fondaparinux; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Count; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombophilia; Time Factors; Venous Thromboembolism; Vitamin K; Warfarin | 2009 |
Direct thrombin inhibitors.
Topics: Anticoagulants; Antithrombins; Arginine; Benzimidazoles; Dabigatran; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Pyridines; Recombinant Proteins; Sulfonamides; Thrombin; Venous Thromboembolism | 2011 |
Thrombosis prophylaxis in critically ill patients.
Topics: Anticoagulants; Arginine; Biological Availability; Chromosome Breakage; Chromosome Disorders; Critical Care; Dose-Response Relationship, Drug; Drug Resistance; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Infusions, Intravenous; Injections, Subcutaneous; Pipecolic Acids; Recombinant Proteins; Risk Factors; Sepsis; Severity of Illness Index; Shock, Septic; Sulfonamides; Thrombin; Thrombocytopenia; Venous Thrombosis | 2011 |
Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children.
Topics: Adolescent; Anticoagulants; Arginine; Benzimidazoles; beta-Alanine; Child; Child, Preschool; Dabigatran; Drug Approval; Factor Xa Inhibitors; Fondaparinux; Hirudins; Humans; Infant; Infant, Newborn; Morpholines; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Risk Factors; Rivaroxaban; Sulfonamides; Thiophenes; Thrombin; Venous Thromboembolism | 2011 |
Old and new antithrombotic drugs in neonates and infants.
Topics: Anticoagulants; Arginine; Fondaparinux; Heparin, Low-Molecular-Weight; Hirudins; Humans; Infant; Infant, Newborn; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Venous Thromboembolism; Warfarin | 2011 |
Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Topics: Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Dose-Response Relationship, Drug; Evidence-Based Medicine; Fibrinolytic Agents; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Infusions, Intravenous; Peptide Fragments; Pipecolic Acids; Polysaccharides; Practice Guidelines as Topic; Recombinant Proteins; Societies, Medical; Sulfonamides; Thrombin; Thrombosis; United States | 2012 |
Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome.
Topics: Acute Coronary Syndrome; Animals; Antithrombins; Arginine; Disease Models, Animal; Drug Evaluation; Heparin; Hirudins; Humans; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2012 |
Translational success stories: development of direct thrombin inhibitors.
Topics: Anticoagulants; Antithrombins; Arginine; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombosis; Translational Research, Biomedical | 2012 |
[Anticoagulation].
Topics: Administration, Oral; Anticoagulants; Antithrombins; Arginine; Arrhythmias, Cardiac; Blood Coagulation Tests; Factor Xa Inhibitors; Hemorrhage; Heparin; Heparinoids; Hirudins; Humans; Infusions, Intravenous; Orthopedic Procedures; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Pulmonary Embolism; Recombinant Proteins; Risk Factors; Secondary Prevention; Sulfonamides; Thromboembolism; Treatment Outcome; Venous Thrombosis; Vitamin K | 2013 |
New developments in parenteral anticoagulation for arterial and venous thromboembolism.
Topics: Acute Coronary Syndrome; Antithrombins; Arginine; Fondaparinux; Hirudin Therapy; Hirudins; Humans; Infusions, Parenteral; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Polysaccharides; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombin; Venous Thromboembolism | 2013 |
Anticoagulants in children and adolescents.
Topics: Adolescent; Anticoagulants; Arginine; Child; Clinical Trials as Topic; Fondaparinux; Hematology; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Treatment Outcome; Warfarin | 2015 |
G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants.
Topics: Anticoagulants; Antithrombins; Aptamers, Nucleotide; Arginine; Blood Coagulation; G-Quadruplexes; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2016 |
Heparin-Induced Thrombocytopenia: A Comprehensive Clinical Review.
Topics: Anticoagulants; Antithrombins; Arginine; Cardiopulmonary Bypass; Fondaparinux; Heparin; Hirudins; Humans; Incidence; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Plasmapheresis; Platelet Function Tests; Platelet Transfusion; Polysaccharides; Recombinant Proteins; Risk Factors; Sulfonamides; Thrombocytopenia | 2016 |
Laboratory Monitoring of Parenteral Direct Thrombin Inhibitors.
