mannitol has been researched along with indomethacin in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (23.53) | 18.7374 |
| 1990's | 17 (25.00) | 18.2507 |
| 2000's | 18 (26.47) | 29.6817 |
| 2010's | 17 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duffy, EM; Jorgensen, WL | 1 |
| Hwang, KK; Mandagere, AK; Thompson, TN | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Caron, G; Ermondi, G | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Grabner, H; Gruber, F; Kolarz, G; Thumb, N | 1 |
| Beubler, E; Juan, H | 1 |
| Beubler, E | 1 |
| Anderson, FL; Jubiz, W; Terashima, R | 1 |
| Amiel, C; Friedlander, G; Herman, P; Huy, PT | 1 |
| Bertolo, C; Colombo, L; Mussini, E; Zuccato, E | 1 |
| Aiba, T; Kakemi, M; Katayama, K; Koizumi, T; Matsui, R; Morigaki, S; Takahashi, O | 1 |
| Hofheinz, H; Hofmann, WJ; Manner, M; Otto, G | 1 |
| Davies, GR; Rampton, DS | 1 |
| Canfield, P | 1 |
| Barrachina, MD; Cortijo, J; Durá, JM; Martí-Cabrera, M; Morcillo, E; Ortiz, JL | 1 |
| Argenzio, RA; Henrikson, CK; Liacos, JA | 1 |
| Caplan, M; Hess, ML; Lucchesi, B; Romson, JL; Rowe, GT | 1 |
| Hess, ML; Ito, H; Kato, Y; Kohno, H; Okabe, E | 1 |
| Gouyon, JB; Guignard, JP | 1 |
| Bose, R; Lesiuk, H; Sima, AA; Sutherland, G | 1 |
| Erickson, RA | 1 |
| Iwata, H; Ochi, K; Takeuchi, M; Yokoyama, M | 1 |
| Al-Bazzaz, F; Westenfelder, C; Yadava, VP | 1 |
| Amstad, P; Cerutti, P; Emerit, I; Levy, A | 1 |
| Dietrich, WD; Ellis, EF; Kontos, HA; Povlishock, JT; Wei, EP | 1 |
| Bernard, DB; Johnston, PA; Levinsky, NG; Perrin, NS | 1 |
| Barrau Coscuyuela, J; Fernández Garnica, JM; Gómez Alamillo, C; Gómez Sánchez, R; Granda Rodríguez, M; Jaurrieta Ansa, F; Sánchez Casajús, A | 1 |
| Daniel, EE; Kwan, CY; Loke, JC; Low, AM | 1 |
| Alberti, RA; Biestro, AA; Borovich, B; Cancela, M; Puppo, CB; Soca, AE | 1 |
| Davies, GR; Rampton, DS; Wilkie, ME | 1 |
| Choi, VM; Chooi, J; Coates, JE; Russell, AS; Thomson, AB | 1 |
| Ma, TY; Pedram, A | 1 |
| Bergholt, B; Bundgaard, H; Cold, GE; Frederiksen, R; Jensen, K; Pless, S | 1 |
| Bharadwaj, LA; Prasad, K | 1 |
| Colavita, AR; FitzGerald, GA; Ghiselli, A; Iuliano, L; Leo, R; Pignatelli, P; Praticò, D; Pulcinelli, FM; Violi, F | 1 |
| Langenstroer, P; Pieper, GM; Siebeneich, W | 1 |
| Rhoney, DH; Slavik, RS | 1 |
| Fukaya, T; Okatani, Y; Taniguchi, K; Wakatsuki, A; Watanabe, K | 1 |
| Bai, JC; Mauriño, E; Meddings, J; Niveloni, S; Pedreira, S; Smecuol, E; Sugai, E; Vazquez, H | 1 |
| Balint, GA; Galfi, M; Gharzouli, K; Juhasz, A; Rimanoczy, A | 1 |
| Cervinková, Z; Kohout, P; Radvaková, D | 1 |
| König, J; Kunzelmann, K; Markovich, D; Schreiber, R; Sun, J | 1 |
| Alexander, JS; Itoh, M; Joh, T; Oshima, T; Seno, K; Suzuki, H; Takezono, Y; Yokoyama, Y | 1 |
| Constable, PD; Eurell, JA; Freeman, DE; Rötting, AK; Wallig, MA | 1 |
| Okumura, T; Otsuka, M | 1 |
| Coombes, AG; Hanson, PJ; Kavvada, KM; Moore, VA; Murray, JG | 1 |
| Blikslager, AT; Engelke, KJ; Moeser, AJ; Nighot, PK; Ueno, R | 1 |
| Bose, R; Cheng, ZQ; Jacobs, H; Kasian, K; Light, RB; Mink, SN; Santos Martinez, LE | 1 |
| Sun, Y; Tao, J; Yu, L; Zhang, GG | 1 |
