mannich-bases has been researched along with acetonitrile* in 2 studies
2 other study(ies) available for mannich-bases and acetonitrile
| Article | Year |
|---|---|
Protease-catalysed direct asymmetric Mannich reaction in organic solvent.
We reported the first enzyme-catalysed, direct, three-component asymmetric Mannich reaction using protease type XIV from Streptomyces griseus (SGP) in acetonitrile. Yields of up to 92% with enantioselectivities of up to 88% e.e. and diastereoselectivities of up to 92:8 (syn:anti) were achieved under the optimised conditions. This enzyme's catalytic promiscuity expands the application of this biocatalyst and provides a potential alternative method for asymmetric Mannich reactions. Topics: Acetonitriles; Catalysis; Mannich Bases; Molecular Structure; Pronase; Solvents; Stereoisomerism; Streptomyces griseus; Substrate Specificity | 2012 |
SnCl4 · 5H2O-catalyzed synthesis of β-amino carbonyl compounds via a direct Mannich-type reaction.
An efficient three-component, one-pot synthesis of β-amino carbonyl compounds from aromatic ketones, aromatic aldehydes, and aromatic amines using tin tetrachloride at room temperature in ethanol is described. The advantages of the new method are good yields (62-96%), simple workup, and inexpensive catalyst. Topics: Acetonitriles; Aldehydes; Catalysis; Ethanol; Ketones; Mannich Bases; Tin Compounds | 2011 |