malondialdehyde has been researched along with simvastatin in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.02) | 18.2507 |
| 2000's | 13 (22.81) | 29.6817 |
| 2010's | 37 (64.91) | 24.3611 |
| 2020's | 3 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, P; Exner, M; Kerjaschki, D; Neale, TJ; Ojha, PP; Poczewski, H; Rüger, B; Witztum, JL | 1 |
| Cordonnier, D; Denis, MC; Mouneimne, A; Richard, MJ; Sirajeddine, K; Tricot, F | 1 |
| de Almeida, E; Jorge, PA; Osaki, MR | 1 |
| Kimura, K; Kishino, M; Maeda, A; Maeda, T; Miyano, M; Mune, M; Nishide, I; Nishide, T; Nishikawa, O; Ogawa, A; Otani, H; Takahashi, T; Tone, Y; Yukawa, S | 1 |
| Chang, JW; Kim, SB; Lee, SK; Min, WK; Park, JS; Yang, WS | 1 |
| Ceska, R; Hilgertová, J; Kvasnicka, J; Skrha, J; Stulc, T; Weiserová, H | 1 |
| Ahn, JY; Ahn, TH; Choi, IS; Chung, WJ; Han, SH; Kang, MH; Koh, KK; Quon, MJ; Seo, YH; Shin, EK | 1 |
| Almeida, EA; Carneiro, A; Jorge, M; Jorge, PA; Ozaki, MR | 1 |
| Ahn, JY; Han, SH; Jin, DK; Kim, DS; Kim, HS; Koh, KK; Quon, MJ; Shin, EK | 1 |
| Alican, I; Ercan, F; Gedik, N; Jahovic, N; Sener, G; Sirvanci, S; Yüksel, M | 1 |
| Ahn, JY; Han, SH; Koh, KK; Lee, Y; Quon, MJ; Shin, EK | 1 |
| Gao, F; Song, T; Wu, JM; Zhang, J; Zhou, FY | 1 |
| Alican, I; Ercan, F; Gedik, N; Işeri, S; Yüksel, M | 1 |
| Cakmak, A; Demirpençe, E; Deniz Dinçer, U; Köksoy, A; Köksoy, C; Okcu-Heper, A; Oziş, E; Yazgan, U | 1 |
| Gryglewski, R; Hassan, M; Heeba, G; Khalifa, M; Malinski, T; Moselhy, ME | 1 |
| Chu, L; Jiang, Y; Li, J; Si, Q; Wang, J; Wu, Y; Zhang, J | 1 |
| Asl, NA; Hajipour, B; Hemmati, MR; Moein, A; Nasirizade, MR; Nourazar, AR; Saberifar, F; Somi, MH; Vatankhah, AM | 1 |
| Andreadou, I; Farmakis, D; Fotopoulou, T; Iliodromitis, EK; Ioannidis, K; Kremastinos, DT; Paraskevaidis, IA; Prokovas, E; Zoga, A | 1 |
| Cao, HY; Li, J; Li, ZQ; Pan, W; Sun, YM; Wang, LF | 1 |
| Basaran, O; Belli, S; Haberal, M; Karabay, G; Karakayali, H; Kut, A; Ozdemir, BH; Türkoğlu, S | 1 |
| Biancini, GB; Biasi, L; Cipriani, F; Dal Vesco, AM; Deon, M; Manfredini, V; Peralba, Mdo C; Treméa, R; Vanzin, CS; Vargas, CR; Wajner, M | 1 |
| Hong, L; Lai, WY; Wu, SZ; Zhang, F; Zhang, L | 1 |
| Hou, SX; Huang, W; Li, DH; Shang, WL; Wu, WW | 1 |
| Bakris, G; de Guzman, E; Lazich, I; Oliva, R; Patel, A; Sarafidis, P | 1 |
| Carru, C; Deiana, L; Loriga, G; Satta, AE; Sotgia, S; Zinellu, A | 1 |
| Carru, C; Deiana, L; Loriga, G; Pisanu, E; Satta, AE; Sotgia, S; Zinellu, A | 1 |
| Gupta, A; Kalonia, H; Kumar, A; Mishra, J; Sharma, N | 1 |
| Brito, GA; Dalcico, R; de Menezes, AM; Deocleciano, OB; Oriá, RB; Ribeiro, RA; Vale, ML | 1 |
| Fang, Y; Li, F; Qin, S; Sang, H; Wang, J; Yao, S; Yuan, N | 1 |
| Atkin, SL; Kilpatrick, ES; Sathyapalan, T; Shepherd, J | 1 |
