Page last updated: 2024-08-17

mannitol and methotrexate

mannitol has been researched along with methotrexate in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (57.14)	18.7374
1990's	9 (14.29)	18.2507
2000's	12 (19.05)	29.6817
2010's	6 (9.52)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Oyanagui, Y	1
Barnett, PA; Beyer, CW; Clark, WK; Diehl, JT; Ehle, AL; Frenkel, EP; Hill, SA; Lewis, SE; Maravilla, KR; Moore, RJ; Neuwelt, EA; Rapoport, SI; Vu, LH	1
Barnett, PA; Frenkel, EP; Hill, SA; Maravilla, KR; Neuwelt, EA; Rapaport, SI	1
Allen, JC; Hasegawa, H; Mehta, BM; Posner, JB; Shapiro, WR	1
Blau, HJ	1
Martin, JB; Riskind, PN	1
Belshe, BD; Gumerlock, MK; Madsen, R; Watts, C	1
Hishida, A; Yonemura, K	1
Erdman, SH; Hart, MH; Park, JH; Vanderhoof, JA	1
Hayashi, A; Kyuma, Y	1
Christophidis, N; Cosolo, WC; Louis, WJ; Martinello, P	1
Shapiro, JR; Shapiro, WR	1
Dimery, IW; Legha, SS	1
Dahlborg, SA; Klein, ML; Millay, RH; Neuwelt, EA; Shults, WT	1
Dahlborg, SA; Neuwelt, EA	1
Aloy, A; Brandstätter, B; Dirnberger, H; Heimberger, K; Hiesmayr, M; Horaczek, A; Zimpfer, M	1
Binder, H; Deecke, L; Dittrich, C; Heimberger, K; Hiesmayr, M; Podreka, I; Reisner, T; Samec, P; Steger, G; Suess, E	1
Christophidis, N; Cosolo, W	1
Abe, H	1
Czyzewska, K; Knapowski, J; Ramlau, C	1
Barnett, PA; Frenkel, EP; McCormick, CI; Minna, JD; Neuwelt, EA	1
Fekete, B; Gergely, P; Petrányi, G; Szabó, G; Szegedi, G	1
Cain, GD; Rahman, F	1
Abbassian, A; Wallace, DM	1
Maher, JF; Rath, CE; Schreiner, GE	1
Stacher, A	1
Clifford, P; Klein, G; Singh, S; Stjernswärd, J	1
Frenkel, EP; Hill, SA; Neuwelt, EA	1
Barnett, P; Frenkel, EP; Hill, S; Maravilla, KR; Moore, RJ; Neuwelt, EA	1
Jahnke, V	1
Barnett, PA; Bigner, DD; Frenkel, EP; Neuwelt, EA	1
Balaban, E; Diehl, J; Frenkel, E; Hill, S; Neuwelt, EA	1
Fraser, DR; Sandhu, JS	1
Bennett, MJ; Frenkel, EP; Haines, JE; Hill, SA; Howieson, J; Neuwelt, EA; Specht, HD	1
Butti, G; Da Prada, GA; Knerich, R; Pavesi, L; Preti, P; Robustelli della Cuna, G	1
Barnett, P; Frenkel, EP; Neuwelt, EA; Rapoport, S	1
Diehl, JT; Frenkel, EP; Hill, SA; Michael, AJ; Neuwelt, EA; Vu, LH	1
Axon, AT; Cobden, I; Rothwell, J	1
Barnett, PA; Beyer, CW; Clark, WK; Diehl, JT; Ehle, AL; Frenkel, EP; Hill, SA; Lewis, SE; Maravilla, KR; Neuwelt, EA; Rapoport, SI; Vu, LH	1
Hill, SA; Neuwelt, EA	1
Garcia, R; Mass, M; McCormick, CI; Neuwelt, EA; Pearse, HD; Remsen, LG; Roman-Goldstein, S; Sexton, G	1
Audus, KL; Avery, M; Liu, F; Shi, F; Soares, MJ; Zhang, X	1
Fishburne, BC; Neuwelt, EA; Rosenbaum, JT; Wilson, DJ	1
Fiamengo, SA; McCormick, CI; Neuwelt, EA; Pagel, MA; Remsen, LG; Sexton, G	1
Liu, GQ; Liu, XD; Pan, GY	1
Barnett, G; Cucullo, L; Fazio, V; Janigro, D; Kight, K; Kinter, M; Marchi, N; Masaryk, T; Mayberg, MR; Rasmussen, P; Vogelbaum, M; Volgelbaum, M	1
Eibl, H; Erdlenbruch, B; Heinemann, DE; Herms, J; Kugler, W; Lakomek, M; Schinkhof, C	1
ONESTI, P; WOODLIFF, HJ	1
Kansara, V; Mitra, AK	1
Angelov, L; Diglaw, T; Fazio, V; Franic, L; Granata, T; Hallene, K; Hernandez, N; Janigro, D; Marchi, N; Masaryk, T; Najm, I	1
Ference, SJ; Galor, A; Lee, MS; Peereboom, DM; Perez, VL; Singh, AD; Stevens, GH	1
Goldstein, DA; Tessler, HH	1
Davis, K; Fabian, E; Greenhaw, J; Groeters, S; Herold, M; Kamp, H; Looser, R; Marxfeld, H; Mattes, W; Mellert, W; Moeller, N; Montoya-Parra, G; Prokoudine, A; Strauss, V; van Ravenzwaay, B; Walk, T	1

