Compounds > malondialdehyde
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malondialdehyde and methotrexate

malondialdehyde has been researched along with methotrexate in 85 studies

Research

Studies (85)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.18)18.2507
2000's11 (12.94)29.6817
2010's55 (64.71)24.3611
2020's18 (21.18)2.80

Authors

AuthorsStudies
Shyamala Devi, CS; Subramaniam, S1
Anichini, M; Cesaretti, S; Cimaz, R; Falcini, F; Generini, S; Matucci Cerinic, M; Simonini, G; Zoppi, M1
Cevik, H; Jahovic, N; Sehirli, AO; Sener, G; Yeğen, BC1
Akpulat, S; Cetiner, M; Ekşioğlu-Demiralp, E; Ercan, F; Gedik, N; Sehirli, AO; Sener, G; Sirvanci, S; Tecimer, T; Yeğen, BC1
Avci, A; Cetin, R; Devrim, E; Durak, I; Ergüder, BI; Kiliçoğlu, B1
Celik, A; Eralp, A; Yüncü, M1
Gultekin, F; Kilbas, S; Koyuncuoglu, HR; Kutluhan, S; Uz, E; Uzar, E; Yilmaz, HR1
Cetiner, M; Ekşioğlu-Demiralp, E; Ercan, F; Sener, G; Yeğen, BC1
Armagan, A; Cam, H; Koyuncuoglu, HR; Kutluhan, S; Serel, TA; Soyupek, S; Uz, E; Uzar, E; Yilmaz, HR1
Cetin, A; Hacioglu, SK; Kaynar, L; Kocyigit, I; Ozturk, A; Sagdic, O; Saraymen, R; Sari, I1
Balamtekin, N; Erdem, O; Gulgun, M; Kesik, V; Kismet, E; Koseoglu, V; Kul, M; Oztas, E; Vurucu, S1
Kesik, V; Kismet, E; Koseoglu, V; Kurt, B; Uysal, B1
Dadhania, VP; Jena, GB; Ramarao, P; Tripathi, DN; Vikram, A1
Hemeida, RA; Mohafez, OM1
Cetin Ozturk, I; Cetin, A; Erdogan, A; Parlakpinar, H; Vardi, N1
Jena, GB; Kushwaha, S; Ramarao, P; Tripathi, DN; Vikram, A1
Aydin, M; Davarci, M; Gökçe, A; Koç, A; Meydan, S; Oktar, S; Oztürk, OH1
Abraham, P; Kolli, VK; Rabi, S1
Erdem, O; Gulgun, M; Karaoglu, A; Kesik, V; Kismet, E; Koseoglu, V; Kurt, B; Ozcan, O; Tok, D1
Abad, GD; Ghabili, K; Hajipour, B; Hemmati, MR; Khodadadi, A; Somi, MH; Vatankhah, AM1
Ates, B; Parlakpinar, H; Vardi, N1
Asl, NA; Asvadi, A; Asvadi, I; Hajipour, B; Khodadadi, A; Roshangar, L1
Çakır, T; Dulundu, E; Ercan, F; Özkan, E; Şehirli, AÖ; Şener, E; Şener, G; Topaloğlu, Ü1
Ekinci, N; Kose, E; Sapmaz, HI; Sarihan, E; Turkoz, Y; Vardi, N1
Abdel-Rahman, MN; Kabel, AM1
Akcay, F; Albayrak, F; Altuner, D; Cetin, N; Demiryilmaz, I; Sener, E; Suleyman, B; Suleyman, H1
Cağlayan Yeğen, B; Can, G; Deniz, M; Duman, DG; Ercan, F; Kumral, ZN1
Çağlar, Y; Gönlüşen, G; Matur, I; Özgür, H; Polat, S; Tuli, A; Yenilmez, ED1
Arıkök, AT; Ergüder, BI; Gürer, B; Kanat, MA; Kertmen, H; Sanlı, AM; Sargon, MF; Sekerci, Z; Sorar, M; Yılmaz, ER1
Dayalan, H; Elango, T; Gnanaraj, P; Malligarjunan, H; Subramanian, S1
Canöz, Ö; Cetin, A; Eser, B; Hacioglu, SK; Karadag, C; Kaynar, L; Koçyigit, İ; Kurnaz, F; Saraymen, R; Silici, S; Tasdemir, A1
Alver, A; Kahraman, C; Türedi, S; Yuluğ, E1
Ali, N; Hasan, SK; Nafees, S; Rashid, S; Sultana, S1
Manafi, H; Mazani, M; Moghadam, AR; Mohajeri, D; Namvaran-Abbas-Abad, A; Shahi, D1
Abdel-Raheem, IT; Khedr, NF1
Aksun, S; Cetin, ES; Dirican, A; Dirican, N; Kalemci, S; Karacam, V; Sözen, H; Sütcü, R; Ulger, E; Uner, AG; Yaylali, A1
Batmaz, I; Bozkurt, M; Bozkurt, Y; Caglayan, M; Em, S; Kuyumcu, M; Nas, K; Oktayoglu, P; Sarıyıldız, MA; Turkcu, G; Yuksel, H1
Abdelrahman, AM; El-Sheikh, AA; Ibrahim, MA; Khalaf, HM1
Aslaner, A; Baştürk, A; Çakır, T; Durgut, H; Gül, M; Gül, S; Öğünç, AV; Oruç, MT; Polat, C; Sabuncuoglu, MZ; Şehirli, AÖ1
