manidipine has been researched along with dihydropyridines in 187 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (4.81) | 18.7374 |
| 1990's | 88 (47.06) | 18.2507 |
| 2000's | 61 (32.62) | 29.6817 |
| 2010's | 25 (13.37) | 24.3611 |
| 2020's | 4 (2.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kimura, K; Matsuoka, H; Sugimoto, T; Tojo, A | 1 |
| Inoue, T; Kanayama, Y; Konishi, Y; Negoro, N; Nishimura, M; Okamura, M; Takeda, T; Umetani, N | 1 |
| Abe, K; Kasai, Y; Saso, S; Sheu, HL; Yabe, T | 1 |
| Hara, K; Itou, S; Kawamura, H; Maki, M; Mitsubayashi, H; Suzuki, K; Usui, W; Yasugi, T | 1 |
| Abe, H; Ashida, T; Imanishi, M; Kawano, Y; Kimura, G; Kojima, S; Murakami, K; Sanai, T; Yoshida, K; Yoshimi, H | 1 |
| Fukuchi, S; Haga, H; Mizuno, K; Takahashi, M; Watanabe, Y | 1 |
| Hiwada, K; Iwata, T; Kitami, Y; Marumoto, K; Okura, T; Wakamiya, R | 2 |
| Fujishima, M; Fujita, S; Hirakata, H; Iino, K; Ishida, I; Kashiwagi, M; Okuda, S; Yoshinari, M | 1 |
| Atarashi, K; Kimura, Y; Matsuoka, H; Minami, M; Sugimoto, T; Takagi, M | 1 |
| Higashimori, K; Ishikawa, H; Kagoshima, T; Mikami, H; Nagano, M; Nakagawa, M; Nonaka, H; Ogihara, T; Sasaki, S; Takeda, K | 1 |
| Ando, A; Arai, M; Fujiwara, Y; Izumi, M; Kamada, T; Nagaoka, A; Ochi, S; Ueda, N; Yokoyama, K | 1 |
| Fukuo, K; Inoue, T; Kitano, S; Koh, E; Momose, N; Morimoto, S; Nabata, T; Ogihara, T; Tamatani, M; Yasuda, O | 1 |
| Eguchi, S; Hirata, Y; Tsujino, M | 1 |
| Itoh, H; Kuwabara, T; Nakagawa, M; Nakata, T; Sasaki, S; Takeda, K; Takenaka, K; Takesako, T | 1 |
| Higaki, J; Mikami, H; Morishita, R; Nagano, M; Nakamura, F; Ogihara, T; Tomita, N; Yu, H | 1 |
| Asayama, J; Itoh, H; Kuwabara, T; Nakagawa, M; Nakata, T; Sasaki, S; Takeda, K; Takesako, T; Tanabe, S; Yamahara, Y | 1 |
| Fukiyama, K; Kawazoe, N; Kimura, Y; Muratani, H; Takishita, S; Tozawa, M | 2 |
| Fukiyama, K; Kawazoe, N; Muratani, H; Takishita, S; Tozawa, M | 1 |
| Abe, Y; Aki, Y; He, H; Iwao, H; Kiyomoto, H; Miyatake, A; Tamaki, T | 1 |
| Ikenaga, H; Saruta, T; Suzuki, H | 1 |
| Hishida, A; Kobayashi, S | 2 |
| Ikeda, K; Nara, Y; Yamori, Y | 1 |
| Ishii, M; Iwata, A; Kawano, Y; Minamisawa, K; Miyakawa, Y; Tochikubo, O | 1 |
| Honma, H; Ishii, H; Kohno, I; Nakamura, T; Tamura, K; Tsuruta, I | 1 |
| Ikeda, H; Miki, N; Nagano, N; Nagaoka, A; Odaka, H | 1 |
| Aoki, I; Hirai, S; Tabata, T; Yamaguchi, M; Yamashita, K; Yashiki, T | 1 |
| Block, LH; Emmons, LR; Hörl, WH; Keul, R; Roth, M | 1 |
| Aoki, I; Miyabayashi, T; Motohashi, M; Yamashita, K; Yashiki, T; Yatani, K | 1 |
| Hisaki, K; Matsumura, Y; Morimoto, S; Ohyama, T | 1 |
| Nagaoka, A; Shibota, M | 1 |
| Kajino, M; Meguro, K; Nagai, Y; Nagaoka, A; Wada, Y | 1 |
| Hamajo, K; Nagaoka, A; Shibota, M | 1 |
| Kitayoshi, T; Kitoh, G; Nishikawa, K; Shibouta, Y | 1 |
| Kakihana, M; Nagaoka, A; Suno, M | 1 |
| Hattori, Y; Kanno, M; Nakao, Y; Nakaya, H | 1 |
| Kitamura, K; Kuriyama, H; Okabe, K; Terada, K | 1 |
| Onuki, T | 1 |
| Demura, H; Hagiwara, H; Hirose, S; Itakura, M; Muraki, T; Naruse, K; Naruse, M; Takagi, K; Tanabe, A; Yoshimoto, T | 1 |
| Bauer, J; Knaus, J; Luger, A; Reams, G; Villareal, D; Wu, Z | 1 |
| Arai, T; Hishida, A; Kobayashi, S; Nakajima, T | 1 |
| Goto, A; Hayakawa, H; Hirata, Y; Kimura, K; Omata, M; Tojo, A | 1 |
| Goto, R; Hasegawa, M; Kaetsu, H; Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Takao, Y; Yaku, H | 1 |
| Dohi, Y; Kojima, M; Sato, K | 1 |
| Chen, HC; Guh, JY; Hwang, SJ; Lai, YH; Tsai, JC; Tsai, JH | 1 |
| Kuno, N; Nakashima, K; Shimoda, M; Takahashi, K | 1 |
| Kotoo, Y; Matsuno, Y; Oda, H; Ohashi, H; Watanabe, S | 1 |
| Echizen, H; Ishizaki, T; Nakamura, Y; Saima, S; Yoshimoto, K | 1 |
| Kanno, M; Takeda, Y; Tohse, N | 1 |
| Ise, T; Kobayashi, K; Ohta, H; Ohta, K; Sasaki, T; Satoh, S; Takabatake, T | 1 |
| Ikeda, M; Imai, M; Kurokawa, K; Naruse, M; Uchida, S; Yoshitomi, K | 1 |
| Dunn, MJ; Huang, S; Simonson, MS | 1 |
| Nagaoka, A | 1 |
| Mathy, MJ; Pfaffendorf, M; van Zwieten, PA | 1 |
| Ise, T; Kobayashi, K; Takabatake, T; Ushiogi, Y | 1 |
| Block, LH; Keul, R; Perruchoud, AP; Roth, M | 1 |
| Badr, KF; Fukunaga, M; Katoh, T; Takahashi, K | 1 |
| Bauer, JH; Luger, AM; Reams, GP; Villarreal, D; Wang, X; Wu, Z | 1 |
| Nayler, WG; Panagiotopoulos, S | 1 |
| Saruta, T; Suzuki, H | 1 |
| Iimura, O; Shimamoto, K | 1 |
| Chatani, F; Hamajo, K; Imamoto, T; Kandori, H; Mihara, T; Nagaoka, A; Nagisa, Y; Oda, E | 1 |
| Block, LH; Nauck, M; Rödler, S; Roth, M; Tamm, M | 1 |
| Demura, H; Hagiwara, H; Hirose, S; Muraki, T; Naruse, K; Naruse, M; Shionoya, K; Tanabe, A; Tanaka, M; Yoshimoto, T | 1 |
| Ando, K; Fujita, T; Shimosawa, T | 1 |
| Block, LH; Eickelberg, O; Erne, P; Kohler, E; Roth, M | 1 |
| Hamaguchi, A; Iwao, H; Kim, S; Wanibuchi, H | 1 |
| Chatani, F; Sato, K; Sato, S | 1 |
| Haraguchi, K; Iga, T; Ito, K; Sawada, Y | 1 |
| Block, LH; Roth, M | 1 |
| Gamba, P; Grassi, G; Mancia, G; Paleari, F; Stella, ML | 1 |
| Akai, H; Hinokio, Y; Hirai, A; Hirai, M; Hirai, S; Kawasaki, H; Ohtomo, M; Onoda, M; Satoh, Y; Suzuki, S; Toyota, T | 1 |
| Rodicio, JL | 1 |
| Fogari, R; Lusardi, P; Mugellini, A; Poletti, L; Preti, P; Zoppi, A | 1 |
| Fogari, R; Lusardi, P; Mugellini, A; Zoppi, A | 1 |
| Celentano, A; Cloro, C; Cosco, C; Crivaro, M; De Divitiis, O; Di Palma Esposito, N; Mattioli, PL; Oliviero, M; Palmieri, V; Perticone, F; Pietropaolo, I; Tammaro, P | 1 |
| Inada, Y; Kanagawa, R; Nishikawa, K; Ojima, M; Sanada, T; Wada, T | 1 |
| Ohkubo, T; Sugawara, K; Uno, T | 1 |
| Chikugo, TA; Hamada, Y; Niisato, E; Ohta, Y; Okamoto, K; Otori, T; Suzuki, T | 1 |
| Akagashi, K; Itoh, N; Kumamoto, Y; Ohta, Y; Suzuki, T; Tsukamoto, T | 1 |
| Chichibu, S; Chikugo, T; Ohta, Y; Suzuki, T | 1 |
| Fujimaki, M; Nagase, M; Uchida, S | 1 |
| Hara, N; Morooka, M; Nakahashi, H; Ogata, K; Wataya, H | 1 |
| Haraguchi, K; Iga, T; Ito, K; Kotaki, H; Sawada, Y | 1 |
| Akioka, K; Hanatani, A; Iwao, H; Kim, S; Omura, T; Takeuchi, K; Teragaki, M; Toda, I; Yoshikawa, J; Yoshiyama, M | 1 |
| Doba, N; Ishikawa, Y; Kimura, Y; Morita, S; Saito, I; Sakuma, Y; Shiojima, K; Tomiyama, H; Yamamoto, A; Yoshida, H | 1 |
| Chiba, A; Chichibu, S; Nakanishi, H; Ohta, Y; Suzuki, T | 1 |
| Acerbi, D; Allemon, A; Deroubaix, X; Jeanbaptiste, B; Lens, S; Lins, RL; Poli, G; Stockis, A; Ventura, P | 1 |
| Dohi, Y; Kojima, M; Miyagawa, K; Sato, K | 1 |
| Iwata, H; Kinoshita, M; Saima, S; Sumiya, M; Tanabe, M | 1 |
| Bettoni, G; Castellano, M; Guelfi, D; Muiesan, ML; Pasini, G; Piccoli, A; Porteri, E; Rizzoni, D; Rosei, EA; Zulli, R | 1 |
| Corradi, L; Fogari, R; Lusardi, P; Mugellini, A; Preti, P; Zoppi, A | 1 |
| Amoroso, S; Annunziato, L; Cataldi, M; de Caprariis, P; di Renzo, G; Palagiano, F; Secondo, A; Taglialatela, M | 1 |
| Fujita, R; Hayashi, Y; Inoue, M; Iwamoto, Y; Kageyama, S; Kitamura, S; Makino, F; Okuda, Y; Shiba, T; Tada, H; Takahasi, C | 1 |
| Amenta, F; Leonardi, A; Sabbatini, M; Testa, R; Vitaioli, L | 1 |
| Fukuzawa, M; Miyaguchi, S; Nakazawa, T; Ohta, S; Qiang, X; Sakata, Y; Satoh, J; Takahashi, K; Takizawa, Y; Toyota, T | 1 |