Reviews

3 review(s) available for mannitol and methotrexate

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Principles of brain tumor chemotherapy. Seminars in oncology, 1986, Volume: 13, Issue:1 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Carbon Radioisotopes; Carmustine; Cell Line; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance; Fluorouracil; Glioma; Humans; Hydroxyurea; Infusions, Intra-Arterial; Karyotyping; Kinetics; Mannitol; Methotrexate; Podophyllotoxin; Procarbazine; Rats; Tumor Stem Cell Assay	1986
Current concepts in therapy: drug-induced malabsorption--a review. Southern medical journal, 1973, Volume: 66, Issue:6 Topics: Aminosalicylic Acids; Calcium Carbonate; Cholestyramine Resin; Clofibrate; Colchicine; Contraceptives, Oral; Diuretics; Ethanol; Humans; Intestinal Absorption; Malabsorption Syndromes; Mannitol; Methotrexate; Phenytoin	1973

Trials

3 trial(s) available for mannitol and methotrexate

Article	Year
Sequential methotrexate, 5-fluorouracil, and cisplatin in the treatment of recurrent squamous-cell carcinoma of the head and neck: failure of hypertonic saline to reduce the nephrotoxicity of cisplatin. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Kidney Diseases; Male; Mannitol; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Random Allocation; Sodium Chloride	1986
Intra-arterial chemotherapy following blood-brain barrier disruption in a patient with malignant glioma. Journal of neurosurgical nursing, 1982, Volume: 14, Issue:2 Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Clinical Trials as Topic; Female; Glioma; Humans; Infusions, Intra-Arterial; Mannitol; Methotrexate; Middle Aged; Tomography, X-Ray Computed	1982
Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Mar-01, Volume: 23, Issue:5 Topics: Biomarkers; Blood Proteins; Blood-Brain Barrier; Blotting, Western; Brain; Brain Neoplasms; Cerebrospinal Fluid Proteins; Electrophoresis, Gel, Two-Dimensional; Haptoglobins; Humans; Infusions, Intra-Arterial; Lymphoma; Mannitol; Methotrexate; Nerve Growth Factors; Phosphopyruvate Hydratase; Prealbumin; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tomography, X-Ray Computed	2003