Topics: Antithrombins; Arginine; Drug Monitoring; Hirudins; Humans; Infusions, Parenteral; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Point-of-Care Systems; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 2017 |
Comparisons of argatroban to lepirudin and bivalirudin in the treatment of heparin-induced thrombocytopenia: a systematic review and meta-analysis.
Topics: Arginine; Female; Heparin; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2017 |
Argatroban and Bivalirudin for Perioperative Anticoagulation in Cardiac Surgery.
Topics: Antithrombins; Arginine; Cardiac Surgical Procedures; Hirudins; Humans; Peptide Fragments; Perioperative Care; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombosis | 2018 |
6 trial(s) available for mci 9038 and hirudin
| Article | Year |
|---|---|
Rationale and design of the PREVENT-HIT study: a randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis.
Topics: Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Pilot Projects; Pipecolic Acids; Prospective Studies; Recombinant Proteins; Research Design; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study.
Topics: Adolescent; Adult; Aged; Anticoagulants; Arginine; Disease Progression; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Platelet Count; Postoperative Complications; Postoperative Period; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; Treatment Outcome; Young Adult | 2011 |
Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia.
Topics: Adult; Aged; Antithrombins; Arginine; Empirical Research; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Nomograms; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2011 |
Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2011 |
Argatroban versus Lepirudin in critically ill patients (ALicia): a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Arginine; Critical Illness; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Recombinant Proteins; Renal Insufficiency; Renal Replacement Therapy; Sulfonamides; Surgical Procedures, Operative; Thrombocytopenia | 2014 |
Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial.
Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Critical Illness; Double-Blind Method; Drug Monitoring; Female; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombelastography | 2018 |
96 other study(ies) available for mci 9038 and hirudin
| Article | Year |
|---|---|
Antithrombotic effects of three thrombin inhibitors in a rat model of laser-induced thrombosis.
Topics: Animals; Antithrombins; Arginine; Disease Models, Animal; Hirudins; Humans; Injections, Intravenous; Lasers; Light Coagulation; Pipecolic Acids; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis | 1989 |
Direct inhibition of protein Ca by site directed thrombin inhibitors: implications in anticoagulant and thrombolytic therapy.
Topics: Antifibrinolytic Agents; Antithrombin III; Antithrombins; Aprotinin; Arginine; Binding Sites; Boron Compounds; Enzyme Activation; Fibrinolysis; Heparin; Hirudins; Humans; Oligopeptides; Peptide Fragments; Pipecolic Acids; Protein C; Recombinant Proteins; Sulfonamides; Thrombin | 1995 |
Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs. Efegatran, argatroban, hirulog, and hirudin.
Topics: Amino Acid Sequence; Anticoagulants; Antithrombins; Arginine; Endopeptidases; Feedback; Hirudins; Humans; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 1995 |
Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: comparison with heparin and recombinant Hirudin.
Topics: Antithrombins; Arginine; Blood Coagulation; Dipeptides; Dose-Response Relationship, Drug; Fibrin; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 1994 |
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Boron; Bridged Bicyclo Compounds; Cells, Cultured; Dipeptides; Hirudins; Humans; Kinetics; Male; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Activation; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin | 1993 |
Inhibition by Argatroban, a specific thrombin inhibitor, of platelet activation by fibrin clot-associated thrombin.
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Fibrin; Fibrinolytic Agents; Heparin; Hirudins; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Thrombosis | 1996 |
Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Coagulants; Crystallization; Crystallography, X-Ray; Fibrinogen; Hirudins; Humans; Hydrogen Bonding; Hydrolysis; Naphthalenesulfonates; Peptide Fragments; Peptides; Pipecolic Acids; Protein Structure, Secondary; Serine Proteinase Inhibitors; Sulfonamides; Thrombin | 1996 |
Comparative anticoagulant effects of various thrombin inhibitors, as determined in the ecarin clotting time method.
