mazindol and cocaine

mazindol has been researched along with cocaine in 103 studies

Research

Studies (103)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (17.48)	18.7374
1990's	59 (57.28)	18.2507
2000's	23 (22.33)	29.6817
2010's	3 (2.91)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH	1
Goodman, MM; Kabalka, GW; Kung, HF; Kung, MP; Switzer, R	1
Johnson, KM; Kozikowski, AP; Prakash, KR; Trzcinska, M	1
Brand, L; Houlihan, WJ; Janowsky, A; Kelly, L; Koletar, J; Kopajtic, TA; Pankuch, J	1
Adkins, S; Duval, RA; Foster, JD; Hauck-Newman, A; Kulkarni, SS; Lever, JR; Parnas, ML; Sakrikar, DS; Vaughan, RA	1
Aggarwal, S; Foster, JD; Huang, Y; Lapinsky, DJ; Lever, JR; Surratt, CK; Vaughan, RA	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Auchampach, JA; Chen, Z; Eshleman, AJ; Gao, ZG; Gizewski, E; Jacobson, KA; Janowsky, A; Salvemini, D; Tosh, DK; Warnick, E	1
Schuster, CR; Wilson, MC	1
Bergmann, JS; Johnson, KM; Kozikowski, AP	1
Bergmann, JS; Callahan, PM; Cunningham, KA; Johnson, KM; Kozikowski, AP; Roberti, M; Xiang, L	1
Brenner, L; Charney, DS; Johnson, R; Krystal, JH; Seibyl, JP	1
Benmansour, S; Brunswick, DJ; Hauptmann, M; Tejani-Butt, SM	1
Cass, WA; Curella, P; Gerhardt, GA; Mayfield, RD; Zahniser, NR	1
Reith, ME; Selmeci, G	1
Goeders, NE	1
De Souza, EB; Mitchell, WM; Pilotte, NS; Sharpe, LG	1
Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH; Philip, A; Rahman, MA	1
George, FR; Goldberg, SR; Porrino, LJ; Ritz, MC	1
Akunne, HC; de Costa, BR; Greig, N; Mele, A; Pert, A; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A	1
Kuhar, MJ; Pögün, S; Scheffel, U	1
Diakogiannis, IA; Kosten, TR; Steinberg, M	1
Bienvenu, OJ; De Souza, EB; Goeders, NE	1
Cofino, JC; Flynn, DD; Hearn, WL; Hime, GW; Mantero-Atienza, E; Mash, DC; Rose, S; Wetli, CV	1
Rothman, RB	1
Cho, AK; Howard, BD; Koide, M; Lin, S; Zhang, MB	1
Boja, JW; Cone, EJ; Kuhar, MJ	1
Berger, P; Elsworth, JD; Reith, ME; Roth, RH; Tanen, D	1
Bergman, J; Johnson, SE; Madras, BK; Spealman, RD	1
Andersen, PH	1
Berger, P; Gawin, F; Kosten, TR	1
Goldberg, SR; Jaffe, JH; Katz, JL; Witkin, JM	1
Farooqui, T; Miller, DD; Uretsky, NJ; Wallace, RA	1
Boja, JW; Kuhar, MJ	1
Peris, J; Zahniser, NR	1
Jacobson, AE; Lajtha, A; Reith, ME; Rice, KC; Zimányi, I	1
Asami, T; Kuribara, H	1
Goldberg, SR; Kuhar, MJ; Lamb, RJ; Ritz, MC	2
Kuhar, MJ; Ritz, MC; Sharkey, J	1
Eriksson, K; Marcusson, J	1
Debler, EA; Hashim, A; Lajtha, A; Sershen, H	1
Risner, ME; Silcox, DL	1
Cohen, G; Dembiec, D	1
Dembiec, D	1
Bergmann, JS; Eddine Saiah, MK; Johnson, KM; Kozikowski, AP	1
Adams, CE; Cline, EJ; Gerhardt, GA; Larson, GA; Zahniser, NR	1
Bonnet, JJ; Costentin, J; Héron, C	1
Gu, H; Rudnick, G; Wall, SC	1
London, ED; Mantione, CR; Ritz, MC	1
Kaufman, MJ; Madras, BK	1
Meiergerd, SM; Schenk, JO	1
Bergmann, JS; Johnson, KM; Kozikowski, AP; Saiah, MK	1