Acipayam, A; Cure, E; Cure, MC; Kalkan, Y; Kurt, A; Sehitoglu, I; Tumkaya, L; Turut, H1
Abdalla, AM; Alhaider, IA; El-Sheikh, AA; Hamouda, AH; Morsy, MA1
Aslaner, A; Aykaç, A; Bahar, L; Baştürk, A; Çakır, T; Durgut, H; Gül, M; Polat, C; Sabuncuoglu, MZ; Şehirli, AÖ1
El-Gowelli, HM; El-Gowilly, SM; Helmy, MM1
Ahmed, W; Nabil, T; Zaki, A1
Bayat, N; Bükücü, N; Sencar, L; Tarakçioğlu, M; Yüncü, M1
Aktas, C; Donmez, YB; Erboga, M; Erboga, ZF; Gurel, A1
Aksoy, N; Aktumen, A; Buyukaslan, H; Gozeneli, O; Kocarslan, S; Ozgonul, A; Şavik, E; Seker, A; Tabur, S; Uzunkoy, A; Yucel, Y1
El-Hamamsy, M; Elbarbary, NS; Farahat, RK; Ismail, EA1
Majumdar, AS; Sankrityayan, H1
Erdogan, E; Gurgor, PN; Ilgaz, Y; Oztas, E; Oztas, Y; Topal, T1
Çilenk, KT; Deligönül, E; Karabulut, D; Kaymak, E; Öztürk, İ; Sönmez, MF; Ünalmış, S1
Burcu, B; Kanter, M; Karabacak, R; Orhon, ZN; Yarali, O1
Gad, A; Hafez, E; Tousson, E; Zaki, S1
Egedigwe, CA; Famurewa, AC; Nwankwo, OE; Obaje, GS; Ufebe, OG1
Arpag, H; Atilla, N; Aydemir, Y; Cakir, T; Gül, M; Polat, C; Sayan, M; Yiğitcan, B; Þehirli, Ö1
Noshy, MM; Said Salem, NI; Said, AA1
Anderson, DR; Chiou, A; Clemens, DL; Duryee, MJ; Hunter, CD; Klassen, LW; Mikuls, TR; O'Dell, JR; Sarmiento, C; Thiele, GM; Tian, J; Zimmerman, MC1
Abid, S; Achour, A; Amara, I; Azzebi, A; Bacha, H; Bousabbeh, M; Guedri, Y; Rjiba-Touati, K; Salem, IB1
Aja, PM; Azubuike-Osu, SO; Ekeleme-Egedigwe, CA; Famurewa, AC; Maduagwuna, EK; Ufebe, OG1
Kaplan, M; Özcan, O; Özgür, T; Pınar, N1
Çakırca, G; Kaplan, M; Özgür, T; Pınar, N1
Belhan, S; Çomaklı, S; Gülyüz, F; Küçükler, S; Yener, Z; Yıldırım, S1
Abd El-Aziz, GS; Abuzinadah, OAH; Alrafiah, AR; Alturkistani, HA; Kelany, AM1
El-Saka, MH; Madi, NM; Shahba, A1
Aja, PM; Aloke, C; Awoke, JN; Famurewa, AC; Maduagwuna, EK; Nwankwo, OE1
Akturan, S; Cimen, FK; Kurt, N; Malkoc, İ; Mammadov, R; Suleyman, B; Suleyman, Z1
Anderson, DR; Clemens, DL; Duryee, MJ; Hall, JH; Klassen, LW; Mikuls, TR; Thiele, GM; Zimmerman, MC1
Akbariani, M; Ebrahimi, R; Gholami, M; Omidi, A; Sabzevari, O; Sepand, MR; Seyednejad, SA1
Kaplan, S; Mammadov, R; Onat, T; Sunar, M; Turkler, C; Yazici, GN; Yildirim, E1
Acar, E; Eraldemir, FC; Kavram Sarihan, K; Yardimoğlu Yilmaz, M; Yazir, Y1
Eftekhari, Z; Jabbari, N; Parivar, K; Roodbari, NH1
Agrawal, YO; Mahajan, HS; Mahajan, UB; Ojha, S1
Goudarzi, M; Kalantar, H; Kalantar, M; Karamallah, MH; Sadeghi, E1
Adel, M; Anbar, HS; El-Gamal, R; Elsayed, HRH; Rabei, MR1
El-Sayyad, SM; Ibrahim, SSA; Kandil, LS; Ragab, GM1
El-Gerbed, MSA; Ghoneum, M1
Bulmus, O; Canpolat, S; Dokumacioglu, E; Kaya, SO; Saral, O; Saral, S; Sumer, A1
Akin, AT; Karabulut, D; Kaymak, E; Kuloglu, N; Ozturk, E; Yakan, B1
Arslan, A; Coban, TA; Gursul, C; Mendil, AS; Ozcicek, A; Ozcicek, F; Ozkaraca, M; Suleyman, H1
Alqahtani, SS; Alshahrani, S; Banji, D; Banji, OJF; Rashida, S1
Alakuş, H; Cellat, M; Etyemez, M; Güvenç, M; İşler, CT; Kutlu, T; Kuzu, M1
Acar, H; Bora, ES; Erbaş, O; Sorgun, O; Yurtseve, G1
Bayramoglu, Z; Bulut, S; Coban, TA; Mammadov, R; Mendil, AS; Mokhtare, B; Suleyman, H; Suleyman, Z1
Awad, EM; El-Sheikh, AAK; El-Tahawy, NFG; Matouk, AI; Waz, S1
Abukhalil, MH; Al-Khawalde, AAA; Aladaileh, SH; Alanezi, AA; Alaryani, FS; Alasmari, F; Aldal'in, HK; Alfwuaires, MA; Algefare, AI; Althunibat, OY; Jghef, MM; Karimulla, S1

