martynoside and acteoside

martynoside has been researched along with acteoside* in 7 studies

Other Studies

7 other study(ies) available for martynoside and acteoside

ArticleYear
Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim.
    Phytotherapy research : PTR, 2017, Volume: 31, Issue:10

    The aim of the present study was to evaluate the antiproliferative effect of phenylpropanoids isolated from the n-BuOH-soluble fraction of an ethanolic extract of Lagotis brevituba Maxim. The phenylpropanoids were identified as echinacoside, lagotioside, glucopyranosyl(1-6)martynoside, plantamoside, and verbascoside. Three of the compounds, lagotioside, glucopyranosyl(1-6)martynoside, and plantamoside, were isolated from L. brevituba for the first time. The antiproliferative activity of the isolates was evaluated in human gastric carcinoma (MGC-803), human colorectal carcinoma (HCT116), human hepatocellar carcinoma (HepG2), and human lung cancer (HCT116) cells using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Plantamoside showed promising activity against MGC-803 cells, with a half maximal inhibitory concentration value of 37.09 μM. The mechanism of the pro-apoptosis effect of plantamoside was then evaluated in MGC-803 cells. Changes in cell morphology, including disorganization of the architecture of actin microfilaments and formation of apoptotic bodies, together with cell cycle arrest in G2/M phases, were observed after treatment of plantamoside. The antiproliferative and pro-apoptotic effects were associated with a decrease in the ratio of Bcl-2/Bax and reduced mitochondrial membrane potential, which was accompanied by the release of reactive oxygen species and Ca

    Topics: Apoptosis; Cell Cycle Checkpoints; G2 Phase; Glucosides; Glycosides; HCT116 Cells; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Phenols; Plantaginaceae; Reactive Oxygen Species

2017
Anti-sports anaemia effects of verbascoside and martynoside in mice.
    International journal of sports medicine, 2010, Volume: 31, Issue:8

    This paper aims to investigate the effects of verbascoside and martynoside isolated from PEDICULARIS DOLICHOCYMBA on sports anaemia. Forty mice were divided into four groups: Group R (control group, nonsupplemented and maintained at rest), Group E (nonsupplemented and undergoing exercise), Group VE (supplemented with verbascoside 10 mg/kg per day and undergoing exercise), and Group ME (supplemented with martynoside 10 mg/kg per day and undergoing exercise). After 5 weeks intensive swimming exercises, we measured the RBC count, the hemoglobin concentration, the hematocrit (Hct), the mean corpuscular hemoglobin concentration (MCHC) and the mean corpuscular hemoglobin (MCH). We studied the shapes of RBC and measured the plasma malonyldialdehyde (MDA). We found Group E showed lower RBC, hemoglobin and Hct levels, higher MCHC, MCH, plasma MDA levels and the abnormally shaped RBCs percentage than Groups R, VE and ME. Group ME showed lower RBC and Hct levels, higher MCH, plasma MDA levels and the abnormally shaped RBCs percentage than Group VE. The results indicated that verbascoside and martynoside have the potential of antagonizing sports anaemia, the mechanism of this effect might be related to preventing RBC from free radical damage. Moreover, verbascoside was found to be more active than martynoside.

    Topics: Anemia; Animals; Erythrocyte Count; Free Radicals; Glucosides; Hematocrit; Hemoglobins; Male; Malondialdehyde; Mice; Pedicularis; Phenols; Physical Conditioning, Animal; Sports; Swimming

2010
[Studies on the chemical constituents of Buddleja albiflora (II)].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2010, Volume: 33, Issue:6

    To study the chemical constituents of Buddleja albiflora.. The constituents were isolated by column chromatography and their structures were elucidated by spectroscopic analyses.. seven compounds were isolated and identified as aucubin (1), catalpol (2), acteoside (3), martynoside (4), ursolicacid (5), daucosterol (6), beta-sitosterol-3-0-beta-D-(6'-0-palmitate) glucopyranosisde (7).. All these compounds are obtained from Buddleja albiflora for the first time.