Bennett, BA; Clodfelter, JE; Hyde, CE; Pecora, JR	1
Patel, A	1
Choi, HL; Stadlin, A; Tsang, D	1
Berger, P; Bigelow, GE; Preston, KL; Sullivan, JT	1
Baraban, JM; Bhat, RV	1
Ball, RG; Bergmann, JS; Johnson, KM; Kozikowski, AP; Simoni, D; Stoelwinder, J	1
Chan, B; Chen, CA; Dannals, RF; Folio, T; Ravert, HT; Ricaurte, GA; Scheffel, U; Shaya, EK; Wong, DF; Yung, B	1
Kleven, MS; Woolverton, WL	1
Balster, RL; Mansbach, RS	1
Bergmann, JS; Gifford, AN; Johnson, KM	1
Cass, WA; Curella, P; Gerhardt, GA; Gillespie, K; Mayfield, RD; Zahniser, NR	1
Charney, DS; Kosten, TR; Krystal, JH; Stine, SM	1
Avants, SK; Kosten, TR; Margolin, A	1
Boulay, D; Costentin, J; Duterte-Boucher, D; Leroux-Nicollet, I; Naudon, L	1
Brockington, A; Carrol, FI; Elmer, GI; Goldberg, SR; Gorelick, DA; Matecka, D; Rice, KC; Rothman, RB	1
Jones, SR; Marshall, JF; O'Dell, SJ; Wightman, RM	1
Bonnet, JJ; Costentin, J; Thibaut, F; Vaugeois, JM	1
Boja, JW; Houlihan, WJ; Kopajtic, TA; Kuhar, MJ; Parrino, VA	1
Daunais, JB; Hedgecock, AA; Letchworth, SR; Porrino, LJ	1
Caron, MG; Ellinwood, EH; Jaber, M; King, GR; Silvia, CP	1
Bittencourt, AL; Takahashi, RN	1
Reith, ME; Xu, C	1
Coffey, LL; Reith, ME; Wu, Q	1
Gorelick, DA	1
Dannals, RF; Hatzidimitriou, G; Mathews, WB; McCann, UD; Musachio, J; Ravert, HT; Ricaurte, GA; Villemagne, V; Wong, DF; Yuan, J	1
Adinoff, B; Groseclose, CH; McGroarty, KK; Middaugh, LD	1
Meiergerd, SM; Schenk, JO; Wayment, H	1
Koob, GF; Lipkin, WI; Solbrig, MV	1
Baldwin, RM; Carpenter, LL; Innis, RB; Kosten, TR; Malison, RT; McCance, E; Price, LH; Seibyl, JP	1
Du, P; Johnson, KM; Kozikowski, AP; Roberti, M; Rondanin, R; Simoni, D; Wang, S	1
Demaria, JE; Fekete, MI; Freeman, ME; Lerant, AA; Levenson, CW; Nagy, GM	1
Carvelli, L; Chen, J; Ferrer, JV; Galli, A; Javitch, JA; Lamb, ME; Leeb-Lundberg, LM; Merrill, G; Saunders, C; Shi, L	1
Bonnet, JJ; Corera, AT; Costentin, J	1
Dutta, AK; Madras, BK; Reith, ME	1
Bonnet, JJ; Costentin, J; Do-Régo, JC; Tidjane Corera, A	1
Enyedy, IJ; Johnson, KM; Kozikowski, AP; Sakamuri, S; Wang, S; Zaman, WA	1
Chen, N; Reith, ME; Vaughan, RA	1
Berfield, JL; Ferrer, JV; Javitch, JA; Reith, ME; Wang, LC	1
Bharat, N; Carroll, FI; Kuhar, MJ; Landry, DW	1
Kankaanpää, A; Meririnne, E; Seppälä, T	1
Lin, Z; Uhl, GR	1
Enyedy, IJ; Johnson, KM; Wang, J; Wang, S; Zaman, WA	1
Ahmad, UF; Brand, L; Houlihan, WJ; Kelly, L; Koletar, J; Kopajtic, TA	1
Houlihan, WJ; Kelly, L	1
Enyedy, IJ; Farkas, T; Flippen-Anderson, JL; Johnson, KM; Kozikowski, AP; Sakamuri, S; Tella, SR; Wang, S; Zaman, WA	1
Bondi, CD; Kozikowski, AP; Kulkarni, SS; Newman, AH; Pan, S; Surratt, CK; Ukairo, OT	1
Adkins, EM; Blakely, RD; Field, JR; Henry, LK; Newman, AH; Parnas, ML; Vaughan, RA; Zou, MF	1
Ramanujapuram, S; Surratt, CK; Ukairo, OT	1
Bailey, A; Kitchen, I; McGee, T; Metaxas, A; Yoo, JH	1
Nikiforuk, A; Papciak, J; Popik, P; Rygula, R; Szczech, E	1

