mannich-bases and 1-2-3-4-tetrahydrocarbazole

mannich-bases has been researched along with 1-2-3-4-tetrahydrocarbazole* in 1 studies

Other Studies

1 other study(ies) available for mannich-bases and 1-2-3-4-tetrahydrocarbazole

ArticleYear
Synthesis and in-vitro antitumor activities of some mannich bases of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones.
    Archiv der Pharmazie, 2009, Volume: 342, Issue:3

    A novel series of 2-substituted aminomethyl-9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones 5a-q was synthesized via aminomethylation of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones 4a-e with hydrochlorides of the respective amines 6a-m. The structures of these newly synthesized compounds were characterized by (1)H-NMR, MS, and elemental analysis. All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines including human non-small lung cancer cells (A549), human gastric adenocarcinoma (SGC), human colon cancer cell (HCT116), human myeoloid leukemia cells (K562), and one multi-drug resistant subline (KB-VCR). Most compounds showed moderate to potent cytotoxic activity against the tested cell lines. Preliminary mechanism research indicated that the most promising compound, 2-diethylaminomethyl-9-methyl-1,2,3,4-tetrahydrocarbazole-1-one 5c, exhibited a potential inhibitory effect against microtubule.

    Topics: Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mannich Bases; Microtubules; Molecular Structure

2009
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