mbx-1090 and indole

mbx-1090 has been researched along with indole* in 1 studies

Other Studies

1 other study(ies) available for mbx-1090 and indole

Article	Year
Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090. Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24 The prevalence of drug-resistant bacteria in the clinic has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We have previously described a set of bisamidine antibiotics that contains a core composed of two indoles and a central linker. The first compounds of the series, MBX 1066 and MBX 1090, have potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria. We have conducted a systematic exploration of the amidine functionalities, the central linker, and substituents at the indole 3-position to determine the factors involved in potent antibacterial activity. Some of the newly synthesized compounds have even more potent and broad-spectrum activity than MBX 1066 and MBX 1090. Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Furans; Imidazoles; Indoles; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship	2013

Article

Year

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24

The prevalence of drug-resistant bacteria in the clinic has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We have previously described a set of bisamidine antibiotics that contains a core composed of two indoles and a central linker. The first compounds of the series, MBX 1066 and MBX 1090, have potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria. We have conducted a systematic exploration of the amidine functionalities, the central linker, and substituents at the indole 3-position to determine the factors involved in potent antibacterial activity. Some of the newly synthesized compounds have even more potent and broad-spectrum activity than MBX 1066 and MBX 1090.

Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Furans; Imidazoles; Indoles; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship

2013