marizomib and 2-pyrrolidone

marizomib has been researched along with 2-pyrrolidone* in 1 studies

Other Studies

1 other study(ies) available for marizomib and 2-pyrrolidone

Article	Year
Concise formal synthesis of (-)-salinosporamide A (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy. The Journal of organic chemistry, 2010, Jun-04, Volume: 75, Issue:11 Expedient access to a highly functionalized 2-pyrrolidinone (8), the gamma-lactam core of 20S proteasome inhibitor (-)-salinosporamide A (marizomib; NPI-0052; 1), using a regio- and stereoselective epoxide formation/reductive oxirane ring-opening strategy is presented. Notably, the sequential construction of the C-4, C-3, and C-2 stereocenters of 1 in a completely stereocontrolled fashion is a key feature of streamlining the synthesis of intermediate 12. A related strategy is also discussed. Topics: Epoxy Compounds; Ethylene Oxide; Lactones; Proteasome Inhibitors; Pyrroles; Pyrrolidinones; Stereoisomerism	2010

Article

Year

Concise formal synthesis of (-)-salinosporamide A (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy.

The Journal of organic chemistry, 2010, Jun-04, Volume: 75, Issue:11

Expedient access to a highly functionalized 2-pyrrolidinone (8), the gamma-lactam core of 20S proteasome inhibitor (-)-salinosporamide A (marizomib; NPI-0052; 1), using a regio- and stereoselective epoxide formation/reductive oxirane ring-opening strategy is presented. Notably, the sequential construction of the C-4, C-3, and C-2 stereocenters of 1 in a completely stereocontrolled fashion is a key feature of streamlining the synthesis of intermediate 12. A related strategy is also discussed.

Topics: Epoxy Compounds; Ethylene Oxide; Lactones; Proteasome Inhibitors; Pyrroles; Pyrrolidinones; Stereoisomerism

2010