mb-5 and malbrancheamide

mb-5 has been researched along with malbrancheamide* in 2 studies

Other Studies

2 other study(ies) available for mb-5 and malbrancheamide

Article	Year
Concise enantioselective synthesis of ent-malbrancheamide B. Journal of the American Chemical Society, 2009, Apr-01, Volume: 131, Issue:12 A concise enantioselective synthesis of the fungal metabolite ent-malbrancheamide B was accomplished through the union of a C-prenylated proline derivative and a substituted indole pyruvic acid SEM enol ether, followed by a cationic double cyclization as the key step. Topics: Aldehydes; Alkaloids; Amides; Biomimetic Materials; Bridged Bicyclo Compounds; Cations; Chemistry, Organic; Cyclization; Ethers; Fungi; Hydroxamic Acids; Indole Alkaloids; Models, Chemical; Molecular Structure; Stereoisomerism	2009
Calmodulin inhibitory activity of the malbrancheamides and various analogs. Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24 The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified. Topics: Alkaloids; Calmodulin; Chlorine; Chlorpromazine; Cyclic Nucleotide Phosphodiesterases, Type 1; Drug Design; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; Models, Chemical; Oxygen; Stereoisomerism	2008

Article

Year

Concise enantioselective synthesis of ent-malbrancheamide B.

Journal of the American Chemical Society, 2009, Apr-01, Volume: 131, Issue:12

A concise enantioselective synthesis of the fungal metabolite ent-malbrancheamide B was accomplished through the union of a C-prenylated proline derivative and a substituted indole pyruvic acid SEM enol ether, followed by a cationic double cyclization as the key step.

Topics: Aldehydes; Alkaloids; Amides; Biomimetic Materials; Bridged Bicyclo Compounds; Cations; Chemistry, Organic; Cyclization; Ethers; Fungi; Hydroxamic Acids; Indole Alkaloids; Models, Chemical; Molecular Structure; Stereoisomerism

2009

Calmodulin inhibitory activity of the malbrancheamides and various analogs.

Bioorganic & medicinal chemistry letters, 2008, Dec-15, Volume: 18, Issue:24

The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.

Topics: Alkaloids; Calmodulin; Chlorine; Chlorpromazine; Cyclic Nucleotide Phosphodiesterases, Type 1; Drug Design; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; Models, Chemical; Oxygen; Stereoisomerism

2008