maleic-acid and arginyl-glycyl-aspartic-acid

Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces.

Topics: Anti-Infective Agents; Biocompatible Materials; Cell Adhesion; Cytokines; Glycosaminoglycans; Gram-Negative Bacteria; Gram-Positive Bacteria; Human Umbilical Vein Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Maleates; Oligopeptides; Polyethylene Glycols; Polymers; Styrene; Surface Properties