malonyl-coenzyme-a and 3-hydroxy-5-8-11-14-eicosatetraenoic-acid
malonyl-coenzyme-a has been researched along with 3-hydroxy-5-8-11-14-eicosatetraenoic-acid* in 1 studies
Other Studies
1 other study(ies) available for malonyl-coenzyme-a and 3-hydroxy-5-8-11-14-eicosatetraenoic-acid
Article | Year |
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High metabolism and subsequent elongation of 3-hydroxyeicosanoyl-CoA in very-long-chain fatty acid deficient PNS of Trembler mice.
The developmental patterns of the overall fatty acid elongation and of the last two partial activities of microsomal elongase (dehydration and reduction of 3-hydroxyacyl-CoA) were investigated in the PNS of normal and Trembler mice. Unexpectedly, Trembler microsomes synthesized normal C22-CoA amounts from 3-hydroxyeicosanoyl-CoA (3-OHC20-CoA), a C18-CoA elongation intermediate. Hydroxy- acyl-CoA dehydrase and enoyl-CoA reductase activities were found to be higher in the mutant than in the control, whatever the stage of development. Moreover, C20-CoA elongation led to normal C22-CoA and C24-CoA formation in the mutant whereas C20-CoA formation from C18-CoA was always far lower in Trembler than in control. C18-CoA condensing enzyme emerges as the only elongation step involved in the VLCFA deficit evidenced in Trembler PNS. Topics: Acyl Coenzyme A; Animals; Coenzyme A; Fatty Acids; Hydroxyeicosatetraenoic Acids; Malonyl Coenzyme A; Mice; Mice, Neurologic Mutants; Microsomes; Peripheral Nervous System | 1999 |