| Ogihara, T | 1 |
| Agabiti-Rosei, E; Casati, R; Fogari, R; Leonetti, G; Mancia, G; Montemurro, G; Nami, R; Omboni, S; Pessina, AC; Pirrelli, A; Zanchetti, A | 1 |
| Amenta, F; Baldoni, E; Sabbatini, M; Vitaioli, L | 1 |
| Eto, T; Imamura, T; Kato, J; Kitamura, K; Koiwaya, Y; Matsuo, T; Onitsuka, H; Tsumori, Y; Yamakawa, H | 1 |
| Corradi, L; Fogari, R; Malalamani, GD; Mugellini, A; Preti, P; Zoppi, A | 1 |
| Deerochanawong, C; Kornthong, P; Phongwiratchai, S; Serirat, S | 1 |
| Amenta, F; Sabbatini, M; Tomassoni, D | 2 |
| Abe, S; Hashimoto, M; Oashi, K; Saikai, T; Suzuki, K; Tanaka, H; Tanaka, S; Teramoto, S | 1 |
| De Cesaris, R; La Commare, P; Omboni, S; Palatini, P; Zanchetti, A | 1 |
| Cheer, SM; McClellan, K | 1 |
| Kohlmann, O; Ribeiro, AB | 1 |
| Amenta, F; Leonardi, A; Sabbatini, M; Testa, R; Tomassoni, D; Vitaioli, L | 1 |
| Ikawa, K; Ikawa, M; Iwakura, M; Sakamoto, S; Shimauchi, H | 1 |
| Acerbi, D; De Bruyn, S; Gengler, C; Goethals, F; Lens, S; Poli, G; Stockis, A | 1 |
| Aiello, F; Garofalo, A; Ioele, G; Ragno, G; Sinicropi, MS | 1 |
| Acerbi, D; Gengler, C; Goethals, F; Jeanbaptiste, B; Lens, S; Poli, G; Stockis, A | 1 |
| Bellinghieri, G; Mazzaglia, G; Santoro, D; Savica, V | 1 |
| Hidekazu, H; Koji, H; Masanori, S; Mitsuharu, H; Shigefumi, S; Takanobu, A; Takeshi, I; Toshihiko, S; Yasuyuki, B | 1 |
| Corradi, L; Derosa, G; Fogari, E; Fogari, R; Mugellini, A; Preti, P; Zoppi, A | 1 |
| Calò, LA; Davis, PA; Pagnin, E; Pessina, AC; Semplicini, A; Zaghetto, F | 1 |
| McKeage, K; Scott, LJ | 1 |
| Miyachi, Y; Ueshiba, H | 1 |
| Kakishita, M; Nakamura, K; Ohe, T; Yamanari, H | 1 |
| Casiglia, E; Mazza, A; Pessina, AC; Tikhonoff, V | 1 |
| Cremonesi, G; Dobovisek, J; Fogari, R; Mugellini, A; Planinc, D | 1 |
| Corradi, L; Fogari, E; Fogari, R; Lazzari, P; Mugellini, A; Rinaldi, A; Zoppi, A | 1 |
| Luque Otero, M; Martell Claros, N | 1 |
| Destro, M; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Rinaldi, A; Zoppi, A | 1 |
| Celentano, A; Fogari, R; Mugellini, A; Scanferla, F; Vaccarella, A; Zoppi, A | 1 |
| Asayama, J; Inoue, R; Kobara, M; Miki, S; Nakagawa, Y; Nakata, T; Shimizu, T; Toba, H; Yoshimura, A | 1 |
| Richard, S | 1 |
| Roca-Cusachs, A; Triposkiadis, F | 1 |
| Wenzel, RR | 1 |
| Zanchetti, A | 1 |
| Chow, MS; Tomlinson, B | 1 |
| Motomura, S; Ohkubo, T; Sugawara, K; Uno, T | 1 |
| Keating, GM; McCormack, PL | 1 |
| Ambrosioni, E; Kahan, T | 1 |
| Du, H; Iwashita, N; Kawamori, R; Shao, JQ; Wang, J; Wang, YT; Wang, YY; Watada, H; Zhao, M | 1 |
| Coca, A | 1 |
| Chen, X; He, H; Jing, J; Ren, W; Sun, Y; Wang, G; Zhou, W; Zhu, X | 1 |
| Hamada, C; Hosaka, S; Kitamori, N; Sadoshima, T; Sato, M; Takahashi, Y | 1 |
| Fogari, E; Fogari, R; Malamani, G; Mugellini, A; Perrone, T; Rinaldi, A; Zoppi, A | 1 |
| Otero, ML | 1 |
| Alberici, M; Lembo, G; Payeras, AC; Sladek, K | 1 |
| Corradi, L; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Rinaldi, A; Zoppi, A | 1 |
| Igari, Y; Imai, Y; Kobayashi, H; Obara, T; Ohkubo, T; Oikawa, T; Saito, S; Takahashi, M; Takahashi, N; Takahashi, T | 1 |
| Martínez Martín, FJ | 2 |
| Corradi, L; Derosa, G; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Zoppi, A | 1 |
| Fogari, R; Kohlmann, O; Laurent, S; Roca-Cusachs, A; Schmieder, RE; Triposkiadis, F; Wenzel, RR | 1 |
| Derosa, G; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Rinaldi, A; Zoppi, A | 1 |
| Berti, F; Civelli, M; Manfredi, B; Razzetti, R; Rossoni, G | 1 |
| Martinez-Martin, FJ; Saiz-Satjes, M | 1 |
| Fogari, R; Kohlmann, O; Laurent, S; Roca-Cusachs, A; Schmieder, RE; Wenzel, RR | 1 |
| Cavalieri, L; Cremonesi, G | 1 |
| Buset Ríos, N; Rodríguez Esparragón, F; Rodríguez Pérez, J | 1 |
| Grobelny, P; Mielcarek, J; Osmałek, T | 1 |
| Bernini, F; Costa, S; Cremonesi, G; Pedrelli, M; Zimetti, F | 1 |
| Felip, A; Galceran, J; Plana, J; Pou, G; Sobrino, J; Vila, J | 1 |
| Laurent, S; Richy, FF | 1 |
| Comi-Diaz, C; Macias-Batista, A; Martinez-Martin, FJ; Pedrianes-Martin, P; Rodriguez-Rosas, H; Soriano-Perera, P | 1 |
| Buset Ríos, N; Fernández-Andrade Rodríguez, C; Rodríguez Esparragón, F; Rodríguez Pérez, JC | 1 |
| de la Cruz, JJ; Martell-Claros, N | 1 |
| Circelli, M; Cremonesi, G; Fogari, R; Mugellini, A | 1 |
| Sangoi, Mda S; Todeschini, V; Volpato, NM | 1 |
| Barlovic, DP; Bossi, A; Cavaletti, G; Chiurchiu, C; Dodesini, AR; Ene-Iordache, B; Fassi, A; Filipponi, M; Frigeni, B; Gaspari, F; Iliev, IP; Ilieva, AP; Lauria, G; Lombardi, R; Motterlini, N; Noris, G; Penza, P; Perna, A; Piatti, ML; Remuzzi, G; Rota, S; Rubis, N; Ruggenenti, P; Sghirlanzoni, A; Trevisan, R; Zaletel, J | 1 |
| Weir, MR | 1 |
| Gil Cunquero, JM; Gutiérrez Rivas, PC; Liébana Cañada, A; Merino García, E; Viñolo López, MC | 1 |
| Barkas, F; Elisaf, MS; Liamis, G; Liberopoulos, EN; Moutzouri, E; Rizos, CV | 1 |
| Alberici, M; Ott, C; Raff, U; Ritt, M; Schmieder, RE; Schneider, MP; Striepe, K | 1 |
| Barden, AT; da Silva Sangoi, M; Sfair, LL; Todeschini, V; Volpato, NM | 1 |
| Barboza, FM; Farago, PV; Fernandes, D; Machado, WM; Olchanheski Junior, LR; Padilha de Paula, J; Zawadzki, SF | 1 |
| Bisenieks, E; Duburs, G; Gall Troselj, K; Krauze, A; Poikans, J; Velena, A; Zarkovic, N | 1 |
| Martinez-Martin, FJ; Saiz Satjes, M | 1 |
| Chamsai, B; Limmatvapirat, S; Sriamornsak, P; Sungthongjeen, S | 2 |
| Martinez-Martin, FJ; Roca-Cusachs, A; Saiz-Satjes, M | 1 |
| Cabassi, A; Cherney, DZI; Crocamo, A; Lazzeroni, D; Lytvyn, Y; Montanari, A; Musiari, L; Pelà, G | 1 |
| Adireddy, V; Bimireddy, BPK; Ponneri, V | 1 |
| Hosaka, S; Tokunaga, Y | 1 |
| Celegato, M; Gribaudo, G; Loregian, A; Luganini, A; Mercorelli, B; Palù, G | 1 |
| Choi, DK; Kim, DK; Kim, JH; Kim, JW; Kwon, OB; Lee, DS; Lee, H; Lee, J; Lee, S; Min, SH; Yu, JH | 1 |
| Kim, JW; Lee, DS; Lee, H; Min, SH | 1 |
| Correa, ITS; da Costa-Silva, TA; Tempone, AG | 1 |
| Abohashrh, M; Ahmad, I; Alam, MM; Baig, MH; Dong, JJ; Sharma, T | 1 |
20 review(s) available for manidipine and dihydropyridines
| Article | Year |
|---|---|
Pharmacologic characteristics of a new calcium antagonist, manidipine: beneficial effects on renal circulation and vascular changes.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Cardiovascular System; Cerebrovascular Disorders; Dihydropyridines; Hemodynamics; Humans; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Renal Circulation | 1993 |
[[Antihypertensive therapy and organ protection].
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Diastole; Dihydropyridines; Heart; Humans; Hypertension; Nitrobenzenes; Piperazines; Systole | 1996 |
Renal effects of calcium antagonists with special reference to manidipine hydrochloride.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation | 1996 |
Manidipine: a review of its use in hypertension.
Topics: Aged; Animals; Antihypertensive Agents; Diabetes Complications; Dihydropyridines; Hemodynamics; Humans; Hypertension; Kidney; Nitrobenzenes; Piperazines | 2001 |