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Boron Compounds; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Precursors; Fibrinolytic Agents; Heparin; Hirudins; Humans; Oligopeptides; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin; Sulfonamides; Thrombin | 1996 |
Comparative intravenous antithrombotic actions of heparin and site directed thrombin inhibitors in a jugular vein clamping model.
Topics: Animals; Antithrombins; Arginine; Constriction; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrinolytic Agents; Heparin; Hirudins; Injections, Intravenous; Jugular Veins; Male; Models, Cardiovascular; Peptide Fragments; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides | 1996 |
Inhibition of thrombin generation in plasma by inhibitors of factor Xa.
Topics: Animals; Anticoagulants; Arginine; Arthropod Proteins; Cattle; Dipeptides; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Structure; Naphthalenes; Partial Thromboplastin Time; Peptides; Pipecolic Acids; Piperidines; Propionates; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Thrombin; Thromboplastin | 1997 |
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 1997 |
BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban.
Topics: Animals; Anticoagulants; Arginine; Arteries; Glycine; Heparin; Hirudins; Humans; Infusions, Intravenous; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Veins | 1998 |
Platelet aggregation induced in vitro by rabbit plasma clot-associated thrombin, and its inhibition by thrombin inhibitors.
Topics: Animals; Antithrombin III; Arginine; Blood Coagulation; Blood Platelets; Heparin; Hirudins; Humans; Male; Microscopy, Electron, Scanning; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Thrombin; Thromboplastin | 1998 |
Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban.
Topics: Amino Acid Sequence; Animals; Arginine; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Chlorides; Drug Evaluation, Preclinical; Ferric Compounds; Fibrinolytic Agents; Glass; Hemorrhage; Heparin; Hirudin Therapy; Hirudins; Molecular Sequence Data; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombosis; Vena Cava, Inferior; Venous Thrombosis | 1999 |
Platelet activation with unfractionated heparin at therapeutic concentrations and comparison with low-molecular-weight heparin and with a direct thrombin inhibitor.
Topics: Angina, Unstable; Anticoagulants; Antithrombins; Arginine; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Sulfonamides; Thrombolytic Therapy | 1999 |
Direct thrombin inhibitors: are they the future of anticoagulation?
Topics: Anticoagulants; Arginine; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2001 |
Comment: treatment of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; International Normalized Ratio; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Warfarin | 2002 |
Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Anticoagulants; Arginine; Autoimmune Diseases; Catheterization, Central Venous; Contraindications; Drug Administration Schedule; Drug Therapy, Combination; Female; Gangrene; Heparin; Hirudin Therapy; Hirudins; Humans; International Normalized Ratio; Leg; Male; Middle Aged; Necrosis; Pipecolic Acids; Protein C Deficiency; Recombinant Proteins; Sulfonamides; Surgical Wound Infection; Thrombin; Thrombocytopenia; Thrombophlebitis; Warfarin | 2002 |
Monitoring of anticoagulant effects of direct thrombin inhibitors.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation Tests; Drug Monitoring; Glycine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sensitivity and Specificity; Sulfonamides; Thrombin | 2002 |
Influence of lepirudin, argatroban, and melagatran on prothrombin time and additional effect of oral anticoagulation.
Topics: Administration, Oral; Anticoagulants; Arginine; Azetidines; Benzylamines; Drug Synergism; Glycine; Hirudins; Humans; Phenprocoumon; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides | 2002 |
Preventing complications in heparin-induced thrombocytopenia. Alternative anticoagulants are improving patient outcomes.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Heparin; Heparinoids; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Direct antithrombin agents ameliorate disseminated intravascular coagulation in suspected heparin-induced thrombocytopenia thrombosis syndrome.
Topics: Adult; Aged; Arginine; Disseminated Intravascular Coagulation; Female; Fibrinolytic Agents; Heparin; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2002 |
Anticoagulation in acute cardiac care in patients with chronic kidney disease.
