Page last updated: 2024-08-17

mannitol and acetaminophen

mannitol has been researched along with acetaminophen in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.14)18.7374
1990's4 (9.52)18.2507
2000's13 (30.95)29.6817
2010's18 (42.86)24.3611
2020's4 (9.52)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Faassen, F; Spanings, H; Vogel, G; Vromans, H1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Farber, JL; Kyle, ME; Miccadei, S; Nakae, D1
Wright, RC1
Fukuse, G; Hikichi, N; Niwa, H; Sakurai, E; Ueda, M1
Lundgren, J; Siesjö, BK; Smith, ML; Uchino, H1
Marks, GJ; Ryan, FM; Smith, PL; Swaan, PW1
Harrison, PM; Keays, R; Wendon, JA; Williams, R1
Bernal, W; Wendon, J1
Abdelbary, G; Eouani, C; Joachim, J; Piccerelle, P; Prinderre, P; Reynier, JP1
Bhatti, A; Gok, MA; Gupta, A; Olschewski, P; Robertson, H; Shenton, BK; Soomro, N; Talbot, D1
Bruce, R; Johnson, MC; Li, W; Rasmussen, H; Ulrich, S; Worosila, GD1
Kaukonen, AM; Laitinen, L; Marvola, M; Takala, E; Vuorela, H; Vuorela, P1
Chen, Y; Cheng, D; Huebert, N; Oulianova, N1
Gonnissen, Y; Remon, JP; Vervaet, C1
Gonçalves, SI; Gonnissen, Y; Remon, JP; Vervaet, C1
Ito, A; Machida, Y; Yamamoto, K1
Fujinami, Y; Itai, S; Iwao, Y; Kajihara, R; Miura, K; Noguchi, S; Suzuki, Y; Terada, Y; Uesugi, K1
Alles, R; Atria, S; Gane, PA; Huwyler, J; Puchkov, M; Schoelkopf, J; Stirnimann, T1
Bailey, M; Bellomo, R; Chiam, E; McNicol, L; Weinberg, L1
De Beer, T; Gomes, P; Monteyne, T; Peeters, E; Remon, JP; Van Bockstal, PJ; Van Snick, B; Vanhoorne, V; Vervaet, C1
Açıksarı, K; Ayvacı, BM; Çelikmen, DM; Çelikmen, MF; Doğan, H; Kandemir, A; Özaşır Abuşka, D; Özüçelik, DN; Sadıllıoğlu, S; Sarıkaya, S; Sever, MŞ; Yazıcıoğlu, M1
Nair, A1
Abrahmsén-Alami, S; Ervasti, T; Folestad, S; Fransson, M; Karttunen, AP; Ketolainen, J; Korhonen, O; Lakio, S; Tajarobi, P; Wikström, H1
Dondorp, AM; Plewes, K; Turner, GDH1
Lorenz, C; Mortellaro, M; Sandoval, W1
Bellucci, MA; Chen, X; Myerson, AS; Stojaković, J; Trout, BL; Wijethunga, TK1
Abrahmsén-Alami, S; Folestad, S; Fransson, M; Karttunen, AP; Ketolainen, J; Korhonen, O; Marucci, M; Sparén, A; Tajarobi, P; Wikström, H1
Cvijić, S; Grujić, B; Ibrić, S; Krkobabić, M; Medarević, D1
Almey, R; De Beer, T; Vanhoorne, V; Vervaet, C1
De Beer, T; Vanbillemont, B1
Cendejas Hernandez, J; Jones, JP; Konsoula, Z; Parker, W; Poulton, J; Smith, C; Suda, N1
Breitkreutz, J; Kokott, M; Lura, A; Wiedey, R1

Reviews

3 review(s) available for mannitol and acetaminophen

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Acute liver failure; clinical features and management.
    European journal of gastroenterology & hepatology, 1999, Volume: 11, Issue:9