Manidipine: a review of its use in the management of hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dihydropyridines; Humans; Hypertension; Middle Aged; Nitrobenzenes; Piperazines; Renal Insufficiency | 2004 |
Fixed combination of manidipine and delapril in the treatment of mild to moderate essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Indans; Male; Middle Aged; Nitrobenzenes; Piperazines; Random Allocation; Time Factors | 2005 |
Vascular effects of calcium channel antagonists: new evidence.
Topics: Animals; Antihypertensive Agents; Arteries; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, P-Type; Calcium Channels, T-Type; Cardiovascular Diseases; Dihydropyridines; Humans; Hypertension, Renal; Ion Channel Gating; Kidney Glomerulus; Muscle Contraction; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Renal Circulation | 2005 |
Antihypertensive effect of manidipine.
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Humans; Hypertension; Kidney Diseases; Male; Nitrobenzenes; Piperazines; Randomized Controlled Trials as Topic; Syndrome | 2005 |
Renal protection in hypertensive patients: selection of antihypertensive therapy.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Dihydropyridines; Drug Therapy, Combination; Humans; Hypertension; Hypertension, Renal; Kidney; Nitrobenzenes; Piperazines; Proteinuria; Randomized Controlled Trials as Topic; Renal Circulation | 2005 |
Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage.
Topics: Blood Pressure Determination; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypertension; Indans; Male; Nitrobenzenes; Piperazines; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Survival Analysis | 2007 |
Manidipine-delapril combination in the management of hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Humans; Hypertension; Indans; Nitrobenzenes; Piperazines | 2007 |
[Calcium channel-blockers for managing metabolic syndrome-associated hypertension. Trials with manidipine].
Topics: Albuminuria; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Humans; Hypertension; Inflammation; Insulin Resistance; Metabolic Syndrome; Nitrobenzenes; Oxidation-Reduction; Piperazines; Thrombosis | 2007 |
Metabolic effects of manidipine.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Endothelium, Vascular; Humans; Hypertension; Insulin; Insulin Secretion; Kidney Diseases; Lipids; Meta-Analysis as Topic; Metabolic Syndrome; Nitrobenzenes; Piperazines; PPAR gamma; Practice Guidelines as Topic | 2009 |
[Cardio-metabolic properties of manidipine: beyond lowering arterial pressure?].
Topics: Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart; Humans; Nitrobenzenes; Piperazines | 2009 |
Manidipine treatment in patients with albuminuria not sufficiently reduced with renin-angiotensin system blockers.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Renin-Angiotensin System | 2010 |
Efficacy and safety profiles of manidipine compared with amlodipine: a meta-analysis of head-to-head trials.
Topics: Adult; Amlodipine; Ankle; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Edema; Humans; Hypertension; Meta-Analysis as Topic; Nitrobenzenes; Piperazines; Publication Bias; Randomized Controlled Trials as Topic; Treatment Outcome | 2011 |
Vascular and metabolic properties of manidipine.
Topics: Albuminuria; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Humans; Insulin Resistance; Nitrobenzenes; Oxidative Stress; Piperazines | 2011 |
Combination delapril/manidipine as antihypertensive therapy in high-risk patients.
Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Diabetes Complications; Dihydropyridines; Drug Combinations; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Indans; Irbesartan; Losartan; Nitrobenzenes; Obesity; Olmesartan Medoxomil; Piperazines; Ramipril; Tetrazoles; Valine; Valsartan | 2011 |
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.
Topics: Amlodipine; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cattle; Dihydropyridines; Epithelial Cells; Humans; Hydrogen; Lipoproteins, LDL; Mice; Microsomes; Mitochondria; Niacinamide; Nifedipine; Nitrobenzenes; Oxidants; Oxidative Stress; Piperazines | 2016 |
Treatment of hypertensive patients with diabetes: beyond blood pressure control and focus on manidipine.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus; Dihydropyridines; Drug Therapy, Combination; Humans; Hypertension; Nitrobenzenes; Piperazines | 2016 |
52 trial(s) available for manidipine and dihydropyridines
| Article | Year |
|---|---|
The effect of manidipine on renal hemodynamics in essential hypertensive patients: responses to acute stress.
Topics: Acute Disease; Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Nitrobenzenes; Piperazines; Renal Circulation; Reproducibility of Results; Stress, Physiological; Vascular Resistance | 1992 |
Effect of manidipine, a new calcium antagonist, on intrarenal hemodynamics in essential hypertension.
Topics: Blood Pressure; Blood Proteins; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Hematocrit; Humans; Hypertension; Kidney; Male; Middle Aged; Nicardipine; Nitrobenzenes; Piperazines; Renal Circulation; Sodium; Sodium, Dietary | 1992 |
Clinical evaluation of the efficacy and safety of manidipine in hypertensive patients with renal disorders.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Blood Urea Nitrogen; Calcium Channel Blockers; Creatinine; Dihydropyridines; Female; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Nitrobenzenes; Piperazines | 1992 |
Effects of a new calcium antagonist, manidipine, on the renal hemodynamics and the vasoactive humoral factors in patients with diabetes mellitus.
Topics: Adult; Angiotensin II; Atrial Natriuretic Factor; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus; Dihydropyridines; Endothelins; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Renal Circulation | 1992 |
Effects of manidipine and delapril on glucose and lipid metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Indans; Lipids; Male; Middle Aged; Nitrobenzenes; Piperazines | 1992 |
Effect of manidipine, a novel calcium channel blocker, on quality of life in hypertensive patients.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Middle Aged; Nitrobenzenes; Piperazines; Quality of Life | 1992 |
A study of the effects of manidipine on the diurnal variation of arterial pressure and hemodynamics in patients with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Diastole; Dihydropyridines; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Monitoring, Physiologic; Nitrobenzenes; Piperazines; Systole | 1992 |
Efficacy of manidipine on circadian blood pressure in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitors; Calcium Channel Blockers; Circadian Rhythm; Diastole; Dihydropyridines; Drug Administration Schedule; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Monitoring, Physiologic; Nitrobenzenes; Piperazines; Systole | 1992 |
Partial attenuation of the cardiovascular responses to tracheal intubation with oral manidipine.