| Groenemeijer, M; Nanayakkara, PW; Scheffer, PG; Schindhelm, RK; Simsek, S; Smulders, YM; van Verschuer, VM | 1 |
| Jiang, QH; Yang, J; Yang, YH | 1 |
| El-Boghdady, NA; Ibrahim, SA; Motawi, TK; Teleb, ZA | 1 |
| Qin, S; Sang, H; Si, Y; Wang, J; Xu, X; Yang, N; Yao, S; Zhai, L; Zhang, Y; Zu, D | 1 |
| Kasprzak, M; Majewski, W; Pioruńska-Stolzmann, M; Strzyżewski, KW; Strzyżewski, W | 1 |
| Al-Gayyar, MM; El-Gayar, AM; Hassan, HM; Ibrahim, TM | 1 |
| Fu, J; Hu, C; Li, Y; Yuan, X | 1 |
| Alupei, MC; Banciu, M; Licarete, E; Patras, L | 1 |
| Huang, CJ; Kao, MC; Li, KY; Shih, PC; Tsai, PS; Yang, CH | 1 |
| Carru, C; Mangoni, AA; Sanna, M; Satta, AE; Sotgia, S; Zinellu, A | 1 |
| Aikemu, A; Begaud, B; Berké, B; Iskandar, G; Moore, N; Umar, A; Yiming, W; Zhou, W | 1 |
| Huo, W; Song, H; Zhao, W | 1 |
| Hu, Y; Liu, K; Miao, C; Ren, L; Sun, B; Yan, M; Zhang, Y | 1 |
| Chartrand, MS; Hazilawati, H; Hemn, HO; Noordin, MM; Rahman, HS; Zuki, A | 1 |
| Araújo, TS; Carvalho, NS; Costa, DS; Medeiros, JV; Nicolau, LA; Silva, MM; Silva, RO; Soares, PM; Sousa, NA; Souza, LK | 1 |
| Amrein, K; Binder, J; Cvirn, G; Ferstl, U; Froehlich, H; Hallström, S; Hörl, G; Jürgens, G; Koidl, C; Ledinski, G; Scharnagl, H; Stojakovic, T; Tafeit, E; Trauner, M | 1 |
| Alfredo, TM; Antunes, KÁ; da Rocha, Pdos S; de Picoli Souza, K; Dos Santos, EL; Espindola, PP; Lopes, RH; Macorini, LF; Pereira, ZV | 1 |
| Carru, C; Ena, S; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A | 1 |
| Dong, X; Shi, D | 1 |
| Assaretti, S; Baralla, A; Carru, C; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A | 1 |
| Abd-Eldayem, AM; Abdel-Zaher, AO; El-Refaiy, AEM; Farghaly, HSM | 1 |
| Wang, Y; Yang, W; Zhang, R; Zhao, X | 1 |
| Cui, R; Feng, Y; Liang, H; Liu, C; Qiu, M; Zhang, J | 1 |
| Ashrafi, M; Karimi, B; Shomali, T; Yektaseresht, A | 1 |
| Chang, C; Cui, ZJ; Gao, Y; Guo, PF; Khan, I; Ma, Z; Meng, QN; Wang, XB; Yang, RQ | 1 |
| Arab Firozjae, A; Assadpour, S; Ghorbanzadeh, B; Goudarzi, M; Houshmand, G; Manouchehr, F; Nikbakht, J; Pourasghar, M; Shiran, M; Shirzad, S | 1 |
| Bilušić, M; Božina, T; Bradamante, V; Konjevoda, P; Lovrić, J; Rašić, D; Vukšić, A; Žunec, S | 1 |
15 trial(s) available for malondialdehyde and simvastatin
| Article | Year |
|---|---|
Effect of simvastatin on the lipid profile of hemodialysis patients.
Topics: Aged; Apolipoproteins B; Apolipoproteins E; Cholesterol; Cholesterol, VLDL; Creatine Kinase; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Kidney Failure, Chronic; Lipids; Male; Malondialdehyde; Middle Aged; Renal Dialysis; Simvastatin; Treatment Outcome; Triglycerides | 1999 |
Effects of simvastatin on high-sensitivity C-reactive protein and serum albumin in hemodialysis patients.