Other Studies

57 other study(ies) available for mannitol and methotrexate

Article	Year
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Exploring the role of different drug transport routes in permeability screening. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2005
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Participation of superoxide anions at the prostaglandin phase of carrageenan foot-oedema. Biochemical pharmacology, 1976, Jul-01, Volume: 25, Issue:13 Topics: Animals; Anti-Inflammatory Agents; Benzoates; Carrageenan; Catalase; Edema; Histamine H1 Antagonists; Male; Manganese; Mannitol; Methotrexate; Oxygen; Prostaglandins; Rats; Serotonin Antagonists; Superoxide Dismutase; Superoxides; Time Factors	1976
Osmotic blood-brain barrier disruption: a new means of increasing chemotherapeutic agent delivery. Transactions of the American Neurological Association, 1979, Volume: 104 Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Dogs; Humans; Hypertonic Solutions; Mannitol; Methotrexate	1979
Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. The Journal of clinical investigation, 1979, Volume: 64, Issue:2 Topics: Animals; Blood-Brain Barrier; Brain; Dogs; Mannitol; Methotrexate; Osmolar Concentration; Sodium Chloride; Tomography, X-Ray Computed	1979
Enhancement of CNS penetration of methotrexate by hyperosmolar intracarotid mannitol or carcinomatous meningitis. Neurology, 1979, Volume: 29, Issue:9 Pt 1 Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Carotid Arteries; Female; Injections, Intra-Arterial; Mannitol; Meningeal Neoplasms; Methotrexate; Osmolar Concentration; Pharmaceutic Aids; Rats	1979
[Side effects of cytostatic therapy in childhood]. Kinderarztliche Praxis, 1976, Volume: 44, Issue:6 Topics: Adolescent; Antineoplastic Agents; Asparaginase; Busulfan; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Female; Fluorouracil; Humans; Male; Mannitol; Mercaptopurine; Methotrexate; Prednisone; Procarbazine; Time Factors; Triaziquone; Vinblastine; Vincristine	1976
Neurologic manifestations of hypothalamic disease. Progress in brain research, 1992, Volume: 93 Topics: Adult; Aged; Bromocriptine; Female; Humans; Hypothalamic Neoplasms; Lymphoma; Magnetic Resonance Imaging; Male; Mannitol; Methotrexate; Middle Aged; Prednisone; Radiotherapy Dosage; Tomography, Emission-Computed; Tomography, X-Ray Computed	1992
Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review. Journal of neuro-oncology, 1992, Volume: 12, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Follow-Up Studies; Glioma; Humans; Mannitol; Methotrexate; Necrosis; Procarbazine; Retrospective Studies; Technetium Tc 99m Pentetate; Tomography, X-Ray Computed	1992
[Drug-induced acute renal failure]. Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50 Suppl Topics: Aminoglycosides; Amphotericin B; Anti-Bacterial Agents; Cisplatin; Contrast Media; Hemolytic-Uremic Syndrome; Humans; Kidney Tubular Necrosis, Acute; Mannitol; Methotrexate; Nephritis, Interstitial; Paraquat	1992
The intestinal absorption of 3-O-methyl-D-glucose in methotrexate-treated rats: an in vivo study of small bowel function. Journal of pediatric gastroenterology and nutrition, 1991, Volume: 13, Issue:4 Topics: 3-O-Methylglucose; alpha-Glucosidases; Animals; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Malabsorption Syndromes; Male; Mannitol; Methotrexate; Methylglucosides; Microvilli; Permeability; Polyethylene Glycols; Rats; Rats, Inbred Strains	1991
[Intra-arterial infusion of high dose methotrexate therapy in recurrent gliomas]. Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Evaluation; Female; Glioma; Humans; Infusions, Intra-Arterial; Leucovorin; Male; Mannitol; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction	1990
Blood-brain barrier disruption using mannitol: time course and electron microscopy studies. The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 2 Topics: Animals; Blood-Brain Barrier; Brain; Carotid Arteries; Evans Blue; Mannitol; Methotrexate; Microscopy, Electron; Rats; Rats, Inbred Strains; Time Factors	1989
Maculopathy associated with combination chemotherapy and osmotic opening of the blood-brain barrier. American journal of ophthalmology, 1986, Nov-15, Volume: 102, Issue:5 Topics: Adolescent; Adult; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Macula Lutea; Mannitol; Methotrexate; Middle Aged; Osmosis; Retinal Diseases	1986
Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases. Journal of neuro-oncology, 1987, Volume: 4, Issue:3 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Humans; Mannitol; Methotrexate; Middle Aged; Procarbazine	1987
