maleic-acid and asenapine

maleic-acid has been researched along with asenapine* in 1 studies

Other Studies

1 other study(ies) available for maleic-acid and asenapine

Article	Year
Asenapine maleate-loaded nanostructured lipid carriers: optimization and in vitro, ex vivo and in vivo evaluations. Nanomedicine (London, England), 2019, Volume: 14, Issue:7 To prepare nanostructured lipid carriers (NLCs) loaded with asenapine maleate (ASPM) to increase its oral bioavailability by intestinal lymphatic uptake.. ASPM-NLCs were prepared by ultrasound dispersion technique, by adopting Design of Experiment approach, and characterized.. The optimized formulation exhibited good physicochemical parameters. Differential scanning calorimetry and x-ray diffraction studies indicated the amorphized nature of ASPM in lipid matrix. In vitro drug release study indicated the sustained release of drug from NLCs. ASPM-NLCs showed greater permeability across Caco2 cells and everted rat ileum. ASPM-NLCs showed greater cellular uptake, superior preclinical oral bioavailability and higher efficacy in reducing the L-DOPA-carbidopa-induced locomotor count compared with plain drug.. ASPM-NLCs were successfully developed that showed enhanced performance both in vitro and in vivo. Topics: Administration, Oral; Animals; Biocompatible Materials; Biological Availability; Biological Transport; Caco-2 Cells; Cell Survival; Dibenzocycloheptenes; Drug Carriers; Drug Compounding; Drug Liberation; Excipients; Heterocyclic Compounds, 4 or More Rings; Humans; Lipids; Male; Maleates; Nanostructures; Particle Size; Rats; Rats, Sprague-Dawley; Tissue Distribution; Treatment Outcome	2019

Article

Year

Asenapine maleate-loaded nanostructured lipid carriers: optimization and in vitro, ex vivo and in vivo evaluations.

Nanomedicine (London, England), 2019, Volume: 14, Issue:7

To prepare nanostructured lipid carriers (NLCs) loaded with asenapine maleate (ASPM) to increase its oral bioavailability by intestinal lymphatic uptake.. ASPM-NLCs were prepared by ultrasound dispersion technique, by adopting Design of Experiment approach, and characterized.. The optimized formulation exhibited good physicochemical parameters. Differential scanning calorimetry and x-ray diffraction studies indicated the amorphized nature of ASPM in lipid matrix. In vitro drug release study indicated the sustained release of drug from NLCs. ASPM-NLCs showed greater permeability across Caco2 cells and everted rat ileum. ASPM-NLCs showed greater cellular uptake, superior preclinical oral bioavailability and higher efficacy in reducing the L-DOPA-carbidopa-induced locomotor count compared with plain drug.. ASPM-NLCs were successfully developed that showed enhanced performance both in vitro and in vivo.

Topics: Administration, Oral; Animals; Biocompatible Materials; Biological Availability; Biological Transport; Caco-2 Cells; Cell Survival; Dibenzocycloheptenes; Drug Carriers; Drug Compounding; Drug Liberation; Excipients; Heterocyclic Compounds, 4 or More Rings; Humans; Lipids; Male; Maleates; Nanostructures; Particle Size; Rats; Rats, Sprague-Dawley; Tissue Distribution; Treatment Outcome

2019