macrocarpal-a and verlukast

macrocarpal-a has been researched along with verlukast* in 1 studies

Other Studies

1 other study(ies) available for macrocarpal-a and verlukast

Article	Year
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model. Bioorganic & medicinal chemistry letters, 2007, Feb-15, Volume: 17, Issue:4 The uptake and transepithelial transport of the three main constituents macrocarpal A (M-A), macrocarpal B (M-B), and cypellocarpa C (Cy-C) from the fruits of Eucalyptus globulus Labill. were investigated. Monolayers of the human intestinal epithelial cancer cell line Caco-2 were incubated with M-A, M-B, and Cy-C to model its intestinal absorption and transport, respectively. The determination of compounds was performed by HPLC. The apparent permeability coefficients (P(app)) for M-A, M-B, and Cy-C in the apical-to-basolateral direction of a Caco-2 monolayer were (1.70+/-0.06)x10(-6), (1.99+/-0.10)x10(-6), and (6.08+/-0.41)x10(-6)cm/s, respectively. In the presence of iodoacetamide, the P(app) of Cy-C were both reducted in apical-to-basolateral and basolateral-to-apical directions. M-A and M-B appear to accumulate in the epithelial cells. The intestinal absorption of M-A, M-B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent. Topics: Alkylating Agents; Antiviral Agents; Biological Availability; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Eucalyptus; Fruit; Humans; Intestinal Absorption; Iodoacetamide; Phloroglucinol; Propionates; Quinolines; Sesquiterpenes; Verapamil	2007

Article

Year

Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.

Bioorganic & medicinal chemistry letters, 2007, Feb-15, Volume: 17, Issue:4

The uptake and transepithelial transport of the three main constituents macrocarpal A (M-A), macrocarpal B (M-B), and cypellocarpa C (Cy-C) from the fruits of Eucalyptus globulus Labill. were investigated. Monolayers of the human intestinal epithelial cancer cell line Caco-2 were incubated with M-A, M-B, and Cy-C to model its intestinal absorption and transport, respectively. The determination of compounds was performed by HPLC. The apparent permeability coefficients (P(app)) for M-A, M-B, and Cy-C in the apical-to-basolateral direction of a Caco-2 monolayer were (1.70+/-0.06)x10(-6), (1.99+/-0.10)x10(-6), and (6.08+/-0.41)x10(-6)cm/s, respectively. In the presence of iodoacetamide, the P(app) of Cy-C were both reducted in apical-to-basolateral and basolateral-to-apical directions. M-A and M-B appear to accumulate in the epithelial cells. The intestinal absorption of M-A, M-B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.

Topics: Alkylating Agents; Antiviral Agents; Biological Availability; Caco-2 Cells; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Eucalyptus; Fruit; Humans; Intestinal Absorption; Iodoacetamide; Phloroglucinol; Propionates; Quinolines; Sesquiterpenes; Verapamil

2007