mbx-1090 has been researched along with indole* in 1 studies
1 other study(ies) available for mbx-1090 and indole
Article | Year |
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Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.
The prevalence of drug-resistant bacteria in the clinic has propelled a concerted effort to find new classes of antibiotics that will circumvent current modes of resistance. We have previously described a set of bisamidine antibiotics that contains a core composed of two indoles and a central linker. The first compounds of the series, MBX 1066 and MBX 1090, have potent antibacterial properties against a wide range of Gram-positive and Gram-negative bacteria. We have conducted a systematic exploration of the amidine functionalities, the central linker, and substituents at the indole 3-position to determine the factors involved in potent antibacterial activity. Some of the newly synthesized compounds have even more potent and broad-spectrum activity than MBX 1066 and MBX 1090. Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Furans; Imidazoles; Indoles; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship | 2013 |