m 79175 has been researched along with sorbinil in 16 studies
| Studies (m 79175) | Trials (m 79175) | Recent Studies (post-2010) (m 79175) | Studies (sorbinil) | Trials (sorbinil) | Recent Studies (post-2010) (sorbinil) |
|---|---|---|---|---|---|
| 43 | 0 | 1 | 500 | 44 | 43 |
| Protein | Taxonomy | m 79175 (IC50) | sorbinil (IC50) |
|---|---|---|---|
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | 5.05 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.8698 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.5 | |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | 5.1333 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 1.3166 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 3.04 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 1.7292 | |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | 2.95 | |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | 0.8845 | |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | 1.1 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, MJ; Tsui, JY; Unakar, NJ | 1 |
| Kador, PF; Sato, S; Takahashi, Y; Wyman, M | 2 |
| Akagi, Y; Kador, PF | 1 |
| Akagi, Y; Ikebe, H; Kador, PF; Kinoshita, JH; Takahashi, Y; Wyman, M | 1 |
| Johnson, M; Tsui, J; Unakar, N | 1 |
| Poulsom, R | 4 |
| Hotta, N; Sakamoto, N | 1 |
| Akagi, Y; Ikebe, H; Kador, PF; Kinoshita, JH; Terubayashi, H | 1 |
| Akagi, Y; Kador, PF; Kinoshita, JH; Terubayashi, H; Wyman, M | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
| Anthony, P; Johnson, M; Tsui, J; Unakar, NJ | 1 |
| Augustin, W; Kador, PF; Takahashi, Y; Wyman, M | 1 |
2 review(s) available for m 79175 and sorbinil
| Article | Year |
|---|---|
[Clinical application of aldose reductase inhibitors--prevention and therapy of diabetic complications].
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Humans; Imidazoles; Imidazolidines; L-Iditol 2-Dehydrogenase; Naphthalenes; Phthalazines; Sugar Alcohol Dehydrogenases | 1987 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
14 other study(ies) available for m 79175 and sorbinil
| Article | Year |
|---|---|
Effect of aldose reductase inhibitors on lenticular dulcitol level in galactose fed rats.
Topics: Aldehyde Reductase; Animals; Cataract; Dietary Carbohydrates; Galactitol; Galactose; Imidazoles; Imidazolidines; Lens, Crystalline; Rats; Rats, Sprague-Dawley | 1992 |
Progression of sugar cataract in the dog.
Topics: Aldehyde Reductase; Animals; Cataract; Dietary Carbohydrates; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Galactose; Humans; Imidazoles; Imidazolidines; Lens, Crystalline; Photography; Random Allocation; Rats; Rats, Inbred Strains | 1991 |
Effect of aldose reductase inhibitors on the progression of retinopathy in galactose-fed dogs.
Topics: Aldehyde Reductase; Animals; Diabetic Retinopathy; Dietary Carbohydrates; Dogs; Galactose; Imidazoles; Imidazolidines; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1990 |
Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors.
Topics: Aldehyde Reductase; Aneurysm; Animals; Capillaries; Diabetic Retinopathy; Dogs; Dose-Response Relationship, Drug; Female; Galactitol; Galactose; Imidazoles; Imidazolidines; Lens, Crystalline; Male; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1990 |
Aldose reductase inhibitors and prevention of galactose cataracts in rats.
Topics: Aldehyde Reductase; Animals; Cataract; Galactose; Imidazoles; Imidazolidines; Lens, Crystalline; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Sugar Alcohol Dehydrogenases; Time Factors | 1989 |
Inhibition of hexonate dehydrogenase and aldose reductase from bovine retina by sorbinil, statil, M79175 and valproate.
Topics: Aldehyde Reductase; Animals; Carbohydrate Dehydrogenases; Cattle; Imidazoles; Imidazolidines; In Vitro Techniques; Kinetics; Male; Molecular Conformation; Phthalazines; Pyridazines; Retina; Sugar Alcohol Dehydrogenases; Valproic Acid; Vitamin K | 1986 |
Inhibition of aldose reductase from human retina.
Topics: Aged; Aldehyde Reductase; Chemical Fractionation; Chromatography; Humans; Imidazoles; Imidazolidines; Middle Aged; Phthalazines; Retina; Sugar Alcohol Dehydrogenases | 1987 |
Comparison of aldose reductase inhibitors in vitro. Effects of enzyme purification and substrate type.
Topics: Aldehyde Reductase; Animals; Benzaldehydes; Cattle; Glucose; Imidazoles; Imidazolidines; Lens, Crystalline; Phthalazines; Sugar Alcohol Dehydrogenases | 1987 |
Aldose reductases from human retina and bovine lens: dependence of inhibition upon the choice of enzyme substrate.
Topics: Aldehyde Reductase; Animals; Cattle; Female; Humans; Imidazoles; Imidazolidines; Kinetics; Lens, Crystalline; Male; Phthalazines; Quercetin; Retina; Substrate Specificity; Sugar Alcohol Dehydrogenases | 1987 |
[Prevention of pericyte ghost formation in retinal capillaries by aldose reductase inhibitor in galactose-fed dogs with diabetic retinopathy].
Topics: Aldehyde Reductase; Animals; Capillaries; Diabetic Retinopathy; Dogs; Galactose; Imidazoles; Imidazolidines; Male; Retinal Vessels; Sugar Alcohol Dehydrogenases | 1988 |
Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors.
Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dogs; Imidazoles; Imidazolidines; Male; Retinal Vessels | 1988 |
Amelioration of diabetes-like retinal changes in galactose-fed dogs.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Retinopathy; Dogs; Dose-Response Relationship, Drug; Galactose; Imidazoles; Imidazolidines; Male; Retina; Retinal Vessels | 1994 |
Aldose reductase inhibitors and galactose toxicity in neonatal and maternal rat lenses.
Topics: Aldehyde Reductase; Animals; Animals, Newborn; Cataract; Female; Galactitol; Galactose; Imidazoles; Imidazolidines; Lens, Crystalline; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Quantitative analysis of retinal vessel changes in galactose-fed dogs.
Topics: Aldehyde Reductase; Animals; Cataract; Cell Count; Diabetic Retinopathy; Dogs; Endothelium, Vascular; Galactose; Image Processing, Computer-Assisted; Imidazoles; Imidazolidines; Male; Retinal Vessels | 1993 |