mannich-bases has been researched along with benzimidazole* in 2 studies
2 other study(ies) available for mannich-bases and benzimidazole
| Article | Year |
|---|---|
Mannich-Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study.
Topics: Acetylcholinesterase; Animals; Antioxidants; Ascorbic Acid; Benzimidazoles; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Ferrous Compounds; Horses; Mannich Bases; Molecular Docking Simulation; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Structure-Activity Relationship | 2017 |
Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.
Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium. Topics: Acetic Acid; Analgesics; Animals; Benzimidazoles; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Hyperkinesis; Inflammation; Male; Mannich Bases; Mice; Pain; Structure-Activity Relationship | 2015 |