| Hirvonen, J; Järvinen, K; Kauppinen, EI; Laaksonen, T; Liu, P; Peltonen, L; Rahikkala, A; Raula, J | 1 |
| Boeckxstaens, G; Farré, R; Holvoet, L; Houben, E; Salim Rasoel, S; Tack, J; Tόth, J; Van Oudenhove, L; van Wanrooy, S; Vanheel, H; Vanormelingen, C; Vanuytsel, T; Verbeke, K; Verschueren, S | 1 |
| Ito, Y; Nagai, N; Okamoto, N; Shimomura, Y | 1 |
| Amharar, Y; Curtin, V; Gallagher, KH; Healy, AM | 1 |
| de Villiers, MM; Derdour, L; Huang, J; Hussain, MA; Qian, F; Yu, L; Zhang, SW | 1 |
| Ji, Y; Paus, R; Prudic, A | 1 |
| Biggart, GD; Clarke, GS; Ewing, AV; Hale, CR; Kazarian, SG | 1 |
| Ebrahimi, A; Langrish, T; Saffari, M | 1 |
| Fujita, K; Hiramatsu, T; Kawashima, Y; Ogawa, N; Okamoto, R; Shibagaki, K; Suzuki, R; Takahashi, C; Yamamoto, H | 1 |
| Korhonen, O; Laitinen, R; Ojarinta, R; Saarinen, J; Strachan, CJ | 1 |
3 review(s) available for mannitol and indomethacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drugs and acute renal insufficiency in the neonate.
Topics: Animals; Anuria; Dopamine; Furosemide; Glomerular Filtration Rate; Humans; Indomethacin; Infant, Newborn; Mannitol; Oliguria; Renal Circulation; Tolazoline | 1986 |
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular Circulation; Clinical Trials as Topic; Combined Modality Therapy; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Hypercapnia; Indomethacin; Infant, Newborn; Infant, Premature; Intracranial Hypertension; Intracranial Pressure; Mannitol; Papio; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Vasoconstrictor Agents | 1999 |
3 trial(s) available for mannitol and indomethacin
| Article | Year |
|---|---|
[Therapy evaluation in rheumatology with an electronic data processing system].
Topics: Anti-Inflammatory Agents; Arthritis; Azathioprine; Clinical Trials as Topic; Computers; Cyclophosphamide; Dexamethasone; Drug Combinations; Drug Evaluation; Electronic Data Processing; Glucocorticoids; Humans; Immunosuppressive Agents; Indomethacin; Mannitol; Nitrogen Mustard Compounds; Oxyphenbutazone; Prednisolone; Procarbazine | 1976 |
Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability.
Topics: Adult; Chromium Radioisotopes; Double-Blind Method; Edetic Acid; Female; Humans; Indomethacin; Intestinal Absorption; Male; Mannitol; Metronidazole; Middle Aged; Misoprostol; Permeability | 1993 |
Effects of perioperative indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients subjected to craniotomy for cerebral tumors.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cerebrovascular Circulation; Craniotomy; Dura Mater; Female; Humans; Hypocapnia; Indomethacin; Injections, Intravenous; Intracranial Pressure; Intraoperative Care; Lactates; Male; Mannitol; Middle Aged; Oxygen; Oxygen Consumption; Placebos; Pseudotumor Cerebri; Supratentorial Neoplasms; Transducers, Pressure | 1996 |
62 other study(ies) available for mannitol and indomethacin
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity | 2002 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Is the effect of diphenolic laxatives mediated via release of prostaglandin E?
