mangostin and paeonol
mangostin has been researched along with paeonol* in 1 studies
Other Studies
1 other study(ies) available for mangostin and paeonol
| Article | Year |
|---|---|
Characterization of Novel α-Mangostin and Paeonol Derivatives With Cancer-Selective Cytotoxicity.
α-Mangostin (aMan) and Paeonol (Pae) have shown anticancer and anti-inflammatory properties. However, these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as potential novel chemicals that increase cancer cell cytotoxicity over nontransformed human cells. We found that two derivative compounds, named α-Mangostin-1 (aMan1) and Paeonol-1 (Pae1) more efficiently and more specifically induced cytotoxicity in HCT116, HT29, and SW48 colorectal cancer cell lines than the parental compounds. Both aMan1 and Pae1 arrested HCT116 cells in the G Topics: Acetophenones; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Proliferation; Colorectal Neoplasms; Humans; Protein Kinase Inhibitors; Xanthones | 2022 |