Topics: Administration, Oral; Adult; Anesthesia, Intravenous; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Elective Surgical Procedures; Electrocardiography; Female; Heart Rate; Humans; Intubation, Intratracheal; Laryngoscopy; Male; Middle Aged; Nitrobenzenes; Piperazines; Placebos; Thiopental; Vecuronium Bromide | 1994 |
Effects of manidipine hydrochloride on blood pressure in hypertensive patients--a comparison with nifedipine retard.
Topics: Adult; Aged; Blood Pressure; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrobenzenes; Piperazines | 1993 |
Efficacy of manidipine in the treatment of hypertension with renal impairment: a multicenter trial.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Antihypertensive Agents; Blood Urea Nitrogen; Calcium Channel Blockers; Creatinine; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Nitrobenzenes; Piperazines; Renin; Treatment Outcome | 1993 |
Evaluation by 24-hour ambulatory blood pressure monitoring of efficacy of manidipine hydrochloride 10, 20 or 40 mg once daily as compared to placebo in treating mild to moderate essential hypertension: a double-blind, randomized, parallel group, placebo-c
Topics: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dihydropyridines; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines | 1996 |
Efficacy and tolerability of manidipine hydrochloride in the long-term treatment of mild-moderate hypertension. Manidipine Efficacy in Long-Term Treatment Group.
Topics: Antihypertensive Agents; Blood Pressure; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Time Factors; Treatment Outcome | 1996 |
Anti-hypertensive effect of manidipine: 24 hours monitoring evaluation and Doppler-echocardiographic remarks.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Ultrasonography, Doppler | 1996 |
Effects of an ACE inhibitor and a calcium channel blocker on cardiovascular autonomic nervous system and carotid distensibility in patients with mild to moderate hypertension.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Autonomic Nervous System; Baroreflex; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Female; Heart; Heart Rate; Humans; Hypertension; Indans; Male; Middle Aged; Nitrobenzenes; Piperazines | 1998 |
Single dose pharmacokinetics of manidipine in hepatic impaired patients and healthy controls.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Dihydropyridines; Half-Life; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Nitrobenzenes; Piperazines; Reference Values; Severity of Illness Index | 1998 |
Effect of low-dose manidipine on ambulatory blood pressure in very elderly hypertensives.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Hypertension; Male; Nitrobenzenes; Piperazines; Placebos | 1999 |
Delapril versus manidipine in hypertensive therapy to halt the type-2-diabetes-mellitus-associated nephropathy.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Female; Humans; Hypertension; Indans; Male; Middle Aged; Nitrobenzenes; Piperazines | 2000 |
Practitioner's Trial on the Efficacy of Antihypertensive Treatment in the Elderly Hypertension (The PATE-Hypertension Study) in Japan.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Female; Humans; Hypertension; Incidence; Indans; Japan; Male; Nitrobenzenes; Piperazines; Prospective Studies; Safety; Stroke; Survival Rate | 2000 |
Antihypertensive efficacy of manidipine and enalapril in hypertensive diabetic patients.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diastole; Dihydropyridines; Double-Blind Method; Enalapril; Glycated Hemoglobin; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Systole; Treatment Outcome; Triglycerides; Uric Acid | 2000 |
Effects of different dihydropyridine calcium antagonists on plasma norepinephrine in essential hypertension.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Norepinephrine; Piperazines; Sympathetic Nervous System | 2000 |
Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diabetic Nephropathies; Dihydropyridines; Humans; Indans; Kidney; Middle Aged; Nitrobenzenes; Piperazines | 2001 |
Effects of candesartan on cough and bronchial hyperresponsiveness in mildly to moderately hypertensive patients with symptomatic asthma.
Topics: Adult; Aged; Antihypertensive Agents; Asthma; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bronchial Hyperreactivity; Calcium Channel Blockers; Cough; Dihydropyridines; Female; Genetic Testing; Humans; Hypertension; Incidence; Male; Methacholine Chloride; Middle Aged; Nifedipine; Nitrobenzenes; Pain Measurement; Peptidyl-Dipeptidase A; Piperazines; Polymorphism, Genetic; Respiratory Function Tests; Tetrazoles; Treatment Outcome | 2001 |
Efficacy, tolerability, and impact on quality of life of long-term treatment with manidipine or amlodipine in patients with essential hypertension.
Topics: Adult; Aged; Amlodipine; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Chi-Square Distribution; Dihydropyridines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Quality of Life; Statistics, Nonparametric | 2001 |
[Manidipine in the treatment of stage I and II essential hypertension patients with overweight or android obesity. A Brazilian multicentre study of efficacy, tolerability and metabolic effects].
Topics: Adult; Antihypertensive Agents; Blood Glucose; Brazil; Dihydropyridines; Female; Humans; Hypertension; Lipid Metabolism; Lipids; Male; Middle Aged; Nitrobenzenes; Obesity; Piperazines; Treatment Outcome | 2001 |
Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.
Topics: Adolescent; Adult; Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Biological Availability; Dihydropyridines; Drug Combinations; Humans; Indans; Male; Nitrobenzenes; Piperazines; Tablets; Therapeutic Equivalency | 2003 |
Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chromatography, Liquid; Cross-Over Studies; Dihydropyridines; Drug Combinations; Drug Interactions; Half-Life; Humans; Indans; Male; Mass Spectrometry; Nitrobenzenes; Piperazines | 2003 |
Effects of manidipine and nifedipine on blood pressure and renal function in patients with chronic renal failure: a multicenter randomized controlled trial.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Nitrobenzenes; Piperazines; Treatment Outcome; Urinary Tract Physiological Phenomena | 2003 |
Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus.
Topics: Adult; Aged; Antihypertensive Agents; Biphenyl Compounds; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolysis; Humans; Hydrochlorothiazide; Hypertension; Indans; Irbesartan; Male; Middle Aged; Nitrobenzenes; Piperazines; Plasminogen Activator Inhibitor 1; Tetrazoles; Tissue Plasminogen Activator; Treatment Outcome | 2004 |
Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.
Topics: Aged; Amlodipine; Analysis of Variance; Body Mass Index; Calcium Channel Blockers; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Delayed-Action Preparations; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Insulin Resistance; Male; Middle Aged; Nitrobenzenes; Obesity; Piperazines; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2004 |
Efficacy and safety of delapril plus manidipine compared with enalapril plus hydrochlorothiazide in mild to moderate essential hypertension: results of a randomized trial.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indans; Male; Middle Aged; Nitrobenzenes; Piperazines; Single-Blind Method; Time Factors; Treatment Outcome | 2004 |
Effect of manidipine as compared to atenolol on platelet aggregation in elderly patients with isolated systolic hypertension and type II diabetes mellitus.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Atenolol; Cross-Over Studies; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Female; Humans; Hypertension; Male; Nitrobenzenes; Piperazines; Platelet Aggregation | 2005 |
Manidipine versus enalapril monotherapy in patients with hypertension and type 2 diabetes mellitus: a multicenter, randomized, double-blind, 24-week study.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Enalapril; Female; Heart Rate; Humans; Hypertension; Lipoproteins; Male; Middle Aged; Nitrobenzenes; Piperazines | 2005 |
Effect of successful hypertension control by manidipine or lisinopril on albuminuria and left ventricular mass in diabetic hypertensive patients with microalbuminuria.
Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Heart Ventricles; Humans; Hypertension; Lisinopril; Male; Middle Aged; Nitrobenzenes; Piperazines | 2005 |
Fixed combination of manidipine and delapril in the treatment of mild to moderate essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Indans; Male; Middle Aged; Nitrobenzenes; Piperazines; Random Allocation; Time Factors | 2005 |
Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Beverages; Calcium Channel Blockers; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dihydropyridines; Food-Drug Interactions; Humans; Male; Nitrobenzenes; Piperazines; Stereoisomerism; Time Factors | 2006 |
Effect on the development of ankle edema of adding delapril to manidipine in patients with mild to moderate essential hypertension: a three-way crossover study.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Ankle; Antihypertensive Agents; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Drug Therapy, Combination; Edema; Female; Humans; Hypertension; Indans; Male; Middle Aged; Nitrobenzenes; Piperazines; Treatment Outcome | 2007 |
Antihypertensive efficacy and safety of manidipine versus amlodipine in elderly subjects with isolated systolic hypertension: MAISH study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Chlorthalidone; Dihydropyridines; Diuretics; Double-Blind Method; Drug Therapy, Combination; Europe; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Risk Assessment; Risk Factors; Systole; Time Factors; Treatment Outcome | 2007 |
Addition of manidipine improves the antiproteinuric effect of candesartan in hypertensive patients with type II diabetes and microalbuminuria.
Topics: Adult; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Prospective Studies; Proteinuria; Single-Blind Method; Tetrazoles | 2007 |
Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Drug Combinations; Female; Fibrinogen; Glucose Clamp Technique; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Indans; Insulin Resistance; Male; Middle Aged; Nitrobenzenes; Obesity; Piperazines; Tetrazoles | 2008 |
Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Diabetes Complications; Diabetes Mellitus, Type 2; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indans; Losartan; Male; Middle Aged; Nitrobenzenes; Piperazines; Treatment Outcome | 2008 |
Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus, Type 2; Dihydropyridines; Diuretics; Drug Combinations; Endpoint Determination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypotension, Orthostatic; Imidazoles; Indans; Male; Nitrobenzenes; Piperazines; Posture; Prospective Studies; Tetrazoles | 2008 |
Add-on manidipine versus amlodipine in diabetic patients with hypertension and microalbuminuria: the AMANDHA study.