    Topics: Acetaminophen; Brain Edema; Diuretics, Osmotic; Hepatitis, Viral, Human; Humans; Liver Failure, Acute; Liver Transplantation; Mannitol; Renal Insufficiency; Renal Replacement Therapy; Survival Analysis

1999
Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria.
    Current opinion in infectious diseases, 2018, Volume: 31, Issue:1

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Coma; Dexamethasone; Disease Models, Animal; Humans; Kidney; Malaria, Falciparum; Mannitol; Oxidative Stress; Treatment Outcome

2018

Trials

1 trial(s) available for mannitol and acetaminophen

ArticleYear
The haemodynamic effects of intravenous paracetamol (acetaminophen) in healthy volunteers: a double-blind, randomized, triple crossover trial.
    British journal of clinical pharmacology, 2016, Volume: 81, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Pressure; Cross-Over Studies; Double-Blind Method; Excipients; Female; Healthy Volunteers; Hemodynamics; Humans; Hypotension; Infusions, Intravenous; Male; Mannitol

2016

Other Studies

38 other study(ies) available for mannitol and acetaminophen

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
    International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport

2003
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen.
    Biochemical and biophysical research communications, 1987, Dec-31, Volume: 149, Issue:3

    Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Carmustine; Catalase; Chlorides; Deferoxamine; Drug Resistance; Ferric Compounds; Ferrous Compounds; Free Radicals; Liver; Male; Mannitol; Methylcholanthrene; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Superoxide Dismutase

1987
A simple plan for the management of drug overdosage.
    Anaesthesia and intensive care, 1974, Volume: 2, Issue:4

    Topics: Absorption; Acetaminophen; Antidepressive Agents; Barbiturates; Body Fluids; Charcoal; Coma; Female; Gastric Lavage; Glutethimide; Humans; Hypotension; Hypothermia; Intubation, Intratracheal; Larynx; Male; Mannitol; Middle Aged; Oxygen Inhalation Therapy; Patient Care Planning; Peptic Ulcer; Poisoning; Positive-Pressure Respiration; Respiratory Tract Diseases; Stress, Physiological

1974
[Effects of maltitol or mannitol on gastrointestinal absorption of drugs (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1980, Volume: 100, Issue:11

    Topics: Acetaminophen; Animals; Depression, Chemical; Gastrointestinal Motility; Intestinal Absorption; Male; Maltose; Mannitol; Mice; Pharmaceutical Preparations; Sugar Alcohols

1980
Preischemic hyperglycemia leads to delayed postischemic hyperthermia.
    Stroke, 1994, Volume: 25, Issue:9

    Topics: Acetaminophen; Animals; Body Temperature Regulation; Brain Ischemia; Fever; Glucose; Hypercapnia; Hyperglycemia; Infusions, Intravenous; Male; Mannitol; Prosencephalon; Rats; Rats, Wistar; Seizures; Time Factors

1994
Determination of transport rates for arginine and acetaminophen in rabbit intestinal tissues in vitro.
    Pharmaceutical research, 1994, Volume: 11, Issue:2

    Topics: Acetaminophen; Animals; Arginine; Biological Availability; Biological Transport; Colon; Epithelium; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kinetics; Mannitol; Rabbits

1994
Cerebral blood flow and metabolism in fulminant liver failure.
    Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Adult; Blood Flow Velocity; Brain; Brain Edema; Drug Overdose; Epoprostenol; Female; Glucose; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Lactates; Male; Mannitol; Middle Aged; Oxygen; Regional Blood Flow; Respiration, Artificial

1994
The preparation of orally disintegrating tablets using a hydrophilic waxy binder.
    International journal of pharmaceutics, 2004, Jul-08, Volume: 278, Issue:2

    Topics: Acetaminophen; Administration, Oral; Compressive Strength; Excipients; Feasibility Studies; Hardness; Mannitol; Particle Size; Polyethylene Glycols; Solubility; Surface Properties; Tablets; Technology, Pharmaceutical