Reviews

1 review(s) available for malondialdehyde and methotrexate

ArticleYear
Relevance of the antioxidant properties of methotrexate and doxycycline to their treatment of cardiovascular disease.
    Pharmacology & therapeutics, 2020, Volume: 205

    Topics: Animals; Antioxidants; Atherosclerosis; Cardiovascular Diseases; Doxycycline; Humans; Inflammation; Lipid Peroxidation; Malondialdehyde; Methotrexate; Oxidative Stress; Reactive Oxygen Species

2020

Trials

1 trial(s) available for malondialdehyde and methotrexate

ArticleYear
ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study.
    Nutrition (Burbank, Los Angeles County, Calif.), 2016, Volume: 32, Issue:1

    Topics: Adolescent; Antioxidants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Double-Blind Method; Fatty Acids, Omega-3; Female; Glutathione Peroxidase; Humans; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Superoxide Dismutase

2016

Other Studies

83 other study(ies) available for malondialdehyde and methotrexate

ArticleYear
Erythrocyte antioxidant enzyme activity in CMF treated breast cancer patients.
    Cancer biochemistry biophysics, 1994, Volume: 14, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Catalase; Cyclophosphamide; Erythrocyte Membrane; Erythrocytes; Fluorouracil; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Glutathione Reductase; Humans; Lipid Peroxidation; Malondialdehyde; Methotrexate; Reference Values; Superoxide Dismutase

1994
Evidence for immune activation against oxidized lipoproteins in inactive phases of juvenile chronic arthritis.
    The Journal of rheumatology, 2001, Volume: 28, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Biomarkers; Child; Drug Therapy, Combination; Female; Humans; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Male; Malondialdehyde; Methotrexate; Oxidative Stress

2001
Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats.
    Journal of pineal research, 2003, Volume: 34, Issue:4

    Topics: Animals; Antioxidants; Female; Glutathione; Kidney; Liver; Male; Malondialdehyde; Melatonin; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar

2003
Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death.
    Toxicology and applied pharmacology, 2005, Nov-15, Volume: 209, Issue:1

    Topics: Alanine Transaminase; Animals; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Aspartate Aminotransferases; Cell Death; Collagen; Female; Free Radical Scavengers; Glutathione; Hematocrit; Hemoglobins; Leukocytes; Male; Malondialdehyde; Methotrexate; Neutrophils; Peroxidase; Rats; Rats, Wistar; Taurine

2005
Methotrexate causes oxidative stress in rat kidney tissues.
    Renal failure, 2005, Volume: 27, Issue:6

    Topics: Animals; Biomarkers; Disease Models, Animal; Female; Glutathione Peroxidase; Infusions, Intravenous; Kidney; Lipid Peroxidation; Malondialdehyde; Methotrexate; Oxidative Stress; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Superoxide Dismutase; Tissue Culture Techniques

2005
Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:6

    Topics: Animals; Diarrhea; Garlic; Intestine, Small; Lactic Acid; Male; Malondialdehyde; Methotrexate; Plant Extracts; Rats; Rats, Wistar; Weight Loss

2006
The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester.
    Molecular and cellular biochemistry, 2006, Volume: 291, Issue:1-2

    Topics: Animals; Antioxidants; Caffeic Acids; Catalase; Cerebellum; Male; Malondialdehyde; Methotrexate; Phenylethyl Alcohol; Rats; Rats, Wistar; Superoxide Dismutase

2006
Beta-glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects.
    European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3

