macroline and indole

macroline has been researched along with indole* in 1 studies

Other Studies

1 other study(ies) available for macroline and indole

ArticleYear
Biology-oriented combined solid- and solution-phase synthesis of a macroline-like compound collection.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2009, Nov-09, Volume: 15, Issue:44

    Macrolines constitute a class of natural products that has more than 100 members and displays diverse biological activities. These compounds feature a cycloocta[b]indole scaffold that represents an interesting target structure for biology-oriented synthesis (BIOS). We have presented a solid-phase synthesis of isomerically pure cycloocta[b]indoles by employing the Pictet-Spengler reaction and the Dieckmann cyclization as key steps. The scope of this reaction sequence was investigated in more detail by using various additional diversification procedures, such as Pd-catalyzed Sonogashira or Suzuki couplings on a solid phase, thus allowing, for example, the generation of 10-substituted cycloocta[b]indole derivatives. Finally, solution-phase decoration of the cycloocta[b]indole skeleton by reduction and saponification was evaluated, thereby further extending the scope of the solid-phase synthesis.

    Topics: Indole Alkaloids; Indoles; Oxindoles; Solutions; Stereoisomerism; Substrate Specificity

2009