mannich-bases and ibacitabine

mannich-bases has been researched along with ibacitabine* in 1 studies

Other Studies

1 other study(ies) available for mannich-bases and ibacitabine

Article	Year
N-Mannich-base prodrugs of 5-iodo-2'-deoxycytidine as topical delivery enhancers. Pharmaceutical research, 1987, Volume: 4, Issue:4 Two Mannich-base prodrugs of 5-iodo-2'-deoxycytidine (5-IDC) have been synthesized. The prodrugs exhibit increased lipid solubility compared to 5-IDC and rapidly revert to 5-IDC in buffer. One of the prodrugs delivered about twice as much 5-IDC from isopropyl myristate (IPM) through hairless mouse skin in diffusion-cell experiments as did 5-IDC from IPM. Subsequent applications of theophylline/propylene glycol onto the diffusion cells to determine the effect of prodrug/IPM, 5-IDC/IPM, or IPM on the resistance of the skins to subsequent applications showed that the prodrug/IPM had no more effect than IPM itself. Topics: Administration, Topical; Amines; Animals; Antiviral Agents; Bromodeoxycytidine; Deoxycytidine; Diffusion; Half-Life; Mannich Bases; Mice; Mice, Hairless; Prodrugs; Solubility	1987

Article

Year

N-Mannich-base prodrugs of 5-iodo-2'-deoxycytidine as topical delivery enhancers.

Pharmaceutical research, 1987, Volume: 4, Issue:4

Two Mannich-base prodrugs of 5-iodo-2'-deoxycytidine (5-IDC) have been synthesized. The prodrugs exhibit increased lipid solubility compared to 5-IDC and rapidly revert to 5-IDC in buffer. One of the prodrugs delivered about twice as much 5-IDC from isopropyl myristate (IPM) through hairless mouse skin in diffusion-cell experiments as did 5-IDC from IPM. Subsequent applications of theophylline/propylene glycol onto the diffusion cells to determine the effect of prodrug/IPM, 5-IDC/IPM, or IPM on the resistance of the skins to subsequent applications showed that the prodrug/IPM had no more effect than IPM itself.

Topics: Administration, Topical; Amines; Animals; Antiviral Agents; Bromodeoxycytidine; Deoxycytidine; Diffusion; Half-Life; Mannich Bases; Mice; Mice, Hairless; Prodrugs; Solubility

1987