mannich-bases and imidazole

3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

Topics: Antifungal Agents; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Imidazoles; Mannich Bases; Mass Spectrometry; Microbial Sensitivity Tests; Mitosporic Fungi; Oxadiazoles; Staphylococcus; Structure-Activity Relationship