mannich-bases has been researched along with acacetin* in 1 studies
1 other study(ies) available for mannich-bases and acacetin
| Article | Year |
|---|---|
Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin.
Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1-8) were synthesised from naringin. The bioactivity evaluation revealed that most of them exhibited moderate or potent acetylcholinesterase (AChE) inhibitory activity. Among them, compound 7 (IC Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Flavanones; Flavones; Inhibitory Concentration 50; Kinetics; Mannich Bases; Methyl Ethers; Molecular Docking Simulation; Rats | 2018 |