Topics: Anticoagulants; Antithrombins; Arginine; Chronic Disease; Coronary Disease; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Kidney Diseases; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; United States | 2003 |
Predicting the pharmacology of thrombin inhibitors.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Computer Simulation; Dose-Response Relationship, Drug; Glycine; Hirudins; Humans; Kinetics; Models, Cardiovascular; Oligopeptides; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2003 |
Argatroban for off-pump coronary artery bypass surgery.
Topics: Anticoagulants; Arginine; Blood Coagulation Tests; Coronary Artery Bypass; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 2003 |
Clinician update: direct thrombin inhibitors in acute coronary syndromes.
Topics: Acute Disease; Arginine; Coronary Disease; Fibrinolytic Agents; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2003 |
Treatment options for heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; United States | 2003 |
Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values.
Topics: Antithrombins; Arginine; Dose-Response Relationship, Drug; Hirudins; Humans; In Vitro Techniques; International Normalized Ratio; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides | 2004 |
Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing.
Topics: Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Endopeptidases; Fibrinolytic Agents; Hirudins; Humans; In Vitro Techniques; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2004 |
Effects of pentasaccharide (fondaparinux) and direct thrombin inhibitors on coagulation testing.
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Fondaparinux; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides | 2004 |
Argatroban treatment for patients with intolerance to heparin and hirudin.
Topics: Adolescent; Adult; Aged; Arginine; Contraindications; Drug Hypersensitivity; Female; Heparin; Hirudins; Humans; Middle Aged; Pipecolic Acids; Sulfonamides | 2005 |
Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban.
Topics: Aged; Antibodies; Anticoagulants; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Heparin; Hirudin Therapy; Hirudins; Humans; Immunoglobulin G; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2005 |
Collaborative study on monitoring methods to determine direct thrombin inhibitors lepirudin and argatroban.
Topics: Arginine; Blood Coagulation Tests; Cooperative Behavior; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Fibrinolytic Agents; Hirudins; Humans; Methods; Pipecolic Acids; Recombinant Proteins; Reproducibility of Results; Sulfonamides; Thrombin | 2005 |
The paradox of heparin-induced thrombocytopenia: the initial management.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2005 |
Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing.
Topics: Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Dose-Response Relationship, Drug; Heparin; Hirudins; Humans; In Vitro Techniques; Lupus Coagulation Inhibitor; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Reference Values; Sulfonamides; Viper Venoms | 2005 |
Direct thrombin inhibitors are not equally effective in vivo against arterial thrombosis: in vivo evaluation of DuP714 and argatroban in a porcine angioplasty model and comparison to r-hirudin.
Topics: Angioplasty, Balloon; Animals; Anticoagulants; Arginine; Boron Compounds; Drug Evaluation, Preclinical; Hirudins; Oligopeptides; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Swine; Thrombin; Thrombosis | 2005 |
Argatroban and lepirudin requirements in a 6-year-old patient with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Child; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2005 |
Argatroban and lepirudin: clinical trials to clinical practice.
Topics: Anticoagulants; Arginine; Clinical Trials as Topic; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 2005 |
A comparison of lepirudin and argatroban outcomes.
Topics: Aged; Anticoagulants; Arginine; Female; Hemorrhage; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Treatment Outcome | 2005 |
Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Cohort Studies; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Activation; Platelet Aggregation; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2005 |
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation.
Topics: Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Cattle; Dose-Response Relationship, Drug; Factor Xa; Factor Xa Inhibitors; Glycine; Hirudins; Humans; In Vitro Techniques; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Species Specificity; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin | 2005 |
Heparin-induced thrombocytopenia and cardiovascular patients: recognition and treatment.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Factor 4; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2006 |
Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombin; Thrombocytopenia; Time Factors; Treatment Outcome | 2006 |
Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro.
Topics: Anticoagulants; Antithrombins; Arginine; Cardiopulmonary Bypass; Child; Dose-Response Relationship, Drug; Fatal Outcome; Female; Fibrinolytic Agents; Heart Transplantation; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombelastography; Thrombocytopenia; Treatment Failure; Whole Blood Coagulation Time | 2006 |
[Two surgical case reports showing atypical heparin-induced thrombocytopenia].
