mannich-bases and indole

The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production.

Topics: Adult; Animals; Cattle; Cell Line; Cell Proliferation; Cytokines; Humans; Immunity, Cellular; Immunologic Factors; Indoles; Mannich Bases; Nitric Oxide; Reactive Oxygen Species; T-Lymphocytes