    Topics: Animals; Antioxidants; Apoptosis; beta-Glucans; Cell Survival; Collagen; Female; Folic Acid Antagonists; Glutathione; Ileum; Immunologic Factors; Kidney; Liver; Lymphocytes; Male; Malondialdehyde; Methotrexate; Neutrophils; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Respiratory Burst; Tumor Necrosis Factor-alpha

2006
Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat.
    Human & experimental toxicology, 2008, Volume: 27, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Caffeic Acids; Cytotoxins; Drug Antagonism; Injections, Intraperitoneal; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Organ Size; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar; Superoxide Dismutase; Testis

2008
Role of grape seed extract on methotrexate induced oxidative stress in rat liver.
    The American journal of Chinese medicine, 2008, Volume: 36, Issue:5

    Topics: Animals; Antioxidants; Catalase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Seeds; Superoxide Dismutase; Vitis

2008
Proanthocyanidin prevents methotrexate-induced intestinal damage and oxidative stress.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2010, Volume: 62, Issue:2

    Topics: Animals; Antineoplastic Agents; Antioxidants; Glutathione Peroxidase; Intestinal Mucosa; Intestine, Small; Male; Malondialdehyde; Methotrexate; Mucositis; Oxidative Stress; Proanthocyanidins; Rats; Rats, Wistar; Superoxide Dismutase

2010
Ozone ameliorates methotrexate-induced intestinal injury in rats.
    Cancer biology & therapy, 2009, Volume: 8, Issue:17

    Topics: Animals; Disease Models, Animal; Glutathione Peroxidase; Ileum; Intestinal Diseases; Kidney; Liver; Malondialdehyde; Methotrexate; Oxidative Stress; Ozone; Rats

2009
Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine.
    Chemico-biological interactions, 2010, Jan-05, Volume: 183, Issue:1

    Topics: Alkaline Phosphatase; Animals; Antimetabolites, Antineoplastic; Comet Assay; DNA Damage; Glutathione; In Situ Nick-End Labeling; Intestines; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tumor Suppressor Protein p53

2010
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
    Journal of the Egyptian National Cancer Institute, 2008, Volume: 20, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antioxidants; Catalase; Curcumin; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Mice; Oxidative Stress; Rats; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2008
Protective effect of beta-carotene on methotrexate-induced oxidative liver damage.
    Toxicologic pathology, 2010, Volume: 38, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; beta Carotene; Chemical and Drug Induced Liver Injury; Glutathione Peroxidase; Histocytochemistry; Lipid Peroxidation; Liver; Malondialdehyde; Methotrexate; Microscopy; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase

2010
Evaluation of multi-organ DNA damage by comet assay from 28 days repeated dose oral toxicity test in mice: a practical approach for test integration in regulatory toxicity testing.
    Regulatory toxicology and pharmacology : RTP, 2010, Volume: 58, Issue:1

    Topics: Animals; Body Weight; Brain; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Glutathione; Hematologic Tests; Liver; Male; Malondialdehyde; Methotrexate; Mice; Mutagens; Organ Size

2010
Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice.
    Toxicology and industrial health, 2010, Volume: 26, Issue:7

    Topics: Analysis of Variance; Animals; Drug Interactions; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Mice; Oxidative Stress; Peroxidase; Statistics, Nonparametric; Testicular Diseases; Testis; Thioglycolates; Thiophenes

2010
Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats.
    Cell biochemistry and function, 2010, Volume: 28, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Creatinine; Injections, Intraperitoneal; Kidney; Male; Malondialdehyde; Melatonin; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar

2010
Effect of proanthocyanidin, arginine and glutamine supplementation on methotrexate-induced gastrointestinal toxicity in rats.
    Methods and findings in experimental and clinical pharmacology, 2010, Volume: 32, Issue:9

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antioxidants; Arginine; Drug Therapy, Combination; Glutamine; Glutathione Peroxidase; Injections, Intraperitoneal; Intestinal Diseases; Male; Malondialdehyde; Methotrexate; Proanthocyanidins; Rats; Rats, Wistar; Severity of Illness Index; Superoxide Dismutase

2010
Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2011, Volume: 30, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Glutathione Peroxidase; Intestinal Mucosa; Intestine, Small; Male; Malondialdehyde; Methotrexate; Models, Animal; Oxidative Stress; Protective Agents; Rabbits; Random Allocation; Superoxide Dismutase; Thioctic Acid

2011
Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats.
    Journal of chemical neuroanatomy, 2012, Volume: 43, Issue:1

    Topics: Animals; Apoptosis; Catalase; Cerebellum; Chlorogenic Acid; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Neuroprotective Agents; Oxidative Stress; Purkinje Cells; Rats; Rats, Wistar; Superoxide Dismutase

2012
Protective effect of pentoxyfilline in renal toxicity after methotrexate administration.
    European review for medical and pharmacological sciences, 2011, Volume: 15, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Blood Urea Nitrogen; Creatinine; Cytoprotection; Disease Models, Animal; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Pentoxifylline; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha

2011
Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Caffeic Acids; Chemical and Drug Induced Liver Injury; Female; Glutathione; Interleukin-1beta; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Phenylethyl Alcohol; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Tumor Necrosis Factor-alpha

2011
Beneficial effects of montelukast against methotrexate-induced liver toxicity: a biochemical and histological study.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Acetates; Animals; Chemical and Drug Induced Liver Injury; Cyclopropanes; Drug Evaluation, Preclinical; Female; Glutathione; Glycogen; Hepatocytes; Liver; Malondialdehyde; Methotrexate; Oxidative Stress; Periodic Acid-Schiff Reaction; Peroxidase; Quinolines; Rats; Rats, Wistar; Sulfides

2012
Comparative study between the effect of methotrexate and valproic acid on solid Ehrlich tumour.
    Journal of the Egyptian National Cancer Institute, 2012, Volume: 24, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Ehrlich Tumor; Catalase; Cholesterol; Drug Screening Assays, Antitumor; Glutathione Peroxidase; Malondialdehyde; Methotrexate; Mice; Neoplasm Transplantation; Tumor Burden; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Valproic Acid

2012
Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver.
    Medical science monitor : international medical journal of experimental and clinical research, 2012, Volume: 18, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Deoxyguanosine; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Thiamine; Thiamine Pyrophosphate

2012
Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats.
    The British journal of nutrition, 2013, Aug-28, Volume: 110, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Clarithromycin; Diarrhea; Gastrointestinal Transit; Glutathione; Ileum; Inflammation; Intestinal Diseases; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Neutrophil Infiltration; Oxidative Stress; Peroxidase; Probiotics; Rats; Rats, Sprague-Dawley; Saccharomyces

2013
Ultrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats.
    Histology and histopathology, 2013, Volume: 28, Issue:7

    Topics: Acetylcysteine; Animals; Blood Urea Nitrogen; Creatinine; Glutathione Peroxidase; Immunohistochemistry; Ki-67 Antigen; Kidney; Kidney Glomerulus; Male; Malondialdehyde; Methotrexate; Rats; Rats, Wistar; Renal Insufficiency; Superoxide Dismutase

2013
The protective effect of low-dose methotrexate on ischemia-reperfusion injury of the rabbit spinal cord.
    European journal of pharmacology, 2013, Aug-15, Volume: 714, Issue:1-3

    Topics: Animals; Caspase 3; Catalase; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Malondialdehyde; Methotrexate; Methylprednisolone; Peroxidase; Rabbits; Reperfusion Injury; Spinal Cord; Xanthine Oxidase

2013
Impact of methotrexate on oxidative stress and apoptosis markers in psoriatic patients.
    Clinical and experimental medicine, 2014, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Aged; Antioxidants; Apoptosis; Dermatologic Agents; Female; Humans; Male; Malondialdehyde; Methotrexate; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Psoriasis; Reactive Oxygen Species; Young Adult

2014
Efficacy of royal jelly on methotrexate-induced systemic oxidative stress and damage to small intestine in rats.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2012, Volume: 9, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Apitherapy; Fatty Acids; Glutathione Peroxidase; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Male; Malondialdehyde; Methotrexate; Mucositis; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Treatment Outcome

2012
Effects of resveratrol on methotrexate-induced testicular damage in rats.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Catalase; In Situ Nick-End Labeling; Male; Malondialdehyde; Methotrexate; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Superoxide Dismutase; Testis

2013
Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis.
    Molecular and cellular biochemistry, 2014, Volume: 385, Issue:1-2

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Immunohistochemistry; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Tumor Suppressor Protein p53

2014
Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress.
    Chinese journal of natural medicines, 2013, Volume: 11, Issue:5

    Topics: Animals; Catalase; Curcuma; Glutathione Peroxidase; Humans; Intestinal Diseases; Intestinal Mucosa; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase

2013
Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:4

    Topics: Acetates; Animals; Antimetabolites, Antineoplastic; Cyclopropanes; Glutathione; Kidney; Kidney Diseases; Leukotriene Antagonists; Male; Malondialdehyde; Methotrexate; NF-kappa B; Peroxidase; Protective Agents; Quinolines; Rats; Rats, Wistar; Sulfides; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2014
The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice.
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:24

    Topics: Animals; Antioxidants; Catalase; Cytoprotection; Disease Models, Animal; Lung; Malondialdehyde; Methotrexate; Mice; Minocycline; Oxidative Stress; Pulmonary Fibrosis; Time Factors

2013
Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats.
    Clinical and investigative medicine. Medecine clinique et experimentale, 2014, Feb-01, Volume: 37, Issue:1

    Topics: Animals; Antioxidants; Cymenes; Folic Acid Antagonists; Kidney; Male; Malondialdehyde; Methotrexate; Monoterpenes; Oxidative Stress; Rats; Rats, Wistar