[Hemodynamic effects of an osmotic bolus for the reversible opening of the blood-brain barrier]. Schweizerische medizinische Wochenschrift, 1987, Mar-21, Volume: 117, Issue:12 Topics: Adult; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Female; Hemodynamics; Humans; Male; Mannitol; Methotrexate; Middle Aged; Osmolar Concentration	1987
[Reversible opening of the blood-brain barrier in the chemotherapy of malignant gliomas]. Wiener klinische Wochenschrift, 1987, May-29, Volume: 99, Issue:11 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Infusions, Intra-Arterial; Mannitol; Methotrexate	1987
Blood-brain barrier disruption and methotrexate in the treatment of a readily transplantable intracerebral osteogenic sarcoma of rats. Cancer research, 1987, Dec-01, Volume: 47, Issue:23 Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carotid Arteries; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Mannitol; Methotrexate; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Inbred Strains	1987
Effects of combination of vasodilator drugs and hypertonic solutions on methotrexate distribution into the rat brain. Japanese journal of pharmacology, 1988, Volume: 48, Issue:3 Topics: Animals; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Hypertonic Solutions; Male; Mannitol; Methotrexate; Nicardipine; Nitroglycerin; Osmotic Pressure; Rats; Rats, Inbred WKY; Vasodilator Agents	1988
[Transperitoneal transport of methotrexate: in vitro studies]. Przeglad lekarski, 1988, Volume: 45, Issue:5 Topics: Animals; Biological Transport; Glucose; In Vitro Techniques; Mannitol; Methotrexate; Osmotic Pressure; Peritoneum; Rabbits	1988
Osmotic blood-brain barrier modification: monoclonal antibody, albumin, and methotrexate delivery to cerebrospinal fluid and brain. Neurosurgery, 1985, Volume: 17, Issue:3 Topics: Animals; Antibodies, Monoclonal; Azo Compounds; Blood-Brain Barrier; Brain; Dogs; Evans Blue; Immunoglobulin M; Mannitol; Methotrexate; Serum Albumin	1985
In-vitro sensitivity to cytostatics in chronic myeloid leukaemia. Acta medica Academiae Scientiarum Hungaricae, 1973, Volume: 29, Issue:3 Topics: Antibiotics, Antineoplastic; Busulfan; Cells, Cultured; Cytotoxicity Tests, Immunologic; Daunorubicin; Drug Hypersensitivity; Humans; Hydroxyurea; Leukemia, Myeloid; Leukocytes; Mannitol; Mannomustine; Methotrexate	1973
Intracavitary chemotherapy of diffuse non-infiltrating papillary carcinoma of the bladder. The Journal of urology, 1966, Volume: 96, Issue:4 Topics: Alkylating Agents; Carcinoma, Papillary; Female; Folic Acid Antagonists; Humans; Male; Mannitol; Methotrexate; Thiotepa; Urinary Bladder Neoplasms	1966
Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis. Archives of internal medicine, 1969, Volume: 123, Issue:2 Topics: Acetazolamide; Acute Kidney Injury; Adult; Allopurinol; Anuria; Bicarbonates; Blood Gas Analysis; Blood Urea Nitrogen; Carbon Dioxide; Cystoscopy; Electroencephalography; Eye Manifestations; Female; Humans; Leukemia, Lymphoid; Leukocytosis; Mannitol; Mercaptopurine; Methotrexate; Peritoneal Dialysis; Prednisone; Splenomegaly; Thrombocytopenia; Uric Acid; Urinary Catheterization; Vincristine; Water-Electrolyte Balance	1969
[Progress in the therapy of leukoses]. Wiener medizinische Wochenschrift (1946), 1970, Jun-13, Volume: 120, Issue:24 Topics: Antineoplastic Agents; Azathioprine; Busulfan; Chlorambucil; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mannitol; Methotrexate; Mitomycins; Triethylenemelamine; Vincristine	1970
Long-term survival of patients with Burkitt's lymphoma: an assessment of treatment and other factors which may relate to survival. Cancer research, 1967, Volume: 27, Issue:12 Topics: Adolescent; Antineoplastic Agents; Burkitt Lymphoma; Busulfan; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Cytarabine; Female; Humans; Immunotherapy; Infant; Kenya; Male; Mannitol; Melphalan; Methotrexate; Nitrogen Mustard Compounds; Nitroso Compounds; Urea	1967
Osmotic blood-brain barrier modification and combination chemotherapy: concurrent tumor regression in areas of barrier opening and progression in brain regions distant to barrier opening. Neurosurgery, 1984, Volume: 15, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Combined Modality Therapy; Cyclophosphamide; Female; Glioma; Humans; Leucovorin; Lymphoma; Male; Mannitol; Methotrexate; Procarbazine; Tomography, X-Ray Computed; Water-Electrolyte Balance	1984