Topics: Adult; Aged; Anticholesteremic Agents; C-Reactive Protein; Female; Fibrin Fibrinogen Degradation Products; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Renal Dialysis; Serum Albumin; Simvastatin | 2002 |
Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.
Topics: Acetylglucosaminidase; Adult; Aged; alpha-Tocopherol; Ascorbic Acid; Cholesterol; Czech Republic; Diabetes Mellitus, Type 2; Drug Administration Schedule; E-Selectin; Endothelium; Female; Fenofibrate; Fibrinolysis; Glutathione; Humans; Hyperlipidemias; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Plasminogen Activator Inhibitor 1; Simvastatin; Superoxide Dismutase; Time Factors; Triglycerides; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2004 |
Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients.
Topics: Adiponectin; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Blood Pressure; C-Reactive Protein; Chemokine CCL2; Cross-Over Studies; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Lipids; Losartan; Male; Malondialdehyde; Middle Aged; Simvastatin; Vasodilation | 2004 |
Vascular and metabolic effects of combined therapy with ramipril and simvastatin in patients with type 2 diabetes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; C-Reactive Protein; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Lipids; Malondialdehyde; Ramipril; Simvastatin; Vasodilation | 2005 |
Combined therapy with ramipril and simvastatin has beneficial additive effects on tissue factor activity and prothrombin fragment 1+2 in patients with type 2 diabetes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; C-Reactive Protein; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Hemostasis; Humans; Hypercholesterolemia; Male; Malondialdehyde; Middle Aged; Peptide Fragments; Prothrombin; Ramipril; Simvastatin; Thromboplastin | 2007 |
Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.
Topics: Aged; Analysis of Variance; Atorvastatin; Biomarkers; Chi-Square Distribution; Coronary Disease; Diet, Fat-Restricted; Female; Glutathione; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Function Tests; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Prospective Studies; Pyrroles; Simvastatin; Superoxide Dismutase; Treatment Outcome | 2010 |
Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients.
Topics: Adult; Aged; Aryldialkylphosphatase; C-Reactive Protein; Comet Assay; Diabetes Mellitus, Type 2; DNA Damage; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Simvastatin | 2010 |
[Effects of simvastatin on plasma SOD, MDA and 8-iso-PGF2α in patients with stable angina].
Topics: Aged; Angina Pectoris; Dinoprost; Female; Humans; Male; Malondialdehyde; Middle Aged; Simvastatin; Superoxide Dismutase | 2010 |
Effects of combining simvastatin with rosiglitazone on inflammation, oxidant stress and ambulatory blood pressure in patients with the metabolic syndrome: the SIROCO study.
Topics: Adiponectin; Adult; Aged; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Inflammation; Isoprostanes; Lipids; Male; Malondialdehyde; Metabolic Syndrome; Middle Aged; Oxidative Stress; Rosiglitazone; Simvastatin; Thiazolidinediones | 2012 |
Oxidative stress improvement is associated with increased levels of taurine in CKD patients undergoing lipid-lowering therapy.
Topics: Aged; Allantoin; Azetidines; Drug Administration Schedule; Drug Combinations; Ezetimibe; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Kidney; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Simvastatin; Sulfhydryl Compounds; Superoxides; Taurine; Uric Acid | 2012 |
LDL S-homocysteinylation decrease in chronic kidney disease patients undergone lipid lowering therapy.
Topics: Allantoin; Apolipoproteins B; Azetidines; Cholesterol, LDL; Drug Combinations; Dyslipidemias; Ezetimibe, Simvastatin Drug Combination; Female; Homocystine; Humans; Hypolipidemic Agents; Lipid Metabolism; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Pilot Projects; Renal Insufficiency, Chronic; Simvastatin; Sulfhydryl Compounds; Uric Acid | 2012 |
No effect of atorvastatin and simvastatin on oxidative stress in patients at high risk for cardiovascular disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Atorvastatin; Cardiovascular Diseases; Cholesterol, LDL; Deoxyguanosine; F2-Isoprostanes; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peroxidase; Pyrroles; Simvastatin; Ubiquinone | 2013 |
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement.
Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Ezetimibe; Female; Healthy Volunteers; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; NF-kappa B; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Taurine; Triglycerides; Tryptophan; Uric Acid | 2015 |
Cholesterol lowering treatment restores blood global DNA methylation in chronic kidney disease (CKD) patients.