2014
Protective effect of peroxisome proliferator activator receptor (PPAR)-α and -γ ligands against methotrexate-induced nephrotoxicity.
    Immunopharmacology and immunotoxicology, 2014, Volume: 36, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; Creatinine; Kidney; Ligands; Male; Malondialdehyde; Methotrexate; NF-kappa B; Nitric Oxide; Oxidative Stress; PPAR alpha; PPAR gamma; Rats; Tumor Necrosis Factor-alpha

2014
Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Female; Glutathione; Interleukin-1beta; Liver; Male; Malondialdehyde; Methotrexate; Necrosis; Peroxidase; Random Allocation; Rats, Wistar; Reproducibility of Results; Thioctic Acid; Treatment Outcome; Tumor Necrosis Factor-alpha

2015
Protective Effects of Infliximab on Lung Injury Induced by Methotrexate.
    Archivos de bronconeumologia, 2015, Volume: 51, Issue:11

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Caspase 3; Drug Evaluation, Preclinical; Endothelin-1; Infliximab; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Neutrophil Infiltration; Peroxidase; Pulmonary Alveoli; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2015
Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats.
    Mediators of inflammation, 2015, Volume: 2015

    Topics: Animals; Antioxidants; Apoptosis; Benzoquinones; Cyclooxygenase 2; Glutathione; Kidney; Liver; Male; Malondialdehyde; Methotrexate; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar

2015
The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Female; Glutathione; Interleukin-1beta; Kidney; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Thioctic Acid; Tumor Necrosis Factor-alpha

2015
Pioglitazone ameliorates methotrexate-induced renal endothelial dysfunction via amending detrimental changes in some antioxidant parameters, systemic cytokines and Fas production.
    Vascular pharmacology, 2015, Volume: 74

    Topics: Animals; Antioxidants; Cytokines; fas Receptor; Glutathione; Kidney; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Pioglitazone; Rats; Rats, Wistar; Thiazolidinediones

2015
Prevention of methotrexate-induced nephrotoxicity by concomitant administration of garlic aqueous extract in rat.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:3

    Topics: Adenosine Deaminase; Animals; Calcium; Catalase; Creatinine; Disease Models, Animal; Garlic; Glutathione; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Nitric Oxide; Phosphorus; Plant Extracts; Potassium; Rats; Rats, Wistar; Sodium; Urea

2015
The effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:3

    Topics: Analysis of Variance; Animals; Antioxidants; Carnitine; Male; Malondialdehyde; Methotrexate; Rats; Rats, Wistar; Superoxide Dismutase; Testicular Diseases; Vitamin B Complex; Vitamin E; Weight Loss

2015
Quercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats.
    Renal failure, 2015, Volume: 37, Issue:9

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Catalase; Glutathione Peroxidase; Kidney; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Quercetin; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2015
The effects of lycopene on intestinal injury due to methotrexate in rats.
    Redox report : communications in free radical research, 2016, Volume: 21, Issue:3

    Topics: Animals; Antioxidants; Carotenoids; Glutathione; Interleukin-1beta; Intestinal Mucosa; Intestines; Lycopene; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2016
Curcumin and folic acid abrogated methotrexate induced vascular endothelial dysfunction.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:1

    Topics: Animals; Antioxidants; Aorta, Thoracic; Collagen; Curcumin; Endothelium, Vascular; Folic Acid; Glutathione; Male; Malondialdehyde; Methotrexate; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilation

2016
Rutin ameliorates methotrexate induced hepatic injury in rats.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:11

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Glutathione Peroxidase; Immunosuppressive Agents; Liver; Malondialdehyde; Methotrexate; Oxidative Stress; Rats, Wistar; Reproducibility of Results; Rutin; Superoxide Dismutase

2015
Protective effects of propolis on methotrexate-induced testis injury in rat.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 79

    Topics: Animals; Apoptosis; HSP70 Heat-Shock Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Male; Malondialdehyde; Methotrexate; Phenols; Proliferating Cell Nuclear Antigen; Propolis; Protective Agents; Rats, Wistar; Seminiferous Tubules; Testis; Xanthine Oxidase

2016
Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats.
    Analytical and quantitative cytopathology and histopathology, 2016, Volume: 38, Issue:2

    Topics: Animals; Antioxidants; Biomarkers; Cytoprotection; Disease Models, Animal; Gastrointestinal Hemorrhage; Glutathione Peroxidase; Intestinal Mucosa; Jejunal Diseases; Jejunum; Male; Malondialdehyde; Methotrexate; Necrosis; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Time Factors; Vitamin E

2016
The cardioprotective effects of L-carnitine on rat cardiac injury, apoptosis, and oxidative stress caused by amethopterin.
    Environmental science and pollution research international, 2016, Volume: 23, Issue:20

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cardiomyopathies; Cardiotonic Agents; Cardiotoxicity; Carnitine; Catalase; Glutathione; Male; Malondialdehyde; Methotrexate; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Tumor Suppressor Protein p53