Topics: Adult; Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Eruptions; Female; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Male; Pipecolic Acids; Platelet Count; Platelet Factor 4; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2007 |
Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Drug Evaluation, Preclinical; Elasticity; Enoxaparin; Fondaparinux; Heparin; Hirudins; Humans; Kinetics; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Stress, Mechanical; Sulfonamides; Thrombelastography; Thrombin | 2007 |
Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin).
Topics: Anticoagulants; Arginine; Boston; Drug Overdose; Drug Therapy, Computer-Assisted; Heparin; Hirudins; Humans; Infusion Pumps; Infusions, Intravenous; Medication Errors; Medication Systems, Hospital; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Research Design; Sulfonamides | 2007 |
Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence.
Topics: Arginine; Female; Headache; Heparin, Low-Molecular-Weight; Hirudins; Humans; Middle Aged; Pipecolic Acids; Recombinant Proteins; Seizures; Sulfonamides; Thrombocytopenia | 2007 |
Inhibition of thrombin generation in recalcified plasma.
Topics: Anticoagulants; Aprotinin; Arginine; Blood Coagulation Tests; Chondroitin Sulfates; Dermatan Sulfate; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Plant Proteins; Plasma; Polysaccharides; Sulfonamides; Thrombin | 2007 |
Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT)--bridging the River Coumarin.
Topics: Acute Disease; Anticoagulants; Arginine; Blood Coagulation; Factor Xa Inhibitors; Fondaparinux; Hemorrhage; Heparin; Hirudins; Humans; International Normalized Ratio; Pipecolic Acids; Platelet Count; Polysaccharides; Recombinant Proteins; Research Design; Sulfonamides; Thrombin; Thrombocytopenia; Treatment Outcome; Venous Thrombosis; Warfarin | 2008 |
Standardizing the management of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Clinical Protocols; Evidence-Based Medicine; Fondaparinux; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Count; Platelet Function Tests; Polysaccharides; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2008 |
[Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy].
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Blood Coagulation Tests; Chondroitin Sulfates; Citrates; Critical Care; Dermatan Sulfate; Diagnostic Errors; Dose-Response Relationship, Drug; Epoprostenol; Fondaparinux; Hemofiltration; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Iloprost; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sodium Citrate; Sulfonamides; Thrombocytopenia; Thrombosis | 2008 |
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Topics: Anticoagulants; Arginine; Biological Availability; Chondroitin Sulfates; Dermatan Sulfate; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Infusions, Parenteral; Injections, Subcutaneous; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2008 |
Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation.
Topics: Adult; Anticoagulants; Arginine; Autoantibodies; Heart Failure; Heart Transplantation; Heparin; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Factor 4; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2008 |
A comparison of direct thrombin inhibitors in the treatment of Heparin-Induced Thrombocytopenia: a single institution experience.
Topics: Aged; Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2009 |
The effect of ex vivo anticoagulants on whole blood platelet aggregation.
Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acid; Arginine; Azetidines; Benzylamines; Blood Platelets; Citric Acid; Collagen; Female; Heparin; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Platelet Aggregation; Platelet Function Tests; Recombinant Proteins; Ristocetin; Sulfonamides; Time Factors | 2009 |
[Heparin-induced thrombocytopenia].
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Risk Factors; Sulfonamides; Thrombocytopenia | 2009 |
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study.
Topics: Anticoagulants; Arginine; Diagnostic Techniques, Cardiovascular; Drug Therapy, Combination; Feasibility Studies; Heart Diseases; Heart-Assist Devices; Heparin; Hirudins; Humans; In Vitro Techniques; Infusion Pumps; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis.
