Page last updated: 2024-08-22

mannose and bimosiamose

mannose has been researched along with bimosiamose in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (64.29)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berens, KL; Dixon, RA; Dupre, B; Feng, L; Han, R; Hancock, WW; Kahan, BD; Kirken, RA; Langer, R; Li, P; Podder, H; Stepkowski, SM; Wang, M1
Romano, SJ1
Beeh, KM; Beier, J; Buhl, R; Meyer, M; Wolff, G; Zahlten, R1
Jilma, B; Meyer, M; Wolff, G; Zahlten, R1
Aydt, E; Bock, D; Dam, TN; Friedrich, M; Kang, S; Ludwig, N; Philipp, S; Sabat, R; Schroeter-Maas, S; Sterry, W; Wolff, G; Wolk, K; Zahlten, R1
Aydt, E; Beeh, KM; Beier, J; Beyer, D; Jilma, B; Meyer, M; Wolff, G; Zahlten, R1
Aydt, EM; Beyer, D; Bock, D; Busemann, AS; Heinemann, B; Kranich, R; Meyer, M; Schierhorn, K; Schroeter-Maas, S; Wolff, G; Zahlten, R1
Beyer, D; Jilma, B; Meyer, M; Vollhardt, K; Woischwill, C; Wolff, G1
Beyer, D; Firbas, C; Jilma, B; Leitner, JM; Mayr, FB; Meyer, M; Reiter, RA; Spiel, AO; Wolff, G1
Bird, NC; Canovas, D; Paschos, KA1
Bock, D; Kirsten, A; Kretschmar, G; Magnussen, H; Meyer-Sabellek, W; Pedersen, F; Watz, H1
Armstrong, PC; Chen, YC; Gardiner, E; Howden, BP; Hu, H; Peter, K; Rigby, S; Rivera, J1
Beeh, KM; Beier, J; Bock, D; Kirsten, A; Magnussen, H; Meyer, M; Meyer-Sabellek, W; Pedersen, F; Schierhorn, K; Vollhardt, K; Watz, H; Woischwill, C1
Gross, NJ1

Reviews

2 review(s) available for mannose and bimosiamose

ArticleYear
Selectin antagonists : therapeutic potential in asthma and COPD.
    Treatments in respiratory medicine, 2005, Volume: 4, Issue:2

    Topics: Animals; Asthma; Hexanes; Humans; Inflammation; Lewis X Antigen; Mannose; Oligosaccharides; P-Selectin; Pulmonary Disease, Chronic Obstructive; Selectins; Sialyl Lewis X Antigen

2005
The engagement of selectins and their ligands in colorectal cancer liver metastases.
    Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:1-2

    Topics: Carbohydrate Conformation; Carbohydrate Sequence; Colorectal Neoplasms; Hexanes; Humans; Lewis X Antigen; Ligands; Liver Neoplasms; Mannose; Molecular Sequence Data; Molecular Structure; Protein Isoforms; Selectins; Sialyl Lewis X Antigen

2010

Trials

8 trial(s) available for mannose and bimosiamose

ArticleYear
Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial.
    Pulmonary pharmacology & therapeutics, 2006, Volume: 19, Issue:4

    Topics: Administration, Inhalation; Adult; Allergens; Anti-Asthmatic Agents; Asthma; Breath Tests; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Hexanes; Humans; Leukocyte Count; Lymphocyte Count; Male; Mannose; Methacholine Chloride; Nitric Oxide; Treatment Outcome

2006
Physiochemical properties, safety and pharmacokinetics of bimosiamose disodium after intravenous administration.
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:10

    Topics: Adult; Area Under Curve; Dermatitis, Contact; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Hexanes; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Male; Mannose; Metabolic Clearance Rate; Molecular Structure; Solubility

2005
Pan-selectin antagonism improves psoriasis manifestation in mice and man.
    Archives of dermatological research, 2006, Volume: 297, Issue:8

