macimorelin and 1-2-4-triazole

macimorelin has been researched along with 1-2-4-triazole* in 1 studies

Other Studies

1 other study(ies) available for macimorelin and 1-2-4-triazole

Article	Year
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center. Bioorganic & medicinal chemistry letters, 2016, 05-15, Volume: 26, Issue:10 Introducing a second chiral center on our previously described 1,2,4-triazole, allowed us to increase diversity and elongate the 'C-terminal part' of the molecule. Therefore, we were able to explore mimics of the substance P analogs described as inverse agonists. Some compounds presented affinities in the nanomolar range and potent biological activities, while one exhibited a partial inverse agonist behavior similar to a Substance P analog. Topics: Fluorescence Resonance Energy Transfer; Indoles; Inhibitory Concentration 50; Ligands; Receptors, Ghrelin; Structure-Activity Relationship; Substance P; Triazoles; Tryptophan	2016

Article

Year

New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.

Bioorganic & medicinal chemistry letters, 2016, 05-15, Volume: 26, Issue:10

Introducing a second chiral center on our previously described 1,2,4-triazole, allowed us to increase diversity and elongate the 'C-terminal part' of the molecule. Therefore, we were able to explore mimics of the substance P analogs described as inverse agonists. Some compounds presented affinities in the nanomolar range and potent biological activities, while one exhibited a partial inverse agonist behavior similar to a Substance P analog.

Topics: Fluorescence Resonance Energy Transfer; Indoles; Inhibitory Concentration 50; Ligands; Receptors, Ghrelin; Structure-Activity Relationship; Substance P; Triazoles; Tryptophan

2016