Topics: Animals; Bisacodyl; Cathartics; Colon; Cresols; Female; Indomethacin; Mannitol; Perfusion; Phenolphthaleins; Prostaglandins E; Rats | 1978 |
[Prostaglandins and gastrointestinal functions (author's transl)].
Topics: Animals; Colchicine; Digestive System; Double-Blind Method; Humans; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Intestinal Secretions; Intestine, Small; Mannitol; Peptic Ulcer; Phenolphthaleins; Physical Stimulation; Prostaglandins; Prostaglandins E; Prostaglandins E, Synthetic; Rats | 1978 |
Prostaglandin E release in the dog: effect of sodium.
Topics: Animals; Blood Pressure; Dogs; Female; Glucose; Indomethacin; Male; Mannitol; Osmolar Concentration; Pressure; Prostaglandins E; Renal Veins; Sodium; Sodium Chloride | 1976 |
Ion transport by primary cultures of Mongolian gerbil middle ear epithelium.
Topics: Amiloride; Animals; Arginine Vasopressin; Biological Transport; Bradykinin; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Dinoprostone; Ear, Middle; Epithelium; Gerbillinae; Glucagon; Histamine; Indomethacin; Isoproterenol; Male; Mannitol; Microscopy, Electron; Parathyroid Hormone; Sodium | 1992 |
Indomethacin-induced enteropathy: effect of the drug regimen on intestinal permeability in rats.
Topics: Administration, Oral; Animals; Chromatography, Gas; Disease Models, Animal; Indomethacin; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestine, Small; Lactulose; Male; Mannitol; Permeability; Rats; Rats, Sprague-Dawley | 1992 |
Effect of l-menthol on the permeation of indomethacin, mannitol and cortisone through excised hairless mouse skin.
Topics: Administration, Cutaneous; Animals; Chromatography, High Pressure Liquid; Cortisone; In Vitro Techniques; Indomethacin; Mannitol; Menthol; Mice; Permeability; Skin | 1992 |
Questionable role of leukocyte sticking in the pathogenesis of preservation damage.
Topics: Animals; Cell Adhesion; Erythrocytes; Glucose; Iloprost; Indomethacin; Leukocytes; Liver Transplantation; Mannitol; Organ Preservation; Potassium Chloride; Procaine; Swine | 1991 |
The pro-drug sulindac may reduce the risk of intestinal damage associated with the use of conventional non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Edetic Acid; Humans; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestines; Mannitol; Middle Aged; Permeability; Prodrugs; Sulindac; Urea | 1991 |
Characteristics of luminal bicarbonate secretion by rat cecum in vitro.
Topics: Animals; Bicarbonates; Cecum; Hydrogen-Ion Concentration; Hypoxia; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ions; Kinetics; Male; Mannitol; Muscle, Smooth; Rats; Rats, Inbred Strains; Tetrodotoxin | 1991 |
Differential effects of cyclooxygenase inhibitors on the cardiovascular response to hyperosmotic mannitol.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dogs; Female; Hemodynamics; Indomethacin; Infusions, Intravenous; Male; Mannitol; Meclofenamic Acid; Myocardial Contraction; Osmolar Concentration; Rabbits | 1991 |
Effect of prostaglandin inhibitors on bile salt-induced mucosal damage of porcine colon.
Topics: Animals; Body Water; Colon; Deoxycholic Acid; Dinoprostone; Female; Indomethacin; Intestinal Mucosa; Mannitol; Masoprocol; Permeability; Prostaglandin Antagonists; Quinacrine; Swine | 1989 |
Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion.
Topics: Adenosine Triphosphatases; Animals; Butylated Hydroxytoluene; Calcium; Catalase; Dogs; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Ibuprofen; Indomethacin; Leukocytes; Male; Mannitol; Myocardial Infarction; Myocardium; Neutrophils; Sarcoplasmic Reticulum; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1985 |
Inhibition by free radical scavengers and by cyclooxygenase inhibitors of the effect of acidosis on calcium transport by masseter muscle sarcoplasmic reticulum.