Topics: 5-Methylcytosine; Aged; Allantoin; Biomarkers; Cholesterol; DNA Methylation; Down-Regulation; Ezetimibe, Simvastatin Drug Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Italy; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Time Factors; Treatment Outcome; Uric Acid | 2017 |
42 other study(ies) available for malondialdehyde and simvastatin
| Article | Year |
|---|---|
Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen.
Topics: Aldehydes; Animals; Anticholesteremic Agents; Antigen-Antibody Complex; Basement Membrane; Cholesterol; Collagen; Disease Models, Animal; Epithelial Cells; Glomerulonephritis; Kidney Glomerulus; Lipid Peroxidation; Lovastatin; Lysine; Male; Malondialdehyde; Probucol; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin | 1994 |
Simvastatin does not increase lipid peroxidation in uremic patients.
Topics: Adult; Aged; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Lovastatin; Male; Malondialdehyde; Middle Aged; Simvastatin; Uremia | 1993 |
Rapid reversal of endothelial dysfunction in hypercholesterolaemic rabbits treated with simvastatin and pravastatin.
Topics: Animals; Anticholesteremic Agents; Aorta, Thoracic; Cholesterol; Endothelium, Vascular; Hypercholesterolemia; Male; Malondialdehyde; Muscle Relaxation; Pravastatin; Rabbits; Simvastatin | 1997 |
[Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits].
Topics: Animals; Anticholesteremic Agents; Aortic Diseases; Arteriosclerosis; Atorvastatin; Cholesterol; Cholesterol, LDL; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hypercholesterolemia; Indoles; Lipid Peroxidation; Male; Malondialdehyde; Pravastatin; Pyrroles; Rabbits; Simvastatin | 2005 |
Effects of statins on experimental colitis in normocholesterolemic rats.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Colitis; Collagen; Colon; Fatty Acids, Monounsaturated; Fluvastatin; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Luminescence; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
[Effects of xuezhikang and simvastatin on cerebral ischemia-reperfusion injury in rat].
Topics: Animals; Brain; Brain Ischemia; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Simvastatin | 2006 |
Simvastatin attenuates cisplatin-induced kidney and liver damage in rats.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bilirubin; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Cisplatin; Creatinine; Female; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; L-Lactate Dehydrogenase; Liver Diseases; Male; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley; Serum Albumin; Simvastatin | 2007 |
Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model.
Topics: Animals; Diabetes Mellitus, Experimental; Edema; Glutathione; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Malondialdehyde; Muscle, Skeletal; Necrosis; Peroxidase; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Severity of Illness Index; Simvastatin; Time Factors; Tourniquets | 2007 |
Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1.
Topics: Animals; Aorta; Arginine; Atherosclerosis; Atorvastatin; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Heme Oxygenase-1; Hemin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protoporphyrins; Pyrroles; Rabbits; Simvastatin; Time Factors | 2009 |
Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet.
Topics: Acids; Animals; Anticholesteremic Agents; Aorta; Arthropods; Atherosclerosis; Diet, Atherogenic; Disease Models, Animal; Endothelin-1; Hemorheology; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Medicine, Chinese Traditional; Nitric Oxide; Proteins; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxide Dismutase | 2009 |
Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat.
Topics: Animals; Antioxidants; Disease Models, Animal; Down-Regulation; Free Radical Scavengers; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Diseases; Ischemia; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Regional Blood Flow; Reperfusion Injury; Simvastatin; Superoxide Dismutase; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Cholesterol, LDL; Hemodynamics; Hypercholesterolemia; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitrites; Oxidative Stress; Rabbits; Simvastatin; Tyrosine | 2010 |
Protective role of simvastatin on lung damage caused by burn and cotton smoke inhalation in rats.
Topics: Acute Lung Injury; Animals; Apoptosis; Burns; Cotton Fiber; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Malondialdehyde; Models, Animal; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Simvastatin; Smoke Inhalation Injury | 2011 |
Simvastatin protects osteoblast against H2O2-induced oxidative damage via inhibiting the upregulation of Nox4.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Antioxidants; Apoptosis; Cell Survival; Cytoprotection; Gene Expression; Gene Knockdown Techniques; Hydrogen Peroxide; Malondialdehyde; Mice; NADPH Oxidase 4; NADPH Oxidases; Osteoblasts; Oxidative Stress; RNA Interference; Simvastatin; Up-Regulation | 2012 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Malondialdehyde; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Oxidopamine; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Simvastatin; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Protective mechanisms of simvastatin in experimental periodontal disease.