Reviews

1 review(s) available for mazindol and cocaine

Article	Year
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter. Journal of medicinal chemistry, 1992, Mar-20, Volume: 35, Issue:6 Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship	1992

Article

Year

Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.

Journal of medicinal chemistry, 1992, Mar-20, Volume: 35, Issue:6

Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship

1992

Trials

4 trial(s) available for mazindol and cocaine

Article	Year
Effects of cocaine alone and in combination with mazindol in human cocaine abusers. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Adult; Affect; Blood Pressure; Body Temperature Regulation; Cocaine; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Male; Mazindol; Neurotransmitter Uptake Inhibitors; Substance-Related Disorders; Surveys and Questionnaires	1993
Mazindol treatment for cocaine dependence. Drug and alcohol dependence, 1995, Volume: 39, Issue:3 Topics: Adult; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Female; Humans; Male; Mazindol; Neurologic Examination; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders	1995
Mazindol for relapse prevention to cocaine abuse in methadone-maintained patients. The American journal of drug and alcohol abuse, 1995, Volume: 21, Issue:4 Topics: Adult; Cocaine; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Mazindol; Methadone; Narcotic Antagonists; Psychotherapy; Recurrence; Substance-Related Disorders	1995
[123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts. Psychopharmacology, 1998, Volume: 137, Issue:4 Topics: Adult; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Image Processing, Computer-Assisted; Iodine Radioisotopes; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Substance-Related Disorders; Tomography, Emission-Computed, Single-Photon	1998

