malagashanine has been researched along with chloroquine in 7 studies
| Studies (malagashanine) | Trials (malagashanine) | Recent Studies (post-2010) (malagashanine) | Studies (chloroquine) | Trials (chloroquine) | Recent Studies (post-2010) (chloroquine) |
|---|---|---|---|---|---|
| 10 | 0 | 1 | 16,405 | 763 | 4,029 |
| Protein | Taxonomy | malagashanine (IC50) | chloroquine (IC50) |
|---|---|---|---|
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | 43 | |
| Spike glycoprotein | Betacoronavirus England 1 | 5.47 | |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | 5.47 | |
| Transmembrane protease serine 2 | Homo sapiens (human) | 5.47 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0301 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 7 | |
| Histidine-rich protein PFHRP-II | Plasmodium falciparum (malaria parasite P. falciparum) | 0.2383 | |
| Procathepsin L | Homo sapiens (human) | 5.47 | |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 5.47 | |
| Replicase polyprotein 1ab | Human coronavirus 229E | 5.47 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 5.47 | |
| Spike glycoprotein | Severe acute respiratory syndrome coronavirus 2 | 3.58 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 6.375 | |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | 1.5 | |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | 0.27 | |
| Beta-secretase 1 | Homo sapiens (human) | 7 | |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | 5.47 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 2.503 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 6.235 | |
| Cysteine proteinase falcipain 2a | Plasmodium falciparum (malaria parasite P. falciparum) | 0.02 | |
| Cysteine proteinase falcipain 2a | Plasmodium falciparum (malaria parasite P. falciparum) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galeffi, C; Milijaona, R; Nicoletti, M; Rafatro, H; Rakoto-Ratsimamanga, A; Rasoanaivo, P; Ratsimamanga-Urverg, S | 1 |
| Frappier, F; Rafatro, H; Rakoto-Ratsimamanga, A; Ramanitrahasimbola, D; Rasoanaivo, P; Ratsimamanga-Urverg, S | 1 |
| De Jonghe, PJ; Gougnard, TY; Laurent, A; Lhoëst, G; Rafatro, H; Rasoanaivo, P; Verbeeck, RK | 1 |
| Federici, E; Galeffi, C; Nicoletti, M; Palazzino, G; Ramanitrahasimbola, D; Rasoanaivo, P; Ratsimamanga-Urverg, S | 1 |
| Rakoto-Ratsimamanga, A; Ramanitrahasimbola, D; Rasoanaivo, P; Ratsimamanga-Urverg, S | 1 |
| Ramanitrahasimbola, D; Rasoanaivo, P; Ratsimamanga, S; Vial, H | 1 |
| Abegaz, B; Bezabih, M; Hayeshi, R; Mangoyi, R; Mukanganyama, S; Ngadjui, B; Ngandeu, F; Rasoanaivo, P; Razafimahefa, S | 1 |
7 other study(ies) available for malagashanine and chloroquine
| Article | Year |
|---|---|
In vitro and in vivo chloroquine-potentiating action of Strychnos myrtoides alkaloids against chloroquine-resistant strains of Plasmodium malaria.
Topics: Alkaloids; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Drug Synergism; HeLa Cells; Humans; Madagascar; Malaria, Falciparum; Mice; Plants, Medicinal; Plasmodium falciparum; Plasmodium yoelii | 1994 |
Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Interactions; Drug Resistance; Malaria, Falciparum; Mice; Plasmodium falciparum; Plasmodium yoelii; Solubility; Verapamil | 2000 |
Isolation from rat urine and human liver microsomes and identification by electrospray and nanospray tandem mass spectrometry of new malagashanine metabolites.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Drug Resistance; Humans; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2000 |
Biological activities of the plant-derived bisindole voacamine with reference to malaria.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Drug Synergism; Ibogaine; Mice; Microbial Sensitivity Tests; Plasmodium falciparum; Plasmodium yoelii | 2001 |
Effects of the naturally-occurring chemosensitizer malagashanine and its combination with chloroquine on KB and P388 cell lines and isolated auricle.
Topics: Alkaloids; Animals; Chloroquine; Drug Synergism; Female; Guinea Pigs; Heart Atria; Inhibitory Concentration 50; Lethal Dose 50; Mice; Tumor Cells, Cultured | 1999 |
Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx.
Topics: Alkaloids; Animals; Antimalarials; Chloroquine; Culture Media; Drug Resistance; Drug Synergism; Erythrocytes; Glucose; Hypoxanthine; Life Cycle Stages; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Time Factors | 2006 |
Glutathione transferase from Plasmodium falciparum--interaction with malagashanine and selected plant natural products.
Topics: Alkaloids; Biological Products; Chloroquine; Coumarins; Curcumin; Dinitrochlorobenzene; Drug Discovery; Drug Resistance; Ellagic Acid; Enzyme Inhibitors; Glutathione; Glutathione Transferase; Kinetics; Malaria, Falciparum; Plants, Medicinal; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins; Sesquiterpenes, Germacrane | 2010 |