2004
Renal transplants from non-heart beating paracetamol overdose donors.
    Clinical transplantation, 2004, Volume: 18, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Edema; Cryopreservation; Diuretics, Osmotic; Drug Overdose; Female; Graft Survival; Heart Arrest; Hepatic Encephalopathy; Humans; Kidney Transplantation; Male; Mannitol; Organ Preservation; Tissue Donors

2004
Mass-balanced blend uniformity analysis of pharmaceutical powders by at-line near-infrared spectroscopy with a fiber-optic probe.
    International journal of pharmaceutics, 2006, Dec-01, Volume: 326, Issue:1-2

    Topics: Acetaminophen; Calibration; Cellulose; Chemistry, Pharmaceutical; Drug Compounding; Fiber Optic Technology; Mannitol; Optical Fibers; Particle Size; Pharmaceutical Preparations; Powders; Spectroscopy, Near-Infrared; Stearic Acids; Technology, Pharmaceutical; Time Factors

2006
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2007, Volume: 66, Issue:1

    Topics: Absorption; Acetaminophen; Anthraquinones; Beverages; Caco-2 Cells; Carbon Radioisotopes; Cathartics; Cell Membrane Permeability; Digoxin; Furosemide; Humans; Ketoprofen; Mannitol; Plant Leaves; Propranolol; Senna Extract; Sennosides; Verapamil

2007
Human oral drugs absorption is correlated to their in vitro uptake by brush border membrane vesicles.
    International journal of pharmaceutics, 2007, May-04, Volume: 336, Issue:1

    Topics: Acetaminophen; Administration, Oral; Animals; Azlocillin; Biological Transport, Active; Cefadroxil; Doxorubicin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lamivudine; Mannitol; Osmolar Concentration; Ouabain; Pharmaceutical Preparations; Pharmacokinetics; Phenolsulfonphthalein; Rabbits; Zidovudine

2007
Development of directly compressible powders via co-spray drying.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2007, Volume: 67, Issue:1

    Topics: Acetaminophen; Carbohydrates; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Desiccation; Erythritol; Excipients; Mannitol; Microscopy, Electron, Scanning; Particle Size; Polysaccharides; Porosity; Powders; X-Ray Diffraction

2007
Mixture design applied to optimize a directly compressible powder produced via cospray drying.
    Drug development and industrial pharmacy, 2008, Volume: 34, Issue:3

    Topics: Acetaminophen; Chemistry, Pharmaceutical; Erythritol; Excipients; Mannitol; Models, Chemical; Particle Size; Polysaccharides; Powders; Tablets; Technology, Pharmaceutical; Tensile Strength; Wettability

2008
Preparation and evaluation of medicinal carbon tablets with different saccharides as binders.
    Chemical & pharmaceutical bulletin, 2009, Volume: 57, Issue:10

    Topics: Acetaminophen; Adsorption; Analgesics, Non-Narcotic; Carbon; Drug Compounding; Maltose; Mannitol; Sorbitol; Sugar Alcohols; Tablets; Xylitol

2009
Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation.
    International journal of pharmaceutics, 2013, Mar-10, Volume: 445, Issue:1-2

    Topics: Acetaminophen; Bromhexine; Calcium Phosphates; Cellulose; Drug Compounding; Excipients; Glycerides; Mannitol; Methacrylates; Microscopy, Electron, Scanning; Particle Size; Pyridones; Synchrotrons; Talc; Waxes; X-Ray Microtomography; X-Rays

2013
Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface.
    International journal of pharmaceutics, 2014, May-15, Volume: 466, Issue:1-2

    Topics: Acetaminophen; Calcium Carbonate; Cellulose; Crystallization; Excipients; Mannitol; Porosity; Surface Properties; Tablets; Tensile Strength

2014
Continuous manufacturing of delta mannitol by cospray drying with PVP.
    International journal of pharmaceutics, 2016, Mar-30, Volume: 501, Issue:1-2

