maleic-acid and itaconic-acid

Preterm birth and enteral feeding are two main factors leading to necrotizing enterocolitis (NEC). The metabolomics of preterm infants before and after feeding can provide a basis for the prediction of NEC. Using the method of cross-sectional study, the mode was established with the serum samples of 19 premature infants at birth and after feeding as the control group. The serum was analyzed using GC-MS. Chemometric analysis includes principal component analysis, partial least squares-discriminant analysis, and orthogonal partial least squares-discriminant analysis. Spectral separation of serum metabolites occurred in premature infants before and after feeding. The levels of xylose, d-talose, phosphoglycolic acid, maleimide, l-gulonolactone, maleic acid, β-hydroxypyruvate, itaconic acid, and pantothenic acid in the serum of premature infants after feeding were significant in both multidimensional and single-dimensional modes (variable importance in projection >2, P < 0.01). There was a moderate correlation between total bilirubin and l-gulonolactone and β-hydroxypyruvate (0.8 > r > 0.5). Maleimide, maleic acid, and itaconic acid have diagnostic value (area under the curve >0.9). The results indicated that serum metabolism of preterm infants changes significantly after feeding. Some metabolites have potential value in predicting NEC.

Topics: Cross-Sectional Studies; Enterocolitis, Necrotizing; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Maleimides; Premature Birth

β-CD maleate (CDM) and β-CD itaconate (CDI) were prepared by esterification of β-cyclodextrin (β-CD) with maleic acid and itaconic acid using phosphate as a catalyst in a semi-dry process. The esterification of β-CD was carried out using [Itaconic acid ] or [Maleic acid ] 4 mol/mol of CD; M/L ratio 1:0.6; temperature 110 °C; [4-methoxyphenol] 2.5% amount of acid; reaction time 3.5h. The esterification rates of CDM and CDI are 70.38% and 21.02%, respectively. We found that CDM and CDI were both monoesters. Here, we also established a new evaluation method for the rate of esterification.

Topics: beta-Cyclodextrins; Esterification; Magnetic Resonance Spectroscopy; Maleates; Molecular Structure; Succinates; Thermogravimetry

Polycarboxylate-type green surfactants with either sulfide- (S-) or imino- (N-) linkages were prepared in high yields by a single addition reaction of fatty mercaptan or fatty amine with unsaturated polycarboxylic acids such as fumaric, maleic, itaconic and aconitic acids. They exhibited surfactant properties and excellent biodegradabilities. Also, green surfactants with S-linkages showed better calcium ion sequestration abilities compared to the corresponding surfactant having an N-linkage. Among these surfactants, aconitic acid-derived polycarboxylate with an S-linkage exhibited calcium ion sequestration capacities similar to that of disodium 3-oxapentanedioate (ODA), a conventional calcium ion sequestrant on a molar basis of the surfactant.

Topics: Aconitic Acid; Biodegradation, Environmental; Calcium; Carboxylic Acids; Cations; Fumarates; Imines; Maleates; Propofol; Succinates; Sulfhydryl Compounds; Sulfides; Surface Properties; Surface-Active Agents

The aggressiveness of three self-etching adhesives on unground enamel was investigated. Ultrastructural features and microtensile bond strength were examined, first using these adhesives as both the etching and resin-infiltration components, and then examining their etching efficacy alone through substitution of the proprietary resins with the same control resins.. For SEM examination, buccal, mid-coronal, unground enamel from human extracted bicuspids were etched with either Clearfil Mega Bond (Kuraray), Non-Rinse Conditioner (NRC; Dentsply DeTrey) or Prompt L-Pop (ESPE). Those in the control group were etched with 32% phosphoric acid (Bisco) for 15s. They were all rinsed off prior to examination of the etching efficacy. For TEM examination, the self-etching adhesives were used as recommended. Unground enamel treated with NRC were further bonded using Prime&Bond NT (Dentsply), while those in the etched, control group were bonded using All-Bond 2 (Bisco). Completely demineralized, resin replicas were embedded in epoxy resin for examination of the extent of resin infiltration. For microtensile bond strength evaluation, specimens were first etched and bonded using the self-etching adhesives. A second group of specimens were etched with the self-etching adhesives, rinsed but bonded using a control adhesive. Following restoration with Z100 (3M Dental Products), they were sectioned into beams of uniform cross-sectional areas and stressed to failure.. Etching patterns of aprismatic enamel, as revealed by SEM, and the subsurface hybrid layer morphology, as revealed by TEM, varied according to the aggressiveness of the self-etching adhesives. Clearfil Mega Bond exhibited the mildest etching patterns, while Prompt L-Pop produced an etching effect that approached that of the total-etch control group. Microtensile bond strength of the three experimental groups were all significantly lower than the control group, but not different from one another. When the self-etching adhesives were replaced with the control adhesive after etching, bond strengths of NRC/Prime&Bond NT and Prompt L-Pop were not significantly different from that of the control group, but were significantly higher than that of Clearfil Mega Bond.. Both etching efficacy and strength of the resins are important contributing factors in bonding of self-etching adhesives to unground enamel.

Topics: Acid Etching, Dental; Analysis of Variance; Bisphenol A-Glycidyl Methacrylate; Composite Resins; Dental Bonding; Dental Enamel; Dentin-Bonding Agents; Epoxy Resins; Humans; Maleates; Materials Testing; Methacrylates; Microscopy, Electron; Microscopy, Electron, Scanning; Phosphoric Acids; Polymethacrylic Acids; Replica Techniques; Resin Cements; Silicon Dioxide; Statistics as Topic; Statistics, Nonparametric; Succinates; Tensile Strength; Zirconium

The purpose of this study was to evaluate the effects of 2 new acid-etching solutions, nonrinse conditioner (NRC) and 17% ethylenediaminetetraacetic acid (EDTA), on enamel surface morphology, and to compare the new solutions with traditional 37% phosphoric acid. The effect of prolonged etching time was also investigated. The buccal surfaces of 80 extracted third molars were etched with one of the 3 acids for 15, 30, or 60 seconds. The central regions of the specimens were examined with a scanning electron microscope. Shorter etching time with phosphoric acid resulted in a relatively smooth enamel surface compared with longer treatments. Irrespective of treatment time, NRC produced an aprismatic etch pattern, which suggested a potentially retentive morphological character. EDTA treatment had the least effect of all etchants tested.

Topics: Acid Etching, Dental; Chelating Agents; Crystallography; Dental Enamel; Dental Enamel Solubility; Edetic Acid; Humans; Maleates; Microscopy, Electron, Scanning; Molar, Third; Phosphoric Acids; Succinates; Time Factors

Topics: Chromatography, Gel; Glutarates; Glyoxylates; Isocitrate Lyase; Kinetics; Maleates; Nitro Compounds; Oxo-Acid-Lyases; Propionates; Pseudomonas; Succinates; Succinic Acid