Topics: Antithrombins; Arginine; Chondroitin Sulfates; Chromatography, Gel; Dermatan Sulfate; Factor VIII; Factor Xa Inhibitors; Fibrin; Fibrinolysis; Heparinoids; Heparitin Sulfate; Hirudins; Humans; In Vitro Techniques; Microscopy, Confocal; Peptide Fragments; Pipecolic Acids; Plasma; Porosity; Protein Multimerization; Recombinant Proteins; Sulfonamides; Thrombosis; Tissue Plasminogen Activator | 2010 |
Monitoring of the anticoagulants argatroban and lepirudin: a comparison of laboratory methods.
Topics: Antithrombins; Arginine; Calibration; Female; Hirudins; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin Time | 2011 |
Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Time Factors | 2010 |
Thrombolytic therapy and thrombectomy in phlegmasia cerulea dolens.
Topics: Anticoagulants; Antithrombins; Arginine; Fibrinolytic Agents; Heparin; Hirudins; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombectomy; Thrombocytopenia; Time Factors; Venous Thrombosis | 2010 |
Practical viewpoints on the diagnosis and management of heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Cardiac Catheterization; Cardiac Surgical Procedures; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Vascular Surgical Procedures; Vitamin K; Young Adult | 2011 |
Development and implementation of a comprehensive heparin-induced thrombocytopenia recognition and management protocol.
Topics: Academic Medical Centers; Anticoagulants; Antithrombins; Arginine; Heparin; Hirudins; Humans; Joint Commission on Accreditation of Healthcare Organizations; Patient Education as Topic; Pharmacists; Pipecolic Acids; Practice Guidelines as Topic; Quality Assurance, Health Care; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; United States | 2012 |
In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity.
Topics: Amino Acid Sequence; Animals; Antithrombins; Aorta; Arginine; Cell-Penetrating Peptides; Fluorescent Dyes; Hirudins; Histocytochemistry; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Pipecolic Acids; Plaque, Atherosclerotic; Receptor, PAR-1; Recombinant Proteins; Sulfonamides; Thrombin | 2012 |
The therapeutic management of bleeding and thrombotic disorders complicating CNS malignancies.
Topics: Antibodies, Monoclonal, Humanized; Anticoagulants; Arginine; Bevacizumab; Central Nervous System Neoplasms; Fondaparinux; Glioblastoma; Glioma; Hemorrhage; Heparin, Low-Molecular-Weight; Hirudins; Humans; Pipecolic Acids; Polysaccharides; Postoperative Complications; Pulmonary Embolism; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Vena Cava Filters; Venous Thromboembolism; Venous Thrombosis; Warfarin | 2012 |
Alternative anticoagulation during cardiovascular procedures in pediatric patients with heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Cardiopulmonary Bypass; Heparin; Hirudins; Humans; Infant; Infant, Newborn; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2012 |
Direct thrombin inhibitors for management of heparin-induced thrombocytopenia in patients receiving renal replacement therapy: comparison of clinical outcomes.
Topics: Adult; Aged; Anticoagulants; Antithrombins; Arginine; Female; Heparin; Hirudins; Humans; International Normalized Ratio; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Platelet Count; Recombinant Proteins; Renal Replacement Therapy; Retrospective Studies; Serum Albumin; Sulfonamides; Thrombocytopenia | 2012 |
Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful?
Topics: Antithrombins; Arginine; Blood Coagulation; Chromogenic Compounds; Diagnostic Tests, Routine; Endopeptidases; Fibrinolytic Agents; Hirudins; Humans; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 2012 |
Safety and effectiveness outcomes of an inpatient collaborative drug therapy management service for direct thrombin inhibitors.
Topics: Adult; Aged; Antithrombins; Arginine; Cohort Studies; Cooperative Behavior; Drug Monitoring; Female; Hemorrhage; Heparin; Hirudins; Humans; Inpatients; Male; Medication Errors; Middle Aged; Outcome Assessment, Health Care; Partial Thromboplastin Time; Peptide Fragments; Pharmacists; Pharmacy Service, Hospital; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Time Factors | 2012 |
Monitoring the direct thrombin inhibitors.
