matrine, (5beta)-isomer has been researched along with topotecan in 1 studies
| Studies (matrine, (5beta)-isomer) | Trials (matrine, (5beta)-isomer) | Recent Studies (post-2010) (matrine, (5beta)-isomer) | Studies (topotecan) | Trials (topotecan) | Recent Studies (post-2010) (topotecan) |
|---|---|---|---|---|---|
| 11 | 0 | 11 | 2,392 | 626 | 792 |
| Protein | Taxonomy | matrine, (5beta)-isomer (IC50) | topotecan (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 1.5211 | |
| DNA topoisomerase 1 | Homo sapiens (human) | 0.8525 | |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | 0.605 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 0.605 | |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 0.06 | |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | 8.6 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.3 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, CW; Deng, HB; Li, YH; Shao, RG; Song, DQ; Tang, S; Wang, Z; Zhang, CX; Zhao, WL | 1 |
1 other study(ies) available for matrine, (5beta)-isomer and topotecan
| Article | Year |
|---|---|
Novel N-substituted sophoridinol derivatives as anticancer agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Hep G2 Cells; Humans; Injections, Intravenous; KB Cells; Male; MCF-7 Cells; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Structure; Quinazolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2014 |