Use of enhanced computerized tomography to evaluate osmotic blood-brain barrier disruption. Neurosurgery, 1980, Volume: 6, Issue:1 Topics: Animals; Blood-Brain Barrier; Brain Chemistry; Brain Neoplasms; Dogs; Evans Blue; Hypertonic Solutions; Iothalamate Meglumine; Mannitol; Methotrexate; Metrizamide; Radiographic Image Enhancement; Staining and Labeling; Tomography, X-Ray Computed; Water-Electrolyte Imbalance	1980
[Experiences using combination chemotherapy with cis-platinum, bleomycin and methotrexate in the management of advanced squamous cell carcinomas of the head and neck (author's transl)]. HNO, 1980, Volume: 28, Issue:12 Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Diuretics; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Mannitol; Methotrexate; Middle Aged	1980
Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:14 Topics: Alpharetrovirus; Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Dexamethasone; Glioma; Mannitol; Methotrexate; Neoplasms, Experimental; Rats; Rats, Inbred F344	1982
Successful treatment of primary central nervous system lymphomas with chemotherapy after osmotic blood-brain barrier opening. Neurosurgery, 1983, Volume: 12, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Dexamethasone; Female; Humans; Hypertonic Solutions; Leucovorin; Lymphatic Diseases; Male; Mannitol; Methotrexate; Middle Aged; Procarbazine; Tomography, X-Ray Computed	1983
Effect of dietary cereals on intestinal permeability in experimental enteropathy in rats. Gut, 1983, Volume: 24, Issue:9 Topics: Animals; Celiac Disease; Cetrimonium; Cetrimonium Compounds; Edible Grain; Intestinal Absorption; Intestinal Mucosa; Male; Mannitol; Methotrexate; Niacin; Rats; Sugar Alcohols; Triparanol	1983
Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning. AJR. American journal of roentgenology, 1983, Volume: 141, Issue:4 Topics: Adult; Blood-Brain Barrier; Brain; Brain Neoplasms; Carotid Artery, Internal; Child; Drug Therapy, Combination; Female; Humans; Iothalamate Meglumine; Male; Mannitol; Methotrexate; Middle Aged; Osmosis; Pentetic Acid; Radionuclide Imaging; Seizures; Technetium; Technetium Tc 99m Pentetate; Tomography, X-Ray Computed	1983
[Chemotherapy, immunotherapy and supportive therapy in cerebral metastases]. Minerva medica, 1984, May-31, Volume: 75, Issue:22-23 Topics: BCG Vaccine; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Diuretics; Humans; Immunotherapy; Injections, Intra-Arterial; Levamisole; Mannitol; Methotrexate; Nitrosourea Compounds; Vincristine	1984
Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog. Neurosurgery, 1980, Volume: 7, Issue:1 Topics: Animals; Blood-Brain Barrier; Brain Chemistry; Dogs; Mannitol; Methotrexate; Osmotic Pressure	1980
Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barrier disruption. Annals of internal medicine, 1981, Volume: 94, Issue:4 pt 1 Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Glioma; Humans; Mannitol; Methotrexate; Tomography, X-Ray Computed	1981
Passive permeability in experimental intestinal damage in rats. Clinical science (London, England : 1979), 1981, Volume: 60, Issue:1 Topics: Animals; Atrophy; Cetrimonium; Cetrimonium Compounds; Intestinal Absorption; Intestinal Mucosa; Lactulose; Male; Mannitol; Methotrexate; Rats	1981
Osmotic blood-brain barrier disruption: pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors. Cancer treatment reports, 1981, Volume: 65 Suppl 2 Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Dogs; Drug Evaluation; Functional Laterality; Humans; Infusions, Intra-Arterial; Kinetics; Mannitol; Methotrexate; Osmolar Concentration	1981
Long-term toxicity and neuropathology associated with the sequencing of cranial irradiation and enhanced chemotherapy delivery. Neurosurgery, 1997, Volume: 40, Issue:5 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain; Carboplatin; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Radiation; Drug Administration Schedule; Etoposide; Mannitol; Methotrexate; Radiation Injuries, Experimental; Radiotherapy, Adjuvant; Rats; Treatment Outcome	1997
Permeability and metabolic properties of a trophoblast cell line (HRP-1) derived from normal rat placenta. Experimental cell research, 1997, Jul-10, Volume: 234, Issue:1 Topics: Animals; Biological Transport; Biomarkers; Carbon Radioisotopes; Cell Culture Techniques; Cell Line; Cell Membrane Permeability; Cytochrome P-450 CYP1A1; Dermatologic Agents; Dextrans; Female; Fluorescein; Fluoresceins; Humans; Linoleic Acid; Linoleic Acids; Mannitol; Methotrexate; Microsomes; Oxazines; Rats; Sucrose; Transferrin; Trophoblasts; Urea	1997