Other Studies

98 other study(ies) available for mazindol and cocaine

Article	Year
Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tropanes	1994
An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes. Bioorganic & medicinal chemistry letters, 2000, Jul-03, Volume: 10, Issue:13 Topics: Animals; Behavior, Animal; Biological Transport; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Design; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Probes; Molecular Structure; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Radioligand Assay; Rats; Reward; Serotonin; Tropanes	2000
Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Animals; Binding Sites; Cell Line; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Guinea Pigs; Humans; In Vitro Techniques; Isoindoles; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Prodrugs; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2002
Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter. The Journal of biological chemistry, 2007, Mar-23, Volume: 282, Issue:12 Topics: Animals; Azides; Cocaine; Cyanogen Bromide; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Epitopes; Humans; Iodine Radioisotopes; Methionine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Rats; Trypsin	2007
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorganic & medicinal chemistry, 2009, Jun-01, Volume: 17, Issue:11 Topics: Cell Line, Tumor; Dopamine Plasma Membrane Transport Proteins; Humans; Ligands; Molecular Structure; Photoaffinity Labels; Pyrrolidines; Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Design; HEK293 Cells; Humans; Mice; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleosides; Purinergic P1 Receptor Agonists; Structure-Activity Relationship	2017
Mazindol self-administration in the rhesus monkey. Pharmacology, biochemistry, and behavior, 1976, Volume: 4, Issue:2 Topics: Animals; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Haplorhini; Indoles; Injections, Intravenous; Macaca mulatta; Male; Mazindol; Reinforcement Schedule	1976
Cocaine and dopamine differentially protect [3H]mazindol binding sites from alkylation by N-ethylmaleimide. European journal of pharmacology, 1992, Dec-01, Volume: 227, Issue:4 Topics: Alkylation; Animals; Binding Sites; Binding, Competitive; Cocaine; Corpus Striatum; Culture Techniques; Dopamine; Ethylmaleimide; Male; Mazindol; Rats; Rats, Sprague-Dawley	1992
Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25 Topics: Animals; Binding, Competitive; Brain; Cocaine; Discrimination Learning; Mazindol; Rats; Structure-Activity Relationship	1992
Mazindol and cocaine addiction in schizophrenia. Biological psychiatry, 1992, Jun-01, Volume: 31, Issue:11 Topics: Adult; Cocaine; Humans; Male; Mazindol; Schizophrenia; Substance-Related Disorders	1992
Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Psychopharmacology, 1992, Volume: 106, Issue:4 Topics: Animals; Autoradiography; Biogenic Monoamines; Brain Chemistry; Cocaine; Imipramine; In Vitro Techniques; Male; Mazindol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists	1992
Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. Journal of neurochemistry, 1992, Volume: 59, Issue:1 Topics: Animals; Autoradiography; Behavior, Animal; Cocaine; Corpus Striatum; Diffusion; Dopamine; Electrochemistry; Injections, Intraperitoneal; Male; Mazindol; Nucleus Accumbens; Rats; Rats, Inbred Strains	1992
Radiolabeling of dopamine uptake sites in mouse striatum: comparison of binding sites for cocaine, mazindol, and GBR 12935. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:3 Topics: Animals; Binding Sites; Buffers; Cocaine; Corpus Striatum; Dopamine; Drug Interactions; Ethylmaleimide; Kinetics; Male; Mazindol; Membranes; Mice; Mice, Inbred BALB C; Phosphates; Piperazines; Radioligand Assay; Temperature; Tritium; Tromethamine	1992
Cocaine differentially affects benzodiazepine receptors in discrete regions of the rat brain: persistence and potential mechanisms mediating these effects. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2 Topics: Animals; Autoradiography; Brain; Cocaine; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Flumazenil; Injections, Intraventricular; Kinetics; Male; Mazindol; Oxidopamine; Rats; Rats, Inbred F344; Receptors, GABA-A; Tritium	1991
Withdrawal of repeated cocaine decreases autoradiographic [3H]mazindol-labelling of dopamine transporter in rat nucleus accumbens. European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1 Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Densitometry; Desipramine; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Rats; Substance Withdrawal Syndrome	1991
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter. Molecular pharmacology, 1991, Volume: 39, Issue:3 Topics: Animals; Benzamides; Binding, Competitive; Brain Stem; Carrier Proteins; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Thiocyanates	1991
Inbred rat strain comparisons indicate different sites of action for cocaine and amphetamine locomotor stimulant effects. Psychopharmacology, 1991, Volume: 104, Issue:4 Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Dose-Response Relationship, Drug; Genotype; In Vitro Techniques; Male; Mazindol; Motor Activity; Rats; Rats, Inbred ACI; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Species Specificity; Stimulation, Chemical	1991
GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine. Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:2 Topics: Animals; Carrier Proteins; Caudate Nucleus; Chromatography, High Pressure Liquid; Cocaine; Dialysis; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electrochemistry; Extracellular Space; Kinetics; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains	1991
Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909. European journal of pharmacology, 1991, Jun-06, Volume: 198, Issue:2-3 Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Injections, Intravenous; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Piperazines; Radioimmunoassay; Receptors, Drug	1991
Mazindol treatment of cocaine abuse. A double-blind investigation. NIDA research monograph, 1990, Volume: 105 Topics: Adult; Cocaine; Double-Blind Method; Female; Humans; Mazindol; Methadone; Opioid-Related Disorders; Psychiatric Status Rating Scales; Substance-Related Disorders	1990