Topics: Adult; Aged; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines; Prospective Studies; Renin-Angiotensin System | 2008 |
Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.
Topics: Aged; Aged, 80 and over; Albuminuria; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Indans; Losartan; Male; Middle Aged; Nitrobenzenes; Piperazines | 2009 |
Manidipine in hypertensive patients with metabolic syndrome: the MARIMBA study.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Albuminuria; Amlodipine; Antihypertensive Agents; Blood Pressure; C-Reactive Protein; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Nitrobenzenes; Piperazines; Prospective Studies; Single-Blind Method; Tumor Necrosis Factor-alpha | 2009 |
Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study.
Topics: Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Biomarkers; Blood Pressure; Dihydropyridines; Drug Combinations; Female; Humans; Hypertension; Insulin Resistance; Lisinopril; Male; Metabolic Syndrome; Middle Aged; Nitrobenzenes; Piperazines; Prospective Studies; Spain; Telmisartan | 2011 |
Manidipine for hypertension not controlled by dual therapy in patients with diabetes mellitus: a non-comparative, open-label study.
Topics: Aged; Antihypertensive Agents; Diabetes Complications; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Piperazines | 2011 |
Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Body Mass Index; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypertension; Indans; Kidney Function Tests; Male; Middle Aged; Nitrobenzenes; Piperazines; Prognosis; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome | 2011 |
Effects of manidipine plus rosuvastatin versus olmesartan plus rosuvastatin on markers of insulin resistance in patients with impaired fasting glucose, hypertension, and mixed dyslipidemia.
Topics: Aged; Blood Glucose; Dihydropyridines; Drug Therapy, Combination; Dyslipidemias; Endpoint Determination; Fasting; Female; Fluorobenzenes; Humans; Hypertension; Imidazoles; Insulin Resistance; Male; Middle Aged; Nitrobenzenes; Piperazines; Prospective Studies; Pyrimidines; Rosuvastatin Calcium; Single-Blind Method; Sulfonamides; Tetrazoles; Treatment Outcome | 2013 |
Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension.
Topics: Adult; Aged; Albuminuria; Amlodipine; Creatinine; Dihydropyridines; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Nitrobenzenes; Piperazines | 2013 |
Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: differential effect of manidipine versus amlodipine.
Topics: Adult; Aged; Albumins; Albuminuria; Amlodipine; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Multivariate Analysis; Nitrobenzenes; Piperazines | 2017 |
Calcium channel blockade blunts the renal effects of acute nitric oxide synthase inhibition in healthy humans.
Topics: Adult; Arterial Pressure; Biomarkers; Calcium Channel Blockers; Dihydropyridines; Dinoprost; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Healthy Volunteers; Hemodynamics; Humans; Infusions, Intravenous; Kidney; Losartan; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrobenzenes; Oxidative Stress; Piperazines; Renal Circulation; Time Factors | 2017 |
116 other study(ies) available for manidipine and dihydropyridines
| Article | Year |
|---|---|
Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Hypertension; Kidney Glomerulus; Male; Microcirculation; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Vascular Resistance | 1992 |
Platelet-derived growth factor gene expression in the kidney of malignant hypertension.
Topics: Animals; Base Sequence; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Gene Expression; Hypertension, Malignant; Kidney; Molecular Sequence Data; Nitrobenzenes; Piperazines; Platelet-Derived Growth Factor; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; RNA-Directed DNA Polymerase | 1992 |
Acute effect of manidipine on renal blood flow measured by pulsed-Doppler flowmeter in normal subjects.
Topics: Adult; Blood Pressure Monitors; Calcium Channel Blockers; Dihydropyridines; Electrocardiography; Female; Humans; Male; Middle Aged; Nitrobenzenes; Piperazines; Renal Artery; Renal Circulation; Ultrasonography | 1992 |
Regulation of the gene expression of type-1 angiotensin II receptor in spontaneously hypertensive rats.
Topics: Adrenal Glands; Angiotensin-Converting Enzyme Inhibitors; Animals; Autoradiography; Base Sequence; Blood Pressure; Body Weight; Brain; Calcium Channel Blockers; Dihydropyridines; Gene Expression Regulation; Heart Rate; Hypertension; Indans; Kidney; Male; Molecular Sequence Data; Myocardium; Nitrobenzenes; Piperazines; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Renin; RNA, Messenger | 1992 |
Mesangial cell growth in genetically hypertensive rats and effect of calcium antagonists upon this growth.
Topics: Animals; Calcium Channel Blockers; Cell Division; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Glomerular Mesangium; Hypertension; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thymidine; Tritium | 1992 |
Effects of manidipine hydrochloride on proliferation and glycosaminoglycan synthesis of cultured vascular smooth muscle cells.
Topics: Animals; Calcium Channel Blockers; Cell Division; Cells, Cultured; Dihydropyridines; DNA; Glycosaminoglycans; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Rats | 1992 |
Effects of manidipine on DNA and protein syntheses in cultured vascular smooth muscle and endothelial cells and on proto-oncogene expression.
Topics: Animals; Blotting, Northern; Calcium Channel Blockers; Cattle; Cells, Cultured; Dihydropyridines; DNA; Endothelins; Endothelium, Vascular; Gene Expression; Genes, fos; Genes, myc; Inositol 1,4,5-Trisphosphate; Kinetics; Mitogens; Muscle Proteins; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Rats; RNA, Messenger; Stimulation, Chemical | 1992 |
Manidipine inhibits the progression of hypertension and atherosclerosis in endothelium-injured and cholesterol-fed Goldblatt 2K1C rats.
Topics: Animals; Aorta; Arteriosclerosis; Blood Pressure; Body Weight; Calcium Channel Blockers; Cholesterol; Dihydropyridines; Endothelium, Vascular; Heart Rate; Hypertension, Renovascular; Male; Nitrobenzenes; Piperazines; Rats; Rats, Wistar | 1992 |
Regression of hypertension-induced vascular hypertrophy by an ACE inhibitor and calcium antagonist in the spontaneously hypertensive rat.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Abdominal; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Hypertension; Hypertrophy; Indans; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 1992 |
Effect of manidipine on cardiac hypertrophy and coronary circulation in DOCA/salt hypertensive rats.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Coronary Circulation; Coronary Vessels; Desoxycorticosterone; Dihydropyridines; Electrolytes; Heart Rate; Hypertension; Male; Nitrobenzenes; Piperazines; Rats; Rats, Wistar; Renin; Sodium Chloride | 1992 |
Nephroprotective actions and other tissue protective effects of manidipine in the management of hypertension.
Topics: Animals; Antihypertensive Agents; Dihydropyridines; Humans; Hypertension; Kidney; Kidney Diseases; Nitrobenzenes; Piperazines | 1992 |
Acute effects of manidipine on renal blood flow and sympathetic nerve activity in conscious, spontaneously hypertensive rats.
Topics: Air Pressure; Animals; Blood Pressure; Consciousness; Dihydropyridines; Heart Rate; Hypertension; Kidney; Male; Nitrobenzenes; Nitroprusside; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation; Stress, Physiological; Sympathetic Nervous System | 1992 |
Renal and extra-renal renin gene expression in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autoradiography; Base Sequence; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Gene Expression; Gene Expression Regulation; Heart Rate; Hypertension; Indans; Kidney; Male; Molecular Sequence Data; Nitrobenzenes; Piperazines; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; Renin; RNA, Messenger | 1992 |
Renal vascular responses in spontaneously hypertensive rats chronically treated with manidipine.
Topics: Air Pressure; Angiotensin II; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Endothelins; Heart Rate; Hypertension; Infusions, Intravenous; Injections, Intraventricular; Kidney; Male; Natriuresis; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Sodium; Stress, Physiological; Stress, Psychological; Time Factors | 1992 |
Effects of the calcium antagonist manidipine on renal hemodynamics and function in dogs: comparison with nifedipine.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; Hemodynamics; Kidney; Lithium; Male; Nifedipine; Nitrobenzenes; Piperazines; Renal Circulation; Sodium; Urine | 1992 |
Effects of manidipine on blood pressure and renal function in salt-loaded, spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Glomerular Filtration Rate; Hypertension; Kidney; Natriuresis; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation; Sodium; Sodium Chloride | 1992 |
Manidipine attenuates a progressive renal injury in remnant kidneys of rats.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Kidney Failure, Chronic; Male; Nephrectomy; Nitrobenzenes; Piperazines; Rats; Rats, Inbred F344 | 1992 |
Preventive effect of manidipine on severe hypertension and proteinuria induced by the inhibition of endothelial-derived relaxation factor formation in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hypertension; Male; Nitric Oxide; Nitroarginine; Nitrobenzenes; Piperazines; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1992 |
Effect of manidipine on balloon catheter-induced arterial smooth muscle cell proliferation in spontaneously diabetic GK rats.
Topics: Animals; Calcium Channel Blockers; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Division; Diabetes Mellitus, Experimental; Dihydropyridines; Male; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Rats | 1992 |
Determination of manidipine enantiomers in human serum using chiral chromatography and column-switching liquid chromatography.