2016
Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 87

    Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Coconut Oil; Dietary Supplements; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Superoxide Dismutase

2017
Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2018, Volume: 31, Issue:2

    Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Humans; Interleukin-1beta; Lung; Lung Injury; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thioctic Acid; Tumor Necrosis Factor-alpha

2018
Modulatory effect of curcumin against genotoxicity and oxidative stress induced by cisplatin and methotrexate in male mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 105

    Topics: Animals; Antineoplastic Agents; Antioxidants; Cisplatin; Curcumin; DNA Damage; Glutathione; Kidney; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Mice; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase

2017
Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging.
    Redox biology, 2017, Volume: 13

    Topics: Acetaldehyde; Albumins; Cell Survival; Free Radical Scavengers; HEK293 Cells; Humans; Malondialdehyde; Methotrexate; NF-E2-Related Factor 2; Protein Binding; Signal Transduction; Superoxides

2017
Recombinant human erythropoietin prevents etoposide- and methotrexate-induced toxicity in kidney and liver tissues via the regulation of oxidative damage and genotoxicity in Wistar rats.
    Human & experimental toxicology, 2018, Volume: 37, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Catalase; Chemical and Drug Induced Liver Injury; DNA Damage; Erythropoietin; Etoposide; Glutathione; Kidney; Kidney Diseases; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Protective Agents; Rats, Wistar; Recombinant Proteins

2018
Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug methotrexate in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 96

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Coconut Oil; Dietary Supplements; Glutathione; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase

2017
Ameliorating effects of tempol on methotrexate-induced liver injury in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 102

    Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Catalase; Cyclic N-Oxides; Female; Glutathione Peroxidase; Liver; Malondialdehyde; Methotrexate; Oxidants; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Spin Labels; Superoxide Dismutase

2018
The protective effects of alpha lipoic acid on methotrexate induced testis injury in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Antioxidants; Catalase; Epithelial Cells; Glutathione Peroxidase; Male; Malondialdehyde; Methotrexate; Oxidants; Peroxidase; Protective Agents; Rats, Wistar; Seminiferous Tubules; Spermatogenesis; Superoxide Dismutase; Testis; Testosterone; Thioctic Acid

2018
Effect of chrysin on methotrexate-induced testicular damage in rats.
    Andrologia, 2019, Volume: 51, Issue:1

    Topics: Animals; Antioxidants; Catalase; Epididymis; Flavonoids; Glutathione Peroxidase; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Sperm Count; Sperm Motility; Superoxide Dismutase; Testis

2019
The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.
    Histology and histopathology, 2019, Volume: 34, Issue:12

    Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Glutathione Peroxidase; Honey; Immunohistochemistry; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Olive Oil; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2019
The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats.
    Physiology international, 2019, Jun-01, Volume: 106, Issue:2

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Collagen; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; Interleukin-17; Male; Malondialdehyde; Matrix Metalloproteinase 9; Methotrexate; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2019
Moringa oleifera seed oil or virgin coconut oil supplementation abrogates cerebral neurotoxicity induced by antineoplastic agent methotrexate by suppression of oxidative stress and neuro-inflammation in rats.
    Journal of food biochemistry, 2019, Volume: 43, Issue:3

    Topics: Animals; Antineoplastic Agents; Coconut Oil; Cytokines; Dietary Supplements; Glutathione; Humans; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Moringa oleifera; Neurotoxicity Syndromes; Nitric Oxide; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Seeds; Superoxide Dismutase

2019
Effect of lutein on methotrexate-induced oxidative lung damage in rats: a biochemical and histopathological assessment.
    The Korean journal of internal medicine, 2019, Volume: 34, Issue:6

    Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Interleukin-1beta; Lung; Lung Diseases; Lutein; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats, Wistar; Tumor Necrosis Factor-alpha

2019
Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2019, Volume: 27, Issue:2

    Topics: Administration, Oral; Animals; Apoptosis; Ellagic Acid; Gene Expression Regulation; Humans; Male; Malondialdehyde; Methotrexate; Mitochondria; NF-E2-Related Factor 2; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Wistar; Up-Regulation

2019
An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused by a single high dose of methotrexate.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2020, Volume: 29, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Female; Glutathione; Infertility, Female; Lycopene; Malondialdehyde; Methotrexate; Ovary; Oxidative Stress; Rats; Rats, Wistar

2020
Protective effects of apocynin on damaged testes of rats exposed to methotrexate
    Turkish journal of medical sciences, 2020, 08-26, Volume: 50, Issue:5

    Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Body Weight; Male; Malondialdehyde; Methotrexate; Peroxidase; Rats; Rats, Wistar; Testis

2020
Evaluation of Encapsulated Eugenol by Chitosan Nanoparticles on the aggressive model of rheumatoid arthritis.
    International immunopharmacology, 2020, Volume: 85