Topics: Alanine Transaminase; Alkaline Phosphatase; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Bone Morphogenetic Protein 2; Female; Gingiva; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-10; Interleukin-1beta; Malondialdehyde; Matrix Metalloproteinase 1; Matrix Metalloproteinase 8; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Osteoprotegerin; Oxidative Stress; Periodontitis; Peroxidase; RANK Ligand; Rats; Rats, Wistar; Receptor Activator of Nuclear Factor-kappa B; Simvastatin; Tumor Necrosis Factor-alpha | 2013 |
Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Drug Combinations; Endothelins; Flavanones; Humans; Lipids; Malondialdehyde; Mice; Nitric Oxide; Simvastatin; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2012 |
The effect of atorvastatin and simvastatin on vitamin D, oxidative stress and inflammatory marker concentrations in patients with type 2 diabetes: a crossover study.
Topics: Atorvastatin; Biomarkers; C-Reactive Protein; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Pyrroles; Simvastatin; Treatment Outcome; Vitamin D | 2013 |
Hypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic rats.
Topics: Animals; Anticholesteremic Agents; Catalase; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Dietary Fats; Glutathione Peroxidase; Gynostemma; Hypercholesterolemia; Lipid Metabolism; Liver; Male; Malondialdehyde; Plant Extracts; Rats; Rats, Wistar; Simvastatin; Superoxide Dismutase; Triglycerides | 2013 |
Effect of simvastatin and naringenin coadministration on rat liver DNA fragmentation and cytochrome P450 activity: an in vivo and in vitro study.
Topics: Alanine Transaminase; Animals; Anticholesteremic Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; DNA Fragmentation; Drug Evaluation, Preclinical; Drug Interactions; Female; Flavanones; Glutathione; Liver; Malondialdehyde; Microsomes, Liver; Rats; Rats, Wistar; Simvastatin; Superoxide Dismutase | 2014 |
Celastrus orbiculatus Thunb. ameliorates high-fat diet-induced non-alcoholic fatty liver disease in guinea pigs.
Topics: Animals; Body Weight; Celastrus; Cholesterol; Cholesterol, LDL; Diet, High-Fat; Fatty Liver; Guinea Pigs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Liver; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Organ Size; Real-Time Polymerase Chain Reaction; Simvastatin; Superoxide Dismutase | 2013 |
Effect of surgical treatment on lipid peroxidation parameters and antioxidant status in the serum of patients with peripheral arterial disease.
Topics: Aged; Anticholesteremic Agents; Antioxidants; Ceruloplasmin; Humans; Lipid Peroxidation; Lipoproteins, LDL; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peripheral Arterial Disease; Postoperative Period; Simvastatin | 2013 |
Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; C-Reactive Protein; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Granuloma; Inflammation Mediators; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Simvastatin | 2014 |
Simvastatin inhibits the proliferation of A549 lung cancer cells through oxidative stress and up-regulation of SOD2.
Topics: Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Malondialdehyde; Oxidative Stress; Reactive Oxygen Species; Simvastatin; Superoxide Dismutase | 2014 |
Liposomal simvastatin inhibits tumor growth via targeting tumor-associated macrophages-mediated oxidative stress.
Topics: Animals; Blotting, Western; Catalase; Cell Proliferation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Liposomes; Macrophages; Male; Malondialdehyde; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Nitric Oxide; Oxidative Stress; Simvastatin; Tumor Cells, Cultured | 2015 |
Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain; Brain Diseases; Chemokine CXCL2; Claudin-3; Claudin-5; Drug Evaluation, Preclinical; Edema; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-6; Male; Malondialdehyde; Oxidative Stress; Random Allocation; Rats, Sprague-Dawley; Sepsis; Simvastatin; Survival Rate | 2015 |
Effects of Cydonia oblonga Miller leaf and fruit flavonoids on blood lipids and anti-oxydant potential in hyperlipidemia rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cholesterol; Flavonoids; Fruit; Glutathione Peroxidase; Hyperlipidemias; Lipids; Liver; Male; Malondialdehyde; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rosaceae; Simvastatin; Superoxide Dismutase | 2015 |
Long-term administration of simvastatin reduces ventilator-induced lung injury and upregulates heme oxygenase 1 expression in a rat model.