    Topics: Adult; Animals; Anti-Inflammatory Agents; Cell Adhesion; Cell Line; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Epidermis; Female; Hexanes; HL-60 Cells; Humans; Jurkat Cells; Leukocytes; Male; Mannose; Mice; Mice, SCID; Middle Aged; P-Selectin; Pilot Projects; Psoriasis; T-Lymphocytes

2006
Tolerability and pharmacokinetics of inhaled bimosiamose disodium in healthy males.
    British journal of clinical pharmacology, 2007, Volume: 63, Issue:4

    Topics: Administration, Inhalation; Adult; Cell Adhesion; Hexanes; Humans; Male; Mannose; Middle Aged; Nasopharyngeal Diseases

2007
The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers.
    Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:9

    Topics: Adult; Anti-Inflammatory Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Half-Life; Hexanes; Humans; Injections, Subcutaneous; Male; Mannose; Selectins

2007
Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia.
    Shock (Augusta, Ga.), 2008, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Blood Coagulation; Blood Platelets; Cell Adhesion Molecules; Cross-Over Studies; Double-Blind Method; Endotoxemia; Flow Cytometry; Hemodynamics; Hexanes; Humans; Inflammation; Interleukin-6; Leukocytes; Lipopolysaccharides; Male; Mannose; Platelet Membrane Glycoprotein IIb; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selectins; Thromboplastin; Time Factors; Tumor Necrosis Factor-alpha

2008
Efficacy of the pan-selectin antagonist Bimosiamose on ozone-induced airway inflammation in healthy subjects--a double blind, randomized, placebo-controlled, cross-over clinical trial.
    Pulmonary pharmacology & therapeutics, 2011, Volume: 24, Issue:5

    Topics: Adult; Cross-Over Studies; Double-Blind Method; Exercise Test; Female; Hexanes; Humans; Inflammation; Inhalation Exposure; Interleukin-8; Male; Mannose; Matrix Metalloproteinase 9; Middle Aged; Nebulizers and Vaporizers; Neutrophils; Ozone; Respiratory System; Sputum

2011
Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD.
    Pulmonary pharmacology & therapeutics, 2013, Volume: 26, Issue:2

    Topics: Administration, Inhalation; Aged; Asthma; Cross-Over Studies; Double-Blind Method; Female; Hexanes; Humans; Interleukin-8; Male; Mannose; Matrix Metalloproteinase 9; Middle Aged; Pulmonary Disease, Chronic Obstructive; Selectins

2013

Other Studies

4 other study(ies) available for mannose and bimosiamose

ArticleYear
Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:11

    Topics: Animals; Chemokines; Cyclosporine; Cytokines; Drug Synergism; Graft Rejection; Graft Survival; Hexanes; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Mannose; Rats; Rats, Inbred Strains; Reperfusion Injury; Selectins; Sirolimus

2004
Rational design of novel, potent small molecule pan-selectin antagonists.
    Journal of medicinal chemistry, 2007, Mar-22, Volume: 50, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Adhesion; Drug Design; E-Selectin; Hexanes; HL-60 Cells; Humans; L-Selectin; Ligands; Mannose; Models, Molecular; P-Selectin; Phenols; Protein Binding; Selectins

2007
Staphylococcal superantigen-like protein 5 induces thrombotic and bleeding complications in vivo: inhibition by an anti-SSL5 antibody and the glycan Bimosiamose.
    Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:12

    Topics: Antibodies; Hemorrhage; Hexanes; Humans; Mannose; Staphylococcus aureus; Superantigens; Thrombosis

2012
The COPD pipeline XXII.
    COPD, 2013, Volume: 10, Issue:3

    Topics: Anti-Inflammatory Agents; Bronchoscopy; Drug Discovery; Hexanes; Humans; Influenza Vaccines; Lung; Mannose; Organ Size; Pulmonary Disease, Chronic Obstructive; RNA, Antisense; Tobacco Use Cessation Devices; Tumor Necrosis Factor-alpha

2013