    Topics: Buddleja; Glucosides; Iridoid Glucosides; Magnetic Resonance Spectroscopy; Phenols; Plant Components, Aerial; Plants, Medicinal; Sitosterols; Triterpenes; Ursolic Acid

2010
Antioxidant phenylethanoid glycosides and a neolignan from Jacaranda caucana.
    Journal of natural products, 2009, May-22, Volume: 72, Issue:5

    Extracts from several plants of the family Bignoniaceae from Panama were submitted to a rapid DPPH TLC test for the detection of radical-scavenging activity. The MeOH extract of the stems of Jacaranda caucana, a tree that grows from Costa Rica to Colombia, was selected due to its interesting activity and the lack of phytochemical studies on the polar extract. This extract was partitioned between ethyl acetate, butanol, and water. The EtOAc fraction afforded two new phenylethanoid glycosides (1, 2), along with protocatechuic acid, acteoside, and jionoside D. Further purifications yielded isoacteoside and martynoside. The BuOH fraction afforded a new rhamnosyl derivative of sisymbrifolin (8), a neolignan. The structures were determined by means of spectrometric methods, including 1D and 2D NMR experiments and MS analysis.

    Topics: Antioxidants; Bignoniaceae; Free Radical Scavengers; Glucosides; Glycosides; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Panama; Phenols; Plant Stems; Plants, Medicinal

2009
A new rearranged abietane diterpene and other constituents from Clerodendrum philipinum.
    Natural product communications, 2009, Volume: 4, Issue:3

    From the methanolic extract of the roots of Clerodendrum philipinum, a new rearranged abietane diterpene (1) and eight known compounds were isolated by various chromatography methods. Their structures were identified by means of spectroscopic methods, including 1D- and 2D-NMR, as 17(15-->16),18(4-->3)-bisabeo-11,12,14,16-tetrahydroxy-3,5,8,11,13,15-abietahexaen-7-one (1), binankadsurin A, clerodenoside A, martynoside, acteoside, isoacteoside, astragalin, p3-sitosterol, and daucosterol. Binankadsurin A was found for the first time from a Clerodendrum species.

    Topics: Abietanes; Chromatography; Clerodendrum; Glucosides; Kaempferols; Lignans; Magnetic Resonance Spectroscopy; Methanol; Molecular Structure; Phenols; Sitosterols

2009
Pensteminoside, an unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae).
    Phytochemistry, 2007, Volume: 68, Issue:13

    From the MeOH and ethyl acetate extracts of aerial parts of Penstemon gentianoides HBK (Plantaginaceae) an unusual iridoid of the catalpol-type, was isolated and characterized as pensteminoside: (8-O-trans-cinnamoyl, 6-hydroxy, 1-[beta-D-glucopyranoside-6'-O-((4''-hydroxy)-cinnamoyl)]-catalpol) was isolated, along with the known iridoids: plantarelanoside and globularisicin, the flavone: luteolin and diosmetin, as well the phenylpropanoids, verbascoside and martynoside. Their structures were established by 1D and 2D NMR spectroscopic analyses.

    Topics: Flavones; Glucosides; Iridoids; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Penstemon; Phenols

2007
Acteoside and martynoside exhibit estrogenic/antiestrogenic properties.
    The Journal of steroid biochemistry and molecular biology, 2006, Volume: 98, Issue:1

    Acteoside and martynoside are plant phenylpropanoid glycosides exhibiting anticancer, cytotoxic and antimetastatic activities. We investigated their potential to activate estrogen receptor isoforms ERalpha and ERbeta in HeLa cells transfected with an estrogen response element (ERE)-driven luciferase (Luc) reporter gene and an ERalpha or ERbeta expression vector. Their estrogenic/antiestrogenic effects were also assessed in breast cancer cells (MCF7), endometrial cancer cells (Ishikawa) and osteoblasts (KS483), by measuring IGFBP3 levels, cell viability and number of mineralized nodules, respectively, seeking for a natural selective estrogen receptor modulator (SERM). Acteoside and martynoside antagonized both ERalpha and ERbeta (p<0.001), whereas they reversed the effect of E(2) mainly via ERalpha (p<0.001). Martynoside was a potent antiestrogen in MCF-7 cells, increasing, like ICI182780, IGFBP3 levels via the ER-pathway. In osteoblasts, martynoside induced nodule mineralization, which was abolished by ICI182780, implicating an ER-mediated mechanism. Furthermore, its antiproliferative effect on endometrial cells suggests that martynoside may be an important natural SERM. Acteoside was an antiestrogen in breast cancer cells and osteoblasts, without any effect on endometrial cells. Our study suggests that the nature is rich in selective ERalpha and ERbeta ligands, the discovery of which may lead to the development of novel neutraceutical agents.

    Topics: Breast Neoplasms; Calcinosis; Cell Survival; Endometrial Neoplasms; Estradiol Congeners; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Glucosides; HeLa Cells; Humans; Insulin-Like Growth Factor Binding Protein 3; Ligands; Osteoblasts; Phenols; Response Elements; Selective Estrogen Receptor Modulators; Transfection; Tumor Cells, Cultured

2006