Topics: Acidosis; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Cyclooxygenase Inhibitors; Dogs; Free Radicals; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Mannitol; Masseter Muscle; Masticatory Muscles; Propiophenones; Sarcoplasmic Reticulum; Superoxide Dismutase; Superoxides | 1985 |
Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Drug Combinations; Indomethacin; Male; Mannitol; Nimodipine; Rats; Rats, Inbred Strains | 1988 |
Effect of 16,16-dimethyl PGE2 and indomethacin on bile acid-induced intestinal injury and restitution in rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Body Water; Chenodeoxycholic Acid; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Male; Mannitol; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains | 1988 |
Pharmacological enhancement of recovery in experimental hydronephrosis.
Topics: Animals; Captopril; Furosemide; Hydronephrosis; Indomethacin; Inosine; Kidney; Kidney Cortex; Kidney Medulla; Male; Mannitol; Methylprednisolone; Rats; Rats, Inbred Strains | 1985 |
Modification of Na and Cl transport in canine tracheal mucosa by prostaglandins.
Topics: Animals; Biological Transport, Active; Chlorides; Cyclic AMP; Dogs; In Vitro Techniques; Indomethacin; Mannitol; Mucous Membrane; Prostaglandins E; Prostaglandins F; Sodium; Trachea | 1981 |
Evidence for membrane-mediated chromosomal damage by aflatoxin B1 in human lymphocytes.
Topics: Aflatoxin B1; Aflatoxins; Antioxidants; Arachidonic Acids; Carcinogens; Catechols; Cell Membrane; Chromosome Aberrations; Crossing Over, Genetic; Flufenamic Acid; Humans; Indomethacin; Lymphocytes; Mannitol; Masoprocol; Sister Chromatid Exchange | 1984 |
Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats.
Topics: Animals; Arterioles; Blood Pressure; Brain Injuries; Cats; Free Radicals; Indomethacin; Mannitol; Nitroblue Tetrazolium; Oxygenases; Pia Mater; Prostaglandins; Superoxide Dismutase | 1981 |
Prostaglandins mediate the vasodilatory effect of mannitol in the hypoperfused rat kidney.
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Epoprostenol; Indomethacin; Kidney; Male; Mannitol; Meclofenamic Acid; Prostaglandins; Rats; Vasodilation | 1981 |
[Hyposaline and mannitol loading tests in the physiopathology of Bartter's syndrome].
Topics: Adult; Bartter Syndrome; Humans; Hyperaldosteronism; Indomethacin; Kidney Tubules; Male; Mannitol; Middle Aged; Prostaglandin Antagonists; Sodium Chloride | 1982 |
Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Calcium; Guinea Pigs; Hypertonic Solutions; In Vitro Techniques; Indomethacin; Isoquinolines; Male; Mannitol; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nicardipine; Phentolamine; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar | 1994 |
Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report.
Topics: Adolescent; Adult; Blood Pressure; Body Temperature; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Child; Cyclooxygenase Inhibitors; Female; Glasgow Coma Scale; Humans; Hyperventilation; Indomethacin; Infusions, Intravenous; Injections, Intravenous; Intracranial Pressure; Male; Mannitol; Pseudotumor Cerebri; Rectum; Subarachnoid Hemorrhage; Thiopental | 1995 |
Small bowel permeability--a variable effect of NSAIDS.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromium Radioisotopes; Diclofenac; Edetic Acid; Female; Humans; Indomethacin; Intestinal Absorption; Intestine, Small; Male; Mannitol; Middle Aged; Permeability; Piroxicam | 1995 |
16,16-Dimethyl Prostaglandin E2 modulation of endothelial monolayer paracellular barrier function.
Topics: 16,16-Dimethylprostaglandin E2; Actins; Animals; Aorta; Cattle; Cell Membrane Permeability; Cyclic AMP; Cyclooxygenase Inhibitors; Cytochalasin B; Dose-Response Relationship, Drug; Endothelium, Vascular; Fluorescent Dyes; Indomethacin; Mannitol | 1996 |
Mechanism of hydroxyl radical-induced modulation of vascular tone.
Topics: Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hydroxyl Radical; Indomethacin; Mannitol; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Rabbits | 1997 |
Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated.