Topics: Administration, Oral; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dihydropyridines; Humans; Nitrobenzenes; Piperazines; Stereoisomerism | 1992 |
Manidipine regulates the transcription of cytokine genes.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Cytokines; Dihydropyridines; DNA; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Genes, jun; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Interleukin-1; Interleukin-6; Nitrobenzenes; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Messenger; Transcription, Genetic | 1992 |
Determination of manidipine and its pyridine metabolite in human serum by high-performance liquid chromatography with ultraviolet detection and column switching.
Topics: Administration, Oral; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Humans; Nitrobenzenes; Piperazines; Pyridines; Spectrophotometry, Ultraviolet | 1989 |
Effects of CV-4093, a new dihydropyridine calcium channel blocker, on renal hemodynamics and function in stroke-prone spontaneously hypertensive rats (SHRSP).
Topics: Animals; Body Weight; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hemodynamics; Hypertension; Injections, Intravenous; Kidney Function Tests; Male; Nicardipine; Nitrobenzenes; Organ Size; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Urodynamics | 1989 |
Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Male; Natriuresis; Nicardipine; Nifedipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation; Urodynamics | 1989 |
Synthesis and biological activities of optical isomers of 2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (manidipine) dihydrochloride.
Topics: Animals; Antihypertensive Agents; Chemical Phenomena; Chemistry; Dihydropyridines; Heart; In Vitro Techniques; Male; Myocardium; Nitrobenzenes; Piperazines; Rats; Stereoisomerism | 1989 |
Effects of a new dihydropyridine derivative, CV-4093.2HCl, on renal hemodynamics in spontaneously hypertensive rats.
Topics: Anesthesia; Angiotensin II; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart Rate; Nicardipine; Nitrobenzenes; Norepinephrine; Piperazines; Rats; Rats, Inbred SHR; Regional Blood Flow; Renal Circulation; Time Factors | 1989 |
Calcium channel blocking action of franidipine hydrochloride (CV-4093.2HCl) in vitro and in vivo.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Decerebrate State; Dihydropyridines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1988 |
Antihypertensive effect of CV-4093.2HCl, a new calcium antagonist, in three rat models of hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hypertension; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1988 |
Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Electrophysiology; Female; Femoral Artery; Guinea Pigs; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Nitrobenzenes; Papillary Muscles; Piperazines | 1988 |
Selective and long-lasting inhibitory actions of the dihydropyridine derivative, CV-4093, on calcium currents in smooth muscle cells of the rabbit pulmonary artery.
Topics: Animals; Antihypertensive Agents; Calcium; Dihydropyridines; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Pulmonary Artery; Rabbits; Sodium; Tetraethylammonium Compounds; Tetrodotoxin | 1987 |
Effects of a calcium antagonist, manidipine, on progressive renal injury associated with mild hypertension in remnant kidneys.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Kidney; Male; Nephrectomy; Nitrobenzenes; Piperazines; Rats; Rats, Inbred F344 | 1995 |
Effects of a calcium channel blocker, manidipine hydrochloride, on the regulatory mechanism of glomerular capillary pressure in SHR.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Capillaries; Dihydropyridines; Feedback; Hypertension; Kidney Glomerulus; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation | 1995 |
Angiotensin converting enzyme inhibitor but not calcium blocker down-regulates gene expression of vascular natriuretic peptide receptor in hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Dihydropyridines; Down-Regulation; Hypertension; Indans; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Atrial Natriuretic Factor; Renin-Angiotensin System; RNA, Messenger | 1994 |
Glomerular function and structure in the sodium-replete and sodium-deplete uninephrectomized spontaneously hypertensive rat: effect of blood pressure reduction, glomerular structure, and blood pressure reduction.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Dihydropyridines; Kidney Glomerulus; Male; Nephrectomy; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Sodium, Dietary | 1995 |
Reduction of albuminuria by a calcium antagonist, manidipine, in rats with passive Heymann nephritis.
Topics: Albuminuria; Animals; Calcium Channel Blockers; Creatinine; Dihydropyridines; Glomerulonephritis; Kidney Cortex; Lipid Peroxidation; Nitrobenzenes; Piperazines; Rats | 1994 |
Effects of a calcium antagonist and an angiotensin II receptor antagonist on rat renal arterioles.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Hydronephrosis; Hypertension; Kidney; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Artery; Tetrazoles | 1994 |
Antihypertensive treatment in patients with a history of accelerated malignant hypertension, with special reference to clinical decision-making in changing treatment.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrobenzenes; Piperazines | 1994 |
Clinical Pharmacology of Manidipine for the Treatment of Hypertension: Importance of Renal and Additional Organ Protective Properties. Proceedings of a symposium. Madrid, Spain, June 13, 1992.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Nitrobenzenes; Piperazines | 1993 |
Temporary symptom worsening caused by manidipine hydrochloride in two patients with Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Antiparkinson Agents; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Neurologic Examination; Nitrobenzenes; Parkinson Disease; Parkinson Disease, Secondary; Piperazines | 1994 |
[Effects of manidipine hydrochloride on renal function in renal parenchymal hypertensive patients].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension, Renal; Kidney; Male; Middle Aged; Nitrobenzenes; Piperazines; Renal Circulation; Vascular Resistance | 1994 |
A drug-induced turbid peritoneal dialysate in five patients treated with continuous ambulatory peritoneal dialysis.
Topics: Adult; Ascitic Fluid; Calcium Channel Blockers; Diagnosis, Differential; Dialysis Solutions; Dihydropyridines; Female; Humans; Male; Middle Aged; Nitrobenzenes; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis; Piperazines; Triglycerides | 1993 |
Neural effects on renal blood flow during acute hypotension vary with antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dihydropyridines; Doxazosin; Hypotension; Kidney; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Regional Blood Flow; Regression Analysis; Sympathetic Nervous System; Time Factors | 1994 |
Voltage-dependent modulation of L-type Ca2+ current by manidipine in guinea-pig heart cells.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electric Stimulation; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Nitrobenzenes; Piperazines | 1993 |
Renal effects of manidipine hydrochloride. A new calcium antagonist in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Metabolic Clearance Rate; Middle Aged; Nitrobenzenes; Piperazines; Renal Circulation; Renal Plasma Flow; Vascular Resistance | 1993 |
Regulation of cortical collecting duct function: effect of endothelin.
Topics: Animals; Arginine Vasopressin; Calcium; Calcium Channel Blockers; Calcium Channels; Cytophotometry; Dihydropyridines; Endothelins; In Vitro Techniques; Kidney Tubules, Collecting; Lasers; Microscopy; Nitrobenzenes; Piperazines; Rabbits | 1993 |
Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Gene Expression Regulation; Genes, fos; Genes, jun; Glomerular Mesangium; Male; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Proto-Oncogenes; Rats; Signal Transduction; Transcriptional Activation | 1993 |
Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrobenzenes; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Renal Artery; Serotonin | 1993 |
Effect of calcium antagonist, manidipine hydrochloride, on renal hemodynamics and tubuloglomerular feedback in spontaneously hypertensive rats.
Topics: Animals; Blood Flow Velocity; Calcium Channel Blockers; Dihydropyridines; Feedback; Hemodynamics; Kidney Glomerulus; Kidney Tubules; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation | 1993 |
Manidipine affects rPDGF-BB-induced gene transcription of low-density lipoprotein receptors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in human mesangial cells.
Topics: Calcium Channel Blockers; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Hydroxymethylglutaryl CoA Reductases; Nitrobenzenes; Piperazines; Platelet-Derived Growth Factor; Receptors, LDL; Recombinant Proteins; Transcription, Genetic | 1993 |
Studies on the glomerular microcirculatory actions of manidipine and its modulation of the systemic and renal effects of endothelin.
Topics: Animals; Arginine; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Endothelins; Glomerular Filtration Rate; Hemodynamics; Kidney Glomerulus; Male; Microcirculation; Nitric Oxide; Nitrobenzenes; omega-N-Methylarginine; Piperazines; Rats; Rats, Wistar; Vasodilation; Verapamil | 1993 |
An evaluation of the renal protective effect of manidipine in the uninephrectomized spontaneously hypertensive rat.
Topics: Angiotensin II; Animals; Calcium Channel Blockers; Dihydropyridines; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Kidney; Male; Nephrectomy; Nitrobenzenes; Piperazines; Proteinuria; Rats; Rats, Inbred SHR | 1993 |
The antiatherosclerotic effect of the calcium antagonists and their implications in hypertension.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cholesterol; Cholesterol, Dietary; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Male; Nitrobenzenes; Piperazines; Rabbits | 1993 |
Efficacy and mode of action of manidipine: a new calcium antagonist.
Topics: Adult; Aldosterone; Calcium; Calcium Channel Blockers; Dihydropyridines; Diuresis; Female; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Natriuresis; Nitrobenzenes; Norepinephrine; Piperazines; Renin; Treatment Outcome | 1993 |
[Beneficial effects of the combination of idebenone and manidipine 2HCl on neurological deficits and histological changes following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats].
Topics: Administration, Oral; Animals; Benzoquinones; Brain; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Kidney; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Ubiquinone | 1995 |
Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells.
