manassantin-b and cryptopleurine

manassantin-b has been researched along with cryptopleurine* in 1 studies

Other Studies

1 other study(ies) available for manassantin-b and cryptopleurine

Article	Year
Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. Journal of natural products, 2006, Volume: 69, Issue:7 A bioassay-guided phytochemical investigation on the methanol extract of Boehmeria pannosa, using a HIF-1-mediated reporter gene assay, led to the isolation of two phenanthroquinolizidine alkaloids, (-)-cryptopleurine (1) and (-)-(15R)-hydroxycryptopleurine (2). The structure of the new compound 2 was determined by spectroscopic methods. Compounds 1 and 2 potently inhibited the hypoxia-induced expression of a reporter gene under the control of a hypoxia response element (HRE) with IC(50) values of 8.7 and 48.1 nM, respectively. Furthermore, 1 and 2 suppressed the accumulation of HIF-1alpha protein in a dose-dependent manner, but not the HIF-1beta protein and inhibited expression of vascular endothelial growth factor (VEGF) by hypoxia. Topics: Alkaloids; Boehmeria; Dose-Response Relationship, Drug; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Inhibitory Concentration 50; Korea; Plant Roots; Plants, Medicinal; Stomach Neoplasms; Vascular Endothelial Growth Factor A	2006

Article

Year

Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells.

Journal of natural products, 2006, Volume: 69, Issue:7

A bioassay-guided phytochemical investigation on the methanol extract of Boehmeria pannosa, using a HIF-1-mediated reporter gene assay, led to the isolation of two phenanthroquinolizidine alkaloids, (-)-cryptopleurine (1) and (-)-(15R)-hydroxycryptopleurine (2). The structure of the new compound 2 was determined by spectroscopic methods. Compounds 1 and 2 potently inhibited the hypoxia-induced expression of a reporter gene under the control of a hypoxia response element (HRE) with IC(50) values of 8.7 and 48.1 nM, respectively. Furthermore, 1 and 2 suppressed the accumulation of HIF-1alpha protein in a dose-dependent manner, but not the HIF-1beta protein and inhibited expression of vascular endothelial growth factor (VEGF) by hypoxia.

Topics: Alkaloids; Boehmeria; Dose-Response Relationship, Drug; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Inhibitory Concentration 50; Korea; Plant Roots; Plants, Medicinal; Stomach Neoplasms; Vascular Endothelial Growth Factor A

2006