mannich-bases and allyl-alcohol

A novel tandem aziridination/rearrangement reaction of allylic alcohols has been discovered, in which the significant accelerating effect of silica gel has been identified. On the basis of this methodology, an efficient and highly stereoselective approach to various 2-quaternary Mannich bases has been put in place, readily providing an alternative route to the conventional vicinal amino-functionalization of alkenes.

Topics: Aziridines; Crystallography, X-Ray; Mannich Bases; Models, Molecular; Molecular Structure; Propanols