Chronic cocaine administration alters corticotropin-releasing factor receptors in the rat brain. Brain research, 1990, Oct-29, Volume: 531, Issue:1-2 Topics: Animals; Autoradiography; Brain; Cerebral Ventricles; Cocaine; Corticotropin-Releasing Hormone; Desipramine; Hydroxydopamines; Male; Mazindol; Organ Specificity; Oxidopamine; Rats; Rats, Inbred F344; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Reference Values; Substance-Related Disorders; Tritium	1990
Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. Journal of neurochemistry, 1991, Volume: 56, Issue:2 Topics: Adult; Brain; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Esterification; Ethanol; Female; Humans; Liver; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins	1991
High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. Life sciences, 1990, Volume: 46, Issue:20 Topics: Benztropine; Bupropion; Cocaine; Dopamine; Drug Evaluation, Preclinical; Humans; Mazindol; Nomifensine; Propiophenones; Substance-Related Disorders	1990
Covalent labeling of the cocaine-sensitive catecholamine transporter. Journal of neuroscience research, 1990, Volume: 26, Issue:2 Topics: Alkylation; Animals; Carrier Proteins; Catecholamines; Cell Line; Cocaine; Indoles; Mazindol; Molecular Weight; Neurons; Neurotransmitter Uptake Inhibitors; Nitrogen Mustard Compounds; Rats	1990
Phencyclidine binding to striatal cocaine receptors. Neuropharmacology, 1990, Volume: 29, Issue:3 Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; In Vitro Techniques; Kinetics; Mazindol; Phencyclidine; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1990
Complex interaction of cocaine with the dopamine uptake carrier. European journal of pharmacology, 1990, Feb-06, Volume: 176, Issue:2 Topics: Animals; Cocaine; Corpus Striatum; Desipramine; In Vitro Techniques; Kinetics; Male; Mazindol; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Vas Deferens	1990
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1 Topics: Animals; Bupropion; Cocaine; Dopamine; Male; Mazindol; Methylphenidate; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Propiophenones; Saimiri; Self Administration	1989
The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Animals; Cocaine; Dopamine; In Vitro Techniques; Kinetics; Male; Mazindol; Methylphenidate; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine	1989
Treatment of cocaine abuse with mazindol. Lancet (London, England), 1989, Feb-04, Volume: 1, Issue:8632 Topics: Cocaine; Humans; Indoles; Mazindol; Substance-Related Disorders; Time Factors	1989
Potential toxic interactions of cocaine and mazindol. Lancet (London, England), 1989, Jul-08, Volume: 2, Issue:8654 Topics: Animals; Cocaine; Drug Synergism; Humans; Indoles; Mazindol; Rodentia; Substance-Related Disorders	1989
Effect of the inhibition of dopamine uptake on the dopamine- and dimethyldopamine-induced-inhibition of the potassium-evoked release of [3H]acetylcholine from striatal slices. General pharmacology, 1989, Volume: 20, Issue:6 Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; In Vitro Techniques; Kinetics; Male; Mazindol; Methyltyrosines; Mice; Potassium; Procaine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Reserpine	1989
[3H]cocaine binding and inhibition of [3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens. European journal of pharmacology, 1989, Dec-07, Volume: 173, Issue:2-3 Topics: Animals; Cocaine; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Mazindol; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Sodium; Synaptosomes	1989
Persistent augmented dopamine release after acute cocaine requires dopamine receptor activation. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1 Topics: Animals; Apomorphine; Benzazepines; Cocaine; Dopamine; Dopamine Antagonists; Fluphenazine; Lidocaine; Male; Mazindol; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride	1989
Long-term blockade of the dopamine uptake complex by metaphit, an isothiocyanate derivative of phencyclidine. Synapse (New York, N.Y.), 1989, Volume: 3, Issue:3 Topics: Animals; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Female; Hydrogen-Ion Concentration; Injections, Intraventricular; Kinetics; Male; Mazindol; Membrane Proteins; Mice; Nerve Tissue Proteins; Phencyclidine; Radioligand Assay	1989
Enhancement of ambulation-increasing effect of methamphetamine by peripherally-administered 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) in mice. Japanese journal of pharmacology, 1989, Volume: 50, Issue:2 Topics: Animals; Biopterins; Bromocriptine; Cocaine; Drug Synergism; Ephedrine; Male; Mazindol; Methamphetamine; Mice; Morphine; Motor Activity; Scopolamine; Time Factors	1989
Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (New York, N.Y.), 1987, Sep-04, Volume: 237, Issue:4819 Topics: Animals; Brain; Cattle; Cocaine; Corpus Striatum; Dopamine; Haplorhini; Male; Mazindol; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Self Administration; Serotonin	1987
Cocaine receptors on dopamine transporters mediate cocaine-reinforced behavior. NIDA research monograph, 1988, Volume: 88 Topics: Animals; Biological Transport; Cocaine; Dopamine; Humans; Mazindol; Receptors, Drug; Receptors, Muscarinic; Reinforcement, Psychology	1988
[3H]GBR-12935 binding to dopamine uptake sites in the human brain. Brain research, 1988, Aug-02, Volume: 457, Issue:1 Topics: Aged; Aged, 80 and over; Binding, Competitive; Brain; Cocaine; Dopamine; Female; Humans; Male; Mazindol; Middle Aged; Piperazines; Receptors, Dopamine	1988
Ascorbic acid and striatal transport of [3H] 1-methyl-4-phenylpyridine (MPP+) and [3H] dopamine. Life sciences, 1988, Volume: 42, Issue:25 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Ascorbic Acid; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Kinetics; Mazindol; Mice; Nicotine; Piperazines; Pyridines; Synaptosomes	1988
Cocaine self-administration appears to be mediated by dopamine uptake inhibition. Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:2-3 Topics: Animals; Brain; Cocaine; Dopamine; Mazindol; Receptors, Dopamine; Self Administration	1988
Psychostimulant self-administration by beagle dogs in a progressive-ratio paradigm. Psychopharmacology, 1981, Volume: 75, Issue:1 Topics: Animals; Cocaine; Dextroamphetamine; Dogs; Female; Fenfluramine; Indoles; Mazindol; Reinforcement Schedule; Self Administration	1981
Potassium-induced release of [3H]catecholamine from brain: effects of pre-exposure to catecholamine uptake inhibitors. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:3 Topics: Acetophenones; Animals; Brain Chemistry; Catecholamines; Cocaine; Corpus Striatum; Desipramine; Dopamine; Drug Interactions; Imidazoles; In Vitro Techniques; Male; Mazindol; Nomifensine; Norepinephrine; Occipital Lobe; Potassium; Rats	1981