Topics: Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Dabigatran; Drug Monitoring; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides | 2013 |
Direct thrombin inhibitors and factor xa inhibitors can influence the diluted prothrombin time used as the initial screen for lupus anticoagulant.
Topics: Anticoagulants; Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Enoxaparin; Factor Xa Inhibitors; False Positive Reactions; Fondaparinux; Heparitin Sulfate; Hirudins; Humans; Lupus Coagulation Inhibitor; Mass Screening; Pipecolic Acids; Polysaccharides; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin | 2013 |
Comparison of the aPTT with alternative tests for monitoring direct thrombin inhibitors in patient samples.
Topics: Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Blood Coagulation; Blood Coagulation Tests; Dabigatran; Drug Monitoring; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin | 2014 |
Bivalirudin for the treatment of patients with confirmed or suspected heparin-induced thrombocytopenia.
Topics: Adult; Aged; Anticoagulants; Antithrombins; Arginine; Female; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Male; Middle Aged; Odds Ratio; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Registries; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2014 |
Trends in parenteral direct thrombin inhibitor use in pediatric patients: analysis of a large administrative database.
Topics: Adolescent; Age Factors; Antithrombins; Arginine; Child; Child, Preschool; Databases, Factual; Female; Health Information Systems; Hemorrhage; Hirudins; Humans; Incidence; Infant; Infant, Newborn; Infusions, Parenteral; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Young Adult | 2014 |
Activated protein C resistance testing for factor V Leiden.
Topics: Activated Protein C Resistance; Adult; Antithrombins; Arginine; Benzimidazoles; beta-Alanine; Biological Assay; Blood Coagulation Tests; Child; Dabigatran; Factor V; Factor Xa; False Positive Reactions; Female; Hirudins; Humans; Lupus Coagulation Inhibitor; Morpholines; Peptide Fragments; Pipecolic Acids; Pregnancy; Protein C; Recombinant Proteins; Rivaroxaban; Sulfonamides; Thiophenes; Warfarin | 2014 |
Efficacy and safety of argatroban and bivalirudine in patients with suspected heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2015 |
Evaluation of a multi-target direct thrombin inhibitor dosing and titration guideline for patients with suspected heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Antithrombins; Arginine; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Practice Guidelines as Topic; Prospective Studies; Recombinant Proteins; Sulfonamides; Survival Analysis; Thrombocytopenia; Treatment Outcome | 2015 |
Comparison of bivalirudin to lepirudin and argatroban in patients with heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Dose-Response Relationship, Drug; Female; Hemorrhage; Heparin; Hirudins; Humans; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia | 2015 |
Challenging Argatroban Management of a Child on Extracorporeal Support and Subsequent Heart Transplant.
Topics: Antithrombins; Arginine; Cardiopulmonary Bypass; Child; Exchange Transfusion, Whole Blood; Extracorporeal Membrane Oxygenation; Heart Transplantation; Heparin; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia | 2016 |
Effect of Thrombin Inhibitors on Positive Feedback in the Coagulation Cascade.
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Feedback, Physiological; Hirudins; Humans; Kinetics; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin | 2016 |
Overtreatment of Heparin-Induced Thrombocytopenia in the Surgical ICU.
Topics: Academic Medical Centers; Aged; Antibodies; Anticoagulants; Antithrombins; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Fondaparinux; Heparin; Hirudins; Humans; Intensive Care Units; Male; Medical Overuse; Middle Aged; Pipecolic Acids; Platelet Factor 4; Polysaccharides; Prospective Studies; Recombinant Proteins; Serotonin; Sulfonamides; Thrombocytopenia | 2017 |
Rapid and durable response to intravenous immunoglobulin in delayed heparin-induced thrombocytopenia: a case report.
Topics: Arginine; Cardiac Surgical Procedures; Heparin; Hirudins; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2017 |
Monitoring of Argatroban and Lepirudin: What is the Input of Laboratory Values in "Real Life"?
Topics: Antithrombins; Arginine; Blood Coagulation Tests; Drug Monitoring; Heparin; Hirudins; Humans; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides; Thrombin Time; Thrombocytopenia | 2018 |
Anticoagulation in children: Making the most of little patients and little evidence.