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Chemokine CCL2; Chitosan; Drug Carriers; Eugenol; Malondialdehyde; Methotrexate; Nanoparticles; Rats, Wistar; Transforming Growth Factor beta

2020
Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Administration, Cutaneous; Administration, Topical; Animals; Catalase; Cytokines; Drug Carriers; Drug Compounding; Drug Liberation; Gels; Glutathione; Humans; Imiquimod; Inflammation; Lipids; Malondialdehyde; Methotrexate; Mice, Inbred BALB C; Nanostructures; Organ Size; Psoriasis; Superoxide Dismutase

2020
Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:3

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Apigenin; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Interleukin-1beta; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Nitric Oxide; Oxidoreductases; Protective Agents; Rats, Wistar; Tumor Necrosis Factor-alpha

2021
Eicosapentaenoic and docosahexaenoic acids attenuate methotrexate-induced apoptosis and suppression of splenic T, B-Lymphocytes and macrophages with modulation of expression of CD3, CD20 and CD68.
    Tissue & cell, 2021, Volume: 72

    Topics: Animals; Antigens, CD; Apoptosis; B-Lymphocytes; Caspase 3; Docosahexaenoic Acids; Eicosapentaenoic Acid; Glutathione; Macrophages; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha

2021
Micro RNAs 26b, 20a inversely correlate with GSK-3 β/NF-κB/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis.
    International immunopharmacology, 2021, Volume: 99

    Topics: Alanine Transaminase; Animals; Antirheumatic Agents; Arthritis, Experimental; Aspartate Aminotransferases; Atorvastatin; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cell Cycle Proteins; Correlation of Data; Cytokines; Glycogen Synthase Kinase 3 beta; I-kappa B Proteins; Male; Malondialdehyde; Methotrexate; MicroRNAs; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Quercetin; Rats, Sprague-Dawley; Signal Transduction

2021
Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses.
    Cancer chemotherapy and pharmacology, 2021, Volume: 88, Issue:6

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Glutathione; Immunosuppressive Agents; Lipid Peroxidation; Liver Function Tests; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Placenta; Placental Extracts; Pregnancy; Rats; Rats, Wistar

2021
The effect of bee pollen on reproductive and biochemical parameters in methotrexate-induced testicular damage in adult rats.
    Journal of basic and clinical physiology and pharmacology, 2020, Dec-14, Volume: 32, Issue:5

    Topics: Animals; Bees; Catalase; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Pollen; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Testis; Testosterone

2020
Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity.
    Journal of molecular histology, 2022, Volume: 53, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Catalase; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Rats; Rats, Wistar; Superoxide Dismutase; Vitamin B 12; Vitamin B Complex

2022
Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats.
    Experimental animals, 2022, May-20, Volume: 71, Issue:2

    Topics: Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury, Chronic; Cymenes; Glutathione; Liver; Malondialdehyde; Methanol; Methotrexate; Oxidative Stress; Phenols; Rats; Rats, Wistar

2022
Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model.
    Journal of ethnopharmacology, 2022, Jun-28, Volume: 292

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Bilirubin; Biological Availability; Boswellia; Diclofenac; Disease Models, Animal; Malondialdehyde; Methotrexate; Plant Extracts; Triterpenes

2022
Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:9

    Topics: Alanine; Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Aspartate Aminotransferases; C-Reactive Protein; Catalase; Creatinine; Cyclohexenes; Cyclooxygenase 2; Freund's Adjuvant; Glutathione; Glutathione Peroxidase; Interleukin-6; Malondialdehyde; Methotrexate; NF-kappa B; Rats; Terpenes; Tumor Necrosis Factor-alpha; Urea

2022
Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexateinduced hepatoxicity model.
    Acta cirurgica brasileira, 2022, Volume: 37, Issue:5

    Topics: Animals; Liver Diseases; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Wistar

2022
Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation.
    Journal of applied oral science : revista FOB, 2022, Volume: 30

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Glutathione; Interleukin-1beta; Interleukin-6; Malondialdehyde; Methotrexate; Oxidants; Oxidative Stress; Quercetin; Rats; Rats, Wistar; Saline Solution; Solvents; Stomatitis; Tumor Necrosis Factor-alpha

2022
Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the ‎TLR4/NF-κB pathway and NLRP3 inflammasome/caspase 1 axis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 155

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 1; Chemical and Drug Induced Liver Injury; Cytokines; Flavonols; Glutathione; Inflammasomes; Interleukin-18; Interleukin-1beta; Malondialdehyde; Methotrexate; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleotides; Rats; Toll-Like Receptor 4

2022
Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death.
    International journal of molecular sciences, 2022, Oct-15, Volume: 23, Issue:20

    Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Catalase; Cell Death; Chemical and Drug Induced Liver Injury; Glutathione; Inflammation; Interleukin-6; Liver; Malondialdehyde; Methotrexate; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase; Transaminases; Tumor Necrosis Factor-alpha

2022