mannich-bases and salicylamide

mannich-bases has been researched along with salicylamide* in 2 studies

Reviews

1 review(s) available for mannich-bases and salicylamide

Article	Year
Some Brief Notes on Theoretical and Experimental Investigations of Intramolecular Hydrogen Bonding. Molecules (Basel, Switzerland), 2016, Dec-02, Volume: 21, Issue:12 A review of selected literature data related to intramolecular hydrogen bonding in Topics: Acetophenones; Amides; Hydrogen Bonding; Ketones; Magnetic Resonance Spectroscopy; Mannich Bases; Protons; Pyridoxal; Quantum Theory; Salicylamides; Schiff Bases	2016

Article

Year

Some Brief Notes on Theoretical and Experimental Investigations of Intramolecular Hydrogen Bonding.

Molecules (Basel, Switzerland), 2016, Dec-02, Volume: 21, Issue:12

A review of selected literature data related to intramolecular hydrogen bonding in

Topics: Acetophenones; Amides; Hydrogen Bonding; Ketones; Magnetic Resonance Spectroscopy; Mannich Bases; Protons; Pyridoxal; Quantum Theory; Salicylamides; Schiff Bases

2016

Other Studies

1 other study(ies) available for mannich-bases and salicylamide

Article	Year
Poly (ethylene glycol) prodrug for anthracyclines via N-Mannich base linker: design, synthesis and biological evaluation. International journal of pharmaceutics, 2009, Sep-08, Volume: 379, Issue:1 Poly (ethylene glycol)s (PEGs) are potential drug carriers for improving the therapeutic index of anticancer agents. In this work, a novel methodology for constructing PEG prodrug of anthracycline anticancer drugs was developed based on N-Mannich base of salicylamide and its 2-acyloxymethylated derivative. The resultant conjugates first subjected to in vitro hydrolysis testing, which revealed the release behavior of newly synthesized PEG prodrugs could be adjusted by the status of 2-hydroxy group of salicylamide. These PEG prodrugs also demonstrated superior cytotoxicity in antiproliferative assay. O-blocked doxorubicin prodrug with PEG20k as carrier was selected for further in vivo assessments and presented longer circulating life in pharmacokinetic experiment. This high molecular prodrug was also found to be more efficacious against S-180 xenografted tumor than equivalent amount of doxorubicin. Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Cell Proliferation; Doxorubicin; Drug Carriers; Humans; Hydrolysis; Male; Mannich Bases; Mice; Mice, Inbred ICR; Polyethylene Glycols; Prodrugs; Salicylamides; Xenograft Model Antitumor Assays	2009

Article

Year

Poly (ethylene glycol) prodrug for anthracyclines via N-Mannich base linker: design, synthesis and biological evaluation.

International journal of pharmaceutics, 2009, Sep-08, Volume: 379, Issue:1

Poly (ethylene glycol)s (PEGs) are potential drug carriers for improving the therapeutic index of anticancer agents. In this work, a novel methodology for constructing PEG prodrug of anthracycline anticancer drugs was developed based on N-Mannich base of salicylamide and its 2-acyloxymethylated derivative. The resultant conjugates first subjected to in vitro hydrolysis testing, which revealed the release behavior of newly synthesized PEG prodrugs could be adjusted by the status of 2-hydroxy group of salicylamide. These PEG prodrugs also demonstrated superior cytotoxicity in antiproliferative assay. O-blocked doxorubicin prodrug with PEG20k as carrier was selected for further in vivo assessments and presented longer circulating life in pharmacokinetic experiment. This high molecular prodrug was also found to be more efficacious against S-180 xenografted tumor than equivalent amount of doxorubicin.

Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Cell Proliferation; Doxorubicin; Drug Carriers; Humans; Hydrolysis; Male; Mannich Bases; Mice; Mice, Inbred ICR; Polyethylene Glycols; Prodrugs; Salicylamides; Xenograft Model Antitumor Assays

2009