mannich-bases and magnolol

mannich-bases has been researched along with magnolol* in 1 studies

Other Studies

1 other study(ies) available for mannich-bases and magnolol

Article	Year
Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy. European journal of medicinal chemistry, 2020, Nov-01, Volume: 205 Magnolol, a natural bioactive neolignan, was found in the bark of a traditional Chinese medicine Magnoliae officinalis ("Hou Po" in Chinese). In this study, thrity-two magnolol-based Mannich base derivatives 3a-p and 4a-p were synthesized, and evaluated for their anti-proliferative activities against a panel of human tumor cell lines (T47D, MCF-7, Hela and A549). Among all derivatives, compound 3p displayed the most potent antiproliferative activity against T47D, MCF-7 and Hela cell lines with IC Topics: Antineoplastic Agents; Autophagy; Biphenyl Compounds; Cell Line, Tumor; Chemistry Techniques, Synthetic; Humans; Lignans; Mannich Bases; Structure-Activity Relationship	2020

Article

Year

Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy.

European journal of medicinal chemistry, 2020, Nov-01, Volume: 205

Magnolol, a natural bioactive neolignan, was found in the bark of a traditional Chinese medicine Magnoliae officinalis ("Hou Po" in Chinese). In this study, thrity-two magnolol-based Mannich base derivatives 3a-p and 4a-p were synthesized, and evaluated for their anti-proliferative activities against a panel of human tumor cell lines (T47D, MCF-7, Hela and A549). Among all derivatives, compound 3p displayed the most potent antiproliferative activity against T47D, MCF-7 and Hela cell lines with IC

Topics: Antineoplastic Agents; Autophagy; Biphenyl Compounds; Cell Line, Tumor; Chemistry Techniques, Synthetic; Humans; Lignans; Mannich Bases; Structure-Activity Relationship

2020