Inhibition of potassium-stimulated release of [3H]dopamine from rat striata as a result of prior exposure to cocaine, nomifensine, or mazindol. Neurochemical research, 1980, Volume: 5, Issue:3 Topics: Animals; Catecholamines; Cocaine; Corpus Striatum; Dopamine; Male; Mazindol; Nomifensine; Potassium; Rats	1980
Chemistry and biology of the 2 beta-alkyl-3 beta-phenyl analogues of cocaine: subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position. Journal of medicinal chemistry, 1995, Aug-04, Volume: 38, Issue:16 Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Receptors, Drug; Structure-Activity Relationship; Synaptosomes; Tropanes	1995
Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to [3H]mazindol binding, but not striosome/matrix. Experimental neurology, 1995, Volume: 134, Issue:1 Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Electrochemistry; Extracellular Matrix; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tritium	1995
Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier. European journal of pharmacology, 1994, Nov-03, Volume: 264, Issue:3 Topics: Amphetamine; Animals; Binding Sites; Carrier Proteins; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Ethylmaleimide; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Neurons; Nomifensine; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley	1994
Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux. Molecular pharmacology, 1995, Volume: 47, Issue:3 Topics: 1-Methyl-4-phenylpyridinium; Amphetamines; Biogenic Monoamines; Biological Transport; Carrier Proteins; Cell Membrane; Cells, Cultured; Cloning, Molecular; Cocaine; DNA, Complementary; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stimulation, Chemical; Substrate Specificity; Symporters; Transfection	1995
Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology, 1994, Volume: 114, Issue:1 Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Inbred F344; Receptors, Drug; Serotonin; Serotonin Plasma Membrane Transport Proteins; Spermine	1994
Cocaine accumulates in dopamine-rich regions of primate brain after i.v. administration: comparison with mazindol distribution. Synapse (New York, N.Y.), 1994, Volume: 18, Issue:3 Topics: Animals; Autoradiography; Brain; Cocaine; Female; Male; Mazindol; Saimiri; Tissue Distribution; Tritium	1994
Kinetic evaluation of the commonality between the site(s) of action of cocaine and some other structurally similar and dissimilar inhibitors of the striatal transporter for dopamine. Journal of neurochemistry, 1994, Volume: 63, Issue:5 Topics: Animals; Benztropine; Biological Transport; Cocaine; Corpus Striatum; Dopamine; Male; Mazindol; Models, Biological; Neurotransmitter Uptake Inhibitors; Nomifensine; Piperazines; Rats; Rats, Sprague-Dawley	1994
Structure-activity relationship studies of N-sulfonyl analogs of cocaine: role of ionic interaction in cocaine binding. Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20 Topics: Animals; Binding Sites; Carrier Proteins; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Structure-Activity Relationship; Sulfinic Acids; Sulfonamides; Synaptosomes	1994
Differing neurotoxic potencies of methamphetamine, mazindol, and cocaine in mesencephalic cultures. Journal of neurochemistry, 1993, Volume: 60, Issue:4 Topics: Animals; Binding, Competitive; Cells, Cultured; Cocaine; Dopamine; Immunohistochemistry; L-Lactate Dehydrogenase; Mazindol; Mesencephalon; Methamphetamine; Neurons; Phosphopyruvate Hydratase; Rats; Tyrosine 3-Monooxygenase	1993
Characterization of [125I]RTI-55 binding to dog caudate dopamine transporter. Neuroreport, 1993, Nov-18, Volume: 5, Issue:2 Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cell Membrane; Cholic Acids; Citalopram; Cocaine; Desipramine; Dogs; Dopamine Plasma Membrane Transport Proteins; Filtration; Iodine Radioisotopes; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Protein Binding; Solubility	1993
Postnatal changes in [3H]mazindol-labelled dopamine uptake sites in the rat striatum following prenatal cocaine exposure. Brain research, 1994, Feb-21, Volume: 637, Issue:1-2 Topics: Animals; Birth Weight; Cocaine; Female; Mazindol; Neostriatum; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Weight Gain	1994
Activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Animals; Citalopram; Cocaine; DNA-Binding Proteins; Dopamine; Early Growth Response Protein 1; Gene Expression; Genes, fos; Immediate-Early Proteins; In Situ Hybridization; Male; Mazindol; Neurotransmitter Uptake Inhibitors; Norepinephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA Probes; Serotonin; Transcription Factors	1993
Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist". Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24 Topics: Cocaine; Dopamine; Mazindol; Molecular Structure; Structure-Activity Relationship	1993
In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [11C]WIN 35,428. Synapse (New York, N.Y.), 1993, Volume: 15, Issue:2 Topics: Adult; Affect; Aged; Aged, 80 and over; Animals; Blood Pressure; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Electrocardiography; Female; Humans; Ligands; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Endings; Nerve Tissue Proteins; Papio; Pulse; Receptors, Dopamine; Tomography, Emission-Computed	1993
Effects of three monoamine uptake inhibitors on behavior maintained by cocaine or food presentation in rhesus monkeys. Drug and alcohol dependence, 1993, Volume: 31, Issue:2 Topics: 1-Naphthylamine; Animals; Appetitive Behavior; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Fluoxetine; Macaca mulatta; Mazindol; Motivation; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors; Self Administration; Sertraline	1993
Effects of mazindol on behavior maintained or occasioned by cocaine. Drug and alcohol dependence, 1993, Volume: 31, Issue:2 Topics: Animals; Appetitive Behavior; Arousal; Behavior, Animal; Cocaine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Mazindol; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Saimiri; Self Administration	1993
GBR 12909 fails to antagonize cocaine-induced elevation of dopamine in striatal slices. Drug and alcohol dependence, 1993, Volume: 32, Issue:1 Topics: Animals; Cocaine; Corpus Striatum; Culture Techniques; Dopamine; Female; Male; Mazindol; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Synaptosomes	1993
Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. Journal of neurochemistry, 1993, Volume: 61, Issue:1 Topics: Animals; Autoradiography; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Electrochemistry; Male; Mazindol; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	1993
Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:1 Topics: Animals; Autoradiography; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Locomotion; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley	1996
Cocaine cross-sensitization to dopamine uptake inhibitors: unique effects of GBR12909. Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4 Topics: Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mazindol; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior	1996
Functional and anatomical evidence for different dopamine dynamics in the core and shell of the nucleus accumbens in slices of rat brain. Synapse (New York, N.Y.), 1996, Volume: 23, Issue:3 Topics: Animals; Autoradiography; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; Electrochemistry; In Vitro Techniques; Kinetics; Male; Mazindol; Microelectrodes; Nomifensine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley	1996
Pharmacological modifications of dopamine transmission do not influence the striatal in vivo binding of [3H]mazindol or [3H]cocaine in mice. Neuroscience letters, 1996, Mar-01, Volume: 205, Issue:3 Topics: 4-Butyrolactone; Analysis of Variance; Animals; Cerebellum; Cocaine; Dextroamphetamine; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; GABA Modulators; Injections, Intravenous; Levodopa; Mazindol; Mice; Neostriatum; Protein Binding; Tritium	1996
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry, 1996, Dec-06, Volume: 39, Issue:25 Topics: Animals; Binding Sites; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats	1996
Effects of chronic cocaine administration on dopamine transporter mRNA and protein in the rat. Brain research, 1997, Mar-07, Volume: 750, Issue:1-2 Topics: Analysis of Variance; Animals; Autoradiography; Binding Sites; Brain; Carrier Proteins; Cocaine; DNA Probes; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; In Situ Hybridization; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Organ Specificity; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Tritium	1997
Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine transporter antisense oligodeoxynucleotides. Neuroscience, 1997, Volume: 76, Issue:3 Topics: Amphetamine; Animals; Carrier Proteins; Cells, Cultured; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Functional Laterality; In Situ Hybridization; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stereotyped Behavior	1997
Mazindol and lidocaine are antinociceptives in the mouse formalin model: involvement of dopamine receptor. European journal of pharmacology, 1997, Jul-09, Volume: 330, Issue:2-3 Topics: Anesthetics, Local; Animals; Benzazepines; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Haloperidol; Lidocaine; Male; Mazindol; Mice; Naloxone; Narcotic Antagonists; Nociceptors; Pain Measurement; Receptors, Dopamine; Receptors, Opioid	1997
WIN 35,428 and mazindol are mutually exclusive in binding to the cloned human dopamine transporter. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: Binding, Competitive; Carrier Proteins; Cloning, Molecular; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Chemical; Nerve Tissue Proteins; Radioligand Assay; Recombinant Proteins; Tritium; Tumor Cells, Cultured	1997
Cations affect [3H]mazindol and [3H]WIN 35,428 binding to the human dopamine transporter in a similar fashion. Journal of neurochemistry, 1997, Volume: 69, Issue:3 Topics: Animals; Carrier Proteins; Cations, Divalent; Cations, Monovalent; Cell Membrane; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Glioma; Humans; Kinetics; Lithium; Magnesium; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mercury; Nerve Tissue Proteins; Potassium; Protein Binding; Rats; Sodium; Tritium; Tumor Cells, Cultured; Zinc	1997
The rate hypothesis and agonist substitution approaches to cocaine abuse treatment. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: Animals; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Humans; Mazindol; Piperazines; Substance-Related Disorders	1998
Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jan-01, Volume: 18, Issue:1 Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Neostriatum; Nerve Tissue Proteins; Neurotoxins; Papio; Substance-Related Disorders; Tomography, Emission-Computed; Tritium	1998
Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology, 1998, Volume: 136, Issue:1 Topics: Anesthetics, Local; Animals; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Food Deprivation; Generalization, Stimulus; Male; Mazindol; Mice; Mice, Inbred C57BL; Neurotransmitter Uptake Inhibitors; Procaine	1998
Relationships between the catechol substrate binding site and amphetamine, cocaine, and mazindol binding sites in a kinetic model of the striatal transporter of dopamine in vitro. Journal of neurochemistry, 1998, Volume: 70, Issue:5 Topics: Amphetamine; Animals; Binding Sites; Carrier Proteins; Catechols; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Kinetics; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Biological; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tyramine	1998
Cocaine sensitivity in Borna disease virus-infected rats. Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4 Topics: Animals; Autoradiography; Behavior, Animal; Borna Disease; Caudate Nucleus; Cocaine; Dopamine Uptake Inhibitors; In Situ Hybridization; Male; Mazindol; Motor Activity; Putamen; Rats; Rats, Inbred Lew	1998
Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & medicinal chemistry letters, 1999, Jul-05, Volume: 9, Issue:13 Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Stereoisomerism	1999
Dopamine transporters participate in the physiological regulation of prolactin. Endocrinology, 2000, Volume: 141, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Estradiol; Female; Hypothalamo-Hypophyseal System; Immunohistochemistry; Mazindol; Median Eminence; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurosecretory Systems; Prolactin; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase	2000
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America, 2000, Jun-06, Volume: 97, Issue:12 Topics: Amphetamine; Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Recombinant Fusion Proteins	2000
Binding of uptake blockers to the neuronal dopamine transporter: further investigation about cationic and anionic requirements. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:3 Topics: Animals; Anions; Binding Sites; Cations; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Mazindol; Rats; Rats, Sprague-Dawley	2000
Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse (New York, N.Y.), 2001, Volume: 39, Issue:2 Topics: Animals; Benzhydryl Compounds; Binding, Competitive; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Ligands; Macaca mulatta; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Piperazines; Piperidines; Radioligand Assay; Tritium	2001
Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes. Neuroscience research, 2001, Volume: 39, Issue:3 Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dextroamphetamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Sodium Chloride	2001
Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. Bioorganic & medicinal chemistry letters, 2001, May-07, Volume: 11, Issue:9 Topics: Biogenic Monoamines; Carrier Proteins; Cocaine; Dopamine Uptake Inhibitors; Mazindol; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Quantitative Structure-Activity Relationship	2001
The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis. Journal of neurochemistry, 2001, Volume: 77, Issue:4 Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Carrier Proteins; Cell Line; Cocaine; Conserved Sequence; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Structure, Secondary; Radioligand Assay; Recombinant Proteins; Transfection; Tritium; Tryptophan	2001
The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. The Journal of biological chemistry, 2001, Aug-03, Volume: 276, Issue:31 Topics: Benztropine; Binding Sites; Binding, Competitive; Carrier Proteins; Cell Membrane; Cocaine; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Indicators and Reagents; Kinetics; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Models, Molecular; Nerve Tissue Proteins; Protein Conformation	2001
Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment. Synapse (New York, N.Y.), 2001, Volume: 41, Issue:2 Topics: Adrenergic Uptake Inhibitors; Antibodies, Catalytic; Antibody Affinity; Brain; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Mazindol; Tropanes	2001
5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat. Psychopharmacology, 2002, Volume: 159, Issue:4 Topics: Animals; Behavior, Animal; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Injections, Subcutaneous; Male; Mazindol; Methylphenidate; Motor Activity; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Tropanes	2002
Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Molecular pharmacology, 2002, Volume: 61, Issue:4 Topics: Amino Acid Substitution; Animals; Binding, Competitive; Chlorocebus aethiops; Cocaine; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Drug Resistance; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Motor Proteins; Mutation; Nerve Tissue Proteins; Transfection; Tritium	2002
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. Bioorganic & medicinal chemistry letters, 2002, Jul-08, Volume: 12, Issue:13 Topics: Binding Sites; Biphenyl Compounds; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Norepinephrine; Serotonin; Structure-Activity Relationship; Thiazoles	2002
Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Animals; Binding Sites; Cell Line; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Guinea Pigs; Humans; In Vitro Techniques; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2002
Assessment of mazindane, a pro-drug form of mazindol, in assays used to define cocaine treatment agents. European journal of pharmacology, 2003, Jan-05, Volume: 458, Issue:3 Topics: Analysis of Variance; Animals; Binding, Competitive; Cell Membrane; Cocaine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Isoindoles; Macaca mulatta; Male; Mazindol; Mice; Motor Activity; Neurotransmitter Agents; Proadifen; Rats; Rats, Sprague-Dawley; Tritium	2003
2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors. Bioorganic & medicinal chemistry, 2003, Mar-20, Volume: 11, Issue:6 Topics: Animals; Behavior, Animal; Binding, Competitive; Cocaine; Discrimination, Psychological; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mazindol; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Models, Molecular; Motor Activity; Nerve Tissue Proteins; Protein Binding; Protein Conformation; Quinuclidines; Rats; Structure-Activity Relationship; Synaptosomes	2003
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2 Topics: Amino Acid Substitution; Animals; Aspartic Acid; Benztropine; Binding, Competitive; CHO Cells; Cocaine; Cricetinae; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Immunohistochemistry; Kinetics; Ligands; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Microscopy, Confocal; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Transfection	2005
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. The Journal of biological chemistry, 2006, Jan-27, Volume: 281, Issue:4 Topics: Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blotting, Western; Cadmium; Cell Line; Cell Membrane; Citalopram; Clomipramine; Cocaine; Cysteine; Dopamine Uptake Inhibitors; Fluoxetine; HeLa Cells; Humans; Immunoprecipitation; Isoleucine; Kinetics; LLC-PK1 Cells; Mazindol; Methionine; Mice; Models, Chemical; Molecular Sequence Data; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Nomifensine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Radiopharmaceuticals; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Species Specificity; Stereoisomerism; Substrate Specificity; Tyrosine	2006
Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter. Brain research, 2007, Feb-02, Volume: 1131, Issue:1 Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Benztropine; Binding, Competitive; Brain; Brain Chemistry; Cell Line, Tumor; Chlorocebus aethiops; CHO Cells; Cocaine; Cocaine-Related Disorders; COS Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Mazindol; Methylphenidate; Neurons; Radioligand Assay	2007
Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. The European journal of neuroscience, 2008, Volume: 28, Issue:4 Topics: Animals; Behavior, Animal; Cocaine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mazindol; Mice; Mice, Inbred C57BL; Motor Activity; Protein Binding; Quinolines; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance-Related Disorders	2008
The effects of cocaine and mazindol on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm. Behavioural brain research, 2014, Aug-15, Volume: 270 Topics: Animals; Cocaine; Cognition; Cues; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Judgment; Male; Mazindol; Neuropsychological Tests; Rats; Rats, Sprague-Dawley	2014