Topics: Anticoagulants; Arginine; Blood Coagulation; Child; Drug Monitoring; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombosis; Venous Thromboembolism; Warfarin | 2017 |
Use of Fondaparinux Off-Label or Approved Anticoagulants for Management of Heparin-Induced Thrombocytopenia.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Factor Xa Inhibitors; Female; Fondaparinux; Hemorrhage; Heparin; Heparitin Sulfate; Hirudins; Hospital Mortality; Hospitalization; Humans; Male; Necrosis; Off-Label Use; Partial Thromboplastin Time; Patient Safety; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Registries; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thromboembolism; Treatment Outcome | 2017 |
Heparin-Induced Thrombocytopenia during Obstetric Hospital Admissions.
Topics: Adolescent; Adult; Arginine; Databases, Factual; Delivery, Obstetric; Female; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Hospitalization; Humans; Middle Aged; Peptide Fragments; Pipecolic Acids; Postpartum Period; Pregnancy; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; United States; Young Adult | 2018 |
Self-assembled, bivalent aptamers on graphene oxide as an efficient anticoagulant.
Topics: Adsorption; Animals; Anticoagulants; Aptamers, Nucleotide; Arginine; Binding, Competitive; Blood Coagulation; DNA, Single-Stranded; Graphite; Heparin; Hirudins; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Oxides; Pipecolic Acids; Protein Binding; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin | 2018 |
American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
Topics: Administration, Oral; Anticoagulants; Arginine; Cardiovascular Surgical Procedures; Chondroitin Sulfates; Dermatan Sulfate; Evidence-Based Medicine; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Count; Recombinant Proteins; Renal Replacement Therapy; Sulfonamides; Thrombocytopenia; Venous Thromboembolism | 2018 |
Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients.
Topics: Adult; Aged; Antithrombins; Arginine; Female; Hirudins; Hospitalization; Humans; Infusions, Intravenous; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time; Treatment Outcome | 2020 |
Argatroban Versus Bivalirudin in the Treatment of Suspected or Confirmed Heparin-Induced Thrombocytopenia.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Sulfonamides; Thrombocytopenia; Treatment Outcome | 2021 |
Survey of Anticoagulation Practices with the Impella Percutaneous Ventricular Assist Device at High-Volume Centers.
Topics: Anticoagulants; Arginine; Heart-Assist Devices; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Practice Patterns, Physicians'; Recombinant Proteins; Sulfonamides; Surveys and Questionnaires; United States | 2019 |
Bivalirudin resistance in a patient on veno-venous extracorporeal membrane oxygenation with a therapeutic response to argatroban.
Topics: Anticoagulants; Arginine; Combined Modality Therapy; Drug Resistance; Extracorporeal Membrane Oxygenation; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Respiratory Insufficiency; Sulfonamides | 2020 |
Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support.
Topics: Adolescent; Antithrombins; Arginine; Child; Child, Preschool; Female; Heart-Assist Devices; Hemorrhage; Hirudins; Humans; Infant; Male; North America; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Stroke; Sulfonamides; Thrombosis; Treatment Outcome | 2020 |
A journey through anticoagulant therapies in the treatment of left ventricular thrombus in post-COVID-19 heparin-induced thrombocytopenia: a case report.
Topics: Acenocoumarol; Anticoagulants; Arginine; COVID-19; COVID-19 Drug Treatment; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Recombinant Proteins; SARS-CoV-2; Sulfonamides; Thrombocytopenia; Thrombosis | 2022 |
Monitoring Direct Thrombin Inhibitors With Calibrated Diluted Thrombin Time vs Activated Partial Thromboplastin Time in Pediatric Patients.
Topics: Anticoagulants; Antithrombins; Blood Coagulation Tests; Child; Hirudins; Humans; Partial Thromboplastin Time; Pipecolic Acids; Recombinant Proteins; Thrombin; Thrombin Time | 2023 |