Topics: Acridines; Aerobiosis; Aspirin; Benzoates; Blood Platelets; Catalase; Cell Hypoxia; Deoxyribose; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro Techniques; Indomethacin; L-Lactate Dehydrogenase; Mannitol; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Superoxide Dismutase; Superoxides | 1997 |
Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Catalase; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diuretics, Osmotic; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxyl Radical; In Vitro Techniques; Indomethacin; Male; Mannitol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Norepinephrine; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Sulfonamides; Superoxide Dismutase; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Melatonin suppresses lysophosphatidylcholine enhancement of serotonin-induced vasoconstriction in the human umbilical artery.
Topics: Adult; Dose-Response Relationship, Drug; Drug Synergism; Female; Free Radical Scavengers; Humans; Indomethacin; Lysophosphatidylcholines; Mannitol; Melatonin; Muscle, Smooth, Vascular; omega-N-Methylarginine; Pregnancy; Serotonin; Umbilical Arteries; Vasoconstriction | 2000 |
Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, High Pressure Liquid; Confidence Intervals; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Female; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Lactulose; Male; Mannitol; Meloxicam; Middle Aged; Naproxen; Permeability; Pyrazoles; Statistics, Nonparametric; Sucrose; Sulfonamides; Thiazines; Thiazoles | 2001 |
The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat.
Topics: Animals; Epoprostenol; Female; Gastric Mucosa; Honey; Indomethacin; Mannitol; Osmolar Concentration; Rats; Rats, Wistar; Stomach Ulcer | 2001 |
Liver response to indomethacin-induced intestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Intestinal Absorption; Intestine, Small; Lactulose; Liver; Liver Function Tests; Male; Mannitol; Permeability; Rats; Rats, Wistar | 2002 |
Effects of purinergic stimulation, CFTR and osmotic stress on amiloride-sensitive Na+ transport in epithelia and Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Female; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Channel Gating; Ion Transport; Mannitol; Membrane Potentials; Mice; Oocytes; Osmotic Pressure; Purines; Receptors, Purinergic; Respiratory Mucosa; Sodium; Sodium Chloride; Trachea; Uridine Triphosphate; Xenopus laevis | 2003 |
Role of prostaglandins in maintaining gastric mucus-cell permeability against acid exposure.
Topics: Animals; Cell Line; Cell Membrane Permeability; Diffusion; Dinoprostone; Drug Combinations; Electrophysiology; Epithelial Cells; Gastric Mucosa; Hydrochloric Acid; Hydrogen-Ion Concentration; Indomethacin; Mannitol; Prostaglandins; Rats | 2004 |
Effects of phenylbutazone, indomethacin, prostaglandin E2, butyrate, and glutamine on restitution of oxidant-injured right dorsal colon of horses in vitro.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weights and Measures; Butyrates; Colon; Dinoprostone; Glutamine; Histological Techniques; Horses; Hypochlorous Acid; Indomethacin; Intestinal Mucosa; Mannitol; Permeability; Phenylbutazone; Time Factors; Wound Healing | 2004 |
Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calibration; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Indomethacin; Mannitol; Models, Statistical; Reference Standards; Spectrum Analysis, Raman; Tablets; X-Ray Diffraction | 2005 |
High permeability of the anionic form restricts accumulation of indomethacin by cultured gastric surface epithelial cells exposed to low apical pH.
Topics: Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells; Gastric Mucosa; Guinea Pigs; Hydrogen-Ion Concentration; Indomethacin; Intracellular Fluid; Mannitol | 2006 |
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.