Intravitreal methotrexate as an adjunctive treatment of intraocular lymphoma. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:9 Topics: Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Diuretics, Osmotic; Eye Neoplasms; Female; Humans; Injections; Lymphoma; Male; Mannitol; Methotrexate; Middle Aged; Radiotherapy, Adjuvant; Survival Rate; Visual Acuity; Vitreous Body	1997
The influence of anesthetic choice, PaCO2, and other factors on osmotic blood-brain barrier disruption in rats with brain tumor xenografts. Anesthesia and analgesia, 1999, Volume: 88, Issue:3 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antimetabolites, Antineoplastic; Arabinose; Blood-Brain Barrier; Brain Neoplasms; Carbon Dioxide; Diuretics, Osmotic; Evans Blue; Female; Humans; Isoflurane; Mannitol; Methotrexate; Nitrous Oxide; Osmolar Concentration; Oxygen; Partial Pressure; Propofol; Rats; Rats, Nude; Transplantation, Heterologous; Tritium	1999
Intracarotid infusion of hypertonic mannitol changes permeability of blood-brain barrier to methotrexate in rats. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:7 Topics: Animals; Blood-Brain Barrier; Carotid Artery, Internal; Cerebral Cortex; Female; Hypertonic Solutions; Infusions, Intra-Arterial; Injections, Intravenous; Mannitol; Methotrexate; Rats; Rats, Sprague-Dawley	2000
Intracarotid administration of short-chain alkylglycerols for increased delivery of methotrexate to the rat brain. British journal of pharmacology, 2003, Volume: 139, Issue:4 Topics: Animals; Blood-Brain Barrier; Bradykinin; Brain; Carotid Arteries; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Carriers; Drug Synergism; Drug Therapy, Combination; Female; Glycerol; Glyceryl Ethers; Humans; Injections, Intra-Arterial; Male; Mannitol; Methotrexate; Monocytes; Permeability; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Time Factors; Vena Cava, Superior	2003
EFFECT OF DRUGS ON CELLS IN VITRO. British medical journal, 1963, Dec-14, Volume: 2, Issue:5371 Topics: Animals; Busulfan; Glioma; In Vitro Techniques; Leukemia; Leukemia, Experimental; Leukemia, Myeloid; Mannitol; Methotrexate; Mice; Nitrogen Mustard Compounds; Pharmacology; Research	1963
Evaluation of an ex vivo model implication for carrier-mediated retinal drug delivery. Current eye research, 2006, Volume: 31, Issue:5 Topics: Animals; Biological Transport; Carrier Proteins; Cell Membrane Permeability; Cell Survival; Choroid; Diazepam; Diffusion Chambers, Culture; Drug Delivery Systems; Electric Conductivity; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Mannitol; Membrane Potentials; Methotrexate; Models, Biological; Pigment Epithelium of Eye; Rabbits; Receptors, Cell Surface; Retina; Sclera; Temperature; Tetrahydrofolates	2006
Seizure-promoting effect of blood-brain barrier disruption. Epilepsia, 2007, Volume: 48, Issue:4 Topics: Adult; Animals; Antineoplastic Agents; Biomarkers; Blood-Brain Barrier; Brain; Brain Neoplasms; Cerebrovascular Disorders; Disease Models, Animal; Electroencephalography; Female; Functional Laterality; Humans; Infusions, Intra-Arterial; Lymphoma; Male; Mannitol; Methotrexate; Middle Aged; Osmotic Pressure; S100 Proteins; Seizures; Swine; Tomography, X-Ray Computed; Treatment Outcome	2007
Maculopathy as a complication of blood-brain barrier disruption in patients with central nervous system lymphoma. American journal of ophthalmology, 2007, Volume: 144, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Carotid Artery, Internal; Catheterization, Peripheral; Cyclophosphamide; Cytarabine; Etoposide; Female; Fluorescein Angiography; Humans; Injections, Spinal; Lymphoma; Male; Mannitol; Methotrexate; Middle Aged; Pigment Epithelium of Eye; Retinal Diseases; Retrospective Studies; Tomography, Optical Coherence; Vertebral Artery	2007
Re: Maculopathy as a complication of blood-brain barrier disruption in patients with central nervous system lymphoma. American journal of ophthalmology, 2007, Volume: 144, Issue:6 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Cytarabine; Etoposide; Fluorescein Angiography; Humans; Injections, Spinal; Lymphoma; Mannitol; Methotrexate; Pigment Epithelium of Eye; Retinal Diseases	2007
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology letters, 2014, Nov-04, Volume: 230, Issue:3 Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Flutamide; Lamivudine; Liver; Male; Mannitol; Metabolomics; Methotrexate; Neomycin; Oxidative Stress; Phenytoin; Piperazines; Propylthiouracil; Rats; Rats, Wistar; Streptomycin; Triazoles; Valproic Acid; Vancomycin; Zidovudine	2014