Topics: Animals; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Malondialdehyde; Peroxidase; Random Allocation; Rats, Sprague-Dawley; Respiration, Artificial; Simvastatin; Superoxide Dismutase; Up-Regulation; Ventilator-Induced Lung Injury | 2015 |
Icariin Attenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of Inflammatory Response and p38 MAPK Signaling Pathway.
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Dyslipidemias; Flavonoids; Inflammation; Interleukin-6; Lipids; Male; Malondialdehyde; MAP Kinase Signaling System; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; RNA, Messenger; Simvastatin; Superoxide Dismutase; Triglycerides; Tumor Necrosis Factor-alpha | 2016 |
Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Cholesterol, Dietary; Dietary Supplements; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Malondialdehyde; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Sesquiterpenes; Simvastatin; Superoxide Dismutase; Time Factors | 2015 |
Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats.
Topics: Alendronate; Animals; Bone Density Conservation Agents; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Gene Expression Regulation; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Malondialdehyde; Peroxidase; Rats; Rats, Wistar; Simvastatin; Stomach Ulcer; Tumor Necrosis Factor-alpha | 2016 |
Simvastatin Efficiently Lowers Small LDL-IgG Immune Complex Levels: A Therapeutic Quality beyond the Lipid-Lowering Effect.
Topics: Adult; Aged; Aged, 80 and over; Antigen-Antibody Complex; Apolipoproteins B; Cholesterol, LDL; Coronary Artery Disease; Coronary Restenosis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin G; Male; Malondialdehyde; Middle Aged; Peripheral Arterial Disease; Simvastatin | 2016 |
Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves.
Topics: Animals; Antioxidants; Diet, Carbohydrate Loading; Dilleniaceae; Erythrocytes; Hemolysis; Hyperlipidemias; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Malondialdehyde; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Simvastatin | 2016 |
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Female; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Uric Acid | 2016 |
Simvastatin Alleviates Pathology in a Rat Model of Preeclampsia Involving ERK/MAPK Pathway.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-10; Malondialdehyde; MAP Kinase Signaling System; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Pre-Eclampsia; Pregnancy; Rats; Simvastatin; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2017 |
Protective effect of the standardized extract of ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms.
Topics: Animals; Blood Pressure; Creatinine; Diastole; Ginkgo biloba; Glutathione; Hypercholesterolemia; Hypertension; Kidney; Lipids; Losartan; Male; Malondialdehyde; Nitric Oxide Synthase Type III; Nitrites; Plant Extracts; Protective Agents; Rats, Wistar; Simvastatin; Systole; Urea | 2017 |
Experimental Study of the Protective Effect of Simvastatin on Lung Injury in Rats with Sepsis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Cytoprotection; Deoxyguanosine; Disease Models, Animal; Inflammation Mediators; Lipocalin-2; Lung; Male; Malondialdehyde; Oxidative Stress; Pulmonary Edema; Rats, Wistar; Sepsis; Signal Transduction; Simvastatin; Superoxide Dismutase; Toll-Like Receptor 4; Transcription Factor RelA | 2018 |
Simvastatin protects against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2018 |
Therapeutic effect of simvastatin on DMBA-induced breast cancer in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Aryldialkylphosphatase; Dinoprostone; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Malondialdehyde; Mammary Neoplasms, Experimental; Mice; Mucin-1; Oxidative Stress; Simvastatin; Tamoxifen | 2019 |
Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury.
Topics: Animals; Caspase 3; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Lung; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Smoke Inhalation Injury; Superoxide Dismutase; Treatment Outcome | 2020 |
Simvastatin prevents morphine antinociceptive tolerance and withdrawal symptoms through antioxidative effect and nitric oxide pathway in mice.
Topics: Animals; Antioxidants; Cerebral Cortex; Drug Tolerance; Hippocampus; Male; Malondialdehyde; Mice; Morphine Dependence; Nitric Oxide; Oxidative Stress; Signal Transduction; Simvastatin; Substance Withdrawal Syndrome | 2021 |
The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats.
Topics: Animals; Antioxidants; Brain; Fenofibrate; Glutathione; Liver; Male; Malondialdehyde; Rats; Rats, Wistar; Rats, Zucker; Simvastatin | 2023 |