Topics: Alprostadil; Animals; Bumetanide; Chloride Channel Agonists; Chloride Channels; Chlorides; CLC-2 Chloride Channels; Colon; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprostone; Electric Impedance; Electrophysiology; Fatty Acids; Female; Ileum; Indomethacin; Intestinal Mucosa; Ischemia; Lubiprostone; Male; Mannitol; Membrane Proteins; Occludin; Permeability; Recovery of Function; Sus scrofa; Urea; Zinc Compounds | 2007 |
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Free Radical Scavengers; Guanylate Cyclase; Humans; Hydrogen Peroxide; Hydroquinones; In Vitro Techniques; Indomethacin; Mannitol; Mesenteric Artery, Superior; Methylene Blue; Muramidase; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Prostaglandins; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sepsis; Signal Transduction; Soluble Guanylyl Cyclase; Thionucleotides; Time Factors; Vasoconstrictor Agents; Vasodilation | 2008 |
Solubility of small-molecule crystals in polymers: D-mannitol in PVP, indomethacin in PVP/VA, and nifedipine in PVP/VA.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Indomethacin; Kinetics; Mannitol; Nifedipine; Povidone; Pyrrolidines; Reproducibility of Results; Solubility; Solvents; Technology, Pharmaceutical; Transition Temperature; Vinyl Compounds; Viscosity | 2009 |
Intact nanoparticulate indomethacin in fast-dissolving carrier particles by combined wet milling and aerosol flow reactor methods.
Topics: Aerosols; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Carriers; Excipients; Indomethacin; Leucine; Mannitol; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Powders; Solubility; Technology, Pharmaceutical; X-Ray Diffraction | 2011 |
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism.
Topics: Corticotropin-Releasing Hormone; Cromolyn Sodium; Electroshock; Female; Humans; Hydrocortisone; Indomethacin; Intestine, Small; Lactulose; Male; Mannitol; Mast Cells; Permeability; Saliva; Speech; Stress, Psychological; Young Adult | 2014 |
A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Load; Benzalkonium Compounds; beta-Cyclodextrins; Cell Line; Cornea; Escherichia coli; Humans; Indomethacin; Male; Mannitol; Methylcellulose; Nanoparticles; Ophthalmic Solutions; Permeability; Rats; Rats, Wistar; Wound Healing; Zirconium | 2014 |
Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation.
Topics: Adipates; Chemistry, Pharmaceutical; Crystallization; Excipients; Glass; Glutarates; Indomethacin; Mannitol; Molecular Weight; Povidone; Solubility; Sulfamethazine; Thermodynamics; Transition Temperature | 2014 |
A method to evaluate the effect of contact with excipients on the surface crystallization of amorphous drugs.
Topics: Cellulose; Chemistry, Pharmaceutical; Crystallization; Excipients; Humidity; Indomethacin; Kinetics; Lactose; Mannitol; Nifedipine; Stearic Acids; Surface Properties; Tablets; Technology, Pharmaceutical; Water | 2014 |
Influence of excipients on solubility and dissolution of pharmaceuticals.
Topics: Chemistry, Pharmaceutical; Diffusion; Excipients; Indomethacin; Kinetics; Mannitol; Models, Chemical; Models, Statistical; Naproxen; Polyethylene Glycols; Povidone; Solubility; Technology, Pharmaceutical; Viscosity; Water | 2015 |
Comparison of pharmaceutical formulations: ATR-FTIR spectroscopic imaging to study drug-carrier interactions.
Topics: Chemistry, Pharmaceutical; Drug Carriers; Drug Liberation; Indomethacin; Mannitol; Niacinamide; Spectroscopy, Fourier Transform Infrared; Urea | 2015 |
A novel formulation for solubility and content uniformity enhancement of poorly water-soluble drugs using highly-porous mannitol.
Topics: Adsorption; Chemistry, Pharmaceutical; Drug Liberation; Excipients; Indomethacin; Mannitol; Nifedipine; Porosity; Solubility | 2016 |
Improvement in the water solubility of drugs with a solid dispersion system by spray drying and hot-melt extrusion with using the amphiphilic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and d-mannitol.
Topics: Computer Simulation; Drug Liberation; Drug Stability; Indomethacin; Mannitol; Microscopy, Electron, Scanning; Models, Chemical; Polyethylene Glycols; Polyvinyls; Solubility; Spectroscopy, Fourier Transform Infrared | 2018 |
Preparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methods.
Topics: Administration, Oral; Arginine; Chemistry, Pharmaceutical; Drug Combinations; Drug Stability; Excipients; Ibuprofen; Indomethacin; Mannitol; Optical Imaging; Povidone; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Technology, Pharmaceutical; X-Ray Diffraction; Xylitol | 2018 |