malonyl-coenzyme-a and 3-hydroxy-5-8-11-14-eicosatetraenoic-acid

malonyl-coenzyme-a has been researched along with 3-hydroxy-5-8-11-14-eicosatetraenoic-acid* in 1 studies

Other Studies

1 other study(ies) available for malonyl-coenzyme-a and 3-hydroxy-5-8-11-14-eicosatetraenoic-acid

ArticleYear
High metabolism and subsequent elongation of 3-hydroxyeicosanoyl-CoA in very-long-chain fatty acid deficient PNS of Trembler mice.
    Neuroscience letters, 1999, Sep-24, Volume: 273, Issue:1

    The developmental patterns of the overall fatty acid elongation and of the last two partial activities of microsomal elongase (dehydration and reduction of 3-hydroxyacyl-CoA) were investigated in the PNS of normal and Trembler mice. Unexpectedly, Trembler microsomes synthesized normal C22-CoA amounts from 3-hydroxyeicosanoyl-CoA (3-OHC20-CoA), a C18-CoA elongation intermediate. Hydroxy- acyl-CoA dehydrase and enoyl-CoA reductase activities were found to be higher in the mutant than in the control, whatever the stage of development. Moreover, C20-CoA elongation led to normal C22-CoA and C24-CoA formation in the mutant whereas C20-CoA formation from C18-CoA was always far lower in Trembler than in control. C18-CoA condensing enzyme emerges as the only elongation step involved in the VLCFA deficit evidenced in Trembler PNS.

    Topics: Acyl Coenzyme A; Animals; Coenzyme A; Fatty Acids; Hydroxyeicosatetraenoic Acids; Malonyl Coenzyme A; Mice; Mice, Neurologic Mutants; Microsomes; Peripheral Nervous System

1999
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