marizomib has been researched along with 2-pyrrolidone* in 1 studies
1 other study(ies) available for marizomib and 2-pyrrolidone
Article | Year |
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Concise formal synthesis of (-)-salinosporamide A (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy.
Expedient access to a highly functionalized 2-pyrrolidinone (8), the gamma-lactam core of 20S proteasome inhibitor (-)-salinosporamide A (marizomib; NPI-0052; 1), using a regio- and stereoselective epoxide formation/reductive oxirane ring-opening strategy is presented. Notably, the sequential construction of the C-4, C-3, and C-2 stereocenters of 1 in a completely stereocontrolled fashion is a key feature of streamlining the synthesis of intermediate 12. A related strategy is also discussed. Topics: Epoxy Compounds; Ethylene Oxide; Lactones; Proteasome Inhibitors; Pyrroles; Pyrrolidinones; Stereoisomerism | 2010 |