Topics: Adrenergic beta-Antagonists; Amlodipine; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Diuretics; Felodipine; Fibroblasts; Furosemide; Gene Expression Regulation; Humans; Interleukin-6; Interleukin-8; Isradipine; Lung; Muscle Proteins; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Propranolol; Transcription, Genetic | 1995 |
Angiotensin II-dependent down-regulation of vascular natriuretic peptide type C receptor gene expression in hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Down-Regulation; Guanylate Cyclase; Hypertension; Male; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitrobenzenes; Piperazines; Proteins; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Tetrazoles | 1996 |
Effect of a calcium antagonist on renal hemodynamics in salt-loaded spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Hypertension; Kidney; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation; Sodium Chloride, Dietary; Vascular Resistance | 1995 |
Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.
Topics: Amlodipine; Becaplermin; Calcium Channel Blockers; Cells, Cultured; Collagen; Collagenases; Dihydropyridines; Diltiazem; Enzyme Activation; Extracellular Matrix; Felodipine; Fibroblasts; Humans; Kinetics; Lung; Metalloendopeptidases; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Platelet-Derived Growth Factor; Procollagen; Proline; Proto-Oncogene Proteins c-sis; Transcription, Genetic; Verapamil | 1996 |
Angiotensin II and calcium blockers prevent glomerular phenotypic changes in remnant kidney model.
Topics: Actins; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Blood Urea Nitrogen; Calcium Channel Blockers; Desmin; Dihydropyridines; Drug Synergism; Drug Therapy, Combination; Extracellular Matrix; Glomerulosclerosis, Focal Segmental; Kidney; Kidney Glomerulus; Male; Metabolic Clearance Rate; Nephrectomy; Nitrobenzenes; Organ Size; Phenotype; Piperazines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1996 |
Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Dihydropyridines; Enalapril; Hemodynamics; Hypotension; Nitrobenzenes; Piperazines; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex; Tachycardia; Tachycardia, Sinus; Telemetry; Tetrazoles; Time Factors | 1996 |
Catalepsy induced by manidipine, a calcium channel blocker, in mice.
Topics: Animals; Calcium Channel Blockers; Catalepsy; Dihydropyridines; Male; Mice; Mice, Inbred Strains; Nitrobenzenes; Parasympatholytics; Piperazines; Receptors, Dopamine D1; Receptors, Dopamine D2; Scopolamine | 1996 |
[Cell proliferation factors and vascular damage].
Topics: Becaplermin; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Cell Division; Cell Line; Cells, Cultured; Dihydropyridines; Glomerular Mesangium; Humans; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Receptors, LDL; Recombinant Proteins; RNA, Messenger | 1996 |
Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension.
Topics: Antihypertensive Agents; Blood Glucose; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Female; Glycated Hemoglobin; Humans; Hypertension; Indans; Insulin Resistance; Male; Middle Aged; Nitrobenzenes; Piperazines | 1996 |
Combined effects of the angiotensin II antagonist candesartan cilexetil (TCV-116) and other classes of antihypertensive drugs in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Atenolol; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Dihydropyridines; Diuretics; Drug Therapy, Combination; Hydrochlorothiazide; Male; Nitrobenzenes; Piperazines; Prazosin; Rats; Rats, Inbred SHR; Renin; Sodium Chloride Symporter Inhibitors; Tetrazoles | 1996 |
Liquid chromatographic determination of manidipine in serum with electrochemical detection.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Electrochemistry; Humans; Nitrobenzenes; Piperazines; Sensitivity and Specificity | 1996 |
Ocular fundus changes in malignant or precocious stroke-prone spontaneously hypertensive rats after administration of antihypertensive drugs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arterioles; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Fundus Oculi; Histocytochemistry; Hypertension; Male; Nitrobenzenes; Organophosphorus Compounds; Piperazines; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Protective effects of manidipine on spermatogenesis in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Cytosol; Dihydropyridines; Hypertension; Male; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Spermatogenesis; Testis | 1995 |
Electroencephalographic evaluation of the therapeutic efficiency of antihypertensive agents on M-SHRSP.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Electroencephalography; Hypertension, Malignant; Longevity; Male; Nitrobenzenes; Organophosphorus Compounds; Piperazines; Proline; Rats; Rats, Inbred SHR | 1995 |
Long-term effect of manidipine on renal function and structure in uninephrectomized spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Hypertension, Renal; Inulin; Kidney; Kidney Cortex; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Nitrobenzenes; Piperazines; Proteinuria; Rats; Rats, Inbred SHR | 1997 |
[Interstitial pneumonia caused by manidipine HCl].
Topics: Antihypertensive Agents; Dihydropyridines; Female; Humans; Lung Diseases, Interstitial; Middle Aged; Nitrobenzenes; Piperazines | 1997 |
Catalepsy induced by calcium channel blockers in mice.
Topics: Amlodipine; Animals; Binding, Competitive; Calcium Channel Blockers; Catalepsy; Dihydropyridines; Diltiazem; Disease Models, Animal; Flunarizine; Male; Mice; Muscarinic Antagonists; Nitrobenzenes; Piperazines; Predictive Value of Tests; Receptors, Cholinergic; Receptors, Dopamine D1; Receptors, Dopamine D2; Scopolamine; Time Factors; Verapamil | 1998 |
Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Blotting, Northern; Body Weight; Calcium Channel Blockers; Collagen; Dihydropyridines; Fibronectins; Heart Ventricles; Hypertrophy, Left Ventricular; Isoproterenol; Male; Myocardium; Nitrobenzenes; Organ Size; Piperazines; Pulse; Rats; Rats, Wistar; RNA, Messenger | 1998 |
Changes in the gastric vascular network of malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) after administration of the calcium antagonist manidipine.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Calcium Channel Blockers; Capillaries; Dihydropyridines; Hypertension; Male; Microscopy, Electron, Scanning; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stomach | 1998 |
Acute antihypertensive effects of calcium channel blockers are not affected by calcium supplementation in patients with essential hypertension.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium, Dietary; Dihydropyridines; Drug Evaluation; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Infusions, Intravenous; Male; Middle Aged; Nicardipine; Nitrobenzenes; Piperazines | 1998 |
Manidipine hydrochloride-induced chyloperitoneum in a patient with systemic lupus erythematosus.
Topics: Adult; Calcium Channel Blockers; Chylous Ascites; Dihydropyridines; Female; Humans; Hypertension; Lupus Erythematosus, Systemic; Nitrobenzenes; Piperazines | 1999 |
Effects of hypotensive and non-hypotensive doses of manidipine on structure, responses to endothelin-1 and ICAM-1 production in mesenteric small resistance arteries of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Endothelin-1; Intercellular Adhesion Molecule-1; Male; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1998 |
Effects of manidipine and nitrendipine enantiomers on the plateau phase of K+-induced intracellular Ca2+ increase in GH3 cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Fluorescent Dyes; Fluorometry; Fura-2; Intracellular Fluid; Nitrendipine; Nitrobenzenes; Patch-Clamp Techniques; Piperazines; Potassium; Rats; Stereoisomerism | 1999 |
Effect of calcium antagonists on glomerular arterioles in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Arterioles; Calcium; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Hypertension, Renal; Juxtaglomerular Apparatus; Male; Nicardipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Vasodilator Agents | 2000 |
Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Diuretics; Doxazosin; Humans; Hydrochlorothiazide; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Metoprolol; Mice; Mice, Inbred BALB C; Monocytes; Nicardipine; Nitrobenzenes; Piperazines; Sodium Chloride Symporter Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Kidney; Kidney Cortex; Kidney Glomerulus; Kidney Tubules; Male; Nicardipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 2000 |
Diastolic wall stress and ANG II in cardiac hypertrophy and gene expression induced by volume overload.
Topics: Adrenomedullin; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Blood Volume; Calcium Channel Blockers; Diastole; Dihydropyridines; Gene Expression; Heart Rate; Hypertrophy, Left Ventricular; Male; Nitrobenzenes; Peptides; Piperazines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Stress, Mechanical; Tetrazoles; Vasoconstrictor Agents | 2000 |
Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Hydralazine; Hypertension; Male; Nimodipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Wistar | 2001 |
Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Brain Injuries; Calcium Channel Blockers; Dihydropyridines; Frontal Lobe; Hippocampus; Hypertension; Male; Nimodipine; Nitrobenzenes; Occipital Lobe; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Hydralazine; Kidney; Male; Nicardipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Tunica Media; Vasodilator Agents | 2002 |
Treatment of gingival overgrowth induced by manidipine administration. A case report.
Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Dental Plaque Index; Dental Scaling; Denture, Partial, Fixed; Dihydropyridines; Female; Gingival Overgrowth; Gingivectomy; Humans; Hypertension; Nitrobenzenes; Oral Hygiene; Periodontal Index; Periodontal Pocket; Piperazines; Root Planing; Saliva; Sjogren's Syndrome | 2002 |
Multivariate least squares regression applied to the spectrophotometric analysis of manidipine and its main photoproduct.
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Stability; Least-Squares Analysis; Light; Multivariate Analysis; Nitrobenzenes; Photochemistry; Piperazines; Spectrophotometry | 2003 |
Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Creatine Kinase; Dihydropyridines; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrobenzenes; Piperazines; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Function, Left | 2004 |
Effect of manidipine on gene expression and protein level of oxidative stress-related proteins: p22phox and HO-1: relevance for antihypertensive and anti-remodeling effects.