    Topics: Acetaminophen; Desiccation; Drug Compounding; Mannitol; Povidone; Tablets; Tensile Strength

2016
Effects of acetaminophen and mannitol on crush injuries in rats: An experimental study.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2016, Volume: 22, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Crush Syndrome; Disease Models, Animal; Diuretics, Osmotic; Kidney; Male; Mannitol; Rats; Rats, Sprague-Dawley

2016
Does mannitol contribute to hypotension after parenteral paracetamol administration in critical care?
    Anaesthesia, 2017, Volume: 72, Issue:1

    Topics: Acetaminophen; Critical Care; Critical Illness; Hemodynamics; Humans; Hypotension; Mannitol

2017
Provoking an end-to-end continuous direct compression line with raw materials prone to segregation.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Nov-15, Volume: 109

    Topics: Acetaminophen; Cellulose; Drug Compounding; Fumarates; Mannitol; Particle Size; Powders; Pressure; Stearates; Tablets; Tensile Strength

2017
Interference Assessment of Various Endogenous and Exogenous Substances on the Performance of the Eversense Long-Term Implantable Continuous Glucose Monitoring System.
    Diabetes technology & therapeutics, 2018, Volume: 20, Issue:5

    Topics: Acetaminophen; Ascorbic Acid; Biosensing Techniques; Blood Glucose; Blood Glucose Self-Monitoring; Humans; Mannitol; Tetracycline

2018
General Method for the Identification of Crystal Faces Using Raman Spectroscopy Combined with Machine Learning and Application to the Epitaxial Growth of Acetaminophen.
    Langmuir : the ACS journal of surfaces and colloids, 2018, 08-21, Volume: 34, Issue:33

    Topics: Acetaminophen; Algorithms; Crystallization; Crystallography, X-Ray; Galactose; Machine Learning; Mannitol; Spectrum Analysis, Raman; X-Ray Diffraction; Xylitol

2018
Comparison between integrated continuous direct compression line and batch processing - The effect of raw material properties.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, May-15, Volume: 133

    Topics: Acetaminophen; Cellulose; Excipients; Mannitol; Particle Size; Powders; Technology, Pharmaceutical

2019
Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate.
    International journal of pharmaceutics, 2019, Dec-15, Volume: 572

    Topics: Acetaminophen; Delayed-Action Preparations; Drug Compounding; Drug Liberation; Excipients; Hardness; Hydrophobic and Hydrophilic Interactions; Kinetics; Light; Mannitol; Phosphines; Polyethylene Glycols; Polymerization; Printing, Three-Dimensional; Sodium Chloride; Solubility; Tablets; Technology, Pharmaceutical; Tensile Strength

2019
Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation.
    International journal of pharmaceutics, 2020, Jun-15, Volume: 583

    Topics: Acetaminophen; Drug Compounding; Drug Stability; Excipients; Mannitol; Particle Size; Surface Properties; Tablets; Technology, Pharmaceutical; Temperature; Time Factors; Water

2020
Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally disintegrating tablets.
    International journal of pharmaceutics, 2020, Oct-15, Volume: 588

    Topics: Acetaminophen; Administration, Oral; Drug Compounding; Excipients; Freeze Drying; Hydrochlorothiazide; Mannitol; Polysaccharides, Bacterial; Polyvinyl Alcohol; Polyvinyls; Solubility; Tablets; Viscosity

2020
Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats.
    PloS one, 2021, Volume: 16, Issue:6

    Topics: Acetaminophen; Animals; Animals, Newborn; Behavior, Animal; Cysteine; Female; Male; Mannitol; Neurogenesis; Rats; Rats, Sprague-Dawley

2021
Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and mini-tablets.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2021, Volume: 168

    Topics: Acetaminophen; Chemistry, Pharmaceutical; Drug Compounding; Enalapril; Excipients; Ibuprofen; Mannitol; Tablets; Tensile Strength

2021