Topics: Adult; Antihypertensive Agents; Antioxidants; Dihydropyridines; Female; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; NADPH Dehydrogenase; NADPH Oxidases; Nitrobenzenes; Oxidative Stress; Phosphoproteins; Piperazines | 2004 |
Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.
Topics: Administration, Sublingual; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Case-Control Studies; Cyclooxygenase Inhibitors; Dihydropyridines; Enalapril; Endothelium, Vascular; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nitrobenzenes; Nitroglycerin; Piperazines; Platelet Aggregation Inhibitors; Regional Blood Flow; Vasodilator Agents | 2004 |
Role of manidipine in the management of patients with hypertension.
Topics: Adult; Aged; Animals; Biological Availability; Blood Pressure Monitoring, Ambulatory; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Male; Maximum Tolerated Dose; Middle Aged; Nitrobenzenes; Piperazines; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2004 |
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Body Weight; Calcium Channel Blockers; Chemokine CCL2; Dihydropyridines; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Hypertension; Inflammation; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitrobenzenes; Oxidative Stress; Peptidyl-Dipeptidase A; Piperazines; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Vascular Cell Adhesion Molecule-1 | 2005 |
Closing remarks: current position of calcium channel antagonists in hypertension--the role of manidipine.
Topics: Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Nitrobenzenes; Piperazines; Practice Guidelines as Topic; Randomized Controlled Trials as Topic | 2005 |
Stereoselective interaction of manidipine and grapefruit juice: a new twist on an old tale.
Topics: Beverages; Biological Availability; Citrus paradisi; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dihydropyridines; Enzyme Inhibitors; Food-Drug Interactions; Herbal Medicine; Humans; Intestines; Liver; Nitrobenzenes; Piperazines; Stereoisomerism | 2006 |
Delapril/manidipine.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Drug Combinations; Humans; Hypertension; Indans; Nitrobenzenes; Piperazines; Treatment Outcome | 2006 |
Delapril/manidipine: viewpoints.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Drug Combinations; Humans; Hypertension; Indans; Nitrobenzenes; Piperazines; Treatment Outcome | 2006 |
Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetes Mellitus, Experimental; Dihydropyridines; Female; Fibrosis; Glucose Tolerance Test; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Nitrobenzenes; Oxidative Stress; Piperazines; Random Allocation; Renin-Angiotensin System; Specific Pathogen-Free Organisms; Tetrazoles | 2007 |
Determination and pharmacokinetics of manidipine in human plasma by HPLC/ESIMS.
Topics: Antihypertensive Agents; Calibration; Chromatography, High Pressure Liquid; Dihydropyridines; Humans; Nitrobenzenes; Piperazines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2007 |
Effects of compression on the interaction between 1,4-dihydropyridine compounds and lactose monohydrate (II): differences in powder properties of 1,4-dihydropyridine compounds.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Dihydropyridines; Lactose; Nitrobenzenes; Particle Size; Piperazines; Powders; Pressure; Tablets; Temperature | 2007 |
[Evaluation of efficacy and safety of manidipine hydrochloride among essential hypertensive patients: Substitution from branded product (Calslot) to Generic Product (Manidip)].
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Drugs, Generic; Female; Humans; Hypertension; Male; Middle Aged; Nitrobenzenes; Patient Compliance; Piperazines; Retrospective Studies; Therapeutic Equivalency | 2007 |
Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Cholesterol; Creatine Kinase; Dihydropyridines; Epoprostenol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Lipids; Male; Nitrobenzenes; Piperazines; Rats; Reperfusion Injury; Simvastatin; Thromboxane B2; Triglycerides; Tumor Necrosis Factor-alpha | 2008 |
Indigotine, azorubine, and cochineal red as photoprotectors of manidipine.
Topics: Antihypertensive Agents; Azo Compounds; Calcium Channel Blockers; Coloring Agents; Dihydropyridines; Drug Stability; Free Radical Scavengers; Indigo Carmine; Kinetics; Naphthalenesulfonates; Nitrobenzenes; Osmolar Concentration; Photolysis; Piperazines; Thiocyanates | 2010 |
Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages.
Topics: Calcium Channel Blockers; Cell Line; Cell Survival; Cells, Cultured; Dihydropyridines; Endothelial Cells; Humans; Interleukin-6; Interleukin-8; Macrophages; NF-kappa B; Nitrobenzenes; Piperazines; Tumor Necrosis Factor-alpha | 2010 |
Delapril and manidipine measurements by liquid chromatography-tandem mass spectrometry in a pharmaceutical formulation.
Topics: Chromatography, High Pressure Liquid; Dihydropyridines; Drug Combinations; Drug Evaluation; Indans; Nitrobenzenes; Piperazines; Spectrometry, Mass, Electrospray Ionization | 2011 |
Optimal treatment strategies for patients with hypertension and diabetes: are effects on metabolism important?
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Humans; Hypertension; Indans; Male; Nitrobenzenes; Piperazines | 2011 |
Clinical case: Peritoneal dialysis patient with cloudy peritoneal fluid following administration of calcium antagonists.
Topics: Adult; Antihypertensive Agents; Ascitic Fluid; Calcium Channel Blockers; Cardiovascular Agents; Chylous Ascites; Diagnosis, Differential; Dihydropyridines; Drug Therapy, Combination; Female; Glomerulonephritis, Membranoproliferative; Humans; Kidney Failure, Chronic; Nifedipine; Nitrobenzenes; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis; Piperazines; Retrospective Studies; Triglycerides | 2011 |
First-order derivative UV spectrophotometric method for simultaneous measurement of delapril and manidipine in tablets.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chromatography, Liquid; Dihydropyridines; Indans; Limit of Detection; Nitrobenzenes; Piperazines; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2013 |
PCL/PHBV microparticles as innovative carriers for oral controlled release of manidipine dihydrochloride.
Topics: Animals; Antihypertensive Agents; Delayed-Action Preparations; Dihydropyridines; Drug Carriers; Female; Nitrobenzenes; Particle Size; Piperazines; Polyesters; Rats; Spectroscopy, Fourier Transform Infrared; Surface Properties; Thermodynamics; X-Ray Diffraction | 2014 |
Improved stability of solid dispersions of manidipine with polyethylene glycol 4000/copovidone blends: application of ternary phase diagram.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Dihydropyridines; Drug Stability; Nitrobenzenes; Piperazines; Polyethylene Glycols; Pyrrolidines; Spectroscopy, Fourier Transform Infrared; Vinyl Compounds | 2017 |
Enantioselective determination of R-(-)-manidipine and S-(+)-manidipine in human plasma by a sensitive and selective chiral LC-MS/MS assay.
Topics: Adolescent; Adult; Chromatography, Liquid; Dihydropyridines; Humans; Linear Models; Male; Middle Aged; Nitrobenzenes; Piperazines; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Young Adult | 2017 |
Enhancement of solubility and oral bioavailability of manidipine by formation of ternary solid dispersion with d-α-tocopherol polyethylene glycol 1000 succinate and copovidone.
Topics: alpha-Tocopherol; Animals; Biological Availability; Calorimetry, Differential Scanning; Dihydropyridines; Nitrobenzenes; Piperazines; Polyethylene Glycols; Powders; Pyrrolidines; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Succinates; Vinyl Compounds; X-Ray Diffraction | 2017 |
Differences in Powder Properties of Two 1,4-Dihydropyridine-Type Compounds Evaluated through Thermal Analysis.
Topics: Calorimetry, Differential Scanning; Compressive Strength; Dihydropyridines; Lactose; Nifedipine; Nitrobenzenes; Piperazines; Stearic Acids; Tablets; Temperature | 2017 |
Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein.
Topics: Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Cytomegalovirus Infections; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation, Viral; Humans; Immediate-Early Proteins; Nitrobenzenes; Piperazines; Promoter Regions, Genetic; Trans-Activators; Transcriptional Activation; Virus Replication | 2018 |
Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells.
Topics: Animals; Antihypertensive Agents; Apoptosis; Calcium Channel Blockers; Calcium Channels; Carcinoma, Ovarian Epithelial; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dihydropyridines; Drug Repositioning; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Neoplastic Stem Cells; Nitrobenzenes; Ovarian Neoplasms; Paclitaxel; Piperazines; Signal Transduction; Tumor Microenvironment | 2020 |
Combined Poziotinib with Manidipine Treatment Suppresses Ovarian Cancer Stem-Cell Proliferation and Stemness.
Topics: AC133 Antigen; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Female; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Nanog Homeobox Protein; Neoplastic Stem Cells; Nitrobenzenes; Ovarian Neoplasms; Piperazines; Quinazolines; STAT5 Transcription Factor; Treatment Outcome; Tumor Suppressor Proteins; Wnt Signaling Pathway | 2020 |
Bioenergetics impairment of Trypanosoma cruzi by the antihypertensive manidipine: A drug repurposing strategy.
Topics: Animals; Antihypertensive Agents; Cell Line; Dihydropyridines; Drug Repositioning; Macaca mulatta; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Nitrobenzenes; Piperazines; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study.
Topics: Antiviral Agents; Binding Sites; Computer Simulation; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Databases, Protein; Diarylquinolines; Dihydropyridines; Humans; Indoles; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitrobenzenes; Nitrophenols; Organophosphorus Compounds; Piperazines; Proline; Protease Inhibitors; Pyrrolidinones; SARS-CoV-2 | 2021 |